P17919 (HXB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-B1

Alternative name(s):
Homeobox protein Hox-2.9

Gene names

Name:	Hoxb1
Synonyms:	Hox-2.9, Hoxb-1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.
Subcellular location	Nucleus.
Developmental stage	Expressed along the entire length of the primitive streak. In early neurogenesis it is expressed in lateral and paraxial mesoderm, endoderm and superficial ectoderm or in the neural tube. From late neurogenesis to mid-embryogenesis, it presents similar spatial domains in the lateral mesoderm, endoderm and superficial ectoderm but is not detectable in the posterior hindbrain and has increased dramatically in rhombomere 4.
Sequence similarities	Belongs to the Antp homeobox family. Labial subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anatomical structure formation involved in morphogenesis Inferred from genetic interaction PubMed 10529420. Source: MGI anterior/posterior pattern specification Inferred from genetic interaction PubMed 10529420PubMed 10885747. Source: MGI embryonic skeletal system morphogenesis Inferred from genetic interaction PubMed 10885747. Source: MGI facial nerve structural organization Inferred from mutant phenotype PubMed 8898234. Source: MGI facial nucleus development Inferred from mutant phenotype PubMed 8898234. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 18787068. Source: MGI rhombomere 4 development Inferred from genetic interaction PubMed 10529420. Source: MGI rhombomere 5 development Inferred from genetic interaction PubMed 10529420. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from genetic interaction PubMed 18787068. Source: MGI sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Homeobox protein Hox-B1		PRO_0000200108
Regions
	DNA binding	199 – 258	60	Homeobox
	Motif	175 – 180	6	Antp-type hexapeptide
Experimental info
	Sequence conflict	38	1	S → T in CAA42078. Ref.2
	Sequence conflict	162	1	S → C in CAA42078. Ref.2
	Sequence conflict	198	1	A → P Ref.2
	Sequence conflict	200	1	G → R Ref.2
	Sequence conflict	217	1	E → G in BAB30874. Ref.3
	Sequence conflict	234	1	A → P in CAA42078. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P17919 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: 9798C2B4E897C324	FASTA	297	31,672
	10 20 30 40 50 60 MDYNRMSSFL EYPLCNRGPS AYSAPTSFPP CSAPAVDSYA GESRYGGGLP SSALQQNSGY 70 80 90 100 110 120 PVQQPPSSLG VSFPSPAPSG YAPAACNPSY GPSQYYSVGQ SEGDGSYFHP SSYGAQLGGL 130 140 150 160 170 180 PDSYGAGGVG SGPYPPPQPP YGTEQTATFA SAYDLLSEDK ESPCSSEPST LTPRTFDWMK 190 200 210 220 230 240 VKRNPPKTAK VSELGLGAPG GLRTNFTTRQ LTELEKEFHF NKYLSRARRV EIAATLELNE 250 260 270 280 290 TQVKIWFQNR RMKQKKRERE GGRMPAGPPG CPKEAAGDAS DQSACTSPEA SPSSITS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm." Frohman M.A., Boyle M., Martin G.R. Development 110:589-607(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Liver.
[2]	"Expression of the mouse labial-like homeobox-containing genes, Hox 2.9 and Hox 1.6, during segmentation of the hindbrain." Murphy P., Hill R.E. Development 111:61-74(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"A yeast artificial chromosome containing the mouse homeobox cluster Hox-2." Rubock M.J., Larin Z., Cook M., Papalopulu N., Krumlauf R., Lehrach H. Proc. Natl. Acad. Sci. U.S.A. 87:4751-4755(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 199-259.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X53063 Genomic DNA. Translation: CAA37238.1. X59474 mRNA. Translation: CAA42078.1. AK017686 mRNA. Translation: BAB30874.1. BC103597 mRNA. Translation: AAI03598.1. BC103598 mRNA. Translation: AAI03599.1. BC103606 mRNA. Translation: AAI03607.1. M34005 Genomic DNA. Translation: AAA37850.1.
IPI	IPI00308822.
PIR	WJMS29. A60082.
RefSeq	NP_032292.3. NM_008266.5.
UniGene	Mm.890.
3D structure databases
ProteinModelPortal	P17919.
SMR	P17919. Positions 174-260.
ModBase	Search...
PTM databases
PhosphoSite	P17919.
Proteomic databases
PRIDE	P17919.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000019117; ENSMUSP00000019117; ENSMUSG00000018973.
GeneID	15407.
KEGG	mmu:15407.
Organism-specific databases
CTD	3211.
MGI	MGI:96182. Hoxb1.
Phylogenomic databases
eggNOG	NOG236971.
GeneTree	ENSGT00700000104161.
HOGENOM	HOG000247020.
HOVERGEN	HBG006089.
InParanoid	P17919.
KO	K09301.
OMA	YAICNRG.
OrthoDB	EOG44F69X.
Gene expression databases
ArrayExpress	P17919.
Bgee	P17919.
CleanEx	MM_HOXB1.
Genevestigator	P17919.
GermOnline	ENSMUSG00000018973. Mus musculus.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. False negative. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	288120.
SOURCE	Search...

Entry information

Entry name

HXB1_MOUSE

Accession

Primary (citable) accession number: P17919
Secondary accession number(s): Q3ZAY6, Q9CYH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	May 1, 2013
This is version 118 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program