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P17897

- LYZ1_MOUSE

UniProt

P17897 - LYZ1_MOUSE

Protein

Lysozyme C-1

Gene

Lyz1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz1 is active against a range of Gram-postive and Gram-negative bacteria. Less effective than Lyz2 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria.1 PublicationPROSITE-ProRule annotation

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei53 – 531PROSITE-ProRule annotation
    Active sitei71 – 711PROSITE-ProRule annotation

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule catabolic process Source: InterPro
    2. cytolysis Source: UniProtKB-KW
    3. defense response to Gram-negative bacterium Source: UniProtKB
    4. defense response to Gram-positive bacterium Source: UniProtKB

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_198563. Amyloids.

    Protein family/group databases

    CAZyiGH22. Glycoside Hydrolase Family 22.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme C-1 (EC:3.2.1.17)
    Alternative name(s):
    1,4-beta-N-acetylmuramidase C
    Lysozyme C type P
    Gene namesi
    Name:Lyz1
    Synonyms:Lzp-s
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:96902. Lyz1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Chaini19 – 148130Lysozyme C-1PRO_0000018473Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 146PROSITE-ProRule annotation
    Disulfide bondi48 ↔ 134PROSITE-ProRule annotation
    Disulfide bondi83 ↔ 99PROSITE-ProRule annotation
    Disulfide bondi95 ↔ 113PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiP17897.
    PaxDbiP17897.
    PRIDEiP17897.

    PTM databases

    PhosphoSiteiP17897.

    Expressioni

    Tissue specificityi

    Expressed strongly only in small intestine.

    Gene expression databases

    BgeeiP17897.
    CleanExiMM_LYZ1.
    GenevestigatoriP17897.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi201260. 1 interaction.
    IntActiP17897. 1 interaction.
    STRINGi10090.ENSMUSP00000089800.

    Structurei

    3D structure databases

    ProteinModelPortaliP17897.
    SMRiP17897. Positions 19-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 22 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG85133.
    GeneTreeiENSGT00550000074398.
    HOGENOMiHOG000037357.
    HOVERGENiHBG052297.
    InParanoidiP17897.
    KOiK13915.
    OMAiWESSFNT.
    OrthoDBiEOG7BW0M5.
    PhylomeDBiP17897.
    TreeFamiTF324882.

    Family and domain databases

    InterProiIPR001916. Glyco_hydro_22.
    IPR019799. Glyco_hydro_22_CS.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view]
    PfamiPF00062. Lys. 1 hit.
    [Graphical view]
    PRINTSiPR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTiSM00263. LYZ1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53955. SSF53955. 1 hit.
    PROSITEiPS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
    PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17897-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKALLTLGLL LLSVTAQAKV YNRCELARIL KRNGMDGYRG VKLADWVCLA    50
    QHESNYNTRA TNYNRGDRST DYGIFQINSR YWCNDGKTPR SKNACGINCS 100
    ALLQDDITAA IQCAKRVVRD PQGIRAWVAW RTQCQNRDLS QYIRNCGV 148
    Length:148
    Mass (Da):16,794
    Last modified:November 1, 1990 - v1
    Checksum:iD849A9D02A49EDE6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51547 mRNA. Translation: CAA35922.1.
    BC061129 mRNA. Translation: AAH61129.1.
    CCDSiCCDS48695.1.
    PIRiS09229.
    RefSeqiNP_038618.1. NM_013590.4.
    UniGeneiMm.177539.

    Genome annotation databases

    EnsembliENSMUST00000092162; ENSMUSP00000089800; ENSMUSG00000069515.
    GeneIDi17110.
    KEGGimmu:17110.
    UCSCiuc007hdc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51547 mRNA. Translation: CAA35922.1 .
    BC061129 mRNA. Translation: AAH61129.1 .
    CCDSi CCDS48695.1.
    PIRi S09229.
    RefSeqi NP_038618.1. NM_013590.4.
    UniGenei Mm.177539.

    3D structure databases

    ProteinModelPortali P17897.
    SMRi P17897. Positions 19-148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201260. 1 interaction.
    IntActi P17897. 1 interaction.
    STRINGi 10090.ENSMUSP00000089800.

    Protein family/group databases

    CAZyi GH22. Glycoside Hydrolase Family 22.

    PTM databases

    PhosphoSitei P17897.

    Proteomic databases

    MaxQBi P17897.
    PaxDbi P17897.
    PRIDEi P17897.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000092162 ; ENSMUSP00000089800 ; ENSMUSG00000069515 .
    GeneIDi 17110.
    KEGGi mmu:17110.
    UCSCi uc007hdc.2. mouse.

    Organism-specific databases

    CTDi 17110.
    MGIi MGI:96902. Lyz1.

    Phylogenomic databases

    eggNOGi NOG85133.
    GeneTreei ENSGT00550000074398.
    HOGENOMi HOG000037357.
    HOVERGENi HBG052297.
    InParanoidi P17897.
    KOi K13915.
    OMAi WESSFNT.
    OrthoDBi EOG7BW0M5.
    PhylomeDBi P17897.
    TreeFami TF324882.

    Enzyme and pathway databases

    Reactomei REACT_198563. Amyloids.

    Miscellaneous databases

    NextBioi 291254.
    PROi P17897.
    SOURCEi Search...

    Gene expression databases

    Bgeei P17897.
    CleanExi MM_LYZ1.
    Genevestigatori P17897.

    Family and domain databases

    InterProi IPR001916. Glyco_hydro_22.
    IPR019799. Glyco_hydro_22_CS.
    IPR000974. Glyco_hydro_22_lys.
    IPR023346. Lysozyme-like_dom.
    [Graphical view ]
    Pfami PF00062. Lys. 1 hit.
    [Graphical view ]
    PRINTSi PR00137. LYSOZYME.
    PR00135. LYZLACT.
    SMARTi SM00263. LYZ1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53955. SSF53955. 1 hit.
    PROSITEi PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit.
    PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Recent origin of the P lysozyme gene in mice."
      Cortopassi G.A., Wilson A.C.
      Nucleic Acids Res. 18:1911-1911(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Small intestine.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart and Lung.
    3. "Repetitive sequence involvement in the duplication and divergence of mouse lysozyme genes."
      Cross M., Renkawitz R.
      EMBO J. 9:1283-1288(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-45.
    4. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 69-80, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    5. "Comparison of the microbicidal and muramidase activities of mouse lysozyme M and P."
      Markart P., Faust N., Graf T., Na C.-L., Weaver T.E., Akinbi H.T.
      Biochem. J. 380:385-392(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiLYZ1_MOUSE
    AccessioniPrimary (citable) accession number: P17897
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3