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P17931 (LEG3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 172. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galectin-3

Short name=Gal-3
Alternative name(s):
35 kDa lectin
Carbohydrate-binding protein 35
Short name=CBP 35
Galactose-specific lectin 3
Galactoside-binding protein
Short name=GALBP
IgE-binding protein
L-31
Laminin-binding protein
Lectin L-29
Mac-2 antigen
Gene names
Name:LGALS3
Synonyms:MAC2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis By similarity. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Ref.15 Ref.16 Ref.18

Subunit structure

Probably forms homo- or heterodimers. Interacts with DMBT1 By similarity. Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA. Ref.14 Ref.15

Subcellular location

Cytoplasm. Nucleus. Secreted. Note: Secreted by a non-classical secretory pathway and associates with the cell surface. Ref.5 Ref.15 Ref.18

Tissue specificity

A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes. Ref.17

Sequence similarities

Contains 1 galectin domain.

Ontologies

Keywords
   Biological processDifferentiation
Immunity
Innate immunity
mRNA processing
mRNA splicing
   Cellular componentCytoplasm
Nucleus
Secreted
Spliceosome
   Coding sequence diversityPolymorphism
   DomainRepeat
   LigandIgE-binding protein
Lectin
   PTMAcetylation
Disulfide bond
Phosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA splicing

Inferred from electronic annotation. Source: UniProtKB-KW

eosinophil chemotaxis

Inferred from direct assay PubMed 10925302. Source: BHF-UCL

epithelial cell differentiation

Inferred from expression pattern PubMed 21492153. Source: UniProt

extracellular matrix organization

Inferred from electronic annotation. Source: Ensembl

innate immune response

Traceable author statement. Source: Reactome

mRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

macrophage chemotaxis

Inferred from direct assay PubMed 10925302. Source: BHF-UCL

monocyte chemotaxis

Inferred from direct assay PubMed 10925302. Source: BHF-UCL

mononuclear cell migration

Inferred from direct assay PubMed 10925302. Source: BHF-UCL

negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Inferred from sequence or structural similarity PubMed 19706535. Source: BHF-UCL

negative regulation of T cell receptor signaling pathway

Inferred from sequence or structural similarity PubMed 19706535. Source: BHF-UCL

negative regulation of endocytosis

Inferred from direct assay PubMed 19706535. Source: BHF-UCL

negative regulation of extrinsic apoptotic signaling pathway

Inferred from direct assay PubMed 22761016. Source: BHF-UCL

negative regulation of immunological synapse formation

Inferred from sequence or structural similarity PubMed 19706535. Source: BHF-UCL

neutrophil chemotaxis

Inferred from direct assay PubMed 10925302. Source: BHF-UCL

positive chemotaxis

Inferred from direct assay PubMed 10925302. Source: BHF-UCL

positive regulation of calcium ion import

Inferred from direct assay PubMed 10925302. Source: BHF-UCL

positive regulation of mononuclear cell migration

Inferred from direct assay PubMed 10925302. Source: BHF-UCL

regulation of T cell apoptotic process

Inferred from direct assay PubMed 8692888. Source: BHF-UCL

regulation of T cell proliferation

Inferred from mutant phenotype PubMed 8692888. Source: BHF-UCL

regulation of extrinsic apoptotic signaling pathway via death domain receptors

Inferred from mutant phenotype PubMed 8692888. Source: BHF-UCL

skeletal system development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 22761016PubMed 9447709. Source: BHF-UCL

extracellular space

Inferred from direct assay PubMed 22664934PubMed 23580065. Source: UniProt

extracellular vesicular exosome

Inferred from direct assay PubMed 19056867PubMed 19199708PubMed 23376485. Source: UniProt

immunological synapse

Inferred from direct assay PubMed 19706535. Source: BHF-UCL

mitochondrial inner membrane

Inferred from direct assay PubMed 19016746. Source: UniProtKB

nucleus

Inferred from direct assay PubMed 22761016Ref.5. Source: BHF-UCL

plasma membrane

Traceable author statement PubMed 9162064. Source: ProtInc

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: Ensembl

spliceosomal complex

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionIgE binding

Inferred from direct assay Ref.1. Source: BHF-UCL

carbohydrate binding

Traceable author statement PubMed 9162064. Source: ProtInc

chemoattractant activity

Inferred from direct assay PubMed 10925302. Source: BHF-UCL

laminin binding

Inferred from direct assay Ref.2. Source: BHF-UCL

poly(A) RNA binding

Inferred from direct assay PubMed 22658674. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 19016746. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MICAQ299832EBI-1170392,EBI-1031130

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 250249Galectin-3
PRO_0000076930

