P17897 (LYZ1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysozyme C-1
EC=3.2.1.17

Alternative name(s):
1,4-beta-N-acetylmuramidase C
Lysozyme C type P

Gene names

Name:	Lyz1
Synonyms:	Lzp-s

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	148 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz1 is active against a range of Gram-postive and Gram-negative bacteria. Less effective than Lyz2 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria. Ref.5
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subunit structure	Monomer.
Subcellular location	Secreted.
Tissue specificity	Expressed strongly only in small intestine.
Miscellaneous	Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to Gram-negative bacterium Inferred from direct assay Ref.5. Source: UniProtKB defense response to Gram-positive bacterium Inferred from direct assay Ref.5. Source: UniProtKB
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	By similarity
	Chain	19 – 148	130	Lysozyme C-1		PRO_0000018473
Sites
	Active site	53	1	By similarity
	Active site	71	1	By similarity
Amino acid modifications
	Disulfide bond	24 ↔ 146		By similarity
	Disulfide bond	48 ↔ 134		By similarity
	Disulfide bond	83 ↔ 99		By similarity
	Disulfide bond	95 ↔ 113		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P17897 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: D849A9D02A49EDE6	FASTA	148	16,794
	10 20 30 40 50 60 MKALLTLGLL LLSVTAQAKV YNRCELARIL KRNGMDGYRG VKLADWVCLA QHESNYNTRA 70 80 90 100 110 120 TNYNRGDRST DYGIFQINSR YWCNDGKTPR SKNACGINCS ALLQDDITAA IQCAKRVVRD 130 140 PQGIRAWVAW RTQCQNRDLS QYIRNCGV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Recent origin of the P lysozyme gene in mice." Cortopassi G.A., Wilson A.C. Nucleic Acids Res. 18:1911-1911(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Tissue: Small intestine.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart and Lung.
[3]	"Repetitive sequence involvement in the duplication and divergence of mouse lysozyme genes." Cross M., Renkawitz R. EMBO J. 9:1283-1288(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-45.
[4]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 69-80, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
[5]	"Comparison of the microbicidal and muramidase activities of mouse lysozyme M and P." Markart P., Faust N., Graf T., Na C.-L., Weaver T.E., Akinbi H.T. Biochem. J. 380:385-392(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X51547 mRNA. Translation: CAA35922.1. BC061129 mRNA. Translation: AAH61129.1.
IPI	IPI00113427.
PIR	S09229.
RefSeq	NP_038618.1. NM_013590.4.
UniGene	Mm.177539.
3D structure databases
ProteinModelPortal	P17897.
SMR	P17897. Positions 19-148.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000089800.
Protein family/group databases
CAZy	GH22. Glycoside Hydrolase Family 22.
PTM databases
PhosphoSite	P17897.
Proteomic databases
PaxDb	P17897.
PRIDE	P17897.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000092162; ENSMUSP00000089800; ENSMUSG00000069515.
GeneID	17110.
KEGG	mmu:17110.
UCSC	uc007hda.1. mouse.
Organism-specific databases
CTD	17110.
MGI	MGI:96902. Lyz1.
Phylogenomic databases
eggNOG	NOG85133.
GeneTree	ENSGT00550000074398.
HOGENOM	HOG000037357.
HOVERGEN	HBG052297.
InParanoid	P17897.
KO	K13915.
OMA	WESSFNT.
OrthoDB	EOG48KRCP.
Gene expression databases
Bgee	P17897.
CleanEx	MM_LYZ1.
Genevestigator	P17897.
GermOnline	ENSMUSG00000069515. Mus musculus.
Family and domain databases
InterPro	IPR001916. Glyco_hydro_22. IPR019799. Glyco_hydro_22_CS. IPR000974. Glyco_hydro_22_lys. IPR023346. Lysozyme-like_dom. [Graphical view]
Pfam	PF00062. Lys. 1 hit. [Graphical view]
PRINTS	PR00137. LYSOZYME. PR00135. LYZLACT.
SMART	SM00263. LYZ1. 1 hit. [Graphical view]
SUPFAM	SSF53955. SSF53955. 1 hit.
PROSITE	PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit. PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	291254.
SOURCE	Search...

Entry information

Entry name

LYZ1_MOUSE

Accession

Primary (citable) accession number: P17897

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	April 3, 2013
This is version 112 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program