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Protein

Probable ATP-dependent RNA helicase DDX5

Gene

DDX5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.10 Publications

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei121ATP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi114 – 116ATP3
Nucleotide bindingi138 – 145ATP8

GO - Molecular functioni

  • androgen receptor binding Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: GO_Central
  • estrogen receptor binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • pre-mRNA binding Source: UniProtKB
  • RNA helicase activity Source: UniProtKB
  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

  • cell growth Source: UniProtKB
  • intrinsic apoptotic signaling pathway by p53 class mediator Source: UniProtKB
  • mRNA splicing, via spliceosome Source: UniProtKB
  • mRNA transcription Source: CACAO
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
  • positive regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
  • regulation of androgen receptor signaling pathway Source: UniProtKB
  • regulation of osteoblast differentiation Source: UniProtKB
  • regulation of skeletal muscle cell differentiation Source: UniProtKB
  • regulation of viral genome replication Source: Ensembl
  • rhythmic process Source: UniProtKB-KW
  • RNA secondary structure unwinding Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Biological rhythms, mRNA processing, mRNA splicing, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108654-MONOMER.
BRENDAi3.6.4.13. 2681.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
SIGNORiP17844.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX5 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 5
RNA helicase p68
Gene namesi
Name:DDX5
Synonyms:G17P1, HELR, HLR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:2746. DDX5.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular matrix Source: BHF-UCL
  • intracellular ribonucleoprotein complex Source: MGI
  • membrane Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi53K → R: Abolishes sumoylation, abolishes interaction with HDAC1, increases TP53 coactivation and promotes polyubiquitination. 2 Publications1
Mutagenesisi55E → A: Abolishes sumoylation. 1 Publication1
Mutagenesisi144K → R: Abolishes RNA helicase activity, no effect on transcriptional coactivator function. 2 Publications1
Mutagenesisi403R → L: Binds to the tau stem-loop-containing RNA. Inhibits tau exon 10 inclusion and RNA cleavage. Does not inhibit interaction with RBM4. 1 Publication1

Organism-specific databases

DisGeNETi1655.
OpenTargetsiENSG00000108654.
PharmGKBiPA27228.

Polymorphism and mutation databases

BioMutaiDDX5.
DMDMi129383.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000549911 – 614Probable ATP-dependent RNA helicase DDX5Add BLAST614

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineCombined sources1
Modified residuei32N6-acetyllysineCombined sources1
Modified residuei33N6-acetyllysineCombined sources1
Modified residuei40N6-acetyllysineCombined sources1
Cross-linki53Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linki53Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki53Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei236N6-acetyllysineBy similarity1
Modified residuei297PhosphotyrosineCombined sources1
Modified residuei480PhosphoserineCombined sources1
Modified residuei520PhosphoserineCombined sources1

Post-translational modificationi

Arg-502 is dimethylated, probably to asymmetric dimethylarginine.
Sumoylated; sumoylation, promoted by PIAS1, promotes interaction with HDAC1 and transcriptional repression activity. Sumoylation also significantly increases stability, and reduces polyubiquitination.2 Publications
Polyubiquitinated, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP17844.
MaxQBiP17844.
PaxDbiP17844.
PeptideAtlasiP17844.
PRIDEiP17844.

2D gel databases

SWISS-2DPAGEP17844.

PTM databases

iPTMnetiP17844.
PhosphoSitePlusiP17844.
SwissPalmiP17844.

Expressioni

Gene expression databases

BgeeiENSG00000108654.
CleanExiHS_DDX5.
ExpressionAtlasiP17844. baseline and differential.
GenevisibleiP17844. HS.

Organism-specific databases

HPAiCAB005868.
HPA020043.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Interacts with RBM4; the interaction occurs in an RNA-independent manner. Interacts with AGO1 and AGO2. Interacts with ESR1; the interaction is enhanced by phosphorylation of ESR1 AF-1 domain. Interacts with AR, NCOA1, NCOA2, NCOA3, EP300, CREBBP, POLR2A, TP53, RUNX2 and HDAC1. Self-associates. Interacts with DDX17. Interacts with BRDT. The large PER complex involved in the repression of transcriptional termination is composed of at least PER2, CDK9, DDX5, DHX9, NCBP1 and POLR2A (active).16 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
P2795812EBI-351962,EBI-6904388From a different organism.
P299913EBI-351962,EBI-8826747From a different organism.
CHD3Q128734EBI-351962,EBI-523590
CrebbpP454813EBI-351962,EBI-296306From a different organism.
DDX17Q928413EBI-351962,EBI-746012
EBNA-LPQ8AZK72EBI-351962,EBI-1185167From a different organism.
EP300Q094724EBI-351962,EBI-447295
ESR1P033729EBI-351962,EBI-78473
EXOSC10Q017803EBI-351962,EBI-358236
FBLP220876EBI-351962,EBI-358318
HDAC1Q135474EBI-351962,EBI-301834
MBD3O959834EBI-351962,EBI-1783068
Myod1P100853EBI-351962,EBI-4405734From a different organism.
NFAT5O949164EBI-351962,EBI-308320
PB1B4URF52EBI-351962,EBI-6050669From a different organism.
POLR2AP249283EBI-351962,EBI-295301
Runx2Q08775-32EBI-351962,EBI-6119991From a different organism.
SF1Q156373EBI-351962,EBI-744603
TP53P046376EBI-351962,EBI-366083
TP53P04637-12EBI-351962,EBI-3895849
TP53P04637-72EBI-351962,EBI-3895873

