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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Chlamydia trachomatis (strain D/UW-3/Cx)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
75 kDa membrane protein
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
Ordered Locus Names:CT_396
OrganismiChlamydia trachomatis (strain D/UW-3/Cx)
Taxonomic identifieri272561 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000431 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 660659Chaperone protein DnaKPRO_0000078446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei201 – 2011Phosphothreonine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

By stress conditions e.g. heat shock (By similarity).By similarity

Interactioni

Protein-protein interaction databases

STRINGi272561.CT396.

Structurei

3D structure databases

ProteinModelPortaliP17821.
SMRiP17821. Positions 8-533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
InParanoidiP17821.
KOiK04043.
OMAiEKMAPPQ.
OrthoDBiEOG6JMMSV.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17821-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKRKSNKI IGIDLGTTNS CVSVMEGGQP KVIASSEGTR TTPSIVAFKG
60 70 80 90 100
GETLVGIPAK RQAVTNPEKT LASTKRFIGR KFSEVESEIK TVPYKVAPNS
110 120 130 140 150
KGDAVFDVEQ KLYTPEEIGA QILMKMKETA EAYLGETVTE AVITVPAYFN
160 170 180 190 200
DSQRASTKDA GRIAGLDVKR IIPEPTAAAL AYGIDKEGDK KIAVFDLGGG
210 220 230 240 250
TFDISILEIG DGVFEVLSTN GDTHLGGDDF DGVIINWMLD EFKKQEGIDL
260 270 280 290 300
SKDNMALQRL KDAAEKAKIE LSGVSSTEIN QPFITIDANG PKHLALTLTR
310 320 330 340 350
AQFEHLASSL IERTKQPCAQ ALKDAKLSAS DIDDVLLVGG MSRMPAVQAV
360 370 380 390 400
VKEIFGKEPN KGVNPDEVVA IGAAIQGGVL GGEVKDVLLL DVIPLSLGIE
410 420 430 440 450
TLGGVMTPLV ERNTTIPTQK KQIFSTAADN QPAVTIVVLQ GERPMAKDNK
460 470 480 490 500
EIGRFDLTDI PPAPRGHPQI EVTFDIDANG ILHVSAKDAA SGREQKIRIE
510 520 530 540 550
ASSGLKEDEI QQMIRDAELH KEEDKQRKEA SDVKNEADGM IFRAEKAVKD
560 570 580 590 600
YHDKIPAELV KEIEEHIEKV RQAIKEDAST TAIKAASDEL STHMQKIGEA
610 620 630 640 650
MQAQSASAAA SSAANAQGGP NINSEDLKKH SFSTRPPAGG SASSTDNIED
660
ADVEIVDKPE
Length:660
Mass (Da):70,824
Last modified:January 23, 2007 - v4
Checksum:i438900096477FF11
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti194 – 21118VFDLG…LEIGD → SLRLRRRNFRYFYLGNRWI in AAA03644 (PubMed:2294048).CuratedAdd
BLAST
Sequence conflicti232 – 2409Missing (PubMed:2294048).Curated
Sequence conflicti353 – 36210EIFGKEPNKG → RSLVKSLIKA in AAA03644 (PubMed:2294048).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti593 – 5931H → R in strain: L2 and E/UW-5/Cx.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52175 Genomic DNA. Translation: CAA36423.1.
M27580 Unassigned DNA. Translation: AAA03644.1.
AE001273 Genomic DNA. Translation: AAC67993.1.
L22180 Unassigned DNA. Translation: AAC36839.1.
PIRiA40158.
B71521.
RefSeqiNP_219906.1. NC_000117.1.
WP_009871748.1. NC_000117.1.

Genome annotation databases

EnsemblBacteriaiAAC67993; AAC67993; CT_396.
GeneIDi884718.
KEGGictr:CT_396.
PATRICi20380343. VBIChlTra43535_0426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52175 Genomic DNA. Translation: CAA36423.1.
M27580 Unassigned DNA. Translation: AAA03644.1.
AE001273 Genomic DNA. Translation: AAC67993.1.
L22180 Unassigned DNA. Translation: AAC36839.1.
PIRiA40158.
B71521.
RefSeqiNP_219906.1. NC_000117.1.
WP_009871748.1. NC_000117.1.

3D structure databases

ProteinModelPortaliP17821.
SMRiP17821. Positions 8-533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272561.CT396.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC67993; AAC67993; CT_396.
GeneIDi884718.
KEGGictr:CT_396.
PATRICi20380343. VBIChlTra43535_0426.

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
InParanoidiP17821.
KOiK04043.
OMAiEKMAPPQ.
OrthoDBiEOG6JMMSV.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The 75-kilodalton cytoplasmic Chlamydia trachomatis L2 polypeptide is a DnaK-like protein."
    Birkelund S., Lundemose A.G., Christiansen G.
    Infect. Immun. 58:2098-2104(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: L2.
  2. "The 75-kilodalton protein of Chlamydia trachomatis: a member of the heat shock protein 70 family?"
    Danilition S.L., Maclean I.W., Peeling R., Winston S., Brunham R.C.
    Infect. Immun. 58:189-196(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: D/UW-3/Cx.
  3. "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis."
    Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L., Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.
    Science 282:754-759(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D/UW-3/Cx.
  4. "Molecular characterization and outer membrane association of a Chlamydia trachomatis protein related to the hsp70 family of proteins."
    Raulston J.E., Davis C.H., Schmiel D.H., Morgan M.M., Wyrick P.B.
    J. Biol. Chem. 268:23139-23147(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-626.
    Strain: E/UW-5/Cx.

Entry informationi

Entry nameiDNAK_CHLTR
AccessioniPrimary (citable) accession number: P17821
Secondary accession number(s): O84401, P16896, Q46400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: December 9, 2015
This is version 124 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Expressed early during infection.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.