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P17919 (HXB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B1
Alternative name(s):
Homeobox protein Hox-2.9
Gene names
Name:Hoxb1
Synonyms:Hox-2.9, Hoxb-1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.

Subcellular location

Nucleus.

Developmental stage

Expressed along the entire length of the primitive streak. In early neurogenesis it is expressed in lateral and paraxial mesoderm, endoderm and superficial ectoderm or in the neural tube. From late neurogenesis to mid-embryogenesis, it presents similar spatial domains in the lateral mesoderm, endoderm and superficial ectoderm but is not detectable in the posterior hindbrain and has increased dramatically in rhombomere 4.

Sequence similarities

Belongs to the Antp homeobox family. Labial subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanatomical structure formation involved in morphogenesis

Inferred from genetic interaction PubMed 10529420. Source: MGI

anatomical structure morphogenesis

Inferred from genetic interaction PubMed 10529420. Source: MGI

anterior/posterior pattern specification

Inferred from genetic interaction PubMed 10529420PubMed 10885747. Source: MGI

embryonic skeletal system morphogenesis

Inferred from genetic interaction PubMed 10885747. Source: MGI

facial nerve structural organization

Inferred from mutant phenotype PubMed 8898234. Source: MGI

facial nucleus development

Inferred from mutant phenotype PubMed 8898234. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 18787068. Source: MGI

rhombomere 4 development

Inferred from genetic interaction PubMed 10529420. Source: MGI

rhombomere 5 development

Inferred from genetic interaction PubMed 10529420. Source: MGI

rhombomere development

Inferred from direct assay PubMed 21320481. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from direct assay PubMed 7911971. Source: MGI

sequence-specific DNA binding

Inferred from genetic interaction PubMed 18787068. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Homeobox protein Hox-B1
PRO_0000200108

Regions

DNA binding199 – 25860Homeobox
Motif175 – 1806Antp-type hexapeptide

Experimental info

Sequence conflict381S → T in CAA42078. Ref.2
Sequence conflict1621S → C in CAA42078. Ref.2
Sequence conflict1981A → P Ref.2
Sequence conflict2001G → R Ref.2
Sequence conflict2171E → G in BAB30874. Ref.3
Sequence conflict2341A → P in CAA42078. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P17919 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 9798C2B4E897C324

FASTA29731,672
        10         20         30         40         50         60 
MDYNRMSSFL EYPLCNRGPS AYSAPTSFPP CSAPAVDSYA GESRYGGGLP SSALQQNSGY 

        70         80         90        100        110        120 
PVQQPPSSLG VSFPSPAPSG YAPAACNPSY GPSQYYSVGQ SEGDGSYFHP SSYGAQLGGL 

       130        140        150        160        170        180 
PDSYGAGGVG SGPYPPPQPP YGTEQTATFA SAYDLLSEDK ESPCSSEPST LTPRTFDWMK 

       190        200        210        220        230        240 
VKRNPPKTAK VSELGLGAPG GLRTNFTTRQ LTELEKEFHF NKYLSRARRV EIAATLELNE 

       250        260        270        280        290 
TQVKIWFQNR RMKQKKRERE GGRMPAGPPG CPKEAAGDAS DQSACTSPEA SPSSITS 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm."
Frohman M.A., Boyle M., Martin G.R.
Development 110:589-607(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.
[2]"Expression of the mouse labial-like homeobox-containing genes, Hox 2.9 and Hox 1.6, during segmentation of the hindbrain."
Murphy P., Hill R.E.
Development 111:61-74(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"A yeast artificial chromosome containing the mouse homeobox cluster Hox-2."
Rubock M.J., Larin Z., Cook M., Papalopulu N., Krumlauf R., Lehrach H.
Proc. Natl. Acad. Sci. U.S.A. 87:4751-4755(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 199-259.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53063 Genomic DNA. Translation: CAA37238.1.
X59474 mRNA. Translation: CAA42078.1.
AK017686 mRNA. Translation: BAB30874.1.
BC103597 mRNA. Translation: AAI03598.1.
BC103598 mRNA. Translation: AAI03599.1.
BC103606 mRNA. Translation: AAI03607.1.
M34005 Genomic DNA. Translation: AAA37850.1.
PIRWJMS29. A60082.
RefSeqNP_032292.3. NM_008266.5.
UniGeneMm.890.

3D structure databases

ProteinModelPortalP17919.
SMRP17919. Positions 174-260.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200375. 2 interactions.

PTM databases

PhosphoSiteP17919.

Proteomic databases

PRIDEP17919.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019117; ENSMUSP00000019117; ENSMUSG00000018973.
GeneID15407.
KEGGmmu:15407.
UCSCuc007lbz.2. mouse.

Organism-specific databases

CTD3211.
MGIMGI:96182. Hoxb1.

Phylogenomic databases

eggNOGNOG236971.
GeneTreeENSGT00750000117389.
HOGENOMHOG000247020.
HOVERGENHBG006089.
InParanoidP17919.
KOK09301.
OMAYAGETRY.
OrthoDBEOG7PK91P.
PhylomeDBP17919.
TreeFamTF317730.

Gene expression databases

BgeeP17919.
CleanExMM_HOXB1.
GenevestigatorP17919.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288120.
PROP17919.
SOURCESearch...

Entry information

Entry nameHXB1_MOUSE
AccessionPrimary (citable) accession number: P17919
Secondary accession number(s): Q3ZAY6, Q9CYH3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 16, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries