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Protein

Homeobox protein Hox-B1

Gene

Hoxb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi199 – 258HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anatomical structure formation involved in morphogenesis Source: MGI
  • anatomical structure morphogenesis Source: MGI
  • anterior/posterior pattern specification Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • facial nerve structural organization Source: MGI
  • facial nucleus development Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • rhombomere 4 development Source: MGI
  • rhombomere 5 development Source: MGI
  • rhombomere development Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B1
Alternative name(s):
Homeobox protein Hox-2.9
Gene namesi
Name:Hoxb1
Synonyms:Hox-2.9, Hoxb-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96182 Hoxb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001081 – 297Homeobox protein Hox-B1Add BLAST297

Proteomic databases

PaxDbiP17919
PRIDEiP17919

PTM databases

PhosphoSitePlusiP17919

Expressioni

Developmental stagei

Expressed along the entire length of the primitive streak. In early neurogenesis it is expressed in lateral and paraxial mesoderm, endoderm and superficial ectoderm or in the neural tube. From late neurogenesis to mid-embryogenesis, it presents similar spatial domains in the lateral mesoderm, endoderm and superficial ectoderm but is not detectable in the posterior hindbrain and has increased dramatically in rhombomere 4.

Gene expression databases

BgeeiENSMUSG00000018973
CleanExiMM_HOXB1
GenevisibleiP17919 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200375, 2 interactors
STRINGi10090.ENSMUSP00000019117

Structurei

3D structure databases

ProteinModelPortaliP17919
SMRiP17919
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi175 – 180Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family. Labial subfamily.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000247020
HOVERGENiHBG006089
InParanoidiP17919
KOiK09301
OMAiYAICNRG
OrthoDBiEOG091G0LR2
PhylomeDBiP17919
TreeFamiTF317730

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P17919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYNRMSSFL EYPLCNRGPS AYSAPTSFPP CSAPAVDSYA GESRYGGGLP
60 70 80 90 100
SSALQQNSGY PVQQPPSSLG VSFPSPAPSG YAPAACNPSY GPSQYYSVGQ
110 120 130 140 150
SEGDGSYFHP SSYGAQLGGL PDSYGAGGVG SGPYPPPQPP YGTEQTATFA
160 170 180 190 200
SAYDLLSEDK ESPCSSEPST LTPRTFDWMK VKRNPPKTAK VSELGLGAPG
210 220 230 240 250
GLRTNFTTRQ LTELEKEFHF NKYLSRARRV EIAATLELNE TQVKIWFQNR
260 270 280 290
RMKQKKRERE GGRMPAGPPG CPKEAAGDAS DQSACTSPEA SPSSITS
Length:297
Mass (Da):31,672
Last modified:November 1, 1990 - v1
Checksum:i9798C2B4E897C324
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38S → T in CAA42078 (PubMed:1673098).Curated1
Sequence conflicti162S → C in CAA42078 (PubMed:1673098).Curated1
Sequence conflicti198A → P (PubMed:1673098).Curated1
Sequence conflicti200G → R (PubMed:1673098).Curated1
Sequence conflicti217E → G in BAB30874 (PubMed:16141072).Curated1
Sequence conflicti234A → P in CAA42078 (PubMed:1673098).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53063 Genomic DNA Translation: CAA37238.1
X59474 mRNA Translation: CAA42078.1
AK017686 mRNA Translation: BAB30874.1
BC103597 mRNA Translation: AAI03598.1
BC103598 mRNA Translation: AAI03599.1
BC103606 mRNA Translation: AAI03607.1
M34005 Genomic DNA Translation: AAA37850.1
CCDSiCCDS25300.1
PIRiA60082 WJMS29
RefSeqiNP_032292.3, NM_008266.5
UniGeneiMm.890

Genome annotation databases

EnsembliENSMUST00000019117; ENSMUSP00000019117; ENSMUSG00000018973
GeneIDi15407
KEGGimmu:15407
UCSCiuc007lbz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHXB1_MOUSE
AccessioniPrimary (citable) accession number: P17919
Secondary accession number(s): Q3ZAY6, Q9CYH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: March 28, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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