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P17931

- LEG3_HUMAN

UniProt

P17931 - LEG3_HUMAN

Protein

Galectin-3

Gene

LGALS3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 174 (01 Oct 2014)
      Sequence version 5 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis By similarity. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.By similarity3 Publications

    GO - Molecular functioni

    1. carbohydrate binding Source: ProtInc
    2. chemoattractant activity Source: BHF-UCL
    3. IgE binding Source: BHF-UCL
    4. laminin binding Source: BHF-UCL
    5. poly(A) RNA binding Source: UniProtKB
    6. protein binding Source: UniProtKB

    GO - Biological processi

    1. eosinophil chemotaxis Source: BHF-UCL
    2. epithelial cell differentiation Source: UniProt
    3. extracellular matrix organization Source: Ensembl
    4. innate immune response Source: Reactome
    5. macrophage chemotaxis Source: BHF-UCL
    6. monocyte chemotaxis Source: BHF-UCL
    7. mononuclear cell migration Source: BHF-UCL
    8. mRNA processing Source: UniProtKB-KW
    9. negative regulation of endocytosis Source: BHF-UCL
    10. negative regulation of extrinsic apoptotic signaling pathway Source: BHF-UCL
    11. negative regulation of immunological synapse formation Source: BHF-UCL
    12. negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Source: BHF-UCL
    13. negative regulation of T cell receptor signaling pathway Source: BHF-UCL
    14. neutrophil chemotaxis Source: BHF-UCL
    15. positive chemotaxis Source: BHF-UCL
    16. positive regulation of calcium ion import Source: BHF-UCL
    17. positive regulation of mononuclear cell migration Source: BHF-UCL
    18. regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
    19. regulation of T cell apoptotic process Source: BHF-UCL
    20. regulation of T cell proliferation Source: BHF-UCL
    21. RNA splicing Source: UniProtKB-KW
    22. skeletal system development Source: Ensembl

    Keywords - Biological processi

    Differentiation, Immunity, Innate immunity, mRNA processing, mRNA splicing

    Keywords - Ligandi

    IgE-binding protein, Lectin

    Enzyme and pathway databases

    ReactomeiREACT_25195. Advanced glycosylation endproduct receptor signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galectin-3
    Short name:
    Gal-3
    Alternative name(s):
    35 kDa lectin
    Carbohydrate-binding protein 35
    Short name:
    CBP 35
    Galactose-specific lectin 3
    Galactoside-binding protein
    Short name:
    GALBP
    IgE-binding protein
    L-31
    Laminin-binding protein
    Lectin L-29
    Mac-2 antigen
    Gene namesi
    Name:LGALS3
    Synonyms:MAC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:6563. LGALS3.

    Subcellular locationi

    Cytoplasm. Nucleus. Secreted
    Note: Secreted by a non-classical secretory pathway and associates with the cell surface.

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. extracellular space Source: UniProt
    3. extracellular vesicular exosome Source: UniProt
    4. immunological synapse Source: BHF-UCL
    5. membrane Source: UniProtKB
    6. mitochondrial inner membrane Source: UniProtKB
    7. nucleus Source: BHF-UCL
    8. plasma membrane Source: ProtInc
    9. proteinaceous extracellular matrix Source: Ensembl
    10. spliceosomal complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Secreted, Spliceosome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30340.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 250249Galectin-3PRO_0000076930Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei6 – 61Phosphoserine1 Publication
    Modified residuei12 – 121Phosphoserine1 Publication
    Disulfide bondi173 – 173InterchainBy similarity

    Keywords - PTMi

    Acetylation, Disulfide bond, Phosphoprotein

    Proteomic databases

    MaxQBiP17931.
    PaxDbiP17931.
    PRIDEiP17931.

    2D gel databases

    DOSAC-COBS-2DPAGEP17931.
    REPRODUCTION-2DPAGEIPI00465431.
    UCD-2DPAGEP17931.

    PTM databases

    PhosphoSiteiP17931.

    Miscellaneous databases

    PMAP-CutDBQ6IBA7.

    Expressioni

    Tissue specificityi

    A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.1 Publication

    Gene expression databases

    ArrayExpressiP17931.
    BgeeiP17931.
    CleanExiHS_LGALS3.
    GenevestigatoriP17931.

    Organism-specific databases

    HPAiCAB005191.
    HPA003162.

