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P17919

- HXB1_MOUSE

UniProt

P17919 - HXB1_MOUSE

Protein

Homeobox protein Hox-B1

Gene

Hoxb1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi199 – 25860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. sequence-specific DNA binding Source: MGI
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anatomical structure formation involved in morphogenesis Source: MGI
    2. anatomical structure morphogenesis Source: MGI
    3. anterior/posterior pattern specification Source: MGI
    4. embryonic skeletal system morphogenesis Source: MGI
    5. facial nerve structural organization Source: MGI
    6. facial nucleus development Source: MGI
    7. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    8. rhombomere 4 development Source: MGI
    9. rhombomere 5 development Source: MGI
    10. rhombomere development Source: MGI
    11. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B1
    Alternative name(s):
    Homeobox protein Hox-2.9
    Gene namesi
    Name:Hoxb1
    Synonyms:Hox-2.9, Hoxb-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96182. Hoxb1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 297297Homeobox protein Hox-B1PRO_0000200108Add
    BLAST

    Proteomic databases

    PRIDEiP17919.

    PTM databases

    PhosphoSiteiP17919.

    Expressioni

    Developmental stagei

    Expressed along the entire length of the primitive streak. In early neurogenesis it is expressed in lateral and paraxial mesoderm, endoderm and superficial ectoderm or in the neural tube. From late neurogenesis to mid-embryogenesis, it presents similar spatial domains in the lateral mesoderm, endoderm and superficial ectoderm but is not detectable in the posterior hindbrain and has increased dramatically in rhombomere 4.

    Gene expression databases

    BgeeiP17919.
    CleanExiMM_HOXB1.
    GenevestigatoriP17919.

    Interactioni

    Protein-protein interaction databases

    BioGridi200375. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP17919.
    SMRiP17919. Positions 174-260.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi175 – 1806Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family. Labial subfamily.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG236971.
    GeneTreeiENSGT00750000117389.
    HOGENOMiHOG000247020.
    HOVERGENiHBG006089.
    InParanoidiP17919.
    KOiK09301.
    OMAiYAICNRG.
    OrthoDBiEOG7PK91P.
    PhylomeDBiP17919.
    TreeFamiTF317730.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17919-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYNRMSSFL EYPLCNRGPS AYSAPTSFPP CSAPAVDSYA GESRYGGGLP    50
    SSALQQNSGY PVQQPPSSLG VSFPSPAPSG YAPAACNPSY GPSQYYSVGQ 100
    SEGDGSYFHP SSYGAQLGGL PDSYGAGGVG SGPYPPPQPP YGTEQTATFA 150
    SAYDLLSEDK ESPCSSEPST LTPRTFDWMK VKRNPPKTAK VSELGLGAPG 200
    GLRTNFTTRQ LTELEKEFHF NKYLSRARRV EIAATLELNE TQVKIWFQNR 250
    RMKQKKRERE GGRMPAGPPG CPKEAAGDAS DQSACTSPEA SPSSITS 297
    Length:297
    Mass (Da):31,672
    Last modified:November 1, 1990 - v1
    Checksum:i9798C2B4E897C324
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti38 – 381S → T in CAA42078. (PubMed:1673098)Curated
    Sequence conflicti162 – 1621S → C in CAA42078. (PubMed:1673098)Curated
    Sequence conflicti198 – 1981A → P(PubMed:1673098)Curated
    Sequence conflicti200 – 2001G → R(PubMed:1673098)Curated
    Sequence conflicti217 – 2171E → G in BAB30874. (PubMed:16141072)Curated
    Sequence conflicti234 – 2341A → P in CAA42078. (PubMed:1673098)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53063 Genomic DNA. Translation: CAA37238.1.
    X59474 mRNA. Translation: CAA42078.1.
    AK017686 mRNA. Translation: BAB30874.1.
    BC103597 mRNA. Translation: AAI03598.1.
    BC103598 mRNA. Translation: AAI03599.1.
    BC103606 mRNA. Translation: AAI03607.1.
    M34005 Genomic DNA. Translation: AAA37850.1.
    CCDSiCCDS25300.1.
    PIRiA60082. WJMS29.
    RefSeqiNP_032292.3. NM_008266.5.
    UniGeneiMm.890.

    Genome annotation databases

    EnsembliENSMUST00000019117; ENSMUSP00000019117; ENSMUSG00000018973.
    GeneIDi15407.
    KEGGimmu:15407.
    UCSCiuc007lbz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53063 Genomic DNA. Translation: CAA37238.1 .
    X59474 mRNA. Translation: CAA42078.1 .
    AK017686 mRNA. Translation: BAB30874.1 .
    BC103597 mRNA. Translation: AAI03598.1 .
    BC103598 mRNA. Translation: AAI03599.1 .
    BC103606 mRNA. Translation: AAI03607.1 .
    M34005 Genomic DNA. Translation: AAA37850.1 .
    CCDSi CCDS25300.1.
    PIRi A60082. WJMS29.
    RefSeqi NP_032292.3. NM_008266.5.
    UniGenei Mm.890.

    3D structure databases

    ProteinModelPortali P17919.
    SMRi P17919. Positions 174-260.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200375. 2 interactions.

    PTM databases

    PhosphoSitei P17919.

    Proteomic databases

    PRIDEi P17919.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019117 ; ENSMUSP00000019117 ; ENSMUSG00000018973 .
    GeneIDi 15407.
    KEGGi mmu:15407.
    UCSCi uc007lbz.2. mouse.

    Organism-specific databases

    CTDi 3211.
    MGIi MGI:96182. Hoxb1.

    Phylogenomic databases

    eggNOGi NOG236971.
    GeneTreei ENSGT00750000117389.
    HOGENOMi HOG000247020.
    HOVERGENi HBG006089.
    InParanoidi P17919.
    KOi K09301.
    OMAi YAICNRG.
    OrthoDBi EOG7PK91P.
    PhylomeDBi P17919.
    TreeFami TF317730.

    Miscellaneous databases

    NextBioi 288120.
    PROi P17919.
    SOURCEi Search...

    Gene expression databases

    Bgeei P17919.
    CleanExi MM_HOXB1.
    Genevestigatori P17919.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm."
      Frohman M.A., Boyle M., Martin G.R.
      Development 110:589-607(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.
    2. "Expression of the mouse labial-like homeobox-containing genes, Hox 2.9 and Hox 1.6, during segmentation of the hindbrain."
      Murphy P., Hill R.E.
      Development 111:61-74(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "A yeast artificial chromosome containing the mouse homeobox cluster Hox-2."
      Rubock M.J., Larin Z., Cook M., Papalopulu N., Krumlauf R., Lehrach H.
      Proc. Natl. Acad. Sci. U.S.A. 87:4751-4755(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 199-259.

    Entry informationi

    Entry nameiHXB1_MOUSE
    AccessioniPrimary (citable) accession number: P17919
    Secondary accession number(s): Q3ZAY6, Q9CYH3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3