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P17852 (ITA3_CRIGR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Integrin alpha-3
Alternative name(s):
CD49 antigen-like family member C
Galactoprotein B3
Short name=GAPB3
VLA-3 subunit alpha
CD_antigen=CD49c

Cleaved into the following 2 chains:

  1. Integrin alpha-3 heavy chain
  2. Integrin alpha-3 light chain
Gene names
Name:ITGA3
OrganismCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Taxonomic identifier10029 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Cricetulus

Protein attributes

Sequence length1051 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration By similarity.

Subunit structure

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Post-translational modification

Isoform 1, but not isoform 2, is phosphorylated on serine residues.

Sequence similarities

Belongs to the integrin alpha chain family.

Contains 7 FG-GAP repeats.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
Metal-binding
   Molecular functionIntegrin
Receptor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
Phosphoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

integrin-mediated signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegrin complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P17852-1)

Also known as: Alpha-3A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P17852-2)

Also known as: Alpha-3B;

The sequence of this isoform differs from the canonical sequence as follows:
     1021-1051: RARTRALYEAKRQKAEMKSQPSETERLTDDY → PTRYYRIMPK...TSWQIRDRYY

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232
Chain33 – 10511019Integrin alpha-3
PRO_0000016235
Chain33 – 872840Integrin alpha-3 heavy chain Potential
PRO_0000016236
Chain876 – 1051176Integrin alpha-3 light chain Potential
PRO_0000016237

Regions

Topological domain33 – 991959Extracellular Potential
Transmembrane992 – 101928Helical; Potential
Topological domain1020 – 105132Cytoplasmic Potential
Repeat38 – 10366FG-GAP 1
Repeat110 – 17162FG-GAP 2
Repeat185 – 23652FG-GAP 3
Repeat237 – 29357FG-GAP 4
Repeat294 – 35461FG-GAP 5
Repeat356 – 41156FG-GAP 6
Repeat415 – 47763FG-GAP 7
Calcium binding315 – 3239 Potential
Calcium binding378 – 3869 Potential
Calcium binding439 – 4479 Potential
Motif1017 – 10215GFFKR motif

Amino acid modifications

Glycosylation861N-linked (GlcNAc...) Potential
Glycosylation5001N-linked (GlcNAc...) Potential
Glycosylation5111N-linked (GlcNAc...) Potential
Glycosylation5731N-linked (GlcNAc...) Potential
Glycosylation6051N-linked (GlcNAc...) Potential
Glycosylation6561N-linked (GlcNAc...) Potential
Glycosylation6971N-linked (GlcNAc...) Potential
Glycosylation8411N-linked (GlcNAc...) Potential
Glycosylation9231N-linked (GlcNAc...) Potential
Glycosylation9261N-linked (GlcNAc...) Potential
Glycosylation9351N-linked (GlcNAc...) Potential
Glycosylation9691N-linked (GlcNAc...) Potential
Disulfide bond94 ↔ 103 By similarity
Disulfide bond140 ↔ 162 By similarity
Disulfide bond185 ↔ 197 By similarity
Disulfide bond485 ↔ 490 By similarity
Disulfide bond496 ↔ 550 By similarity
Disulfide bond615 ↔ 621 By similarity
Disulfide bond694 ↔ 702 By similarity
Disulfide bond846 ↔ 904Interchain (between heavy and light chains) By similarity
Disulfide bond911 ↔ 916 By similarity

Natural variations

Alternative sequence1021 – 105131RARTR…LTDDY → PTRYYRIMPKYHAVRIREEE RYPPPGSTLPTKKHWVTSWQ IRDRYY in isoform 2.
VSP_002720

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Alpha-3A) [UniParc].

