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Protein

Hepatocyte growth factor

Gene

Hgf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity).By similarity

GO - Molecular functioni

  • chemoattractant activity Source: Ensembl
  • growth factor activity Source: RGD
  • protein heterodimerization activity Source: RGD
  • serine-type endopeptidase activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Serine protease homolog

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.

Protein family/group databases

MEROPSiS01.978.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte growth factor
Alternative name(s):
Hepatopoietin-A
Scatter factor
Short name:
SF
Cleaved into the following 2 chains:
Gene namesi
Name:Hgf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2794. Hgf.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232By similarityAdd
BLAST
Chaini33 – 495463Hepatocyte growth factor alpha chainPRO_0000028095Add
BLAST
Chaini496 – 728233Hepatocyte growth factor beta chainPRO_0000028096Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331Pyrrolidone carboxylic acidBy similarity
Disulfide bondi71 ↔ 97By similarity
Disulfide bondi75 ↔ 85By similarity
Disulfide bondi129 ↔ 207By similarity
Disulfide bondi150 ↔ 190By similarity
Disulfide bondi178 ↔ 202By similarity
Disulfide bondi212 ↔ 289By similarity
Disulfide bondi233 ↔ 272By similarity
Disulfide bondi261 ↔ 284By similarity
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence analysis
Disulfide bondi306 ↔ 384By similarity
Disulfide bondi327 ↔ 366By similarity
Disulfide bondi355 ↔ 378By similarity
Disulfide bondi392 ↔ 470By similarity
Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi413 ↔ 453By similarity
Disulfide bondi441 ↔ 465By similarity
Disulfide bondi488 ↔ 607Interchain (between alpha and beta chains)PROSITE-ProRule annotation
Disulfide bondi520 ↔ 536By similarity
Glycosylationi569 – 5691N-linked (GlcNAc...)Sequence analysis
Disulfide bondi615 ↔ 682By similarity
Disulfide bondi645 ↔ 661By similarity
Glycosylationi656 – 6561N-linked (GlcNAc...)Sequence analysis
Disulfide bondi672 ↔ 700By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP17945.
PRIDEiP17945.

Miscellaneous databases

PMAP-CutDBP17945.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007027.
GenevisibleiP17945. RN.

Interactioni

Subunit structurei

Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.

GO - Molecular functioni

  • growth factor activity Source: RGD
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

BioGridi246610. 2 interactions.
MINTiMINT-219643.
STRINGi10116.ENSRNOP00000009764.