    Interactioni

    Subunit structurei

    Probably forms homo- or heterodimers. Interacts with DMBT1 By similarity. Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AHSGP127632EBI-1170392,EBI-9396660From a different organism.
    ALCAMQ137403EBI-1170392,EBI-1188108
    CD6P302032EBI-1170392,EBI-2873748
    MICAQ299832EBI-1170392,EBI-1031130

    Protein-protein interaction databases

    BioGridi110149. 22 interactions.
    DIPiDIP-45623N.
    IntActiP17931. 46 interactions.
    STRINGi9606.ENSP00000254301.

    Structurei

    Secondary structure

    1
    250
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi116 – 1216
    Beta strandi130 – 1389
    Beta strandi144 – 1518
    Beta strandi154 – 16512
    Beta strandi168 – 17710
    Beta strandi185 – 1873
    Beta strandi197 – 2048
    Beta strandi206 – 2138
    Beta strandi216 – 2227
    Helixi228 – 2303
    Beta strandi233 – 24917

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1A3KX-ray2.10A114-250[»]
    1KJLX-ray1.40A105-250[»]
    1KJRX-ray1.55A105-250[»]
    2NMNX-ray2.45A113-250[»]
    2NMOX-ray1.35A113-250[»]
    2NN8X-ray1.35A113-250[»]
    2XG3X-ray1.20A114-250[»]
    3AYAX-ray2.00A/B117-250[»]
    3AYCX-ray1.80A/B117-250[»]
    3AYDX-ray1.90A117-250[»]
    3AYEX-ray2.00A/B117-250[»]
    3T1LX-ray1.60A108-250[»]
    3T1MX-ray1.55A108-250[»]
    3ZSJX-ray0.86A113-250[»]
    3ZSKX-ray0.90A114-250[»]
    3ZSLX-ray1.08A114-250[»]
    3ZSMX-ray1.25A114-250[»]
    4BLIX-ray1.08A114-250[»]
    4BLJX-ray1.20A114-250[»]
    4BM8X-ray0.96A114-250[»]
    4JC1X-ray1.50A108-250[»]
    4JCKX-ray1.15A108-250[»]
    4LBJX-ray1.80A114-250[»]
    4LBKX-ray1.60A114-250[»]
    4LBLX-ray1.58A114-250[»]
    4LBMX-ray1.55A112-250[»]
    4LBNX-ray1.70A112-250[»]
    4LBOX-ray1.65A113-250[»]
    ProteinModelPortaliP17931.
    SMRiP17931. Positions 113-250.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP17931.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati36 – 4491
    Repeati45 – 5392
    Repeati54 – 6293
    Repeati63 – 6974; approximate
    Repeati70 – 7895
    Repeati79 – 88106; approximate
    Repeati89 – 100127; approximateAdd
    BLAST
    Repeati101 – 10998; approximate
    Domaini118 – 248131GalectinPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni36 – 109748 X 9 AA tandem repeats of Y-P-G-X(3)-P-G-AAdd
    BLAST
    Regioni181 – 1877Beta-galactoside bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi226 – 24116Nuclear export signalBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 galectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG312075.
    HOVERGENiHBG006255.
    InParanoidiP17931.
    KOiK06831.
    OMAiQGPPGAY.
    PhylomeDBiP17931.
    TreeFamiTF315551.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view]
    PfamiPF00337. Gal-bind_lectin. 1 hit.
    [Graphical view]
    SMARTiSM00908. Gal-bind_lectin. 1 hit.
    SM00276. GLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS51304. GALECTIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17931-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADNFSLHDA LSGSGNPNPQ GWPGAWGNQP AGAGGYPGAS YPGAYPGQAP    50
    PGAYPGQAPP GAYPGAPGAY PGAPAPGVYP GPPSGPGAYP SSGQPSATGA 100
    YPATGPYGAP AGPLIVPYNL PLPGGVVPRM LITILGTVKP NANRIALDFQ 150
    RGNDVAFHFN PRFNENNRRV IVCNTKLDNN WGREERQSVF PFESGKPFKI 200
    QVLVEPDHFK VAVNDAHLLQ YNHRVKKLNE ISKLGISGDI DLTSASYTMI 250
    Length:250
    Mass (Da):26,152
    Last modified:November 25, 2008 - v5
    Checksum:iC49DDF6D67AE0C88
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 5220AGGYP…QAPPG → QGLPRGFLSWGLPRAGTPR(PubMed:2402511)CuratedAdd
    BLAST
    Sequence conflicti88 – 881Missing(PubMed:2402511)Curated
    Sequence conflicti232 – 2321S → R in M64303. (PubMed:2009535)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti64 – 641P → H.3 Publications
    Corresponds to variant rs4644 [ dbSNP | Ensembl ].
    VAR_012988
    Natural varianti98 – 981T → P.4 Publications
    Corresponds to variant rs4652 [ dbSNP | Ensembl ].
    VAR_012989
    Natural varianti183 – 1831R → K.
    Corresponds to variant rs10148371 [ dbSNP | Ensembl ].
    VAR_049768

