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P17809

- GTR1_MOUSE

UniProt

P17809 - GTR1_MOUSE

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Protein
Solute carrier family 2, facilitated glucose transporter member 1
Gene
Slc2a1, Glut-1, Glut1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei317 – 3171Monosaccharide By similarity
Binding sitei388 – 3881Monosaccharide By similarity

GO - Molecular functioni

  1. D-glucose transmembrane transporter activity Source: UniProtKB
  2. dehydroascorbic acid transporter activity Source: UniProtKB
  3. protein binding Source: MGI
  4. protein self-association Source: UniProtKB
  5. xenobiotic transporter activity Source: Ensembl

GO - Biological processi

  1. cellular response to glucose starvation Source: MGI
  2. dehydroascorbic acid transport Source: UniProtKB
  3. glucose transport Source: UniProtKB
  4. protein complex assembly Source: UniProtKB
  5. response to osmotic stress Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiREACT_206357. Facilitative Na+-independent glucose transporters.
REACT_215258. Vitamin C (ascorbate) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 1
Alternative name(s):
Glucose transporter type 1, erythrocyte/brain
Short name:
GLUT-1
Short name:
GT1
Gene namesi
Name:Slc2a1
Synonyms:Glut-1, Glut1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:95755. Slc2a1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Melanosome By similarity
Note: Localizes primarily at the cell surface By similarity.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111Cytoplasmic By similarity
Add
BLAST
Transmembranei12 – 3322Helical; Name=1; By similarity
Add
BLAST
Topological domaini34 – 6633Extracellular By similarity
Add
BLAST
Transmembranei67 – 8721Helical; Name=2; By similarity
Add
BLAST
Topological domaini88 – 903Cytoplasmic By similarity
Transmembranei91 – 11222Helical; Name=3; By similarity
Add
BLAST
Topological domaini113 – 1208Extracellular By similarity
Transmembranei121 – 14424Helical; Name=4; By similarity
Add
BLAST
Topological domaini145 – 15511Cytoplasmic By similarity
Add
BLAST
Transmembranei156 – 17621Helical; Name=5; By similarity
Add
BLAST
Topological domaini177 – 1859Extracellular By similarity
Transmembranei186 – 20621Helical; Name=6; By similarity
Add
BLAST
Topological domaini207 – 27165Cytoplasmic By similarity
Add
BLAST
Transmembranei272 – 29322Helical; Name=7; By similarity
Add
BLAST
Topological domaini294 – 30613Extracellular By similarity
Add
BLAST
Transmembranei307 – 32822Helical; Name=8; By similarity
Add
BLAST
Topological domaini329 – 3346Cytoplasmic By similarity
Transmembranei335 – 35521Helical; Name=9; By similarity
Add
BLAST
Topological domaini356 – 36510Extracellular By similarity
Transmembranei366 – 38823Helical; Name=10; By similarity
Add
BLAST
Topological domaini389 – 40113Cytoplasmic By similarity
Add
BLAST
Transmembranei402 – 42221Helical; Name=11; By similarity
Add
BLAST
Topological domaini423 – 4297Extracellular By similarity
Transmembranei430 – 45021Helical; Name=12; By similarity
Add
BLAST
Topological domaini451 – 49242Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: MGI
  2. caveola Source: Ensembl
  3. cell-cell junction Source: Ensembl
  4. cortical actin cytoskeleton Source: UniProtKB
  5. cytoplasm Source: UniProtKB
  6. female pronucleus Source: MGI
  7. integral component of membrane Source: UniProtKB-KW
  8. intracellular Source: MGI
  9. melanosome Source: UniProtKB-SubCell
  10. membrane Source: MGI
  11. midbody Source: Ensembl
  12. plasma membrane Source: UniProtKB
  13. vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Solute carrier family 2, facilitated glucose transporter member 1
PRO_0000050339Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Glycosylationi45 – 451N-linked (GlcNAc...)2 Publications
Glycosylationi49 – 491N-linked (GlcNAc...); atypical2 Publications
Modified residuei478 – 4781Phosphothreonine By similarity
Modified residuei490 – 4901Phosphoserine By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP17809.
PaxDbiP17809.
PRIDEiP17809.

PTM databases

PhosphoSiteiP17809.

Expressioni

Developmental stagei

Levels decline 3-fold between days 7.5 and 12.5 of gestation. At 7.5 dpc, expressed more strongly in extraembryonic tissues than in the embryo proper. Expressed in amnion, chorion, and ectoplacental cone. In the yolk sac, expressed more strongly in the mesoderm layer than the ectoderm. Expression fairly widespread in the embryo at 8.5 dpc, but by 10.5 dpc, expression is down-regulated and observed in the eye and the spinal cord.2 Publications

Gene expression databases

ArrayExpressiP17809.
BgeeiP17809.
GenevestigatoriP17809.

Interactioni

Subunit structurei

Found in a complex with ADD2, DMTN and SLC2A1. Interacts (via C-terminus cytoplasmic region) with DMTN isoform 2. Interacts with SNX27; the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with GIPC (via PDZ domain). Interacts with STOM By similarity.

Protein-protein interaction databases

BioGridi203304. 1 interaction.
IntActiP17809. 2 interactions.
MINTiMINT-348833.

Structurei

3D structure databases

ProteinModelPortaliP17809.
SMRiP17809. Positions 19-465.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni282 – 2887Monosaccharide binding By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00720000108560.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiQ6GTI3.
KOiK07299.
OMAiQTWIHRY.
OrthoDBiEOG7QVM2R.
TreeFamiTF313762.

Family and domain databases

InterProiIPR002439. Glu_transpt_1.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01190. GLUCTRSPORT1.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17809-1 [UniParc]FASTAAdd to Basket

« Hide

MDPSSKKVTG RLMLAVGGAV LGSLQFGYNT GVINAPQKVI EEFYNQTWNH    50
RYGEPIPSTT LTTLWSLSVA IFSVGGMIGS FSVGLFVNRF GRRNSMLMMN 100
LLAFVAAVLM GFSKLGKSFE MLILGRFIIG VYCGLTTGFV PMYVGEVSPT 150
ALRGALGTLH QLGIVVGILI AQVFGLDSIM GNADLWPLLL SVIFIPALLQ 200
CILLPFCPES PRFLLINRNE ENRAKSVLKK LRGTADVTRD LQEMKEEGRQ 250
MMREKKVTIL ELFRSPAYRQ PILIAVVLQL SQQLSGINAV FYYSTSIFEK 300
AGVQQPVYAT IGSGIVNTAF TVVSLFVVER AGRRTLHLIG LAGMAGCAVL 350
MTIALALLER LPWMSYLSIV AIFGFVAFFE VGPGPIPWFI VAELFSQGPR 400
PAAIAVAGFS NWTSNFIVGM CFQYVEQLCG PYVFIIFTVL LVLFFIFTYF 450
KVPETKGRTF DEIASGFRQG GASQSDKTPE ELFHPLGADS QV 492
Length:492
Mass (Da):53,985
Last modified:July 27, 2011 - v4
Checksum:i464B668853D7636E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521Y → I in AAA37752. 1 Publication
Sequence conflicti193 – 1953IFI → VFV in AAA37752. 1 Publication
Sequence conflicti357 – 3604LLER → MQEQ in AAB20846. 1 Publication
Sequence conflicti403 – 4031A → R in AAA37752. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23384 mRNA. Translation: AAA37752.1.
M22998 mRNA. Translation: AAA37707.1.
AK170873 mRNA. Translation: BAE42084.1.
AL606975 Genomic DNA. Translation: CAM21633.1.
CH466552 Genomic DNA. Translation: EDL30474.1.
BC055340 mRNA. Translation: AAH55340.1.
X69697 mRNA. Translation: CAA49367.1.
S77924 mRNA. Translation: AAB20846.2.
CCDSiCCDS18569.1.
PIRiA44887.
S09705.
RefSeqiNP_035530.2. NM_011400.3.
UniGeneiMm.21002.

Genome annotation databases

EnsembliENSMUST00000030398; ENSMUSP00000030398; ENSMUSG00000028645.
GeneIDi20525.
KEGGimmu:20525.
UCSCiuc008ule.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23384 mRNA. Translation: AAA37752.1 .
M22998 mRNA. Translation: AAA37707.1 .
AK170873 mRNA. Translation: BAE42084.1 .
AL606975 Genomic DNA. Translation: CAM21633.1 .
CH466552 Genomic DNA. Translation: EDL30474.1 .
BC055340 mRNA. Translation: AAH55340.1 .
X69697 mRNA. Translation: CAA49367.1 .
S77924 mRNA. Translation: AAB20846.2 .
CCDSi CCDS18569.1.
PIRi A44887.
S09705.
RefSeqi NP_035530.2. NM_011400.3.
UniGenei Mm.21002.

3D structure databases

ProteinModelPortali P17809.
SMRi P17809. Positions 19-465.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203304. 1 interaction.
IntActi P17809. 2 interactions.
MINTi MINT-348833.

PTM databases

PhosphoSitei P17809.

Proteomic databases

MaxQBi P17809.
PaxDbi P17809.
PRIDEi P17809.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030398 ; ENSMUSP00000030398 ; ENSMUSG00000028645 .
GeneIDi 20525.
KEGGi mmu:20525.
UCSCi uc008ule.2. mouse.

Organism-specific databases

CTDi 6513.
MGIi MGI:95755. Slc2a1.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00720000108560.
HOGENOMi HOG000202871.
HOVERGENi HBG014816.
InParanoidi Q6GTI3.
KOi K07299.
OMAi QTWIHRY.
OrthoDBi EOG7QVM2R.
TreeFami TF313762.

Enzyme and pathway databases

Reactomei REACT_206357. Facilitative Na+-independent glucose transporters.
REACT_215258. Vitamin C (ascorbate) metabolism.

Miscellaneous databases

ChiTaRSi SLC2A1. mouse.
NextBioi 298763.
PROi P17809.
SOURCEi Search...

Gene expression databases

ArrayExpressi P17809.
Bgeei P17809.
Genevestigatori P17809.

Family and domain databases

InterProi IPR002439. Glu_transpt_1.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
PRINTSi PR01190. GLUCTRSPORT1.
PR00171. SUGRTRNSPORT.
SUPFAMi SSF103473. SSF103473. 2 hits.
TIGRFAMsi TIGR00879. SP. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes."
    Kaestner K.H., Christy R.J., McLenithan J.C., Braiterman L.T., Cornelius P., Pekala P.H., Lane M.D.
    Proc. Natl. Acad. Sci. U.S.A. 86:3150-3154(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "3T3-L1 adipocyte glucose transporter (HepG2 class): sequence and regulation of protein and mRNA expression by insulin, differentiation, and glucose starvation."
    Reed B.C., Shade D., Alperovich F., Vang M.
    Arch. Biochem. Biophys. 279:261-274(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  7. "Identification of two enhancer elements in the gene encoding the type 1 glucose transporter from the mouse which are responsive to serum, growth factor, and oncogenes."
    Murakami T., Nishiyama T., Shirotani T., Shinohara Y., Kan M., Ishii K., Kanai F., Nakazuru S., Ebina Y.
    J. Biol. Chem. 267:9300-9306(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-6.
  8. "Differential screening of a PCR-generated mouse embryo cDNA library: glucose transporters are differentially expressed in early postimplantation mouse embryos."
    Smith D.E., Gridley T.
    Development 116:555-561(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 151-237, DEVELOPMENTAL STAGE.
    Strain: C57BL/6.
    Tissue: Embryo.
  9. "Glucose transporter gene expression in early mouse embryos."
    Hogan A., Heyner S., Charron M.J., Copeland N.G., Gilbert D.J., Jenkins N.A., Thorens B., Schultz G.A.
    Development 113:363-372(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 357-463, DEVELOPMENTAL STAGE.
    Strain: CD-1.
    Tissue: Embryo.
  10. "PACSIN3 overexpression increases adipocyte glucose transport through GLUT1."
    Roach W., Plomann M.
    Biochem. Biophys. Res. Commun. 355:745-750(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  11. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-45 AND ASN-49.
    Tissue: Myoblast.
  12. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-45 AND ASN-49.

Entry informationi

Entry nameiGTR1_MOUSE
AccessioniPrimary (citable) accession number: P17809
Secondary accession number(s): Q61608, Q6GTI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 145 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi