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P17891

- CLC1_YEAST

UniProt

P17891 - CLC1_YEAST

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Protein
Clathrin light chain
Gene
CLC1, YGR167W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. In yeast, it is involved in the retention of proteins in an intracellular membrane compartment, presumably the trans-Golgi. The yeast light chain is important for cell growth. The light chain may help to properly orient the assembly/ disassembly of the clathrin coats.

GO - Molecular functioni

  1. structural molecule activity Source: SGD

GO - Biological processi

  1. endocytosis Source: SGD
  2. intracellular protein transport Source: InterPro
  3. positive regulation of endocytosis Source: SGD
  4. vesicle-mediated transport Source: SGD
Complete GO annotation...

Keywords - Ligandi

Calcium, Calmodulin-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30865-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin light chain
Short name:
CLC
Gene namesi
Name:CLC1
Ordered Locus Names:YGR167W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGR167w.
SGDiS000003399. CLC1.

Subcellular locationi

GO - Cellular componenti

  1. clathrin coat of coated pit Source: InterPro
  2. clathrin coat of trans-Golgi network vesicle Source: InterPro
  3. clathrin vesicle coat Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Clathrin light chain
PRO_0000205776Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491Phosphothreonine1 Publication
Modified residuei52 – 521Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP17891.
PaxDbiP17891.
PeptideAtlasiP17891.

Expressioni

Gene expression databases

GenevestigatoriP17891.

Interactioni

Subunit structurei

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with the auxilin-like clathrin uncoating factor SWA2.1 Publication

Protein-protein interaction databases

BioGridi33419. 399 interactions.
DIPiDIP-2280N.
IntActiP17891. 12 interactions.
MINTiMINT-527297.
STRINGi4932.YGR167W.

Structurei

3D structure databases

ProteinModelPortaliP17891.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni144 – 20461Involved in binding clathrin heavy chain Reviewed prediction
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili125 – 18662 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG251359.
HOGENOMiHOG000190326.
OMAiSTFESQF.
OrthoDBiEOG7Z95XB.

Family and domain databases

InterProiIPR000996. Clathrin_L-chain.
[Graphical view]
PANTHERiPTHR10639. PTHR10639. 1 hit.
PfamiPF01086. Clathrin_lg_ch. 1 hit.
[Graphical view]
PROSITEiPS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17891-1 [UniParc]FASTAAdd to Basket

« Hide

MSEKFPPLED QNIDFTPNDK KDDDTDFLKR EAEILGDEFK TEQDDILETE    50
ASPAKDDDEI RDFEEQFPDI NSANGAVSSD QNGSATVSSG NDNGEADDDF 100
STFEGANQST ESVKEDRSEV VDQWKQRRAV EIHEKDLKDE ELKKELQDEA 150
IKHIDDFYDS YNKKKEQQLE DAAKEAEAFL KKRDEFFGQD NTTWDRALQL 200
INQDDADIIG GRDRSKLKEI LLRLKGNAKA PGA 233
Length:233
Mass (Da):26,532
Last modified:November 1, 1990 - v1
Checksum:i27BAB175780EC8B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52272 Genomic DNA. Translation: CAA36515.1.
Z72952 Genomic DNA. Translation: CAA97192.1.
Z72953 Genomic DNA. Translation: CAA97193.1.
AY558272 Genomic DNA. Translation: AAS56598.1.
BK006941 Genomic DNA. Translation: DAA08261.1.
PIRiA36425.
RefSeqiNP_011683.3. NM_001181296.3.

Genome annotation databases

EnsemblFungiiYGR167W; YGR167W; YGR167W.
GeneIDi853077.
KEGGisce:YGR167W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52272 Genomic DNA. Translation: CAA36515.1 .
Z72952 Genomic DNA. Translation: CAA97192.1 .
Z72953 Genomic DNA. Translation: CAA97193.1 .
AY558272 Genomic DNA. Translation: AAS56598.1 .
BK006941 Genomic DNA. Translation: DAA08261.1 .
PIRi A36425.
RefSeqi NP_011683.3. NM_001181296.3.

3D structure databases

ProteinModelPortali P17891.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33419. 399 interactions.
DIPi DIP-2280N.
IntActi P17891. 12 interactions.
MINTi MINT-527297.
STRINGi 4932.YGR167W.

Proteomic databases

MaxQBi P17891.
PaxDbi P17891.
PeptideAtlasi P17891.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGR167W ; YGR167W ; YGR167W .
GeneIDi 853077.
KEGGi sce:YGR167W.

Organism-specific databases

CYGDi YGR167w.
SGDi S000003399. CLC1.

Phylogenomic databases

eggNOGi NOG251359.
HOGENOMi HOG000190326.
OMAi STFESQF.
OrthoDBi EOG7Z95XB.

Enzyme and pathway databases

BioCyci YEAST:G3O-30865-MONOMER.

Miscellaneous databases

NextBioi 973038.

Gene expression databases

Genevestigatori P17891.

Family and domain databases

InterProi IPR000996. Clathrin_L-chain.
[Graphical view ]
PANTHERi PTHR10639. PTHR10639. 1 hit.
Pfami PF01086. Clathrin_lg_ch. 1 hit.
[Graphical view ]
PROSITEi PS00581. CLATHRIN_LIGHT_CHN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Yeast clathrin has a distinctive light chain that is important for cell growth."
    Silveira L.A., Wong D.H., Masiarz F.R., Schekman R.
    J. Cell Biol. 111:1437-1449(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 31-39.
  2. "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII."
    Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.
    Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. "The auxilin-like phosphoprotein Swa2p is required for clathrin function in yeast."
    Gall W.E., Higginbotham M.A., Chen C.-Y., Ingram M.F., Cyr D.M., Graham T.R.
    Curr. Biol. 10:1349-1358(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SWA2.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-49 AND SER-52, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCLC1_YEAST
AccessioniPrimary (citable) accession number: P17891
Secondary accession number(s): D6VUV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 14, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

CLC1 binds calcium, and calmodulin in presence of calcium.
Present with 3490 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3

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