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P17818 (CHSY_MATIN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase
Gene names
Name:CHS
OrganismMatthiola incana (Common stock) (Cheiranthus incanus)
Taxonomic identifier3724 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeAnchonieaeMatthiola

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
   PTMAcetylation
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 394393Chalcone synthase
PRO_0000216005

Sites

Active site1681 By similarity

Amino acid modifications

Modified residue21N-acetylvaline By similarity

Sequences

Sequence LengthMass (Da)Tools
P17818 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: EF2DA6C0FB550714

FASTA39442,969
        10         20         30         40         50         60 
MVMGATSLDE IRKAQRADGP AGILGIGTAN PANHVIQAEY PDYYFRITNS EHMTDLKEKF 

        70         80         90        100        110        120 
QRMCDKSMIR KRHMHLTEDF LKENPNMCAY MAPSLDARQD IVVVEVPKLG KEAAVRAIKE 

       130        140        150        160        170        180 
WGQPKSKITH LVFCTTSGVD MPGADYQLTK LLGLRPSVKR LMMYQQGCFA GGTVLRLAKD 

       190        200        210        220        230        240 
LAENNRGARV LVVCSEITAV TFRGPSDTHL DSLVGQALFS DGAAALIVGS DPDTSVGEKP 

       250        260        270        280        290        300 
IFEMVSAAQT ILPDSDGAID GHLREVGLTF HLLKDVPGLI SKNIEKSLEE AFKPLGISDW 

       310        320        330        340        350        360 
NSLFWIAHPG GPAILDQVEI KLGLKAEKMR ATRHVLSEYG NMSSACVLFI LDEMRKKSAQ 

       370        380        390 
DGVATTGEGL EWGVLFGFGP GLTVETVVLR SVPL 

« Hide

References

[1]"Isolation and sequence analysis of a chalcone synthase cDNA of Matthiola incana R. Br. (Brassicaceae)."
Epping B., Kittel M., Ruhnau B., Hemleben V.
Plant Mol. Biol. 14:1061-1063(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Petal.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X17577 mRNA. Translation: CAA35600.1.
PIRSYJCCS. S11876.

3D structure databases

ProteinModelPortalP17818.
SMRP17818. Positions 7-394.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHSY_MATIN
AccessionPrimary (citable) accession number: P17818
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: March 19, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways