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Protein

Phosphoserine phosphatase RsbX

Gene

rsbX

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of sigma-B activity. Dephosphorylates RsbS. Plays a role both in maintaining low sigma-B activity during growth and in reestablishing prestress sigma-B activity after induction. Could have a negative feedback role by indirectly communicating sigma-B protein levels.4 Publications

Catalytic activityi

O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate.

GO - Molecular functioni

GO - Biological processi

  • response to heat Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciBSUB:BSU04740-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoserine phosphatase RsbX (EC:3.1.3.3)
Alternative name(s):
Sigma-B negative effector
Gene namesi
Name:rsbX
Ordered Locus Names:BSU04740
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577911 – 199Phosphoserine phosphatase RsbXAdd BLAST199

Proteomic databases

PaxDbiP17906.
PRIDEiP17906.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002678.

Structurei

Secondary structure

1199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Beta strandi8 – 17Combined sources10
Beta strandi26 – 33Combined sources8
Beta strandi35 – 48Combined sources14
Helixi49 – 65Combined sources17
Turni66 – 68Combined sources3
Helixi71 – 81Combined sources11
Turni82 – 84Combined sources3
Beta strandi88 – 96Combined sources9
Turni97 – 100Combined sources4
Beta strandi101 – 109Combined sources9
Beta strandi111 – 115Combined sources5
Beta strandi127 – 129Combined sources3
Beta strandi140 – 144Combined sources5
Beta strandi150 – 154Combined sources5
Helixi163 – 169Combined sources7
Helixi173 – 179Combined sources7
Helixi180 – 183Combined sources4
Beta strandi184 – 186Combined sources3
Beta strandi191 – 198Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3W40X-ray1.30A/B1-199[»]
3W41X-ray1.42A1-199[»]
3W42X-ray1.06A/B1-199[»]
3W43X-ray1.22A1-199[»]
3W44X-ray2.30A/B1-199[»]
3W45X-ray1.70A/B1-199[»]
ProteinModelPortaliP17906.
SMRiP17906.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 198PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST188

Sequence similaritiesi

Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41064BQ. Bacteria.
ENOG41126YW. LUCA.
HOGENOMiHOG000270275.
InParanoidiP17906.
KOiK05518.
OMAiMIGIEDK.
PhylomeDBiP17906.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PfamiPF07228. SpoIIE. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17906-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQVEENEHI QTLVYQLNKE GKSICGDSFF MKADDKELIC AVADGLGSGS
60 70 80 90 100
LANESSAAIK DLVENYASED VESIIERCNQ AMKNKRGATA SILKINFEQR
110 120 130 140 150
QFTYCSVGNV RFILHSPSGE SFYPLPISGY LSGKPQKYKT HTATYEKGSK
160 170 180 190
FIIHTDGLNV PDIRSHLKKG QSVEEISNSL KMYTTSRKDD LTYILGQLS
Length:199
Mass (Da):22,144
Last modified:November 1, 1990 - v1
Checksum:i2AAEFB96FB072E33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34995 Genomic DNA. Translation: AAA22714.1.
AB001488 Genomic DNA. Translation: BAA19311.1.
AL009126 Genomic DNA. Translation: CAB12281.1.
PIRiD36131.
RefSeqiNP_388355.1. NC_000964.3.
WP_003246608.1. NZ_JNCM01000031.1.

Genome annotation databases

EnsemblBacteriaiCAB12281; CAB12281; BSU04740.
GeneIDi938155.
KEGGibsu:BSU04740.
PATRICi18972532. VBIBacSub10457_0494.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34995 Genomic DNA. Translation: AAA22714.1.
AB001488 Genomic DNA. Translation: BAA19311.1.
AL009126 Genomic DNA. Translation: CAB12281.1.
PIRiD36131.
RefSeqiNP_388355.1. NC_000964.3.
WP_003246608.1. NZ_JNCM01000031.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3W40X-ray1.30A/B1-199[»]
3W41X-ray1.42A1-199[»]
3W42X-ray1.06A/B1-199[»]
3W43X-ray1.22A1-199[»]
3W44X-ray2.30A/B1-199[»]
3W45X-ray1.70A/B1-199[»]
ProteinModelPortaliP17906.
SMRiP17906.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002678.

Proteomic databases

PaxDbiP17906.
PRIDEiP17906.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12281; CAB12281; BSU04740.
GeneIDi938155.
KEGGibsu:BSU04740.
PATRICi18972532. VBIBacSub10457_0494.

Phylogenomic databases

eggNOGiENOG41064BQ. Bacteria.
ENOG41126YW. LUCA.
HOGENOMiHOG000270275.
InParanoidiP17906.
KOiK05518.
OMAiMIGIEDK.
PhylomeDBiP17906.

Enzyme and pathway databases

BioCyciBSUB:BSU04740-MONOMER.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PfamiPF07228. SpoIIE. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRSBX_BACSU
AccessioniPrimary (citable) accession number: P17906
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.