Reviewed, UniProtKB/Swiss-Prot P17948 (VGFR1_HUMAN)

Names and origin

Protein names

Recommended name:
    Vascular endothelial growth factor receptor 1
      Short name=VEGFR-1
    EC=2.7.10.1
Alternative name(s):
    Vascular permeability factor receptor
    Tyrosine-protein kinase receptor FLT
    Flt-1
    Tyrosine-protein kinase FRT
    Fms-like tyrosine kinase 1

Gene names

Name:	FLT1
Synonyms:	FLT, FRT

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit structure	Interacts in vitro with various phosphotyrosine-binding proteins, including PLC-gammas, PTPN11, GRB2, CRK and NCK1.
Subcellular location	Isoform Flt1: Cell membrane; Single-pass type I membrane protein. Isoform sFlt1: Secreted.
Tissue specificity	Mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. It is not expressed in tumor cell lines. Isoform sFlt1 is strongly expressed in placenta.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. Contains 7 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Angiogenesis Differentiation
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Developmental protein Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW female pregnancy Traceable author statement. Source: ProtInc positive regulation of cell proliferation Traceable author statement. Source: ProtInc positive regulation of vascular endothelial growth factor receptor signaling pathway Inferred from direct assay. Source: UniProtKB protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase signaling pathway Ref.1 Traceable author statement. Source: ProtInc
Cellular component	extracellular space Ref.3 Traceable author statement. Source: ProtInc integral to plasma membrane Ref.3 Traceable author statement. Source: ProtInc
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW growth factor binding Inferred from physical interaction. Source: UniProtKB vascular endothelial growth factor receptor activity Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform Flt1 (identifier: P17948-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform sFlt1 (identifier: P17948-2)

The sequence of this isoform differs from the canonical sequence as follows:
     657-687: DQEAPYLLRNLSDHTVAISSSTTLDCHANGV → GEHCNKKAVFSRISKFKSTRNDCTTQSNVKH
     688-1338: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 26

26

Chain

27 – 1338

1312

Vascular endothelial growth factor receptor 1

PRO_0000016768

Regions

Topological domain

27 – 758

732

Extracellular Potential

Transmembrane

759 – 780

22

Potential

Topological domain

781 – 1338

558

Cytoplasmic Potential

Domain

32 – 123

92

Ig-like C2-type 1

Domain

151 – 214

64

Ig-like C2-type 2

Domain

230 – 327

98

Ig-like C2-type 3

Domain

335 – 421

87

Ig-like C2-type 4

Domain

428 – 553

126

Ig-like C2-type 5

Domain

556 – 654

99

Ig-like C2-type 6

Domain

661 – 747

87

Ig-like C2-type 7

Domain

827 – 1158

332

Protein kinase

Nucleotide binding

833 – 841

9

ATP By similarity

Sites

Active site

1022

1

Proton acceptor By similarity

Binding site

861

1

ATP By similarity

Amino acid modifications

Modified residue

1048

1

Phosphotyrosine Ref.7

Modified residue

1053

1

Phosphotyrosine; by autocatalysis By similarity

Modified residue

1169

1

Phosphotyrosine; by autocatalysis By similarity

Modified residue

1213

1

Phosphotyrosine; by autocatalysis Ref.6

Modified residue

1242

1

Phosphotyrosine; by autocatalysis Ref.6

Modified residue

1327

1

Phosphotyrosine; by autocatalysis Ref.6

Modified residue

1333

1

Phosphotyrosine; by autocatalysis Ref.6

Glycosylation

100

1

N-linked (GlcNAc...) Potential

Glycosylation

164

1

N-linked (GlcNAc...) Potential

Glycosylation

196

1

N-linked (GlcNAc...) Potential

Glycosylation

251

1

N-linked (GlcNAc...) Potential

Glycosylation

323

1

N-linked (GlcNAc...) Potential

Glycosylation

402

1

N-linked (GlcNAc...) Potential

Glycosylation

417

1

N-linked (GlcNAc...) Potential

Glycosylation

474

1

N-linked (GlcNAc...) Potential

Glycosylation

547

1

N-linked (GlcNAc...) Potential

Glycosylation

597

1

N-linked (GlcNAc...) Potential

Glycosylation

620

1

N-linked (GlcNAc...) Potential

Glycosylation

625

1

N-linked (GlcNAc...) Potential

Glycosylation

666

1

N-linked (GlcNAc...) Potential

Disulfide bond

53 ↔ 107

Potential

Disulfide bond

158 ↔ 207

Disulfide bond

252 ↔ 311

Potential

Disulfide bond

454 ↔ 535

Potential

Disulfide bond

577 ↔ 636

Potential

Disulfide bond

682 ↔ 731

Potential

Natural variations

Alternative sequence

657 – 687

31

DQEAP…HANGV → GEHCNKKAVFSRISKFKSTR NDCTTQSNVKH in isoform sFlt1.

