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Protein

Lysozyme C-1

Gene

Lyz1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz1 is active against a range of Gram-positive and Gram-negative bacteria. Less effective than Lyz2 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria.PROSITE-ProRule annotation1 Publication

Miscellaneous

Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53PROSITE-ProRule annotation1
Active sitei71PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cell wall macromolecule catabolic process Source: GO_Central
  • cytolysis Source: UniProtKB-KW
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-6803157 Antimicrobial peptides

Protein family/group databases

CAZyiGH22 Glycoside Hydrolase Family 22

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme C-1 (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase C
Lysozyme C type P
Gene namesi
Name:Lyz1
Synonyms:Lzp-s
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:96902 Lyz1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000001847319 – 148Lysozyme C-1Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 146PROSITE-ProRule annotation
Disulfide bondi48 ↔ 134PROSITE-ProRule annotation
Disulfide bondi83 ↔ 99PROSITE-ProRule annotation
Disulfide bondi95 ↔ 113PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP17897
PaxDbiP17897
PeptideAtlasiP17897
PRIDEiP17897

PTM databases

PhosphoSitePlusiP17897

Expressioni

Tissue specificityi

Expressed strongly only in small intestine.

Gene expression databases

BgeeiENSMUSG00000069515
CleanExiMM_LYZ1
ExpressionAtlasiP17897 baseline and differential
GenevisibleiP17897 MM

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201260, 2 interactors
IntActiP17897, 1 interactor
MINTiP17897
STRINGi10090.ENSMUSP00000089800

Structurei

3D structure databases

ProteinModelPortaliP17897
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXGD Eukaryota
ENOG4111QHM LUCA
GeneTreeiENSGT00550000074398
HOGENOMiHOG000037357
HOVERGENiHBG052297
InParanoidiP17897
KOiK13915
OMAiQINDKYW
OrthoDBiEOG091G0R9V
PhylomeDBiP17897
TreeFamiTF324882

Family and domain databases

CDDicd00119 LYZ1, 1 hit
InterProiView protein in InterPro
IPR001916 Glyco_hydro_22
IPR019799 Glyco_hydro_22_CS
IPR000974 Glyco_hydro_22_lys
IPR023346 Lysozyme-like_dom_sf
IPR030056 Lysozyme_C
PANTHERiPTHR11407:SF28 PTHR11407:SF28, 1 hit
PfamiView protein in Pfam
PF00062 Lys, 1 hit
PRINTSiPR00137 LYSOZYME
PR00135 LYZLACT
SMARTiView protein in SMART
SM00263 LYZ1, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
PROSITEiView protein in PROSITE
PS00128 LACTALBUMIN_LYSOZYME_1, 1 hit
PS51348 LACTALBUMIN_LYSOZYME_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALLTLGLL LLSVTAQAKV YNRCELARIL KRNGMDGYRG VKLADWVCLA
60 70 80 90 100
QHESNYNTRA TNYNRGDRST DYGIFQINSR YWCNDGKTPR SKNACGINCS
110 120 130 140
ALLQDDITAA IQCAKRVVRD PQGIRAWVAW RTQCQNRDLS QYIRNCGV
Length:148
Mass (Da):16,794
Last modified:November 1, 1990 - v1
Checksum:iD849A9D02A49EDE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51547 mRNA Translation: CAA35922.1
BC061129 mRNA Translation: AAH61129.1
CCDSiCCDS48695.1
PIRiS09229
RefSeqiNP_038618.1, NM_013590.4
UniGeneiMm.177539

Genome annotation databases

EnsembliENSMUST00000092162; ENSMUSP00000089800; ENSMUSG00000069515
GeneIDi17110
KEGGimmu:17110
UCSCiuc007hdc.2 mouse

Similar proteinsi

Entry informationi

Entry nameiLYZ1_MOUSE
AccessioniPrimary (citable) accession number: P17897
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: March 28, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health