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Protein

Complement receptor type 1

Gene

CR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates cellular binding of particles and immune complexes that have activated complement.
(Microbial infection) Acts as a receptor for Epstein-Barr virus.1 Publication

GO - Molecular functioni

  • complement component C3b binding Source: UniProtKB
  • complement component C3b receptor activity Source: UniProtKB
  • complement component C4b binding Source: UniProtKB
  • complement component C4b receptor activity Source: UniProtKB
  • virus receptor activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Blood group antigen, Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Complement pathway, Host-virus interaction, Immunity, Innate immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170429-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
R-HSA-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement receptor type 1
Alternative name(s):
C3b/C4b receptor
CD_antigen: CD35
Gene namesi
Name:CR1
Synonyms:C3BR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:2334. CR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini42 – 1971ExtracellularSequence analysisAdd BLAST1930
Transmembranei1972 – 1996HelicalSequence analysisAdd BLAST25
Topological domaini1997 – 2039CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1378.
MalaCardsiCR1.
MIMi607486. phenotype.
611162. phenotype.
PharmGKBiPA26855.

Polymorphism and mutation databases

BioMutaiCR1.
DMDMi290457678.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 41Add BLAST41
ChainiPRO_000000600942 – 2039Complement receptor type 1Add BLAST1998

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42Pyrrolidone carboxylic acidSequence analysis1
Disulfide bondi43 ↔ 86PROSITE-ProRule annotation
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi73 ↔ 99PROSITE-ProRule annotation
Disulfide bondi104 ↔ 145PROSITE-ProRule annotation
Disulfide bondi131 ↔ 161PROSITE-ProRule annotation
Disulfide bondi166 ↔ 215PROSITE-ProRule annotation
Disulfide bondi195 ↔ 232PROSITE-ProRule annotation
Disulfide bondi238 ↔ 280PROSITE-ProRule annotation
Glycosylationi252N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi266 ↔ 293PROSITE-ProRule annotation
Disulfide bondi297 ↔ 340PROSITE-ProRule annotation
Disulfide bondi326 ↔ 353PROSITE-ProRule annotation
Disulfide bondi358 ↔ 400PROSITE-ProRule annotation
Disulfide bondi386 ↔ 416PROSITE-ProRule annotation
Glycosylationi410N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi421 ↔ 470PROSITE-ProRule annotation
Glycosylationi447N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi450 ↔ 487PROSITE-ProRule annotation
Disulfide bondi493 ↔ 536PROSITE-ProRule annotation
Glycosylationi509N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi523 ↔ 549PROSITE-ProRule annotation
Disulfide bondi554 ↔ 595PROSITE-ProRule annotation
Glycosylationi578N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi581 ↔ 611PROSITE-ProRule annotation
