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P17809

- GTR1_MOUSE

UniProt

P17809 - GTR1_MOUSE

Protein

Solute carrier family 2, facilitated glucose transporter member 1

Gene

Slc2a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 4 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei317 – 3171MonosaccharideBy similarity
    Binding sitei388 – 3881MonosaccharideBy similarity

    GO - Molecular functioni

    1. dehydroascorbic acid transporter activity Source: UniProtKB
    2. D-glucose transmembrane transporter activity Source: UniProtKB
    3. glucose transmembrane transporter activity Source: UniProtKB
    4. protein binding Source: MGI
    5. protein self-association Source: UniProtKB
    6. xenobiotic transporter activity Source: Ensembl

    GO - Biological processi

    1. cellular response to glucose starvation Source: MGI
    2. dehydroascorbic acid transport Source: UniProtKB
    3. glucose transport Source: UniProtKB
    4. protein complex assembly Source: UniProtKB
    5. response to osmotic stress Source: Ensembl

    Keywords - Biological processi

    Sugar transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_206357. Facilitative Na+-independent glucose transporters.
    REACT_215258. Vitamin C (ascorbate) metabolism.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 1
    Alternative name(s):
    Glucose transporter type 1, erythrocyte/brain
    Short name:
    GLUT-1
    Short name:
    GT1
    Gene namesi
    Name:Slc2a1
    Synonyms:Glut-1, Glut1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:95755. Slc2a1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Melanosome By similarity
    Note: Localizes primarily at the cell surface.By similarity

    GO - Cellular componenti

    1. basolateral plasma membrane Source: MGI
    2. caveola Source: Ensembl
    3. cell-cell junction Source: Ensembl
    4. cortical actin cytoskeleton Source: UniProtKB
    5. cytoplasm Source: UniProtKB
    6. female pronucleus Source: MGI
    7. integral component of plasma membrane Source: UniProtKB
    8. intracellular Source: MGI
    9. melanosome Source: UniProtKB-SubCell
    10. membrane Source: MGI
    11. midbody Source: Ensembl
    12. plasma membrane Source: UniProtKB
    13. vesicle Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492Solute carrier family 2, facilitated glucose transporter member 1PRO_0000050339Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Glycosylationi45 – 451N-linked (GlcNAc...)2 Publications
    Glycosylationi49 – 491N-linked (GlcNAc...); atypical2 Publications
    Modified residuei478 – 4781PhosphothreonineBy similarity
    Modified residuei490 – 4901PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP17809.
    PaxDbiP17809.
    PRIDEiP17809.

    PTM databases

    PhosphoSiteiP17809.

    Expressioni

    Developmental stagei

    Levels decline 3-fold between days 7.5 and 12.5 of gestation. At 7.5 dpc, expressed more strongly in extraembryonic tissues than in the embryo proper. Expressed in amnion, chorion, and ectoplacental cone. In the yolk sac, expressed more strongly in the mesoderm layer than the ectoderm. Expression fairly widespread in the embryo at 8.5 dpc, but by 10.5 dpc, expression is down-regulated and observed in the eye and the spinal cord.2 Publications

    Gene expression databases

    ArrayExpressiP17809.
    BgeeiP17809.
    GenevestigatoriP17809.

    Interactioni

    Subunit structurei

    Found in a complex with ADD2, DMTN and SLC2A1. Interacts (via C-terminus cytoplasmic region) with DMTN isoform 2. Interacts with SNX27; the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with GIPC (via PDZ domain). Interacts with STOM By similarity.By similarity

    Protein-protein interaction databases

    BioGridi203304. 1 interaction.
    IntActiP17809. 2 interactions.
    MINTiMINT-348833.