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57710 mRNA. Translation: AAA35607.1.
    M35368 mRNA. Translation: AAA88086.1.
    M36682 mRNA. Translation: AAA36163.1.
    M64303 mRNA. No translation available.
    S59012 mRNA. Translation: AAB26229.1.
    AF031425
    , AF031422, AF031423, AF031424 Genomic DNA. Translation: AAB86584.1.
    AB006780 mRNA. Translation: BAA22164.1.
    AK314929 mRNA. Translation: BAG37435.1.
    CR456897 mRNA. Translation: CAG33178.1.
    AL139316 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW80658.1.
    BC001120 mRNA. Translation: AAH01120.1.
    BC053667 mRNA. Translation: AAH53667.1.
    CCDSiCCDS41956.1.
    PIRiA35820.
    RefSeqiNP_002297.2. NM_002306.3.
    UniGeneiHs.531081.

    Genome annotation databases

    EnsembliENST00000254301; ENSP00000254301; ENSG00000131981.
    GeneIDi3958.
    KEGGihsa:3958.
    UCSCiuc001xbr.3. human.

    Polymorphism databases

    DMDMi215274262.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Galectin-3

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57710 mRNA. Translation: AAA35607.1 .
    M35368 mRNA. Translation: AAA88086.1 .
    M36682 mRNA. Translation: AAA36163.1 .
    M64303 mRNA. No translation available.
    S59012 mRNA. Translation: AAB26229.1 .
    AF031425
    , AF031422 , AF031423 , AF031424 Genomic DNA. Translation: AAB86584.1 .
    AB006780 mRNA. Translation: BAA22164.1 .
    AK314929 mRNA. Translation: BAG37435.1 .
    CR456897 mRNA. Translation: CAG33178.1 .
    AL139316 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW80658.1 .
    BC001120 mRNA. Translation: AAH01120.1 .
    BC053667 mRNA. Translation: AAH53667.1 .
    CCDSi CCDS41956.1.
    PIRi A35820.
    RefSeqi NP_002297.2. NM_002306.3.
    UniGenei Hs.531081.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1A3K X-ray 2.10 A 114-250 [» ]
    1KJL X-ray 1.40 A 105-250 [» ]
    1KJR X-ray 1.55 A 105-250 [» ]
    2NMN X-ray 2.45 A 113-250 [» ]
    2NMO X-ray 1.35 A 113-250 [» ]
    2NN8 X-ray 1.35 A 113-250 [» ]
    2XG3 X-ray 1.20 A 114-250 [» ]
    3AYA X-ray 2.00 A/B 117-250 [» ]
    3AYC X-ray 1.80 A/B 117-250 [» ]
    3AYD X-ray 1.90 A 117-250 [» ]
    3AYE X-ray 2.00 A/B 117-250 [» ]
    3T1L X-ray 1.60 A 108-250 [» ]
    3T1M X-ray 1.55 A 108-250 [» ]
    3ZSJ X-ray 0.86 A 113-250 [» ]
    3ZSK X-ray 0.90 A 114-250 [» ]
    3ZSL X-ray 1.08 A 114-250 [» ]
    3ZSM X-ray 1.25 A 114-250 [» ]
    4BLI X-ray 1.08 A 114-250 [» ]
    4BLJ X-ray 1.20 A 114-250 [» ]
    4BM8 X-ray 0.96 A 114-250 [» ]
    4JC1 X-ray 1.50 A 108-250 [» ]
    4JCK X-ray 1.15 A 108-250 [» ]
    4LBJ X-ray 1.80 A 114-250 [» ]
    4LBK X-ray 1.60 A 114-250 [» ]
    4LBL X-ray 1.58 A 114-250 [» ]
    4LBM X-ray 1.55 A 112-250 [» ]
    4LBN X-ray 1.70 A 112-250 [» ]
    4LBO X-ray 1.65 A 113-250 [» ]
    ProteinModelPortali P17931.
    SMRi P17931. Positions 113-250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110149. 22 interactions.
    DIPi DIP-45623N.
    IntActi P17931. 46 interactions.
    STRINGi 9606.ENSP00000254301.

    Chemistry

    BindingDBi P17931.
    ChEMBLi CHEMBL4531.

    PTM databases

    PhosphoSitei P17931.