Disulfide bondi616 ↔ 665PROSITE-ProRule annotation
Disulfide bondi645 ↔ 682PROSITE-ProRule annotation
Disulfide bondi688 ↔ 730PROSITE-ProRule annotation
Glycosylationi702N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi716 ↔ 743PROSITE-ProRule annotation
Disulfide bondi747 ↔ 790PROSITE-ProRule annotation
Disulfide bondi776 ↔ 803PROSITE-ProRule annotation
Disulfide bondi808 ↔ 850PROSITE-ProRule annotation
Disulfide bondi836 ↔ 866PROSITE-ProRule annotation
Glycosylationi860N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi871 ↔ 920PROSITE-ProRule annotation
Glycosylationi897N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi900 ↔ 937PROSITE-ProRule annotation
Disulfide bondi943 ↔ 986PROSITE-ProRule annotation
Glycosylationi959N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi973 ↔ 999PROSITE-ProRule annotation
Disulfide bondi1004 ↔ 1045
Glycosylationi1028N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1031 ↔ 1061
Disulfide bondi1066 ↔ 1115
Disulfide bondi1095 ↔ 1132
Disulfide bondi1138 ↔ 1180PROSITE-ProRule annotation
Glycosylationi1152N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1166 ↔ 1193PROSITE-ProRule annotation
Disulfide bondi1197 ↔ 1240PROSITE-ProRule annotation
Disulfide bondi1226 ↔ 1253PROSITE-ProRule annotation
Disulfide bondi1258 ↔ 1300PROSITE-ProRule annotation
Disulfide bondi1286 ↔ 1316PROSITE-ProRule annotation
Glycosylationi1310N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1321 ↔ 1370PROSITE-ProRule annotation
Disulfide bondi1350 ↔ 1387PROSITE-ProRule annotation
Disulfide bondi1396 ↔ 1439PROSITE-ProRule annotation
Disulfide bondi1426 ↔ 1452PROSITE-ProRule annotation
Disulfide bondi1457 ↔ 1498PROSITE-ProRule annotation
Glycosylationi1481N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1484 ↔ 1514PROSITE-ProRule annotation
Glycosylationi1504N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1519 ↔ 1568PROSITE-ProRule annotation
Glycosylationi1534N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1540N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1548 ↔ 1585PROSITE-ProRule annotation
Disulfide bondi1591 ↔ 1633PROSITE-ProRule annotation
Glycosylationi1605N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1619 ↔ 1646PROSITE-ProRule annotation
Disulfide bondi1650 ↔ 1693PROSITE-ProRule annotation
Disulfide bondi1679 ↔ 1706PROSITE-ProRule annotation
Disulfide bondi1711 ↔ 1753PROSITE-ProRule annotation
Disulfide bondi1739 ↔ 1769PROSITE-ProRule annotation
Glycosylationi1763N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1774 ↔ 1823PROSITE-ProRule annotation
Disulfide bondi1803 ↔ 1840PROSITE-ProRule annotation
Disulfide bondi1848 ↔ 1891PROSITE-ProRule annotation
Disulfide bondi1877 ↔ 1904PROSITE-ProRule annotation
Glycosylationi1908N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1909 ↔ 1952PROSITE-ProRule annotation
Disulfide bondi1938 ↔ 1965PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP17927.
PaxDbiP17927.
PeptideAtlasiP17927.
PRIDEiP17927.

PTM databases

iPTMnetiP17927.
PhosphoSitePlusiP17927.

Expressioni

Tissue specificityi

Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.

Gene expression databases

BgeeiENSG00000203710.
CleanExiHS_CR1.
ExpressionAtlasiP17927. baseline and differential.
GenevisibleiP17927. HS.

Organism-specific databases

HPAiCAB002491.
CAB016271.
HPA042455.
HPA043579.
HPA049348.

Interactioni

Subunit structurei

Monomer.
(Microbial infection) Interacts with Epstein-Barr virus gp350.1 Publication

GO - Molecular functioni

  • complement component C3b binding Source: UniProtKB
  • complement component C4b binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107769. 1 interactor.
IntActiP17927. 7 interactors.
MINTiMINT-1508305.
STRINGi9606.ENSP00000356016.

Structurei

Secondary structure

12039
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni57 – 59Combined sources3
Beta strandi85 – 88Combined sources4
Beta strandi91 – 93Combined sources3
Beta strandi111 – 113Combined sources3
Beta strandi115 – 119Combined sources5
Beta strandi126 – 128Combined sources3
Beta strandi135 – 139Combined sources5
Beta strandi141 – 147Combined sources7
Beta strandi149 – 156Combined sources8
Beta strandi161 – 163Combined sources3
Beta strandi173 – 175Combined sources3
Beta strandi180 – 183Combined sources4
Beta strandi190 – 192Combined sources3
Beta strandi197 – 201Combined sources5
Beta strandi212 – 215Combined sources4
Beta strandi219 – 223Combined sources5
Beta strandi225 – 228Combined sources4
Beta strandi950 – 954Combined sources5
Beta strandi961 – 963Combined sources3
Beta strandi971 – 973Combined sources3
Beta strandi977 – 979Combined sources3
Beta strandi982 – 986Combined sources5
Beta strandi988 – 990Combined sources3
Beta strandi1013 – 1017Combined sources5
Beta strandi1026 – 1031Combined sources6
Beta strandi1035 – 1039Combined sources5
Beta strandi1041 – 1047Combined sources7
Beta strandi1049 – 1056Combined sources8
Beta strandi1060 – 1063Combined sources4
Beta strandi1089 – 1093Combined sources5
Beta strandi1107 – 1109Combined sources3
Beta strandi1113 – 1116Combined sources4
Beta strandi1118 – 1122Combined sources5
Beta strandi1124 – 1126Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GKGNMR-A1002-1133[»]
1GKNNMR-A942-1065[»]
1GOPmodel-A942-1133[»]
1PPQNMR-A1002-1065[»]
2MCYNMR-A102-233[»]
2MCZNMR-A41-163[»]
2Q7ZX-ray-A42-1972[»]
5FO9X-ray3.30C/F941-1136[»]
ProteinModelPortaliP17927.
SMRiP17927.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17927.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 101Sushi 1PROSITE-ProRule annotationAdd BLAST60
Domaini102 – 163Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini164 – 234Sushi 3PROSITE-ProRule annotationAdd BLAST71
Domaini236 – 295Sushi 4PROSITE-ProRule annotationAdd BLAST60
Domaini295 – 355Sushi 5PROSITE-ProRule annotationAdd BLAST61
Domaini356 – 418Sushi 6PROSITE-ProRule annotationAdd BLAST63
Domaini419 – 489Sushi 7PROSITE-ProRule annotationAdd BLAST71
Domaini491 – 551Sushi 8PROSITE-ProRule annotationAdd BLAST61
Domaini552 – 613Sushi 9PROSITE-ProRule annotationAdd BLAST62
Domaini614 – 684Sushi 10PROSITE-ProRule annotationAdd BLAST71
Domaini686 – 745Sushi 11PROSITE-ProRule annotationAdd BLAST60
Domaini745 – 805Sushi 12PROSITE-ProRule annotationAdd BLAST61
Domaini806 – 868Sushi 13PROSITE-ProRule annotationAdd BLAST63
Domaini869 – 939Sushi 14PROSITE-ProRule annotationAdd BLAST71
Domaini941 – 1001Sushi 15PROSITE-ProRule annotationAdd BLAST61
Domaini1002 – 1063Sushi 16PROSITE-ProRule annotationAdd BLAST62
Domaini1064 – 1134Sushi 17PROSITE-ProRule annotationAdd BLAST71
Domaini1136 – 1195Sushi 18PROSITE-ProRule annotationAdd BLAST60
Domaini1195 – 1255Sushi 19PROSITE-ProRule annotationAdd BLAST61
Domaini1256 – 1318Sushi 20PROSITE-ProRule annotationAdd BLAST63
Domaini1319 – 1389Sushi 21PROSITE-ProRule annotationAdd BLAST71
Domaini1394 – 1454Sushi 22PROSITE-ProRule annotationAdd BLAST61
Domaini1455 – 1516Sushi 23PROSITE-ProRule annotationAdd BLAST62
Domaini1517 – 1587Sushi 24PROSITE-ProRule annotationAdd BLAST71
Domaini1589 – 1648Sushi 25PROSITE-ProRule annotationAdd BLAST60
Domaini1648 – 1708Sushi 26PROSITE-ProRule annotationAdd BLAST61
Domaini1709 – 1771Sushi 27PROSITE-ProRule annotationAdd BLAST63
Domaini1772 – 1842Sushi 28PROSITE-ProRule annotationAdd BLAST71
Domaini1846 – 1906Sushi 29PROSITE-ProRule annotationAdd BLAST61
Domaini1907 – 1967Sushi 30PROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Contains 30 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KDF5. Eukaryota.
ENOG410YE3Q. LUCA.
HOGENOMiHOG000139590.
HOVERGENiHBG005397.
InParanoidiP17927.
KOiK04011.
PhylomeDBiP17927.