GO - Molecular functioni

  • androgen receptor binding Source: UniProtKB
  • estrogen receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108021. 215 interactors.
DIPiDIP-29844N.
IntActiP17844. 116 interactors.
MINTiMINT-5000516.
STRINGi9606.ENSP00000225792.

Structurei

Secondary structure

1614
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi64 – 66Combined sources3
Helixi72 – 80Combined sources9
Beta strandi82 – 87Combined sources6
Turni96 – 99Combined sources4
Helixi103 – 110Combined sources8
Turni111 – 113Combined sources3
Helixi119 – 130Combined sources12
Beta strandi134 – 138Combined sources5
Helixi144 – 157Combined sources14
Beta strandi169 – 173Combined sources5
Helixi177 – 193Combined sources17
Beta strandi198 – 201Combined sources4
Helixi207 – 216Combined sources10
Beta strandi219 – 223Combined sources5
Helixi225 – 233Combined sources9
Turni234 – 236Combined sources3
Beta strandi239 – 241Combined sources3
Beta strandi244 – 247Combined sources4
Helixi250 – 255Combined sources6
Helixi259 – 266Combined sources8
Beta strandi274 – 280Combined sources7
Helixi284 – 293Combined sources10
Beta strandi298 – 302Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FE2X-ray2.60A/B68-307[»]
4A4DX-ray2.70A52-304[»]
ProteinModelPortaliP17844.
SMRiP17844.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17844.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 300Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST176
Domaini328 – 475Helicase C-terminalPROSITE-ProRule annotationAdd BLAST148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni477 – 614Transactivation domainAdd BLAST138

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi94 – 122Q motifAdd BLAST29
Motifi248 – 251DEAD box4

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0331. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00820000126976.
HOGENOMiHOG000268804.
HOVERGENiHBG015893.
InParanoidiP17844.
KOiK12823.
PhylomeDBiP17844.
TreeFamiTF300332.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR033488. DDX5.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR012587. P68_rpt.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PANTHERiPTHR24031:SF257. PTHR24031:SF257. 1 hit.
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF08061. P68HR. 2 hits.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM01414. P68HR. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17844-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGYSSDRDR GRDRGFGAPR FGGSRAGPLS GKKFGNPGEK LVKKKWNLDE
60 70 80 90 100
LPKFEKNFYQ EHPDLARRTA QEVETYRRSK EITVRGHNCP KPVLNFYEAN
110 120 130 140 150
FPANVMDVIA RQNFTEPTAI QAQGWPVALS GLDMVGVAQT GSGKTLSYLL
160 170 180 190 200
PAIVHINHQP FLERGDGPIC LVLAPTRELA QQVQQVAAEY CRACRLKSTC
210 220 230 240 250
IYGGAPKGPQ IRDLERGVEI CIATPGRLID FLECGKTNLR RTTYLVLDEA
260 270 280 290 300
DRMLDMGFEP QIRKIVDQIR PDRQTLMWSA TWPKEVRQLA EDFLKDYIHI
310 320 330 340 350
NIGALELSAN HNILQIVDVC HDVEKDEKLI RLMEEIMSEK ENKTIVFVET
360 370 380 390 400
KRRCDELTRK MRRDGWPAMG IHGDKSQQER DWVLNEFKHG KAPILIATDV
410 420 430 440 450
ASRGLDVEDV KFVINYDYPN SSEDYIHRIG RTARSTKTGT AYTFFTPNNI
460 470 480 490 500
KQVSDLISVL REANQAINPK LLQLVEDRGS GRSRGRGGMK DDRRDRYSAG
510 520 530 540 550
KRGGFNTFRD RENYDRGYSS LLKRDFGAKT QNGVYSAANY TNGSFGSNFV
560 570 580 590 600
SAGIQTSFRT GNPTGTYQNG YDSTQQYGSN VPNMHNGMNQ QAYAYPATAA
610
APMIGYPMPT GYSQ
Length:614
Mass (Da):69,148
Last modified:August 1, 1990 - v1
Checksum:i84DF684FD6871594
GO
Isoform 2 (identifier: P17844-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-163: Missing.