    Structurei

    3D structure databases

    ProteinModelPortaliP17809.
    SMRiP17809. Positions 19-465.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1111CytoplasmicBy similarityAdd
    BLAST
    Topological domaini34 – 6633ExtracellularBy similarityAdd
    BLAST
    Topological domaini88 – 903CytoplasmicBy similarity
    Topological domaini113 – 1208ExtracellularBy similarity
    Topological domaini145 – 15511CytoplasmicBy similarityAdd
    BLAST
    Topological domaini177 – 1859ExtracellularBy similarity
    Topological domaini207 – 27165CytoplasmicBy similarityAdd
    BLAST
    Topological domaini294 – 30613ExtracellularBy similarityAdd
    BLAST
    Topological domaini329 – 3346CytoplasmicBy similarity
    Topological domaini356 – 36510ExtracellularBy similarity
    Topological domaini389 – 40113CytoplasmicBy similarityAdd
    BLAST
    Topological domaini423 – 4297ExtracellularBy similarity
    Topological domaini451 – 49242CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3322Helical; Name=1By similarityAdd
    BLAST
    Transmembranei67 – 8721Helical; Name=2By similarityAdd
    BLAST
    Transmembranei91 – 11222Helical; Name=3By similarityAdd
    BLAST
    Transmembranei121 – 14424Helical; Name=4By similarityAdd
    BLAST
    Transmembranei156 – 17621Helical; Name=5By similarityAdd
    BLAST
    Transmembranei186 – 20621Helical; Name=6By similarityAdd
    BLAST
    Transmembranei272 – 29322Helical; Name=7By similarityAdd
    BLAST
    Transmembranei307 – 32822Helical; Name=8By similarityAdd
    BLAST
    Transmembranei335 – 35521Helical; Name=9By similarityAdd
    BLAST
    Transmembranei366 – 38823Helical; Name=10By similarityAdd
    BLAST
    Transmembranei402 – 42221Helical; Name=11By similarityAdd
    BLAST
    Transmembranei430 – 45021Helical; Name=12By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni282 – 2887Monosaccharide bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00720000108560.
    HOGENOMiHOG000202871.
    HOVERGENiHBG014816.
    InParanoidiQ6GTI3.
    KOiK07299.
    OMAiQTWIHRY.
    OrthoDBiEOG7QVM2R.
    TreeFamiTF313762.

    Family and domain databases

    InterProiIPR002439. Glu_transpt_1.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR01190. GLUCTRSPORT1.
    PR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17809-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPSSKKVTG RLMLAVGGAV LGSLQFGYNT GVINAPQKVI EEFYNQTWNH    50
    RYGEPIPSTT LTTLWSLSVA IFSVGGMIGS FSVGLFVNRF GRRNSMLMMN 100
    LLAFVAAVLM GFSKLGKSFE MLILGRFIIG VYCGLTTGFV PMYVGEVSPT 150
    ALRGALGTLH QLGIVVGILI AQVFGLDSIM GNADLWPLLL SVIFIPALLQ 200
    CILLPFCPES PRFLLINRNE ENRAKSVLKK LRGTADVTRD LQEMKEEGRQ 250
    MMREKKVTIL ELFRSPAYRQ PILIAVVLQL SQQLSGINAV FYYSTSIFEK 300
    AGVQQPVYAT IGSGIVNTAF TVVSLFVVER AGRRTLHLIG LAGMAGCAVL 350
    MTIALALLER LPWMSYLSIV AIFGFVAFFE VGPGPIPWFI VAELFSQGPR 400
    PAAIAVAGFS NWTSNFIVGM CFQYVEQLCG PYVFIIFTVL LVLFFIFTYF 450
    KVPETKGRTF DEIASGFRQG GASQSDKTPE ELFHPLGADS QV 492
    Length:492
    Mass (Da):53,985
    Last modified:July 27, 2011 - v4
    Checksum:i464B668853D7636E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti52 – 521Y → I in AAA37752. (PubMed:2654938)Curated
    Sequence conflicti193 – 1953IFI → VFV in AAA37752. (PubMed:2654938)Curated
    Sequence conflicti357 – 3604LLER → MQEQ in AAB20846. (PubMed:1765007)Curated
    Sequence conflicti403 – 4031A → R in AAA37752. (PubMed:2654938)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23384 mRNA. Translation: AAA37752.1.
    M22998 mRNA. Translation: AAA37707.1.
    AK170873 mRNA. Translation: BAE42084.1.
    AL606975 Genomic DNA. Translation: CAM21633.1.
    CH466552 Genomic DNA. Translation: EDL30474.1.
    BC055340 mRNA. Translation: AAH55340.1.
    X69697 mRNA. Translation: CAA49367.1.
    S77924 mRNA. Translation: AAB20846.2.
    CCDSiCCDS18569.1.
    PIRiA44887.
    S09705.
    RefSeqiNP_035530.2. NM_011400.3.
    UniGeneiMm.21002.

    Genome annotation databases

    EnsembliENSMUST00000030398; ENSMUSP00000030398; ENSMUSG00000028645.
    GeneIDi20525.
    KEGGimmu:20525.
    UCSCiuc008ule.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23384 mRNA. Translation: AAA37752.1 .
    M22998 mRNA. Translation: AAA37707.1 .
    AK170873 mRNA. Translation: BAE42084.1 .
    AL606975 Genomic DNA. Translation: CAM21633.1 .
    CH466552 Genomic DNA. Translation: EDL30474.1 .
    BC055340 mRNA. Translation: AAH55340.1 .
    X69697 mRNA. Translation: CAA49367.1 .
    S77924 mRNA. Translation: AAB20846.2 .
    CCDSi CCDS18569.1.
    PIRi A44887.
    S09705.
    RefSeqi NP_035530.2. NM_011400.3.
    UniGenei Mm.21002.

    3D structure databases

    ProteinModelPortali P17809.
    SMRi P17809. Positions 19-465.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203304. 1 interaction.
    IntActi P17809. 2 interactions.
    MINTi MINT-348833.

    PTM databases

    PhosphoSitei P17809.

    Proteomic databases

    MaxQBi P17809.
    PaxDbi P17809.
    PRIDEi P17809.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030398 ; ENSMUSP00000030398 ; ENSMUSG00000028645 .
    GeneIDi 20525.
    KEGGi mmu:20525.
    UCSCi uc008ule.2. mouse.

    Organism-specific databases

    CTDi 6513.
    MGIi MGI:95755. Slc2a1.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00720000108560.
    HOGENOMi HOG000202871.
    HOVERGENi HBG014816.
    InParanoidi Q6GTI3.
    KOi K07299.
    OMAi QTWIHRY.
    OrthoDBi EOG7QVM2R.
    TreeFami TF313762.

    Enzyme and pathway databases

    Reactomei REACT_206357. Facilitative Na+-independent glucose transporters.
    REACT_215258. Vitamin C (ascorbate) metabolism.

    Miscellaneous databases

    ChiTaRSi SLC2A1. mouse.
    NextBioi 298763.
    PROi P17809.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P17809.
    Bgeei P17809.
    Genevestigatori P17809.

    Family and domain databases

    InterProi IPR002439. Glu_transpt_1.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    PRINTSi PR01190. GLUCTRSPORT1.
    PR00171. SUGRTRNSPORT.
    SUPFAMi SSF103473. SSF103473. 2 hits.
    TIGRFAMsi TIGR00879. SP. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes."
      Kaestner K.H., Christy R.J., McLenithan J.C., Braiterman L.T., Cornelius P., Pekala P.H., Lane M.D.
      Proc. Natl. Acad. Sci. U.S.A. 86:3150-3154(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "3T3-L1 adipocyte glucose transporter (HepG2 class): sequence and regulation of protein and mRNA expression by insulin, differentiation, and glucose starvation."
      Reed B.C., Shade D., Alperovich F., Vang M.
      Arch. Biochem. Biophys. 279:261-274(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    7. "Identification of two enhancer elements in the gene encoding the type 1 glucose transporter from the mouse which are responsive to serum, growth factor, and oncogenes."
      Murakami T., Nishiyama T., Shirotani T., Shinohara Y., Kan M., Ishii K., Kanai F., Nakazuru S., Ebina Y.
      J. Biol. Chem. 267:9300-9306(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-6.
    8. "Differential screening of a PCR-generated mouse embryo cDNA library: glucose transporters are differentially expressed in early postimplantation mouse embryos."
      Smith D.E., Gridley T.
      Development 116:555-561(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 151-237, DEVELOPMENTAL STAGE.
      Strain: C57BL/6.
      Tissue: Embryo.
    9. "Glucose transporter gene expression in early mouse embryos."
      Hogan A., Heyner S., Charron M.J., Copeland N.G., Gilbert D.J., Jenkins N.A., Thorens B., Schultz G.A.
      Development 113:363-372(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 357-463, DEVELOPMENTAL STAGE.
      Strain: CD-1.
      Tissue: Embryo.
    10. "PACSIN3 overexpression increases adipocyte glucose transport through GLUT1."
      Roach W., Plomann M.
      Biochem. Biophys. Res. Commun. 355:745-750(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    11. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-45 AND ASN-49.
      Tissue: Myoblast.
    12. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-45 AND ASN-49.

    Entry informationi

    Entry nameiGTR1_MOUSE
    AccessioniPrimary (citable) accession number: P17809
    Secondary accession number(s): Q61608, Q6GTI3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 146 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3