Family and domain databases

CDDicd00033. CCP. 30 hits.
InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 30 hits.
[Graphical view]
SMARTiSM00032. CCP. 30 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 30 hits.
PROSITEiPS50923. SUSHI. 30 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGASSPRSPE PVGPPAPGLP FCCGGSLLAV VVLLALPVAW GQCNAPEWLP
60 70 80 90 100
FARPTNLTDE FEFPIGTYLN YECRPGYSGR PFSIICLKNS VWTGAKDRCR
110 120 130 140 150
RKSCRNPPDP VNGMVHVIKG IQFGSQIKYS CTKGYRLIGS SSATCIISGD
160 170 180 190 200
TVIWDNETPI CDRIPCGLPP TITNGDFIST NRENFHYGSV VTYRCNPGSG
210 220 230 240 250
GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS
260 270 280 290 300
DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP
310 320 330 340 350
PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA
360 370 380 390 400
PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC
410 420 430 440 450
VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKTVNYTC
460 470 480 490 500
DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL
510 520 530 540 550
FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK
560 570 580 590 600
RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN
610 620 630 640 650
AAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNPGSG
660 670 680 690 700
GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS
710 720 730 740 750
DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP
760 770 780 790 800
PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA
810 820 830 840 850
PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC
860 870 880 890 900
VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKAVNYTC
910 920 930 940 950
DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL
960 970 980 990 1000
FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK
1010 1020 1030 1040 1050
RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN
1060 1070 1080 1090 1100
TAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNLGSR
1110 1120 1130 1140 1150
GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS
1160 1170 1180 1190 1200
DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP
1210 1220 1230 1240 1250
PEILHGEHTP SHQDNFSPGQ EVFYSCEPGY DLRGAASLHC TPQGDWSPEA
1260 1270 1280 1290 1300
PRCAVKSCDD FLGQLPHGRV LFPLNLQLGA KVSFVCDEGF RLKGSSVSHC
1310 1320 1330 1340 1350
VLVGMRSLWN NSVPVCEHIF CPNPPAILNG RHTGTPSGDI PYGKEISYTC
1360 1370 1380 1390 1400
DPHPDRGMTF NLIGESTIRC TSDPHGNGVW SSPAPRCELS VRAGHCKTPE
1410 1420 1430 1440 1450
QFPFASPTIP INDFEFPVGT SLNYECRPGY FGKMFSISCL ENLVWSSVED
1460 1470 1480 1490 1500
NCRRKSCGPP PEPFNGMVHI NTDTQFGSTV NYSCNEGFRL IGSPSTTCLV
1510 1520 1530 1540 1550
SGNNVTWDKK APICEIISCE PPPTISNGDF YSNNRTSFHN GTVVTYQCHT
1560 1570 1580 1590 1600
GPDGEQLFEL VGERSIYCTS KDDQVGVWSS PPPRCISTNK CTAPEVENAI
1610 1620 1630 1640 1650
RVPGNRSFFS LTEIIRFRCQ PGFVMVGSHT VQCQTNGRWG PKLPHCSRVC
1660 1670 1680 1690 1700
QPPPEILHGE HTLSHQDNFS PGQEVFYSCE PSYDLRGAAS LHCTPQGDWS
1710 1720 1730 1740 1750
PEAPRCTVKS CDDFLGQLPH GRVLLPLNLQ LGAKVSFVCD EGFRLKGRSA
1760 1770 1780 1790 1800
SHCVLAGMKA LWNSSVPVCE QIFCPNPPAI LNGRHTGTPF GDIPYGKEIS
1810 1820 1830 1840 1850
YACDTHPDRG MTFNLIGESS IRCTSDPQGN GVWSSPAPRC ELSVPAACPH
1860 1870 1880 1890 1900
PPKIQNGHYI GGHVSLYLPG MTISYICDPG YLLVGKGFIF CTDQGIWSQL
1910 1920 1930 1940 1950
DHYCKEVNCS FPLFMNGISK ELEMKKVYHY GDYVTLKCED GYTLEGSPWS
1960 1970 1980 1990 2000
QCQADDRWDP PLAKCTSRTH DALIVGTLSG TIFFILLIIF LSWIILKHRK
2010 2020 2030
GNNAHENPKE VAIHLHSQGG SSVHPRTLQT NEENSRVLP
Length:2,039
Mass (Da):223,663
Last modified:March 2, 2010 - v3
Checksum:iFB01870F19D5E6DD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173T → A in CAI16042 (PubMed:16710414).Curated1
Sequence conflicti173T → A in CAI16723 (PubMed:16710414).Curated1
Sequence conflicti445T → A in CAA68755 (PubMed:2972794).Curated1
Sequence conflicti445T → A in AAB60694 (PubMed:8245463).Curated1
Sequence conflicti445T → A in CAA32541 (PubMed:2971757).Curated1
Sequence conflicti1876I → T in CAA68755 (PubMed:2972794).Curated1
Sequence conflicti1876I → T in CAA28933 (PubMed:2951479).Curated1

