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Protein

Major capsid protein

Gene

MCP

Organism
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.UniRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid proteinUniRule annotation
Short name:
MCPUniRule annotation
Gene namesi
Name:MCPUniRule annotation
Synonyms:4L, U57
OrganismiHuman herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus)
Taxonomic identifieri10370 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009295 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, T=16 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001157051 – 1345Major capsid proteinAdd BLAST1345

Interactioni

Subunit structurei

Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2. Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus. Interacts with capsid vertex component 2/CVC2. Interacts with the small capsomere-interacting protein/SCP.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP17887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae major capsid protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900000D.

Family and domain databases

HAMAPiMF_04016. HSV_MCP. 1 hit.
InterProiView protein in InterPro
IPR000912. Herpes_MCP.
IPR023233. Herpes_MCP_upper.
PfamiView protein in Pfam
PF03122. Herpes_MCP. 1 hit.
PRINTSiPR00235. HSVCAPSIDMCP.
SUPFAMiSSF103417. SSF103417. 1 hit.

Sequencei

Sequence statusi: Complete.

P17887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENWQATEIL PKIEAPLNIF NDIKTYTAEQ LFDNLRIYFG DDPSRYNISF
60 70 80 90 100
EALLGIYCNK IEWINFFTTP IAVAANVIRF NDVSRMTLGK VLFFIQLPRV
110 120 130 140 150
ATGNDVTASK ETTIMVAKHS EKHPINISFD LSAACLEHLE NTFKNTVIDQ
160 170 180 190 200
ILNINALHTV LRSLKNSADS LERGLIHAFM QTLLRKSPPQ FIVLTMNENK
210 220 230 240 250
VHNKQALSRV QRSNMFQSLK NRLLTSLFFL NRNNNISYIY RILNDMMESV
260 270 280 290 300
TESILNDTNN YTSKENVPLD GVLLGPIGSI QKLTSILSQY ISTQVVSAPI
310 320 330 340 350
SYGHFIMGKE NAVTAIAYRA IMADFTQFTV NAGTEQQDTN NKSEIFDKSR
360 370 380 390 400
AYADLKLNTL KLGDKLVAFD HLHKVYKNTD VNDPLEQSLQ LTFFFPLGIY
410 420 430 440 450
IPSETGFSTM ETRVKLNDTM ENNLPTSVFF HNKDQVVQRI DFADILPSVC
460 470 480 490 500
HPIVHDSTIV ERLMKSEPLP TGHRFSQLCQ LKITRENPAR ILQTLYNLYE
510 520 530 540 550
SRQEVPKNTN VLKNELNIED FYKPDNPTLP TERHPFFDLT YIQKNRATEV
560 570 580 590 600
LCTPRIMIGN IPLPLAPVSF HEARTNQILE HAKTNCQKYD FTLKIVTESL
610 620 630 640 650
TSGSYPELAY VIETLVHGNK HAFMILKQVI SQCISYWFNM KHILLFCNSF
660 670 680 690 700
EMIMLISNHM GDELIPGAAF AHYRNLVSLI RLVKRTISIS NLNEQLCGEP
710 720 730 740 750
LVNFANALFD GRLFCPFVHT MPRNDTNAKI TADDTPLTQN TVRVRNYEIS
760 770 780 790 800
DVQRMNLIDS SVVFTDNDRP SNETTILSKI FYFCVLPALS NNKACGAGVN
810 820 830 840 850
VKELVLDLFY TEPFISPDDY FQENPITSDV LMSLIREGMG PGYTVANTSC
860 870 880 890 900
IAKQLFKSLI YINENTKILE VEVSLDPAQR HGNSVHFQSL QHILYNGLCL
910 920 930 940 950
ISPITTLRRY YQPIPFHRFF SDPGICGTMN ADIQVFLNTF PHCQRNDGGF
960 970 980 990 1000
PLPPPLALEF YNWQRTPFSV YSAFCPNSLL SIMTLAAMHS KLSPVAIAIQ
1010 1020 1030 1040 1050
SKNKIHPGFA ATLVRTDNFD VECLLYSSRA ATSIILDDPT VTAEAKDIAT
1060 1070 1080 1090 1100
TYNFTQHLSF VDMGLGFSST TATANLKRIK SDMGSKIQNL FSAFPIHAFT
1110 1120 1130 1140 1150
NADINTWIRH HVGIEKPNPS ESEALNIITF GGINKNPPSI LLHGQQAICE
1160 1170 1180 1190 1200
VILTPVTTNI NFFKSPHNPR GRESCMMGTD PHNEEAARKA LYDHTQTDSD
1210 1220 1230 1240 1250
TFAATTNPWA SLPGSLGDIL YNTAHREQLC YNPKTYSPNA QFFTESDILK
1260 1270 1280 1290 1300
TNKMMYKVIS EYCMKSNSCL NSDSEIQYSC SEGTDSFVSR PCQFLQNALP
1310 1320 1330 1340
LHCSSNQALL ESRSKTGNTQ ISETHYCNYA IGETIPFQLI IESSI
Length:1,345
Mass (Da):151,951
Last modified:October 1, 1996 - v3
Checksum:iF1DE8D083A85A949
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti344E → K (PubMed:2153237).Curated1
Sequence conflicti344E → K (PubMed:2152817).Curated1
Sequence conflicti779K → E (PubMed:2153237).Curated1
Sequence conflicti779K → E (PubMed:2152817).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33515 Genomic DNA. Translation: AAA51531.1.
M68963 Genomic DNA. Translation: AAA65567.1.
X83413 Genomic DNA. Translation: CAA58391.1.
PIRiE33560. VCBEH6.
RefSeqiNP_042950.1. NC_001664.2.

Genome annotation databases

GeneIDi1487939.
KEGGivg:1487939.

Similar proteinsi

Entry informationi

Entry nameiMCP_HHV6U
AccessioniPrimary (citable) accession number: P17887
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 1, 1996
Last modified: September 27, 2017
This is version 72 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families