Regions

Repeat36 – 4491
Repeat45 – 5392
Repeat54 – 6293
Repeat63 – 6974; approximate
Repeat70 – 7895
Repeat79 – 88106; approximate
Repeat89 – 100127; approximate
Repeat101 – 10998; approximate
Domain118 – 248131Galectin
Region36 – 109748 X 9 AA tandem repeats of Y-P-G-X(3)-P-G-A
Region181 – 1877Beta-galactoside binding By similarity
Motif226 – 24116Nuclear export signal By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue61Phosphoserine Ref.13
Modified residue121Phosphoserine Ref.13
Disulfide bond173Interchain By similarity

Natural variations

Natural variant641P → H. Ref.1 Ref.3 Ref.12
Corresponds to variant rs4644 [ dbSNP | Ensembl ].
VAR_012988
Natural variant981T → P. Ref.1 Ref.2 Ref.3 Ref.12
Corresponds to variant rs4652 [ dbSNP | Ensembl ].
VAR_012989
Natural variant1831R → K.
Corresponds to variant rs10148371 [ dbSNP | Ensembl ].
VAR_049768

Experimental info

Sequence conflict33 – 5220AGGYP…QAPPG → QGLPRGFLSWGLPRAGTPR Ref.2
Sequence conflict881Missing Ref.2
Sequence conflict2321S → R in M64303. Ref.4

Secondary structure

....................... 250
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P17931 [UniParc].

Last modified November 25, 2008. Version 5.
Checksum: C49DDF6D67AE0C88

FASTA25026,152
        10         20         30         40         50         60 
MADNFSLHDA LSGSGNPNPQ GWPGAWGNQP AGAGGYPGAS YPGAYPGQAP PGAYPGQAPP 

        70         80         90        100        110        120 
GAYPGAPGAY PGAPAPGVYP GPPSGPGAYP SSGQPSATGA YPATGPYGAP AGPLIVPYNL 

       130        140        150        160        170        180 
PLPGGVVPRM LITILGTVKP NANRIALDFQ RGNDVAFHFN PRFNENNRRV IVCNTKLDNN 

       190        200        210        220        230        240 
WGREERQSVF PFESGKPFKI QVLVEPDHFK VAVNDAHLLQ YNHRVKKLNE ISKLGISGDI 