Note: No experimental confirmation available.
Show »
Length:535
Mass (Da):60,563
Checksum:iA665AD0571ABC456
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029241480S → A.Corresponds to variant rs1140409dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05615485 – 163Missing in isoform 2. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52104 mRNA. Translation: CAA36324.1.
AF015812 Genomic DNA. Translation: AAB84094.1.
BT006943 mRNA. Translation: AAP35589.1.
AK297192 mRNA. Translation: BAG59680.1.
AB451257 mRNA. Translation: BAG70071.1.
AC009994 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94202.1.
CH471109 Genomic DNA. Translation: EAW94203.1.
BC016027 mRNA. Translation: AAH16027.1.
X15729 mRNA. Translation: CAA33751.1.
AJ010931 Genomic DNA. Translation: CAA09408.1.
CCDSiCCDS11659.1. [P17844-1]
PIRiJC1087.
RefSeqiNP_001307524.1. NM_001320595.1. [P17844-1]
NP_001307525.1. NM_001320596.1. [P17844-1]
NP_004387.1. NM_004396.4. [P17844-1]
UniGeneiHs.279806.

Genome annotation databases

EnsembliENST00000225792; ENSP00000225792; ENSG00000108654. [P17844-1]
ENST00000450599; ENSP00000403085; ENSG00000108654. [P17844-2]
GeneIDi1655.
KEGGihsa:1655.
UCSCiuc002jek.3. human. [P17844-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52104 mRNA. Translation: CAA36324.1.
AF015812 Genomic DNA. Translation: AAB84094.1.
BT006943 mRNA. Translation: AAP35589.1.
AK297192 mRNA. Translation: BAG59680.1.
AB451257 mRNA. Translation: BAG70071.1.
AC009994 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94202.1.
CH471109 Genomic DNA. Translation: EAW94203.1.
BC016027 mRNA. Translation: AAH16027.1.
X15729 mRNA. Translation: CAA33751.1.
AJ010931 Genomic DNA. Translation: CAA09408.1.
CCDSiCCDS11659.1. [P17844-1]
PIRiJC1087.
RefSeqiNP_001307524.1. NM_001320595.1. [P17844-1]
NP_001307525.1. NM_001320596.1. [P17844-1]
NP_004387.1. NM_004396.4. [P17844-1]
UniGeneiHs.279806.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FE2X-ray2.60A/B68-307[»]
4A4DX-ray2.70A52-304[»]
ProteinModelPortaliP17844.
SMRiP17844.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108021. 215 interactors.
DIPiDIP-29844N.
IntActiP17844. 116 interactors.
MINTiMINT-5000516.
STRINGi9606.ENSP00000225792.

PTM databases

iPTMnetiP17844.
PhosphoSitePlusiP17844.
SwissPalmiP17844.

Polymorphism and mutation databases

BioMutaiDDX5.
DMDMi129383.

2D gel databases

SWISS-2DPAGEP17844.

Proteomic databases

EPDiP17844.
MaxQBiP17844.
PaxDbiP17844.
PeptideAtlasiP17844.
PRIDEiP17844.

Protocols and materials databases

DNASUi1655.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225792; ENSP00000225792; ENSG00000108654. [P17844-1]
ENST00000450599; ENSP00000403085; ENSG00000108654. [P17844-2]
GeneIDi1655.
KEGGihsa:1655.
UCSCiuc002jek.3. human. [P17844-1]

Organism-specific databases

CTDi1655.
DisGeNETi1655.
GeneCardsiDDX5.
HGNCiHGNC:2746. DDX5.
HPAiCAB005868.
HPA020043.
MIMi180630. gene.
neXtProtiNX_P17844.
OpenTargetsiENSG00000108654.
PharmGKBiPA27228.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0331. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00820000126976.
HOGENOMiHOG000268804.
HOVERGENiHBG015893.
InParanoidiP17844.
KOiK12823.
PhylomeDBiP17844.
TreeFamiTF300332.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108654-MONOMER.
BRENDAi3.6.4.13. 2681.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
SIGNORiP17844.

Miscellaneous databases

ChiTaRSiDDX5. human.
EvolutionaryTraceiP17844.
GeneWikiiDDX5.
GenomeRNAii1655.
PROiP17844.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108654.
CleanExiHS_DDX5.
ExpressionAtlasiP17844. baseline and differential.
GenevisibleiP17844. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR033488. DDX5.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR012587. P68_rpt.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PANTHERiPTHR24031:SF257. PTHR24031:SF257. 1 hit.
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF08061. P68HR. 2 hits.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM01414. P68HR. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDX5_HUMAN
AccessioniPrimary (citable) accession number: P17844
Secondary accession number(s): B4DLW8
, B5BU21, D3DU32, E7ETL9, O75681, Q53Y61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 30, 2016
This is version 193 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.