Reviewed, UniProtKB/Swiss-Prot P17817 (P5CR_SOYBN)

Names and origin

Protein names	Recommended name:     Pyrroline-5-carboxylate reductase       Short name=P5C reductase       Short name=P5CR     EC=1.5.1.2
Organism	Glycine max (Soybean)
Taxonomic identifier	3847 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids I › Fabales › Fabaceae › Papilionoideae › Phaseoleae › Glycine

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	Cytoplasm.
Tissue specificity	Expressed in all plant tissues, but mostly in nodules.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Pyrroline-5-carboxylate reductase		PRO_0000187325

Sequences

	Sequence		Length	Mass (Da)
	P17817-1 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: 933CFCFDD7598B63	FASTA	274	28,586
	10 20 30 40 50 60 MEIFPIPAES YTLGFIGAGK MAESIARGAV RSGVLPPSRI RTAVHFNLAR RGAFESFGVT 70 80 90 100 110 120 VLPSNDDVVR ESDVVVLSVK PQLVKDVVSK LTPLLTKHKL LVSVAAGTKL KDLQEWAGND 130 140 150 160 170 180 RFIRVMPNTP AAVGQAASVM SLGGSATEED GNIIAQLFGS IGKIWKAEEK YFDAITGLSG 190 200 210 220 230 240 SGPAYVYLAI EALADGGVAA GLPRDLSLSL ASQTVLGAAS MVSQTGKHPG QLKDDVTSPG 250 260 270 GTTITGIHEL ENGGFRGTLM NAVVAAAKRS RELS

References

[1]	"A soybean gene encoding delta 1-pyrroline-5-carboxylate reductase was isolated by functional complementation in Escherichia coli and is found to be osmoregulated." Delauney A.J., Verma D.P.S. Mol. Gen. Genet. 221:299-305(1990) [PubMed: 2199815] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X16352 mRNA. Translation: CAA34401.1.
PIR	S10186.
UniGene	Gma.3572
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.5.1.2. 299.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMs	TIGR00112. proC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR_SOYBN

Accession

Primary (citable) accession number: P17817

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	June 16, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)