Polymorphismi

CR1 contains a system of antigens called the Knops blood group system. Polymorphisms within this system are involved in malarial rosetting, a process associated with cerebral malaria, the major cause of mortality in Plasmodium falciparum malaria. Common Knops system antigens include McCoy (McC) and Sl(a)/Vil (Kn4, or Swain-Langley; Vil or Villien). Sl(a-) phenotype is more common in persons of African descent and may protect against fatal malaria.
Other polymorphic forms of CR1 contain 23, 37 or 44 Sushi (CCP/SCR) domains instead of the 30 Sushi (CCP/SCR) domains. The most frequent alleles are the F allotype (shown here) and the S allotype (37 repeat Sushi domains). The gene frequencies of the F allotype and S allotype are 0.87 and 0.11 in Caucasians, 0.82 and 0.11 in African Americans, 0.89 and 0.11 in Mexicans.
Genetic variations in CR1 resulting in CR1 deficiency are involved in protection against severe malaria [MIMi:611162]. Parasitized red blood cells (RBCs) from children suffering from severe malaria often adhere to complement receptor 1 (CR1) on uninfected RBCs to form clumps of cells known as rosettes. CR1-deficient red blood cells show greatly reduced rosetting and CR1 deficiency occurs in healthy individuals from malaria-endemic regions.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0138191208H → R.1 PublicationCorresponds to variant rs2274567dbSNPEnsembl.1
Natural variantiVAR_0138201408T → I.1
Natural variantiVAR_0202631408T → M.Corresponds to variant rs3737002dbSNPEnsembl.1
Natural variantiVAR_0556851540N → S.Corresponds to variant rs17259045dbSNPEnsembl.1
Natural variantiVAR_0138211590K → E in MCC(b) antigen. 1 PublicationCorresponds to variant rs17047660dbSNPEnsembl.1
Natural variantiVAR_0138221601R → G in Sl(2)/Vil antigen and Sl(3) antigen. 2 PublicationsCorresponds to variant rs17047661dbSNPEnsembl.1
Natural variantiVAR_0138231610S → T in Sl(3) antigen. 3 PublicationsCorresponds to variant rs4844609dbSNPEnsembl.1
Natural variantiVAR_0138241615I → V.2 PublicationsCorresponds to variant rs6691117dbSNPEnsembl.1
Natural variantiVAR_0138251827P → R.2 PublicationsCorresponds to variant rs3811381dbSNPEnsembl.1
Natural variantiVAR_0138261850H → D.2 Publications1
Natural variantiVAR_0556861969T → A.2 PublicationsCorresponds to variant rs2296160dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00816 mRNA. Translation: CAA68755.1.
L17418
, L17390, L17399, L17409, L17419, L17420, L17421, L17422, L17423, L17391, L17392, L17393, L17394, L17395, L17396, L17397, L17398, L17400, L17401, L17402, L17403, L17404, L17405, L17406, L17407, L17408, L17410, L17411, L17412, L17413, L17414, L17415, L17416, L17417 Genomic DNA. Translation: AAB60694.1.
L17418
, L17390, L17391, L17392, L17393, L17394, L17395, L17396, L17397, L17398, L17399, L17400, L17401, L17402, L17403, L17404, L17405, L17406, L17407, L17408, L17409, L17410, L17411, L17412, L17413, L17414, L17415, L17416, L17417, L17419, L17420, L17421, L17422, L17423, L17424, L17425, L17426, L17427, L17428, L17429, L17430 Genomic DNA. Translation: AAB60695.1.
AL137789, AL691452 Genomic DNA. Translation: CAI16042.1.
AL137789, AL691452 Genomic DNA. Translation: CAI16043.1.
AL691452, AL137789 Genomic DNA. Translation: CAI16723.1.
AL691452, AL137789 Genomic DNA. Translation: CAI16725.1.
X14362 mRNA. Translation: CAA32541.1.
X05309 mRNA. Translation: CAA28933.1.
M11569 mRNA. Translation: AAA52297.1.
M11617 mRNA. Translation: AAA52298.1.
M11618 mRNA. Translation: AAA52299.1.
CCDSiCCDS44309.1.
PIRiI73012.
RefSeqiNP_000564.2. NM_000573.3.
NP_000642.3. NM_000651.4.
UniGeneiHs.334019.

