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Protein

Lysozyme C-1

Gene

Lyz1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz1 is active against a range of Gram-positive and Gram-negative bacteria. Less effective than Lyz2 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria.PROSITE-ProRule annotation1 Publication

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53PROSITE-ProRule annotation1
Active sitei71PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cell wall macromolecule catabolic process Source: GO_Central
  • cytolysis Source: UniProtKB-KW
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-6803157. Antimicrobial peptides.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme C-1 (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase C
Lysozyme C type P
Gene namesi
Name:Lyz1
Synonyms:Lzp-s
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:96902. Lyz1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000001847319 – 148Lysozyme C-1Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 146PROSITE-ProRule annotation
Disulfide bondi48 ↔ 134PROSITE-ProRule annotation
Disulfide bondi83 ↔ 99PROSITE-ProRule annotation
Disulfide bondi95 ↔ 113PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP17897.
PaxDbiP17897.
PeptideAtlasiP17897.
PRIDEiP17897.

PTM databases

PhosphoSitePlusiP17897.

Expressioni

Tissue specificityi

Expressed strongly only in small intestine.

Gene expression databases

BgeeiENSMUSG00000069515.
CleanExiMM_LYZ1.
ExpressionAtlasiP17897. baseline and differential.
GenevisibleiP17897. MM.

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201260. 1 interactor.
IntActiP17897. 1 interactor.
STRINGi10090.ENSMUSP00000089800.

Structurei

3D structure databases

ProteinModelPortaliP17897.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXGD. Eukaryota.
ENOG4111QHM. LUCA.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiP17897.
KOiK13915.
OMAiWVAWKNH.
OrthoDBiEOG091G0R9V.
PhylomeDBiP17897.
TreeFamiTF324882.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALLTLGLL LLSVTAQAKV YNRCELARIL KRNGMDGYRG VKLADWVCLA
60 70 80 90 100
QHESNYNTRA TNYNRGDRST DYGIFQINSR YWCNDGKTPR SKNACGINCS
110 120 130 140
ALLQDDITAA IQCAKRVVRD PQGIRAWVAW RTQCQNRDLS QYIRNCGV
Length:148
Mass (Da):16,794
Last modified:November 1, 1990 - v1
Checksum:iD849A9D02A49EDE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51547 mRNA. Translation: CAA35922.1.
BC061129 mRNA. Translation: AAH61129.1.
CCDSiCCDS48695.1.
PIRiS09229.
RefSeqiNP_038618.1. NM_013590.4.
UniGeneiMm.177539.

Genome annotation databases

EnsembliENSMUST00000092162; ENSMUSP00000089800; ENSMUSG00000069515.
GeneIDi17110.
KEGGimmu:17110.
UCSCiuc007hdc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51547 mRNA. Translation: CAA35922.1.
BC061129 mRNA. Translation: AAH61129.1.
CCDSiCCDS48695.1.
PIRiS09229.
RefSeqiNP_038618.1. NM_013590.4.
UniGeneiMm.177539.

3D structure databases

ProteinModelPortaliP17897.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201260. 1 interactor.
IntActiP17897. 1 interactor.
STRINGi10090.ENSMUSP00000089800.

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.

PTM databases

PhosphoSitePlusiP17897.

Proteomic databases

MaxQBiP17897.
PaxDbiP17897.
PeptideAtlasiP17897.
PRIDEiP17897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092162; ENSMUSP00000089800; ENSMUSG00000069515.
GeneIDi17110.
KEGGimmu:17110.
UCSCiuc007hdc.2. mouse.

Organism-specific databases

CTDi17110.
MGIiMGI:96902. Lyz1.

Phylogenomic databases

eggNOGiENOG410IXGD. Eukaryota.
ENOG4111QHM. LUCA.
GeneTreeiENSGT00550000074398.
HOGENOMiHOG000037357.
HOVERGENiHBG052297.
InParanoidiP17897.
KOiK13915.
OMAiWVAWKNH.
OrthoDBiEOG091G0R9V.
PhylomeDBiP17897.
TreeFamiTF324882.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-6803157. Antimicrobial peptides.

Miscellaneous databases

PROiP17897.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069515.
CleanExiMM_LYZ1.
ExpressionAtlasiP17897. baseline and differential.
GenevisibleiP17897. MM.

Family and domain databases

CDDicd00119. LYZ1. 1 hit.
InterProiIPR001916. Glyco_hydro_22.
IPR019799. Glyco_hydro_22_CS.
IPR000974. Glyco_hydro_22_lys.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PfamiPF00062. Lys. 1 hit.
[Graphical view]
PRINTSiPR00137. LYSOZYME.
PR00135. LYZLACT.
SMARTiSM00263. LYZ1. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYZ1_MOUSE
AccessioniPrimary (citable) accession number: P17897
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 30, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.