Last modified September 21, 2011. Version 3.
Checksum: 96A8983E8DCD9D5D

FASTA1,051116,456
        10         20         30         40         50         60 
MGPGPRCAPG DPGWMLGALA LMVAASGRFA FAFNLDTRFL VVKEAVNPGS LFGYSVALHR 

        70         80         90        100        110        120 
QTERQQRYLL LAGAPRDLSV ADGYTNRTGA VYLCPLTALK DDCERMDISE KSDPDHHIIE 

       130        140        150        160        170        180 
DMWLGVTVAS QGPAGRVLVC AHRYTQVLWS GMEDQRRMVG KCYVRGNDLQ LDPGDDWQTY 

       190        200        210        220        230        240 
HNEMCNSNTD YLQTGMCQLG TSGGFTQNTV YFGAPGAYNW KGNSYMIQRK DWDLSEYSYK 

       250        260        270        280        290        300 
GSEDQGNLYI GYTVQVGSAV LHPTYITVVA GAPRHQHMGA VFLLSQESGG DLKRKQVLEG 

       310        320        330        340        350        360 
TQVGAYFGSA IALADLNNDG WQDLLVGAPY YFERKEEVGG AVYVFMNQAG TSFPDQPSLL 

       370        380        390        400        410        420 
LHGPSRSAFG ISIASIGDIN QDGFQDIAVG APFEGLGKVY IYHSSSGGLL RQPQQIVHGD 

       430        440        450        460        470        480 
KLGLPGLSTF GYSLSGKMDV DDNSYPDLLV GSLSDHIVLL RARPVINILQ RTLVARPAVL 

       490        500        510        520        530        540 
DPSLCTPTSC VQVELCFAYN QSAGNPSYRR NITLAYTLEA DRDRRPPRLR FARSQSAVFH 

       550        560        570        580        590        600 
GFLSMPETHC QTLELLLMDN VRDKLRPIVI AMNYSLPLRM PDRLKLGMRS LDAYPVLNQA 

       610        620        630        640        650        660 
QALENHTEVH FQKECGPDNK CDSNLQMRAA FVSEQLQPLS RLQYSRDTKK LFLSINVTNT 

       670        680        690        700        710        720 
PSRERAGEDA HEALLTLEVP PALLLSSVRP SGTCQANETI LCELGNPFKR NQRMELLIAF 

       730        740        750        760        770        780 
EVIGVTLHTR DLKAQLQLST SSHQDNLQPM TLILQVDYTL QASLSLMTHR LQSFFGGTVM 

       790        800        810        820        830        840 
GEAGMKTVED VGSPLKYEFQ VSPVGDGLAA LGTLVLGLEW PYEVTNGKWL LYPTEIIIHS 

       850        860        870        880        890        900 
NESWPCQPPG NLVNPLNLIL SDPGDKPHSP QRRRRQLDPG GDQGSPPVTL AAAKKAKSET 

       910        920        930        940        950        960 
VLTCASGRAR CVWLECPIPD TSNVTNVTVK ARVWNSTFIE DYRDFDRVRV DGWATLFLRT 

       970        980        990       1000       1010       1020 
SIPTINMENK TTWFSVDIDS ELVEELPAEI ELWLVLVAVS AGLLLLGLII ILLWKCGFFK 

      1030       1040       1050 
RARTRALYEA KRQKAEMKSQ PSETERLTDD Y

« Hide

Isoform 2 (Alpha-3B) [UniParc].

Checksum: FD089C2431F57684
Show »

FASTA1,066118,550

References

[1]"Characterization through cDNA cloning of galactoprotein b3 (Gap b3), a cell surface membrane glycoprotein showing enhanced expression on oncogenic transformation. Identification of Gap b3 as a member of the integrin superfamily."
Tsuji T., Yamamoto F., Miura Y., Takio K., Titani K., Pawar S., Osawa T., Hakomori S.
J. Biol. Chem. 265:7016-7021(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE.
Tissue: Fibroblast.
[2]"Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains."
Tamura R.N., Cooper H.M., Collo G., Quaranta V.
Proc. Natl. Acad. Sci. U.S.A. 88:10183-10187(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: ALTERNATIVE SPLICING.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		J05281 mRNA. Translation: AAA56794.1.
PIRA35761.

3D structure databases

ProteinModelPortalP17852.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG108011.

Family and domain databases

InterProIPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
[Graphical view]
PfamPF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSPR01185. INTEGRINA.
SMARTSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameITA3_CRIGR
AccessionPrimary (citable) accession number: P17852
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: September 21, 2011
Last modified: April 3, 2013
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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