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Protein

Solute carrier family 2, facilitated glucose transporter member 1

Gene

Slc2a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei317MonosaccharideBy similarity1
Binding sitei388MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-189200 Cellular hexose transport
R-MMU-196836 Vitamin C (ascorbate) metabolism
R-MMU-422356 Regulation of insulin secretion
R-MMU-5653890 Lactose synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 1
Alternative name(s):
Glucose transporter type 1, erythrocyte/brain
Short name:
GLUT-1
Short name:
GT1
Gene namesi
Name:Slc2a1
Synonyms:Glut-1, Glut1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95755 Slc2a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicBy similarityAdd BLAST11
Transmembranei12 – 33Helical; Name=1By similarityAdd BLAST22
Topological domaini34 – 66ExtracellularBy similarityAdd BLAST33
Transmembranei67 – 87Helical; Name=2By similarityAdd BLAST21
Topological domaini88 – 90CytoplasmicBy similarity3
Transmembranei91 – 112Helical; Name=3By similarityAdd BLAST22
Topological domaini113 – 120ExtracellularBy similarity8
Transmembranei121 – 144Helical; Name=4By similarityAdd BLAST24
Topological domaini145 – 155CytoplasmicBy similarityAdd BLAST11
Transmembranei156 – 176Helical; Name=5By similarityAdd BLAST21
Topological domaini177 – 185ExtracellularBy similarity9
Transmembranei186 – 206Helical; Name=6By similarityAdd BLAST21
Topological domaini207 – 271CytoplasmicBy similarityAdd BLAST65
Transmembranei272 – 293Helical; Name=7By similarityAdd BLAST22
Topological domaini294 – 306ExtracellularBy similarityAdd BLAST13
Transmembranei307 – 328Helical; Name=8By similarityAdd BLAST22
Topological domaini329 – 334CytoplasmicBy similarity6
Transmembranei335 – 355Helical; Name=9By similarityAdd BLAST21
Topological domaini356 – 365ExtracellularBy similarity10
Transmembranei366 – 388Helical; Name=10By similarityAdd BLAST23
Topological domaini389 – 401CytoplasmicBy similarityAdd BLAST13
Transmembranei402 – 422Helical; Name=11By similarityAdd BLAST21
Topological domaini423 – 429ExtracellularBy similarity7
Transmembranei430 – 450Helical; Name=12By similarityAdd BLAST21
Topological domaini451 – 492CytoplasmicBy similarityAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503391 – 492Solute carrier family 2, facilitated glucose transporter member 1Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi45N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi49N-linked (GlcNAc...) asparagine; atypical2 Publications1
Modified residuei465PhosphoserineBy similarity1
Modified residuei478PhosphothreonineBy similarity1
Modified residuei490PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP17809
MaxQBiP17809
PaxDbiP17809
PeptideAtlasiP17809
PRIDEiP17809

PTM databases

iPTMnetiP17809
PhosphoSitePlusiP17809
SwissPalmiP17809

Expressioni

Developmental stagei

Levels decline 3-fold between days 7.5 and 12.5 of gestation. At 7.5 dpc, expressed more strongly in extraembryonic tissues than in the embryo proper. Expressed in amnion, chorion, and ectoplacental cone. In the yolk sac, expressed more strongly in the mesoderm layer than the ectoderm. Expression fairly widespread in the embryo at 8.5 dpc, but by 10.5 dpc, expression is down-regulated and observed in the eye and the spinal cord.2 Publications

Gene expression databases

BgeeiENSMUSG00000028645
ExpressionAtlasiP17809 baseline and differential
GenevisibleiP17809 MM

Interactioni

Subunit structurei

Found in a complex with ADD2, DMTN and SLC2A1. Interacts (via C-terminus cytoplasmic region) with DMTN isoform 2. Interacts with SNX27; the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with GIPC (via PDZ domain). Interacts with STOM. Interacts with SGTA (via Gln-rich region).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203304, 2 interactors
IntActiP17809, 2 interactors
MINTiP17809
STRINGi10090.ENSMUSP00000030398

Structurei

3D structure databases

ProteinModelPortaliP17809
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni282 – 288Monosaccharide bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000119022
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP17809
KOiK07299
OMAiAFAMFYI
OrthoDBiEOG091G0A9K
TreeFamiTF313762

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002439 Glu_transpt_1
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01190 GLUCTRSPORT1
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P17809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSSKKVTG RLMLAVGGAV LGSLQFGYNT GVINAPQKVI EEFYNQTWNH
60 70 80 90 100
RYGEPIPSTT LTTLWSLSVA IFSVGGMIGS FSVGLFVNRF GRRNSMLMMN
110 120 130 140 150
LLAFVAAVLM GFSKLGKSFE MLILGRFIIG VYCGLTTGFV PMYVGEVSPT
160 170 180 190 200
ALRGALGTLH QLGIVVGILI AQVFGLDSIM GNADLWPLLL SVIFIPALLQ
210 220 230 240 250
CILLPFCPES PRFLLINRNE ENRAKSVLKK LRGTADVTRD LQEMKEEGRQ
260 270 280 290 300
MMREKKVTIL ELFRSPAYRQ PILIAVVLQL SQQLSGINAV FYYSTSIFEK
310 320 330 340 350
AGVQQPVYAT IGSGIVNTAF TVVSLFVVER AGRRTLHLIG LAGMAGCAVL
360 370 380 390 400
MTIALALLER LPWMSYLSIV AIFGFVAFFE VGPGPIPWFI VAELFSQGPR
410 420 430 440 450
PAAIAVAGFS NWTSNFIVGM CFQYVEQLCG PYVFIIFTVL LVLFFIFTYF
460 470 480 490
KVPETKGRTF DEIASGFRQG GASQSDKTPE ELFHPLGADS QV
Length:492
Mass (Da):53,985
Last modified:July 27, 2011 - v4
Checksum:i464B668853D7636E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52Y → I in AAA37752 (PubMed:2654938).Curated1
Sequence conflicti193 – 195IFI → VFV in AAA37752 (PubMed:2654938).Curated3
Sequence conflicti357 – 360LLER → MQEQ in AAB20846 (PubMed:1765007).Curated4
Sequence conflicti403A → R in AAA37752 (PubMed:2654938).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23384 mRNA Translation: AAA37752.1
M22998 mRNA Translation: AAA37707.1
AK170873 mRNA Translation: BAE42084.1
AL606975 Genomic DNA Translation: CAM21633.1
CH466552 Genomic DNA Translation: EDL30474.1
BC055340 mRNA Translation: AAH55340.1
X69697 mRNA Translation: CAA49367.1
S77924 mRNA Translation: AAB20846.2
CCDSiCCDS18569.1
PIRiA44887
S09705
RefSeqiNP_035530.2, NM_011400.3
UniGeneiMm.21002

Genome annotation databases

EnsembliENSMUST00000030398; ENSMUSP00000030398; ENSMUSG00000028645
GeneIDi20525
KEGGimmu:20525
UCSCiuc008ule.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGTR1_MOUSE
AccessioniPrimary (citable) accession number: P17809
Secondary accession number(s): Q61608, Q6GTI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 180 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health