       250 
DLTSASYTMI 

« Hide

References

« Hide 'large scale' references
[1]"Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms."
Robertson M.W., Albrandt K., Keller D., Liu F.-T.
Biochemistry 29:8093-8100(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS HIS-64 AND PRO-98.
[2]"Molecular cloning of a human macrophage lectin specific for galactose."
Cherayil B., Chaitovitz S., Wong C., Pillai S.
Proc. Natl. Acad. Sci. U.S.A. 87:7324-7328(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-98.
Tissue: Carcinoma.
[3]"Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen."
Oda Y., Leffler H., Sakakura Y., Kasai K., Barondes S.H.
Gene 99:279-283(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS HIS-64 AND PRO-98.
[4]"Molecular cloning and chromosomal mapping of a human galactoside-binding protein."
Raz A., Carmi P., Raz T., Hogan V., Mohamed A., Wolman S.R.
Cancer Res. 51:2173-2178(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma."
Lotz M.M., Andrews C.W. Jr., Korzelius C.A., Lee E.C., Steele G.D. Jr., Clarke A., Mercurio A.M.
Proc. Natl. Acad. Sci. U.S.A. 90:3466-3470(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
[6]"The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter."
Kadrofske M.M., Openo K.P., Wang J.L.
Arch. Biochem. Biophys. 349:7-20(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"Human galectin-3 full-length cDNA."
Kato S.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Gastric adenocarcinoma.
[8]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thalamus.
[9]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[10]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[12]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-64 AND PRO-98.
Tissue: Skin.
[13]"L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I."
Huflejt M.E., Turck C.W., Lindstedt R., Barondes S.H., Leffler H.
J. Biol. Chem. 268:26712-26718(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-6 AND SER-12.
[14]"Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin."
Sasaki T., Brakebusch C., Engel J., Timpl R.
EMBO J. 17:1606-1613(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH LGALS3BP.
[15]"NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin."
Fukushi J., Makagiansar I.T., Stallcup W.B.
Mol. Biol. Cell 15:3580-3590(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ITGB1; ITGA3 AND CSPG4, SUBCELLULAR LOCATION, FUNCTION.
[16]"The regulation of inflammation by galectin-3."
Henderson N.C., Sethi T.
Immunol. Rev. 230:160-171(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN INFLAMMATION.
[17]"A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death."
Than N.G., Romero R., Goodman M., Weckle A., Xing J., Dong Z., Xu Y., Tarquini F., Szilagyi A., Gal P., Hou Z., Tarca A.L., Kim C.J., Kim J.S., Haidarian S., Uddin M., Bohn H., Benirschke K. expand/collapse author list , Santolaya-Forgas J., Grossman L.I., Erez O., Hassan S.S., Zavodszky P., Papp Z., Wildman D.E.
Proc. Natl. Acad. Sci. U.S.A. 106:9731-9736(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[18]"Dynamics of galectin-3 in the nucleus and cytoplasm."
Haudek K.C., Spronk K.J., Voss P.G., Patterson R.J., Wang J.L., Arnoys E.J.
Biochim. Biophys. Acta 1800:181-189(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, FUNCTION.
[19]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[20]"X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution."
Seetharaman J., Kanigsberg A., Slaaby R., Leffler H., Barondes S.H., Rini J.M.
J. Biol. Chem. 273:13047-13052(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 114-250.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M57710 mRNA. Translation: AAA35607.1.
M35368 mRNA. Translation: AAA88086.1.
M36682 mRNA. Translation: AAA36163.1.
M64303 mRNA. No translation available.
S59012 mRNA. Translation: AAB26229.1.
AF031425 expand/collapse EMBL AC list , AF031422, AF031423, AF031424 Genomic DNA. Translation: AAB86584.1.
AB006780 mRNA. Translation: BAA22164.1.
AK314929 mRNA. Translation: BAG37435.1.
CR456897 mRNA. Translation: CAG33178.1.
AL139316 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80658.1.
BC001120 mRNA. Translation: AAH01120.1.
BC053667 mRNA. Translation: AAH53667.1.
CCDSCCDS41956.1.
PIRA35820.
RefSeqNP_002297.2. NM_002306.3.
UniGeneHs.531081.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1A3KX-ray2.10A114-250[»]
1KJLX-ray1.40A105-250[»]
1KJRX-ray1.55A105-250[»]
2NMNX-ray2.45A113-250[»]
2NMOX-ray1.35A113-250[»]
2NN8X-ray1.35A113-250[»]
2XG3X-ray1.20A114-250[»]
3AYAX-ray2.00A/B117-250[»]
3AYCX-ray1.80A/B117-250[»]
3AYDX-ray1.90A117-250[»]
3AYEX-ray2.00A/B117-250[»]
3T1LX-ray1.60A108-250[»]
3T1MX-ray1.55A108-250[»]
3ZSJX-ray0.86A113-250[»]
3ZSKX-ray0.90A114-250[»]
3ZSLX-ray1.08A114-250[»]
3ZSMX-ray1.25A114-250[»]
4BLIX-ray1.08A114-250[»]
4BLJX-ray1.20A114-250[»]
4BM8X-ray0.96A114-250[»]
4JC1X-ray1.50A108-250[»]
4JCKX-ray1.15A108-250[»]
4LBJX-ray1.80A114-250[»]
4LBKX-ray1.60A114-250[»]
4LBLX-ray1.58A114-250[»]
4LBMX-ray1.55A112-250[»]
4LBNX-ray1.70A112-250[»]
4LBOX-ray1.65A113-250[»]
ProteinModelPortalP17931.
SMRP17931. Positions 113-250.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110149. 22 interactions.
DIPDIP-45623N.
IntActP17931. 43 interactions.
STRING9606.ENSP00000254301.

Chemistry

BindingDBP17931.
ChEMBLCHEMBL4531.

PTM databases

PhosphoSiteP17931.

Polymorphism databases

DMDM215274262.

2D gel databases

DOSAC-COBS-2DPAGEP17931.
REPRODUCTION-2DPAGEIPI00465431.
UCD-2DPAGEP17931.

Proteomic databases

MaxQBP17931.
PaxDbP17931.
PRIDEP17931.

Protocols and materials databases

DNASU3958.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254301; ENSP00000254301; ENSG00000131981.
GeneID3958.
KEGGhsa:3958.
UCSCuc001xbr.3. human.

Organism-specific databases

CTD3958.
GeneCardsGC14P055595.
HGNCHGNC:6563. LGALS3.
HPACAB005191.
HPA003162.
MIM153619. gene.
neXtProtNX_P17931.
PharmGKBPA30340.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG312075.
HOVERGENHBG006255.
InParanoidP17931.
KOK06831.
OMAQGPPGAY.
PhylomeDBP17931.
TreeFamTF315551.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressP17931.
BgeeP17931.
CleanExHS_LGALS3.
GenevestigatorP17931.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001079. Galectin_CRD.
[Graphical view]
PfamPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SMARTSM00908. Gal-bind_lectin. 1 hit.
SM00276. GLECT. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP17931.
GeneWikiLGALS3.
GenomeRNAi3958.
NextBio15531.
PMAP-CutDBQ6IBA7.
PROP17931.
SOURCESearch...

Entry information

Entry nameLEG3_HUMAN
AccessionPrimary (citable) accession number: P17931
Secondary accession number(s): B2RC38 expand/collapse secondary AC list , Q16005, Q6IBA7, Q96J47
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 172 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM