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P17814

- 4CL1_ORYSJ

UniProt

P17814 - 4CL1_ORYSJ

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Protein
Probable 4-coumarate--CoA ligase 1
Gene
4CL1, 4CL, Os08g0245200, LOC_Os08g14760, OJ1033_B09.16
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei440 – 4401ATP By similarity
Binding sitei455 – 4551ATP By similarity
Binding sitei547 – 5471ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi209 – 2179ATP By similarity
Nucleotide bindingi352 – 3576ATP By similarity

GO - Molecular functioni

  1. 4-coumarate-CoA ligase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. phenylpropanoid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Phenylpropanoid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00372; UER00547.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 4-coumarate--CoA ligase 1 (EC:6.2.1.12)
Short name:
4CL 1
Short name:
Os4CL1
Alternative name(s):
4-coumaroyl-CoA synthase 1
Gene namesi
Name:4CL1
Synonyms:4CL
Ordered Locus Names:Os08g0245200, LOC_Os08g14760
ORF Names:OJ1033_B09.16
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 8

Organism-specific databases

GrameneiP17814.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Probable 4-coumarate--CoA ligase 1
PRO_0000193031Add
BLAST

Proteomic databases

PRIDEiP17814.

Expressioni

Inductioni

By fungal elicitor and UV irradiation.

Structurei

3D structure databases

ProteinModelPortaliP17814.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni282 – 35170SBD1
Add
BLAST
Regioni352 – 41968SBD2
Add
BLAST

Domaini

Both substrate-binding domains (SBD1 and SBD2) are involved in the substrate recognition, and are sufficient to confer the substrate specificity.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000230009.
KOiK01904.
OMAiAGTNKID.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17814-1 [UniParc]FASTAAdd to Basket

« Hide

MGSMEQQQPE SAAPATEASP EIIFRSKLQD IAITNTLPLH RYCFERLPEV    50
AARPCLIDGA TGGVLTYADV DRLSRRLAAA LRRAPLGLRR GGVVMSLLRN 100
SPEFVLSFFA ASRVGAAVTT ANPMSTPHEI ESQLAAAGAT VVITESMAAD 150
KLPSHSHGAL TVVLIDERRD GCLHFWDDLM SEDEASPLAG DEDDEKVFDP 200
DDVVALPYSS GTTGLPKGVM LTHRSLSTSV AQQVDGENPN IGLHAGDVIL 250
CALPMFHIYS LNTIMMCGLR VGAAIVVMRR FDLAAMMDLV ERHRVTIAPL 300
VPPIVVAVAK SEAAAARDLS SVRMVLSGAA PMGKDIEDAF MAKLPGAVLG 350
QGYGMTEAGP VLSMCLAFAK EPFKVKSGAC GTVVRNAELK IIDPDTGKSL 400
GRNLPGEICI RGQQIMKGYL NNPEATKNTI DAEGWLHTGD IGYVDDDDEI 450
FIVDRLKEII KYRGFQVAPA ELEALLITHP SIADAAVVGK QIEPEIGEIP 500
VAFVAKTEGS ELSEDDVKQF VAKEVIYYKK IREVFFVDKI PKAPSGKILR 550
KELRKQLQHL QQEA 564
Length:564
Mass (Da):60,902
Last modified:September 27, 2005 - v2
Checksum:i9725A4B4A72F8C6E
GO

Sequence cautioni

The sequence CAA36850.1 differs from that shown. Reason: Frameshift at position 496.
The sequence BAD05189.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAA36850.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti405 – 4051P → R in CAA36850. 1 Publication
Sequence conflicti477 – 4771I → N in CAA36850. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52623 Genomic DNA. Translation: CAA36850.1. Sequence problems.
AP003859 Genomic DNA. Translation: BAD05189.1. Different initiation.
AP008214 Genomic DNA. Translation: BAF23267.1.
AK069932 mRNA. No translation available.
PIRiJU0311.
RefSeqiNP_001061353.1. NM_001067888.1.
UniGeneiOs.52921.

Genome annotation databases

EnsemblPlantsiOS08T0245200-01; OS08T0245200-01; OS08G0245200.
GeneIDi4345054.
KEGGiosa:4345054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52623 Genomic DNA. Translation: CAA36850.1 . Sequence problems.
AP003859 Genomic DNA. Translation: BAD05189.1 . Different initiation.
AP008214 Genomic DNA. Translation: BAF23267.1 .
AK069932 mRNA. No translation available.
PIRi JU0311.
RefSeqi NP_001061353.1. NM_001067888.1.
UniGenei Os.52921.

3D structure databases

ProteinModelPortali P17814.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P17814.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS08T0245200-01 ; OS08T0245200-01 ; OS08G0245200 .
GeneIDi 4345054.
KEGGi osa:4345054.

Organism-specific databases

Gramenei P17814.

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000230009.
KOi K01904.
OMAi AGTNKID.

Enzyme and pathway databases

UniPathwayi UPA00372 ; UER00547 .

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of rice 4-coumarate:CoA ligase gene, 4-CL.1."
    Zhao Y., Kung S.D., Dube S.K.
    Nucleic Acids Res. 18:6144-6144(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  4. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.
  5. "Genome-wide analysis of a land plant-specific acyl:coenzyme A synthetase (ACS) gene family in Arabidopsis, poplar, rice and Physcomitrella."
    de Azevedo Souza C., Barbazuk B., Ralph S.G., Bohlmann J., Hamberger B., Douglas C.J.
    New Phytol. 179:987-1003(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry namei4CL1_ORYSJ
AccessioniPrimary (citable) accession number: P17814
Secondary accession number(s): Q0J6Z8, Q6ZKV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: September 27, 2005
Last modified: May 14, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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