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Protein

Solute carrier family 2, facilitated glucose transporter member 1

Gene

Slc2a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei317MonosaccharideBy similarity1
Binding sitei388MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular response to glucose starvation Source: MGI
  • dehydroascorbic acid transport Source: UniProtKB
  • glucose transmembrane transport Source: MGI
  • glucose transport Source: UniProtKB
  • protein complex assembly Source: UniProtKB
  • response to osmotic stress Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-196836. Vitamin C (ascorbate) metabolism.
R-MMU-422356. Regulation of insulin secretion.
R-MMU-428790. Facilitative Na+-independent glucose transporters.
R-MMU-5653890. Lactose synthesis.
R-MMU-70153. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 1
Alternative name(s):
Glucose transporter type 1, erythrocyte/brain
Short name:
GLUT-1
Short name:
GT1
Gene namesi
Name:Slc2a1
Synonyms:Glut-1, Glut1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95755. Slc2a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicBy similarityAdd BLAST11
Transmembranei12 – 33Helical; Name=1By similarityAdd BLAST22
Topological domaini34 – 66ExtracellularBy similarityAdd BLAST33
Transmembranei67 – 87Helical; Name=2By similarityAdd BLAST21
Topological domaini88 – 90CytoplasmicBy similarity3
Transmembranei91 – 112Helical; Name=3By similarityAdd BLAST22
Topological domaini113 – 120ExtracellularBy similarity8
Transmembranei121 – 144Helical; Name=4By similarityAdd BLAST24
Topological domaini145 – 155CytoplasmicBy similarityAdd BLAST11
Transmembranei156 – 176Helical; Name=5By similarityAdd BLAST21
Topological domaini177 – 185ExtracellularBy similarity9
Transmembranei186 – 206Helical; Name=6By similarityAdd BLAST21
Topological domaini207 – 271CytoplasmicBy similarityAdd BLAST65
Transmembranei272 – 293Helical; Name=7By similarityAdd BLAST22
Topological domaini294 – 306ExtracellularBy similarityAdd BLAST13
Transmembranei307 – 328Helical; Name=8By similarityAdd BLAST22
Topological domaini329 – 334CytoplasmicBy similarity6
Transmembranei335 – 355Helical; Name=9By similarityAdd BLAST21
Topological domaini356 – 365ExtracellularBy similarity10
Transmembranei366 – 388Helical; Name=10By similarityAdd BLAST23
Topological domaini389 – 401CytoplasmicBy similarityAdd BLAST13
Transmembranei402 – 422Helical; Name=11By similarityAdd BLAST21
Topological domaini423 – 429ExtracellularBy similarity7
Transmembranei430 – 450Helical; Name=12By similarityAdd BLAST21
Topological domaini451 – 492CytoplasmicBy similarityAdd BLAST42

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • basolateral plasma membrane Source: MGI
  • blood microparticle Source: MGI
  • caveola Source: Ensembl
  • cell-cell junction Source: Ensembl
  • cortical actin cytoskeleton Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: MGI
  • extracellular exosome Source: MGI
  • female pronucleus Source: MGI
  • integral component of plasma membrane Source: UniProtKB
  • intracellular Source: MGI
  • melanosome Source: UniProtKB-SubCell
  • membrane Source: MGI
  • membrane raft Source: MGI
  • midbody Source: MGI
  • plasma membrane Source: UniProtKB
  • vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503391 – 492Solute carrier family 2, facilitated glucose transporter member 1Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi45N-linked (GlcNAc...)2 Publications1
Glycosylationi49N-linked (GlcNAc...); atypical2 Publications1
Modified residuei465PhosphoserineBy similarity1
Modified residuei478PhosphothreonineBy similarity1
Modified residuei490PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP17809.
MaxQBiP17809.
PaxDbiP17809.
PeptideAtlasiP17809.
PRIDEiP17809.

PTM databases

iPTMnetiP17809.
PhosphoSitePlusiP17809.
SwissPalmiP17809.