    Polymorphism databases

    DMDMi 215274262.

    2D gel databases

    DOSAC-COBS-2DPAGE P17931.
    REPRODUCTION-2DPAGE IPI00465431.
    UCD-2DPAGE P17931.

    Proteomic databases

    MaxQBi P17931.
    PaxDbi P17931.
    PRIDEi P17931.

    Protocols and materials databases

    DNASUi 3958.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254301 ; ENSP00000254301 ; ENSG00000131981 .
    GeneIDi 3958.
    KEGGi hsa:3958.
    UCSCi uc001xbr.3. human.

    Organism-specific databases

    CTDi 3958.
    GeneCardsi GC14P055595.
    HGNCi HGNC:6563. LGALS3.
    HPAi CAB005191.
    HPA003162.
    MIMi 153619. gene.
    neXtProti NX_P17931.
    PharmGKBi PA30340.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG312075.
    HOVERGENi HBG006255.
    InParanoidi P17931.
    KOi K06831.
    OMAi QGPPGAY.
    PhylomeDBi P17931.
    TreeFami TF315551.

    Enzyme and pathway databases

    Reactomei REACT_25195. Advanced glycosylation endproduct receptor signaling.

    Miscellaneous databases

    EvolutionaryTracei P17931.
    GeneWikii LGALS3.
    GenomeRNAii 3958.
    NextBioi 15531.
    PMAP-CutDB Q6IBA7.
    PROi P17931.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P17931.
    Bgeei P17931.
    CleanExi HS_LGALS3.
    Genevestigatori P17931.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view ]
    Pfami PF00337. Gal-bind_lectin. 1 hit.
    [Graphical view ]
    SMARTi SM00908. Gal-bind_lectin. 1 hit.
    SM00276. GLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS51304. GALECTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms."
      Robertson M.W., Albrandt K., Keller D., Liu F.-T.
      Biochemistry 29:8093-8100(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS HIS-64 AND PRO-98.
    2. "Molecular cloning of a human macrophage lectin specific for galactose."
      Cherayil B., Chaitovitz S., Wong C., Pillai S.
      Proc. Natl. Acad. Sci. U.S.A. 87:7324-7328(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-98.
      Tissue: Carcinoma.
    3. "Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen."
      Oda Y., Leffler H., Sakakura Y., Kasai K., Barondes S.H.
      Gene 99:279-283(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS HIS-64 AND PRO-98.
    4. "Molecular cloning and chromosomal mapping of a human galactoside-binding protein."
      Raz A., Carmi P., Raz T., Hogan V., Mohamed A., Wolman S.R.
      Cancer Res. 51:2173-2178(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma."
      Lotz M.M., Andrews C.W. Jr., Korzelius C.A., Lee E.C., Steele G.D. Jr., Clarke A., Mercurio A.M.
      Proc. Natl. Acad. Sci. U.S.A. 90:3466-3470(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    6. "The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter."
      Kadrofske M.M., Openo K.P., Wang J.L.
      Arch. Biochem. Biophys. 349:7-20(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "Human galectin-3 full-length cDNA."
      Kato S.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Gastric adenocarcinoma.
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thalamus.
    9. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    10. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-64 AND PRO-98.
      Tissue: Skin.
    13. "L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I."
      Huflejt M.E., Turck C.W., Lindstedt R., Barondes S.H., Leffler H.
      J. Biol. Chem. 268:26712-26718(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-6 AND SER-12.
    14. "Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin."
      Sasaki T., Brakebusch C., Engel J., Timpl R.
      EMBO J. 17:1606-1613(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LGALS3BP.
    15. "NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin."
      Fukushi J., Makagiansar I.T., Stallcup W.B.
      Mol. Biol. Cell 15:3580-3590(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ITGB1; ITGA3 AND CSPG4, SUBCELLULAR LOCATION, FUNCTION.
    16. "The regulation of inflammation by galectin-3."
      Henderson N.C., Sethi T.
      Immunol. Rev. 230:160-171(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN INFLAMMATION.
    17. Cited for: TISSUE SPECIFICITY.
    18. Cited for: SUBCELLULAR LOCATION, FUNCTION.
    19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. "X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution."
      Seetharaman J., Kanigsberg A., Slaaby R., Leffler H., Barondes S.H., Rini J.M.
      J. Biol. Chem. 273:13047-13052(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 114-250.

    Entry informationi

    Entry nameiLEG3_HUMAN
    AccessioniPrimary (citable) accession number: P17931
    Secondary accession number(s): B2RC38
    , Q16005, Q6IBA7, Q96J47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 174 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3