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Protein

Mannitol-specific phosphotransferase enzyme IIA component

Gene

mtlF

Organism
Staphylococcus carnosus (strain TM300)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannitol transport.

Catalytic activityi

Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei63 – 631Tele-phosphohistidine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciSCAR396513:GJ9G-1712-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannitol-specific phosphotransferase enzyme IIA component (EC:2.7.1.-)
Alternative name(s):
EIIA-Mtl
EIII-Mtl
PTS system mannitol-specific EIIA component
Gene namesi
Name:mtlF
Ordered Locus Names:Sca_1660
OrganismiStaphylococcus carnosus (strain TM300)
Taxonomic identifieri396513 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000444 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 144143Mannitol-specific phosphotransferase enzyme IIA componentPRO_0000186643Add
BLAST

Interactioni

Subunit structurei

Homotrimer.

Protein-protein interaction databases

STRINGi396513.Sca_1660.

Structurei

3D structure databases

ProteinModelPortaliP17876.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 142140PTS EIIA type-2PROSITE-ProRule annotationAdd
BLAST

Domaini

The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.

Sequence similaritiesi

Contains 1 PTS EIIA type-2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105DTZ. Bacteria.
COG4668. LUCA.
HOGENOMiHOG000227563.
KOiK02798.
OMAiISIVQVP.

Family and domain databases

Gene3Di3.40.930.10. 1 hit.
InterProiIPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_type-2_dom.
[Graphical view]
PfamiPF00359. PTS_EIIA_2. 1 hit.
[Graphical view]
SUPFAMiSSF55804. SSF55804. 1 hit.
PROSITEiPS51094. PTS_EIIA_TYPE_2. 1 hit.
PS00372. PTS_EIIA_TYPE_2_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELFSNENI FLNQSFEDQN EAIEKAGQAL VDAGAVTEDY IQAMKDREAV
60 70 80 90 100
VSTFMGNGLA IPHGTDEAKS AVLQSGLTLL QIPEGVQWGD DVAKVVVGIA
110 120 130 140
GKDGEHLDLL SKIAITFSEE ENVDRIVNTK SPEEIKAVFE EADV
Length:144
Mass (Da):15,566
Last modified:January 23, 2007 - v3
Checksum:i77ACE463AFF17957
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30781 Genomic DNA. Translation: AAA26656.1.
AM295250 Genomic DNA. Translation: CAL28566.1.
PIRiB31048.
JQ0088.
RefSeqiWP_015900906.1. NC_012121.1.

Genome annotation databases

KEGGisca:SCA_1660.
PATRICi19604169. VBIStaCar105558_1657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30781 Genomic DNA. Translation: AAA26656.1.
AM295250 Genomic DNA. Translation: CAL28566.1.
PIRiB31048.
JQ0088.
RefSeqiWP_015900906.1. NC_012121.1.

3D structure databases

ProteinModelPortaliP17876.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi396513.Sca_1660.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGisca:SCA_1660.
PATRICi19604169. VBIStaCar105558_1657.

Phylogenomic databases

eggNOGiENOG4105DTZ. Bacteria.
COG4668. LUCA.
HOGENOMiHOG000227563.
KOiK02798.
OMAiISIVQVP.

Enzyme and pathway databases

BioCyciSCAR396513:GJ9G-1712-MONOMER.

Family and domain databases

Gene3Di3.40.930.10. 1 hit.
InterProiIPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_type-2_dom.
[Graphical view]
PfamiPF00359. PTS_EIIA_2. 1 hit.
[Graphical view]
SUPFAMiSSF55804. SSF55804. 1 hit.
PROSITEiPS51094. PTS_EIIA_TYPE_2. 1 hit.
PS00372. PTS_EIIA_TYPE_2_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTMA_STACT
AccessioniPrimary (citable) accession number: P17876
Secondary accession number(s): B9DM95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.