Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P17880

- GP_SEOUS

UniProt

P17880 - GP_SEOUS

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Envelope glycoprotein

Gene

GP

Organism
Seoul virus (strain SR-11) (Sapporo rat virus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei646 – 6472Cleavage; by host signal peptidaseBy similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. signal transduction Source: InterPro
  3. suppression by virus of host innate immune response Source: UniProtKB-KW
  4. suppression by virus of host TRAF activity Source: UniProtKB-KW
  5. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiSeoul virus (strain SR-11) (Sapporo rat virus)
Taxonomic identifieri11610 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Rattus norvegicus (Rat) [TaxID: 10116]
Rattus rattus (Black rat) [TaxID: 10117]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 484468LumenalSequence AnalysisAdd
BLAST
Transmembranei485 – 50420HelicalSequence AnalysisAdd
BLAST
Topological domaini505 – 646142CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini647 – 1105459LumenalSequence AnalysisAdd
BLAST
Transmembranei1106 – 112520HelicalSequence AnalysisAdd
BLAST
Topological domaini1126 – 11338CytoplasmicSequence Analysis

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell membrane Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 16161 PublicationAdd
BLAST
Chaini17 – 11331117Envelope glycoproteinPRO_0000036841Add
BLAST
Chaini17 – 646630Glycoprotein G1By similarityPRO_0000036842Add
BLAST
Chaini647 – 1133487Glycoprotein G2By similarityPRO_0000036843Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi132 – 1321N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi233 – 2331N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi345 – 3451N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi397 – 3971N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi926 – 9261N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini609 – 63224ITAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17880-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWSLLLLAAL VGQGFALKNV FDMRIQLPHS VNFGETSVSG YTEFPPLSLQ
60 70 80 90 100
EAEQLVPESS CNMDNHQSLS TINKLTKVIW RKKANQESAN QNSFEVVESE
110 120 130 140 150
VSFKGLCMLK HRMVEESYRN RRSVICYDLA CNSTFCKPTV YMIVPIHACN
160 170 180 190 200
MMKSCLIGLG PYRIQVVYER TYCTTGILTE GKCFVPDKAV VSALKRGMYA
210 220 230 240 250
IASIETICFF IHQKGNTYKI VTAITSAMGS KCNNTDTKVQ GYYICIIGGN
260 270 280 290 300
SAPVYAPAGE DFRAMEVFSG IITSPHGEDH DLPGEEIATY QISGQIEAKI
310 320 330 340 350
PHTVSSKNLK LTAFAGIPSY SSTSILAASE DGRFIFSPGL FPNLNQSVCD
360 370 380 390 400
NNALPLIWRG LIDLTGYYEA VHPCNVFCVL SGPGASCEAF SEGGIFNITS
410 420 430 440 450
PMCLVSKQNR FRAAEQQISF VCQRVDMDII VYCNGQKKTI LTKTLVIGQC
460 470 480 490 500
IYTITSLFSL LPGVAHSIAI ELCVPGFHGW ATAALLITFC FGWVLIPACT
510 520 530 540 550
LAILLVLKFF ANILHTSNQE NRFKAILRKI KEEFEKTKGS MVCEICKYEC
560 570 580 590 600
ETLKELKAHN LSCVQGECPY CFTHCEPTET AIQAHYKVCQ ATHRFREDLK
610 620 630 640 650
KTVTPQNIGP GCYRTLNLFR YKSRCYILTM WTLLLIIESI LWAASAAEIP
660 670 680 690 700
LVPLWTDNAH GVGSVPMHTD LELDFSLPSS SKYTYKRHLT NPVNDQQSVS
710 720 730 740 750
LHIEIESQGI GAAVHHLGHW YDARLNLKTS FHCYGACTKY QYPWHTAKCH
760 770 780 790 800
FEKDYEYENS WACNPPDCPG VGTGCTACGL YLDQLKPVGT AFKIISVRYS
810 820 830 840 850
RKVCVQFGEE HLCKTIDMND CFVTRHAKIC IIGTVSKFSQ GDTLLFLGPM
860 870 880 890 900
EGGGIIFKHW CTSTCHFGDP GDVMGPKDKP FICPEFPGQF RKKCNFATTP
910 920 930 940 950
VCEYDGNIIS GYKKVLATID SFQSFNTSNI HFTDERIEWR DPDGMLRDHI
960 970 980 990 1000
NIVISKDIDF ENLAENPCKV GLQAANIEGA WGSGVGFTLT CKVSLTECPT
1010 1020 1030 1040 1050
FLTSIKACDM AICYGAESVT LSRGQNTVKI TGKGGHSGSS FKCCHGKECS
1060 1070 1080 1090 1100
STGLQASAPH LDKVNGISEL ENEKVYDDGA PECGITCWFK KSGEWVMGII
1110 1120 1130
NGNWVVLIVL CVLLLFSLIL LSILCPVRKH KKS
Length:1,133
Mass (Da):125,592
Last modified:August 1, 1990 - v1
Checksum:i8120721933A8AE5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34882 Genomic RNA. Translation: AAA47825.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34882 Genomic RNA. Translation: AAA47825.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view ]
Pfami PF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view ]
PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
ProDomi PD001813. Hanta_G2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS51056. ITAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Coding properties of the S and the M genome segments of Sapporo rat virus: comparison to other causative agents of hemorrhagic fever with renal syndrome."
    Arikawa J., Lapenotiere H.F., Iacono-Connors L., Wang M., Schmaljohn C.S.
    Virology 176:114-125(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA], PROTEIN SEQUENCE OF 17-23 AND 647-654.

Entry informationi

Entry nameiGP_SEOUS
AccessioniPrimary (citable) accession number: P17880
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3