ID   HXB1_MOUSE              Reviewed;         297 AA.
AC   P17919; Q3ZAY6; Q9CYH3;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   27-MAR-2024, entry version 176.
DE   RecName: Full=Homeobox protein Hox-B1;
DE   AltName: Full=Homeobox protein Hox-2.9;
GN   Name=Hoxb1; Synonyms=Hox-2.9, Hoxb-1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=1983472; DOI=10.1242/dev.110.2.589;
RA   Frohman M.A., Boyle M., Martin G.R.;
RT   "Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression
RT   suggests that positional information along the anterior-posterior axis is
RT   specified by mesoderm.";
RL   Development 110:589-607(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1673098; DOI=10.1242/dev.111.1.61;
RA   Murphy P., Hill R.E.;
RT   "Expression of the mouse labial-like homeobox-containing genes, Hox 2.9 and
RT   Hox 1.6, during segmentation of the hindbrain.";
RL   Development 111:61-74(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 199-259.
RX   PubMed=1972280; DOI=10.1073/pnas.87.12.4751;
RA   Rubock M.J., Larin Z., Cook M., Papalopulu N., Krumlauf R., Lehrach H.;
RT   "A yeast artificial chromosome containing the mouse homeobox cluster
RT   Hox-2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:4751-4755(1990).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis. Acts on the
CC       anterior body structures.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Expressed along the entire length of the primitive
CC       streak. In early neurogenesis it is expressed in lateral and paraxial
CC       mesoderm, endoderm and superficial ectoderm or in the neural tube. From
CC       late neurogenesis to mid-embryogenesis, it presents similar spatial
CC       domains in the lateral mesoderm, endoderm and superficial ectoderm but
CC       is not detectable in the posterior hindbrain and has increased
CC       dramatically in rhombomere 4.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC       {ECO:0000305}.
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DR   EMBL; X53063; CAA37238.1; -; Genomic_DNA.
DR   EMBL; X59474; CAA42078.1; -; mRNA.
DR   EMBL; AK017686; BAB30874.1; -; mRNA.
DR   EMBL; BC103597; AAI03598.1; -; mRNA.
DR   EMBL; BC103598; AAI03599.1; -; mRNA.
DR   EMBL; BC103606; AAI03607.1; -; mRNA.
DR   EMBL; M34005; AAA37850.1; -; Genomic_DNA.
DR   CCDS; CCDS25300.1; -.
DR   PIR; A60082; WJMS29.
DR   RefSeq; NP_032292.3; NM_008266.5.
DR   AlphaFoldDB; P17919; -.
DR   SMR; P17919; -.
DR   BioGRID; 200375; 2.
DR   IntAct; P17919; 2.
DR   STRING; 10090.ENSMUSP00000019117; -.
DR   PhosphoSitePlus; P17919; -.
DR   PaxDb; 10090-ENSMUSP00000019117; -.
DR   Antibodypedia; 30258; 391 antibodies from 35 providers.
DR   DNASU; 15407; -.
DR   Ensembl; ENSMUST00000019117.3; ENSMUSP00000019117.3; ENSMUSG00000018973.3.
DR   GeneID; 15407; -.
DR   KEGG; mmu:15407; -.
DR   UCSC; uc007lbz.2; mouse.
DR   AGR; MGI:96182; -.
DR   CTD; 3211; -.
DR   MGI; MGI:96182; Hoxb1.
DR   VEuPathDB; HostDB:ENSMUSG00000018973; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000159503; -.
DR   HOGENOM; CLU_058839_1_0_1; -.
DR   InParanoid; P17919; -.
DR   OMA; ACNPSYG; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; P17919; -.
DR   TreeFam; TF317730; -.
DR   BioGRID-ORCS; 15407; 5 hits in 76 CRISPR screens.
DR   ChiTaRS; Hoxb1; mouse.
DR   PRO; PR:P17919; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; P17919; Protein.
DR   Bgee; ENSMUSG00000018973; Expressed in primitive streak and 65 other cell types or tissues.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IDA:MGI.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0019904; F:protein domain specific binding; ISO:MGI.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IGI:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IGI:MGI.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IGI:MGI.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IGI:MGI.
DR   GO; GO:0021612; P:facial nerve structural organization; IMP:MGI.
DR   GO; GO:0021754; P:facial nucleus development; IMP:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0021570; P:rhombomere 4 development; IGI:MGI.
DR   GO; GO:0021571; P:rhombomere 5 development; IGI:MGI.
DR   GO; GO:0021546; P:rhombomere development; IDA:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   InterPro; IPR046327; HXA1/B1/D1.
DR   PANTHER; PTHR45946:SF5; HOMEOBOX PROTEIN HOX-B1; 1.
DR   PANTHER; PTHR45946; HOMEOBOX PROTEIN ROUGH-RELATED; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; P17919; MM.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..297
FT                   /note="Homeobox protein Hox-B1"
FT                   /id="PRO_0000200108"
FT   DNA_BIND        199..258
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          38..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          124..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          251..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           175..180
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        49..74
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..297
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        38
FT                   /note="S -> T (in Ref. 2; CAA42078)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        162
FT                   /note="S -> C (in Ref. 2; CAA42078)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        198
FT                   /note="A -> P (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        200
FT                   /note="G -> R (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        217
FT                   /note="E -> G (in Ref. 3; BAB30874)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        234
FT                   /note="A -> P (in Ref. 2; CAA42078)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   297 AA;  31672 MW;  9798C2B4E897C324 CRC64;
     MDYNRMSSFL EYPLCNRGPS AYSAPTSFPP CSAPAVDSYA GESRYGGGLP SSALQQNSGY
     PVQQPPSSLG VSFPSPAPSG YAPAACNPSY GPSQYYSVGQ SEGDGSYFHP SSYGAQLGGL
     PDSYGAGGVG SGPYPPPQPP YGTEQTATFA SAYDLLSEDK ESPCSSEPST LTPRTFDWMK
     VKRNPPKTAK VSELGLGAPG GLRTNFTTRQ LTELEKEFHF NKYLSRARRV EIAATLELNE
     TQVKIWFQNR RMKQKKRERE GGRMPAGPPG CPKEAAGDAS DQSACTSPEA SPSSITS
//