VSP_002955

Alternative sequence

688 – 1338

651

Missing in isoform sFlt1.

VSP_002956

Natural variant

60

1

K → T Ref.9

VAR_042045

Natural variant

128

1

I → L: dbSNP rs35073261.

VAR_049719

Natural variant

144

1

E → K Ref.9

VAR_042046

Natural variant

281

1

R → Q Ref.9

VAR_042047

Natural variant

422

1

L → I in a lung adenocarcinoma sample; somatic mutation. Ref.9

VAR_042048

Natural variant

781

1

R → Q in a glioma low grade oligodendroglioma sample; somatic mutation. Ref.9

VAR_042049

Natural variant

938

1

M → V Ref.9

VAR_042050

Natural variant

982

1

E → A: dbSNP rs35832528. Ref.9

VAR_042051

Natural variant

1061

1

L → V in a bladder transitional cell carcinoma sample; somatic mutation. Ref.9

VAR_042052

Experimental info

Mutagenesis

914

1

Y → F: No loss of phosphorylation. Ref.6

Mutagenesis

1213

1

Y → F: Loss of phosphorylation. Ref.6

Mutagenesis

1242

1

Y → F: Loss of phosphorylation. Ref.6

Mutagenesis

1327

1

Y → F: Loss of phosphorylation. Ref.6

Mutagenesis

1333

1

Y → F: Loss of phosphorylation. Ref.6

Sequence conflict

490

1

F → S in AAC16449. Ref.2

Sequence conflict

779

1

F → L in CAA35946. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1338

Helix Strand Turn

Details...

