SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P17919

- HXB1_MOUSE

UniProt

P17919 - HXB1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Homeobox protein Hox-B1
Gene
Hoxb1, Hox-2.9, Hoxb-1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi199 – 25860Homeobox
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anatomical structure formation involved in morphogenesis Source: MGI
  2. anatomical structure morphogenesis Source: MGI
  3. anterior/posterior pattern specification Source: MGI
  4. embryonic skeletal system morphogenesis Source: MGI
  5. facial nerve structural organization Source: MGI
  6. facial nucleus development Source: MGI
  7. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  8. rhombomere 4 development Source: MGI
  9. rhombomere 5 development Source: MGI
  10. rhombomere development Source: MGI
  11. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B1
Alternative name(s):
Homeobox protein Hox-2.9
Gene namesi
Name:Hoxb1
Synonyms:Hox-2.9, Hoxb-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96182. Hoxb1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Homeobox protein Hox-B1
PRO_0000200108Add
BLAST

Proteomic databases

PRIDEiP17919.

PTM databases

PhosphoSiteiP17919.

Expressioni

Developmental stagei

Expressed along the entire length of the primitive streak. In early neurogenesis it is expressed in lateral and paraxial mesoderm, endoderm and superficial ectoderm or in the neural tube. From late neurogenesis to mid-embryogenesis, it presents similar spatial domains in the lateral mesoderm, endoderm and superficial ectoderm but is not detectable in the posterior hindbrain and has increased dramatically in rhombomere 4.

Gene expression databases

BgeeiP17919.
CleanExiMM_HOXB1.
GenevestigatoriP17919.

Interactioni

Protein-protein interaction databases

BioGridi200375. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP17919.
SMRiP17919. Positions 174-260.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi175 – 1806Antp-type hexapeptide

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG236971.
GeneTreeiENSGT00750000117389.
HOGENOMiHOG000247020.
HOVERGENiHBG006089.
InParanoidiP17919.
KOiK09301.
OMAiYAICNRG.
OrthoDBiEOG7PK91P.
PhylomeDBiP17919.
TreeFamiTF317730.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17919-1 [UniParc]FASTAAdd to Basket

« Hide

MDYNRMSSFL EYPLCNRGPS AYSAPTSFPP CSAPAVDSYA GESRYGGGLP    50
SSALQQNSGY PVQQPPSSLG VSFPSPAPSG YAPAACNPSY GPSQYYSVGQ 100
SEGDGSYFHP SSYGAQLGGL PDSYGAGGVG SGPYPPPQPP YGTEQTATFA 150
SAYDLLSEDK ESPCSSEPST LTPRTFDWMK VKRNPPKTAK VSELGLGAPG 200
GLRTNFTTRQ LTELEKEFHF NKYLSRARRV EIAATLELNE TQVKIWFQNR 250
RMKQKKRERE GGRMPAGPPG CPKEAAGDAS DQSACTSPEA SPSSITS 297
Length:297
Mass (Da):31,672
Last modified:November 1, 1990 - v1
Checksum:i9798C2B4E897C324
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381S → T in CAA42078. 1 Publication
Sequence conflicti162 – 1621S → C in CAA42078. 1 Publication
Sequence conflicti198 – 1981A → P1 Publication
Sequence conflicti200 – 2001G → R1 Publication
Sequence conflicti217 – 2171E → G in BAB30874. 1 Publication
Sequence conflicti234 – 2341A → P in CAA42078. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53063 Genomic DNA. Translation: CAA37238.1.
X59474 mRNA. Translation: CAA42078.1.
AK017686 mRNA. Translation: BAB30874.1.
BC103597 mRNA. Translation: AAI03598.1.
BC103598 mRNA. Translation: AAI03599.1.
BC103606 mRNA. Translation: AAI03607.1.
M34005 Genomic DNA. Translation: AAA37850.1.
CCDSiCCDS25300.1.
PIRiA60082. WJMS29.
RefSeqiNP_032292.3. NM_008266.5.
UniGeneiMm.890.

Genome annotation databases

EnsembliENSMUST00000019117; ENSMUSP00000019117; ENSMUSG00000018973.
GeneIDi15407.
KEGGimmu:15407.
UCSCiuc007lbz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53063 Genomic DNA. Translation: CAA37238.1 .
X59474 mRNA. Translation: CAA42078.1 .
AK017686 mRNA. Translation: BAB30874.1 .
BC103597 mRNA. Translation: AAI03598.1 .
BC103598 mRNA. Translation: AAI03599.1 .
BC103606 mRNA. Translation: AAI03607.1 .
M34005 Genomic DNA. Translation: AAA37850.1 .
CCDSi CCDS25300.1.
PIRi A60082. WJMS29.
RefSeqi NP_032292.3. NM_008266.5.
UniGenei Mm.890.

3D structure databases

ProteinModelPortali P17919.
SMRi P17919. Positions 174-260.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200375. 2 interactions.

PTM databases

PhosphoSitei P17919.

Proteomic databases

PRIDEi P17919.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019117 ; ENSMUSP00000019117 ; ENSMUSG00000018973 .
GeneIDi 15407.
KEGGi mmu:15407.
UCSCi uc007lbz.2. mouse.

Organism-specific databases

CTDi 3211.
MGIi MGI:96182. Hoxb1.

Phylogenomic databases

eggNOGi NOG236971.
GeneTreei ENSGT00750000117389.
HOGENOMi HOG000247020.
HOVERGENi HBG006089.
InParanoidi P17919.
KOi K09301.
OMAi YAICNRG.
OrthoDBi EOG7PK91P.
PhylomeDBi P17919.
TreeFami TF317730.

Miscellaneous databases

NextBioi 288120.
PROi P17919.
SOURCEi Search...

Gene expression databases

Bgeei P17919.
CleanExi MM_HOXB1.
Genevestigatori P17919.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm."
    Frohman M.A., Boyle M., Martin G.R.
    Development 110:589-607(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  2. "Expression of the mouse labial-like homeobox-containing genes, Hox 2.9 and Hox 1.6, during segmentation of the hindbrain."
    Murphy P., Hill R.E.
    Development 111:61-74(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "A yeast artificial chromosome containing the mouse homeobox cluster Hox-2."
    Rubock M.J., Larin Z., Cook M., Papalopulu N., Krumlauf R., Lehrach H.
    Proc. Natl. Acad. Sci. U.S.A. 87:4751-4755(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 199-259.

Entry informationi

Entry nameiHXB1_MOUSE
AccessioniPrimary (citable) accession number: P17919
Secondary accession number(s): Q3ZAY6, Q9CYH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: July 9, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi