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Protein

Peripherin-2

Gene

PRPH2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cell surface receptor signaling pathway Source: GO_Central
  • protein homotetramerization Source: UniProtKB
  • protein polymerization Source: UniProtKB
  • regulation of membrane tubulation Source: UniProtKB
  • visual perception Source: InterPro

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Peripherin-2
Alternative name(s):
Retinal degeneration slow protein
Gene namesi
Name:PRPH2
Synonyms:RDS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 40HelicalSequence analysisAdd BLAST23
Topological domaini41 – 61LumenalSequence analysisAdd BLAST21
Transmembranei62 – 78HelicalSequence analysisAdd BLAST17
Topological domaini79 – 100CytoplasmicSequence analysisAdd BLAST22
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 263LumenalSequence analysisAdd BLAST142
Transmembranei264 – 282HelicalSequence analysisAdd BLAST19
Topological domaini283 – 345CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi314 – 318TWKAF → AWGAT: Loss of interaction with MREG. 1 Publication5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001681021 – 345Peripherin-2Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi262N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP17810.
PRIDEiP17810.

Expressioni

Tissue specificityi

Retina (photoreceptor). In rim region of ROS (rod outer segment) disks.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Probably forms a complex with a ROM1 homodimer. Other proteins could associate with this complex in rods (By similarity). Interacts with MREG.By similarity1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007836.

Structurei

3D structure databases

DisProtiDP00220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni340 – 345Interaction with MREG1 Publication6

Sequence similaritiesi

Belongs to the PRPH2/ROM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
HOGENOMiHOG000026780.
HOVERGENiHBG004964.
InParanoidiP17810.
OMAiGKICYDS.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiView protein in InterPro
IPR000830. Peripherin/rom-1.
IPR018498. Peripherin/rom-1_CS.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
PfamiView protein in Pfam
PF00335. Tetraspannin. 1 hit.
PRINTSiPR00218. PERIPHERNRDS.
SUPFAMiSSF48652. SSF48652. 2 hits.
PROSITEiView protein in PROSITE
PS00930. RDS_ROM1. 1 hit.

Sequencei

Sequence statusi: Complete.

P17810-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ALLKVKFDQK KRVKLAQGLW LMNWFSVLAG IIIFGLGLFL KIELRKRSDV
60 70 80 90 100
MNNSESHFVP NSLIGVGVLS CVFNSLAGKI CYDALDPAKY AKWKPWLKPY
110 120 130 140 150
LAVCVLFNVV LFLVALCCFL LRGSLESTLA HGLKNGMKFY RDTDTPGRCF
160 170 180 190 200
MKKTIDMLQI EFKCCGNNGF RDWFEIQWIS NRYLDFSSKE VKDRIKSNVD
210 220 230 240 250
GRYLVDGVPF SCCNPNSPRP CIQYQLTNNS AHYSYDHQTE ELNLWLRGCR
260 270 280 290 300
AALLSYYSNL MNTTGAVTLL VWLFEVTITV GLRYLHTALE GMANPEDPEC
310 320 330 340
ESEGWLLEKS VPETWKAFLE SVKKLGKGNQ VEAEGEDAGQ APAAG
Length:345
Mass (Da):38,992
Last modified:August 1, 1990 - v1
Checksum:i519DB2C460DCDFD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02884 mRNA. Translation: AAA30693.1.
PIRiA34608.
UniGeneiBt.12752.

Similar proteinsi

Entry informationi

Entry nameiPRPH2_BOVIN
AccessioniPrimary (citable) accession number: P17810
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: August 30, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families