Beta strand

135 – 137

3

Beta strand

144 – 148

5

Beta strand

154 – 156

3

Beta strand

168 – 171

4

Turn

172 – 174

3

Beta strand

175 – 177

3

Beta strand

181 – 187

7

Turn

188 – 190

3

Beta strand

191 – 196

6

Helix

199 – 201

3

Beta strand

203 – 211

9

Beta strand

214 – 224

11

Sequences

	Sequence		Length	Mass (Da)
	Isoform Flt1 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: FF3381EEFAF0787C	FASTA	1,338	150,769
	10 20 30 40 50 60 MVSYWDTGVL LCALLSCLLL TGSSSGSKLK DPELSLKGTQ HIMQAGQTLH LQCRGEAAHK 70 80 90 100 110 120 WSLPEMVSKE SERLSITKSA CGRNGKQFCS TLTLNTAQAN HTGFYSCKYL AVPTSKKKET 130 140 150 160 170 180 ESAIYIFISD TGRPFVEMYS EIPEIIHMTE GRELVIPCRV TSPNITVTLK KFPLDTLIPD 190 200 210 220 230 240 GKRIIWDSRK GFIISNATYK EIGLLTCEAT VNGHLYKTNY LTHRQTNTII DVQISTPRPV 250 260 270 280 290 300 KLLRGHTLVL NCTATTPLNT RVQMTWSYPD EKNKRASVRR RIDQSNSHAN IFYSVLTIDK 310 320 330 340 350 360 MQNKDKGLYT CRVRSGPSFK SVNTSVHIYD KAFITVKHRK QQVLETVAGK RSYRLSMKVK 370 380 390 400 410 420 AFPSPEVVWL KDGLPATEKS ARYLTRGYSL IIKDVTEEDA GNYTILLSIK QSNVFKNLTA 430 440 450 460 470 480 TLIVNVKPQI YEKAVSSFPD PALYPLGSRQ ILTCTAYGIP QPTIKWFWHP CNHNHSEARC 490 500 510 520 530 540 DFCSNNEESF ILDADSNMGN RIESITQRMA IIEGKNKMAS TLVVADSRIS GIYICIASNK 550 560 570 580 590 600 VGTVGRNISF YITDVPNGFH VNLEKMPTEG EDLKLSCTVN KFLYRDVTWI LLRTVNNRTM 610 620 630 640 650 660 HYSISKQKMA ITKEHSITLN LTIMNVSLQD SGTYACRARN VYTGEEILQK KEITIRDQEA 670 680 690 700 710 720 PYLLRNLSDH TVAISSSTTL DCHANGVPEP QITWFKNNHK IQQEPGIILG PGSSTLFIER 730 740 750 760 770 780 VTEEDEGVYH CKATNQKGSV ESSAYLTVQG TSDKSNLELI TLTCTCVAAT LFWLLLTLFI 790 800 810 820 830 840 RKMKRSSSEI KTDYLSIIMD PDEVPLDEQC ERLPYDASKW EFARERLKLG KSLGRGAFGK 850 860 870 880 890 900 VVQASAFGIK KSPTCRTVAV KMLKEGATAS EYKALMTELK ILTHIGHHLN VVNLLGACTK 910 920 930 940 950 960 QGGPLMVIVE YCKYGNLSNY LKSKRDLFFL NKDAALHMEP KKEKMEPGLE QGKKPRLDSV 970 980 990 1000 1010 1020 TSSESFASSG FQEDKSLSDV EEEEDSDGFY KEPITMEDLI SYSFQVARGM EFLSSRKCIH 1030 1040 1050 1060 1070 1080 RDLAARNILL SENNVVKICD FGLARDIYKN PDYVRKGDTR LPLKWMAPES IFDKIYSTKS 1090 1100 1110 1120 1130 1140 DVWSYGVLLW EIFSLGGSPY PGVQMDEDFC SRLREGMRMR APEYSTPEIY QIMLDCWHRD 1150 1160 1170 1180 1190 1200 PKERPRFAEL VEKLGDLLQA NVQQDGKDYI PINAILTGNS GFTYSTPAFS EDFFKESISA 1210 1220 1230 1240 1250 1260 PKFNSGSSDD VRYVNAFKFM SLERIKTFEE LLPNATSMFD DYQGDSSTLL ASPMLKRFTW 1270 1280 1290 1300 1310 1320 TDSKPKASLK IDLRVTSKSK ESGLSDVSRP SFCHSSCGHV SEGKRRFTYD HAELERKIAC 1330 CSPPPDYNSV VLYSTPPI
	Isoform sFlt1. Checksum: 3F73F4942469DA36	FASTA	687	77,474
	10 20 30 40 50 60 MVSYWDTGVL LCALLSCLLL TGSSSGSKLK DPELSLKGTQ HIMQAGQTLH LQCRGEAAHK 70 80 90 100 110 120 WSLPEMVSKE SERLSITKSA CGRNGKQFCS TLTLNTAQAN HTGFYSCKYL AVPTSKKKET 130 140 150 160 170 180 ESAIYIFISD TGRPFVEMYS EIPEIIHMTE GRELVIPCRV TSPNITVTLK KFPLDTLIPD 190 200 210 220 230 240 GKRIIWDSRK GFIISNATYK EIGLLTCEAT VNGHLYKTNY LTHRQTNTII DVQISTPRPV 250 260 270 280 290 300 KLLRGHTLVL NCTATTPLNT RVQMTWSYPD EKNKRASVRR RIDQSNSHAN IFYSVLTIDK 310 320 330 340 350 360 MQNKDKGLYT CRVRSGPSFK SVNTSVHIYD KAFITVKHRK QQVLETVAGK RSYRLSMKVK 370 380 390 400 410 420 AFPSPEVVWL KDGLPATEKS ARYLTRGYSL IIKDVTEEDA GNYTILLSIK QSNVFKNLTA 430 440 450 460 470 480 TLIVNVKPQI YEKAVSSFPD PALYPLGSRQ ILTCTAYGIP QPTIKWFWHP CNHNHSEARC 490 500 510 520 530 540 DFCSNNEESF ILDADSNMGN RIESITQRMA IIEGKNKMAS TLVVADSRIS GIYICIASNK 550 560 570 580 590 600 VGTVGRNISF YITDVPNGFH VNLEKMPTEG EDLKLSCTVN KFLYRDVTWI LLRTVNNRTM 610 620 630 640 650 660 HYSISKQKMA ITKEHSITLN LTIMNVSLQD SGTYACRARN VYTGEEILQK KEITIRGEHC 670 680 NKKAVFSRIS KFKSTRNDCT TQSNVKH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family." Shibuya M., Yamaguchi S., Yamane A., Ikeda T., Tojo A., Matsushime H., Sato M. Oncogene 5:519-524(1990) [PubMed: 2158038] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FLT1). Tissue: Placenta.
[2]	"Coding region for human VEGF receptor FLT1 (VEGFR-1)." Yu Y., Whitney R.G., Sato J.D. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM FLT1). Tissue: Umbilical vein.
[3]	"Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor." Kendall R.L., Thomas K.A. Proc. Natl. Acad. Sci. U.S.A. 90:10705-10709(1993) [PubMed: 8248162] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SFLT1), PROTEIN SEQUENCE OF N-TERMINUS. Tissue: Umbilical vein.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SFLT1). Tissue: Ovary.
[5]	"A possible new member of tyrosine kinase family, human frt sequence, is highly conserved in vertebrates and located on human chromosome 13." Matsushime H., Yoshida M.C., Sasaki M., Shibuya M. Jpn. J. Cancer Res. 78:655-661(1987) [PubMed: 3040650] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1018-1058 (ISOFORM FLT1).
[6]	"Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules." Ito N., Wernstedt C., Engstrom U., Claesson-Welsh L. J. Biol. Chem. 273:23410-23418(1998) [PubMed: 9722576] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE, PHOSPHORYLATION AT TYR-1213; TYR-1242; TYR-1327 AND TYR-1333, MUTAGENESIS OF TYR-914; TYR-1213; TYR-1242; TYR-1327 AND TYR-1333.
[7]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1048 AND TYR-1053, MASS SPECTROMETRY.
[8]	"Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states." Starovasnik M.A., Christinger H.W., Wiesmann C., Champe M.A., de Vos A.M., Skelton N.J. J. Mol. Biol. 293:531-544(1999) [PubMed: 10543948] [Abstract] Cited for: STRUCTURE BY NMR OF 129-229.
[9]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-60; LYS-144; GLN-281; ILE-422; GLN-781; VAL-938; ALA-982 AND VAL-1061.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