Genome annotation databases

EnsembliENST00000367051; ENSP00000356018; ENSG00000203710.
ENST00000367053; ENSP00000356020; ENSG00000203710.
ENST00000400960; ENSP00000383744; ENSG00000203710.
GeneIDi1378.
KEGGihsa:1378.
UCSCiuc057ozo.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00816 mRNA. Translation: CAA68755.1.
L17418
, L17390, L17399, L17409, L17419, L17420, L17421, L17422, L17423, L17391, L17392, L17393, L17394, L17395, L17396, L17397, L17398, L17400, L17401, L17402, L17403, L17404, L17405, L17406, L17407, L17408, L17410, L17411, L17412, L17413, L17414, L17415, L17416, L17417 Genomic DNA. Translation: AAB60694.1.
L17418
, L17390, L17391, L17392, L17393, L17394, L17395, L17396, L17397, L17398, L17399, L17400, L17401, L17402, L17403, L17404, L17405, L17406, L17407, L17408, L17409, L17410, L17411, L17412, L17413, L17414, L17415, L17416, L17417, L17419, L17420, L17421, L17422, L17423, L17424, L17425, L17426, L17427, L17428, L17429, L17430 Genomic DNA. Translation: AAB60695.1.
AL137789, AL691452 Genomic DNA. Translation: CAI16042.1.
AL137789, AL691452 Genomic DNA. Translation: CAI16043.1.
AL691452, AL137789 Genomic DNA. Translation: CAI16723.1.
AL691452, AL137789 Genomic DNA. Translation: CAI16725.1.
X14362 mRNA. Translation: CAA32541.1.
X05309 mRNA. Translation: CAA28933.1.
M11569 mRNA. Translation: AAA52297.1.
M11617 mRNA. Translation: AAA52298.1.
M11618 mRNA. Translation: AAA52299.1.
CCDSiCCDS44309.1.
PIRiI73012.
RefSeqiNP_000564.2. NM_000573.3.
NP_000642.3. NM_000651.4.
UniGeneiHs.334019.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GKGNMR-A1002-1133[»]
1GKNNMR-A942-1065[»]
1GOPmodel-A942-1133[»]
1PPQNMR-A1002-1065[»]
2MCYNMR-A102-233[»]
2MCZNMR-A41-163[»]
2Q7ZX-ray-A42-1972[»]
5FO9X-ray3.30C/F941-1136[»]
ProteinModelPortaliP17927.
SMRiP17927.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107769. 1 interactor.
IntActiP17927. 7 interactors.
MINTiMINT-1508305.
STRINGi9606.ENSP00000356016.

PTM databases

iPTMnetiP17927.
PhosphoSitePlusiP17927.

Polymorphism and mutation databases

BioMutaiCR1.
DMDMi290457678.

Proteomic databases

EPDiP17927.
PaxDbiP17927.
PeptideAtlasiP17927.
PRIDEiP17927.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367051; ENSP00000356018; ENSG00000203710.
ENST00000367053; ENSP00000356020; ENSG00000203710.
ENST00000400960; ENSP00000383744; ENSG00000203710.
GeneIDi1378.
KEGGihsa:1378.
UCSCiuc057ozo.1. human.

Organism-specific databases

CTDi1378.
DisGeNETi1378.
GeneCardsiCR1.
HGNCiHGNC:2334. CR1.
HPAiCAB002491.
CAB016271.
HPA042455.
HPA043579.
HPA049348.
MalaCardsiCR1.
MIMi120620. gene.
607486. phenotype.
611162. phenotype.
neXtProtiNX_P17927.
PharmGKBiPA26855.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KDF5. Eukaryota.
ENOG410YE3Q. LUCA.
HOGENOMiHOG000139590.
HOVERGENiHBG005397.
InParanoidiP17927.
KOiK04011.
PhylomeDBiP17927.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170429-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.
R-HSA-977606. Regulation of Complement cascade.

Miscellaneous databases

EvolutionaryTraceiP17927.
GeneWikiiComplement_receptor_1.
GenomeRNAii1378.
PROiP17927.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000203710.
CleanExiHS_CR1.
ExpressionAtlasiP17927. baseline and differential.
GenevisibleiP17927. HS.

Family and domain databases

CDDicd00033. CCP. 30 hits.
InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 30 hits.
[Graphical view]
SMARTiSM00032. CCP. 30 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 30 hits.
PROSITEiPS50923. SUSHI. 30 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCR1_HUMAN
AccessioniPrimary (citable) accession number: P17927
Secondary accession number(s): Q16744
, Q16745, Q5SR43, Q5SR45, Q9UQV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: March 2, 2010
Last modified: November 30, 2016
This is version 175 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  8. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.