Structurei

3D structure databases

ProteinModelPortaliP17945.
SMRiP17945. Positions 39-210, 496-725.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 12487PANPROSITE-ProRule annotationAdd
BLAST
Domaini129 – 20779Kringle 1PROSITE-ProRule annotationAdd
BLAST
Domaini212 – 28978Kringle 2PROSITE-ProRule annotationAdd
BLAST
Domaini306 – 38479Kringle 3PROSITE-ProRule annotationAdd
BLAST
Domaini392 – 47079Kringle 4PROSITE-ProRule annotationAdd
BLAST
Domaini496 – 724229Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Plasminogen subfamily.PROSITE-ProRule annotation
Contains 4 kringle domains.PROSITE-ProRule annotation
Contains 1 PAN domain.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IDXR. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119133.
HOGENOMiHOG000112892.
HOVERGENiHBG004381.
InParanoidiP17945.
KOiK05460.
OMAiGSESPWC.
OrthoDBiEOG091G0AH5.
PhylomeDBiP17945.
TreeFamiTF329901.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR027284. Hepatocyte_GF.
IPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
[Graphical view]
PfamiPF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF500183. Hepatocyte_GF. 1 hit.
PIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiPS00021. KRINGLE_1. 4 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMWGTKLLPV LLLQHVLLHL LLLPVTIPYA EGQKKRRNTL HEFKKSAKTT
60 70 80 90 100
LTKEDPLVKI KTKKVNSADE CANRCIRNKG FPFTCKAFVF DKSRKRCYWY
110 120 130 140 150
PFNSMSSGVK KGFGHEFDLY ENKDYIRNCI IGKGGSYKGT VSITKSGIKC
160 170 180 190 200
QPWNSMIPHE HSFLPSSYRG KDLQENYCRN PRGEEGGPWC FTSNPEVRYE
210 220 230 240 250
VCDIPQCSEV ECMTCNGESY RGPMDHTESG KTCQRWDQQT PHRHKFLPER
260 270 280 290 300
YPDKGFDDNY CRNPDGKPRP WCYTLDPDTP WEYCAIKMCA HSAVNETDVP
310 320 330 340 350
METTECIKGQ GEGYRGTTNT IWNGIPCQRW DSQYPHKHDI TPENFKCKDL
360 370 380 390 400
RENYCRNPDG AESPWCFTTD PNIRVGYCSQ IPKCDVSSGQ DCYRGNGKNY
410 420 430 440 450
MGNLSKTRSG LTCSMWDKNM EDLHRHIFWE PDASKLTKNY CRNPDDDAHG
460 470 480 490 500
PWCYTGNPLV PWDYCPISRC EGDTTPTIVN LDHPVISCAK TKQLRVVNGI
510 520 530 540 550
PTQTTVGWMV SLKYRNKHIC GGSLIKESWV LTARQCFPAR NKDLKDYEAW
560 570 580 590 600
LGIHDVHERG EEKRKQILNI SQLVYGPEGS DLVLLKLARP AILDNFVSTI
610 620 630 640 650
DLPSYGCTIP EKTTCSIYGW GYTGLINADG LLRVAHLYIM GNEKCSQHHQ
660 670 680 690 700
GKVTLNESEL CAGAEKIGSG PCEGDYGGPL ICEQHKMRMV LGVIVPGRGC
710 720
AIPNRPGIFV RVAYYAKWIH KVILTYKL
Length:728
Mass (Da):82,906
Last modified:November 1, 1990 - v1
Checksum:i3E0BF1F96ADCEDFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90102 mRNA. Translation: BAA14133.1.
X54400 mRNA. Translation: CAA38266.1.
PIRiA35644.
RefSeqiNP_058713.1. NM_017017.2.
UniGeneiRn.10468.

Genome annotation databases

EnsembliENSRNOT00000009763; ENSRNOP00000009764; ENSRNOG00000007027.
GeneIDi24446.
KEGGirno:24446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90102 mRNA. Translation: BAA14133.1.
X54400 mRNA. Translation: CAA38266.1.
PIRiA35644.
RefSeqiNP_058713.1. NM_017017.2.
UniGeneiRn.10468.

3D structure databases

ProteinModelPortaliP17945.
SMRiP17945. Positions 39-210, 496-725.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246610. 2 interactions.
MINTiMINT-219643.
STRINGi10116.ENSRNOP00000009764.

Protein family/group databases

MEROPSiS01.978.

Proteomic databases

PaxDbiP17945.
PRIDEiP17945.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009763; ENSRNOP00000009764; ENSRNOG00000007027.
GeneIDi24446.
KEGGirno:24446.

Organism-specific databases

CTDi3082.
RGDi2794. Hgf.

Phylogenomic databases

eggNOGiENOG410IDXR. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000119133.
HOGENOMiHOG000112892.
HOVERGENiHBG004381.
InParanoidiP17945.
KOiK05460.
OMAiGSESPWC.
OrthoDBiEOG091G0AH5.
PhylomeDBiP17945.
TreeFamiTF329901.

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.

Miscellaneous databases

PMAP-CutDBP17945.
PROiP17945.

Gene expression databases

BgeeiENSRNOG00000007027.
GenevisibleiP17945. RN.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR027284. Hepatocyte_GF.
IPR024174. HGF-like.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
[Graphical view]
PfamiPF00051. Kringle. 4 hits.
PF00024. PAN_1. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF500183. Hepatocyte_GF. 1 hit.
PIRSF001152. HGF_MST1. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00130. KR. 4 hits.
SM00473. PAN_AP. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 4 hits.
PROSITEiPS00021. KRINGLE_1. 4 hits.
PS50070. KRINGLE_2. 4 hits.
PS50948. PAN. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHGF_RAT
AccessioniPrimary (citable) accession number: P17945
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 7, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Has lost two of the three essential catalytic residues and so probably has no enzymatic activity.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.