X51602 mRNA. Translation: CAA35946.1.
AF063657 mRNA. Translation: AAC16449.2.
U01134 mRNA. Translation: AAC50060.1.
BC039007 mRNA. Translation: AAH39007.1.
D00133 Genomic DNA. Translation: BAA00080.1.

IPI

IPI00018335.
IPI00216043.

PIR

A49636.
S09982.

RefSeq

NP_002010.2.

UniGene

Hs.654360

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1FLT	X-ray	1.70	X/Y	132-226	[»]
1QSV	NMR	-	A	129-229	[»]
1QSZ	NMR	-	A	129-229	[»]
1QTY	X-ray	2.70	T/U/X/Y	129-229	[»]
1RV6	X-ray	2.45	X/Y	130-229	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:643N.

PTM databases

PhosphoSite

P17948.

Proteomic databases

PRIDE

P17948.

Genome annotation databases

Ensembl

ENSG00000102755. Homo sapiens. [Contig view]

GeneID

2321.

KEGG

hsa:2321.

Organism-specific databases

GeneCards

GC13M027773.

H-InvDB

HIX0026543.
HIX0037569.

HGNC

HGNC:3763. FLT1.

MIM

165070. gene.

PharmGKB

PA28180.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

P17948.

HOVERGEN

P17948.

OMA

P17948. DYNSVVL.

Enzyme and pathway databases

BRENDA

2.7.10.1. 247.

Pathway_Interaction_DB

glypican_1pathway. Glypican 1 network.
s1p_s1p3_pathway. S1P3 pathway.
vegfr1_2_pathway. Signaling events mediated by VEGFR1 and VEGFR2.
vegfr1_pathway. VEGFR1 specific signals.

Reactome

REACT_12529. Signaling by VEGF.

Gene expression databases

ArrayExpress

P17948.

Bgee

P17948.

CleanEx

HS_FLT1.

GermOnline

ENSG00000102755. Homo sapiens.

Family and domain databases

InterPro

IPR013151. Ig.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR001824. Recept_tyr_kinase-III_CS.
IPR001245. Tyr_pkinase.
IPR008266. Tyr_pkinase_AS.
IPR009135. VEGFR1_N.
IPR009134. VEGFR_N.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 6 hits.

Pfam

PF07679. I-set. 2 hits.
PF00047. ig. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]

PRINTS

PR01832. VEGFRECEPTOR.
PR01833. VEGFRECEPTR1.

ProDom

PD000001. Prot_kinase. 2 hits.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00409. IG. 5 hits.
SM00408. IGc2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 6 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

DrugBank

DB01268. Sunitinib.

NextBio

9421.

SOURCE

Search...

Entry information

Entry name

VGFR1_HUMAN

Accession

Primary (citable) accession number: P17948
Secondary accession number(s): O60722, P16057, Q12954

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	April 3, 2007
Last modified:	June 16, 2009
This is version 120 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)