Expressioni

Developmental stagei

Levels decline 3-fold between days 7.5 and 12.5 of gestation. At 7.5 dpc, expressed more strongly in extraembryonic tissues than in the embryo proper. Expressed in amnion, chorion, and ectoplacental cone. In the yolk sac, expressed more strongly in the mesoderm layer than the ectoderm. Expression fairly widespread in the embryo at 8.5 dpc, but by 10.5 dpc, expression is down-regulated and observed in the eye and the spinal cord.2 Publications

Gene expression databases

BgeeiENSMUSG00000028645.
ExpressionAtlasiP17809. baseline and differential.
GenevisibleiP17809. MM.

Interactioni

Subunit structurei

Found in a complex with ADD2, DMTN and SLC2A1. Interacts (via C-terminus cytoplasmic region) with DMTN isoform 2. Interacts with SNX27; the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with GIPC (via PDZ domain). Interacts with STOM (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203304. 1 interactor.
IntActiP17809. 2 interactors.
MINTiMINT-348833.
STRINGi10090.ENSMUSP00000030398.

Structurei

3D structure databases

ProteinModelPortaliP17809.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni282 – 288Monosaccharide bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP17809.
KOiK07299.
OMAiMLMMNLL.
OrthoDBiEOG091G0A9K.
TreeFamiTF313762.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002439. Glu_transpt_1.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01190. GLUCTRSPORT1.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSSKKVTG RLMLAVGGAV LGSLQFGYNT GVINAPQKVI EEFYNQTWNH
60 70 80 90 100
RYGEPIPSTT LTTLWSLSVA IFSVGGMIGS FSVGLFVNRF GRRNSMLMMN
110 120 130 140 150
LLAFVAAVLM GFSKLGKSFE MLILGRFIIG VYCGLTTGFV PMYVGEVSPT
160 170 180 190 200
ALRGALGTLH QLGIVVGILI AQVFGLDSIM GNADLWPLLL SVIFIPALLQ
210 220 230 240 250
CILLPFCPES PRFLLINRNE ENRAKSVLKK LRGTADVTRD LQEMKEEGRQ
260 270 280 290 300
MMREKKVTIL ELFRSPAYRQ PILIAVVLQL SQQLSGINAV FYYSTSIFEK
310 320 330 340 350
AGVQQPVYAT IGSGIVNTAF TVVSLFVVER AGRRTLHLIG LAGMAGCAVL
360 370 380 390 400
MTIALALLER LPWMSYLSIV AIFGFVAFFE VGPGPIPWFI VAELFSQGPR
410 420 430 440 450
PAAIAVAGFS NWTSNFIVGM CFQYVEQLCG PYVFIIFTVL LVLFFIFTYF
460 470 480 490
KVPETKGRTF DEIASGFRQG GASQSDKTPE ELFHPLGADS QV
Length:492
Mass (Da):53,985
Last modified:July 27, 2011 - v4
Checksum:i464B668853D7636E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52Y → I in AAA37752 (PubMed:2654938).Curated1
Sequence conflicti193 – 195IFI → VFV in AAA37752 (PubMed:2654938).Curated3
Sequence conflicti357 – 360LLER → MQEQ in AAB20846 (PubMed:1765007).Curated4
Sequence conflicti403A → R in AAA37752 (PubMed:2654938).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23384 mRNA. Translation: AAA37752.1.
M22998 mRNA. Translation: AAA37707.1.
AK170873 mRNA. Translation: BAE42084.1.
AL606975 Genomic DNA. Translation: CAM21633.1.
CH466552 Genomic DNA. Translation: EDL30474.1.
BC055340 mRNA. Translation: AAH55340.1.
X69697 mRNA. Translation: CAA49367.1.
S77924 mRNA. Translation: AAB20846.2.
CCDSiCCDS18569.1.
PIRiA44887.
S09705.
RefSeqiNP_035530.2. NM_011400.3.
UniGeneiMm.21002.

Genome annotation databases

EnsembliENSMUST00000030398; ENSMUSP00000030398; ENSMUSG00000028645.
GeneIDi20525.
KEGGimmu:20525.
UCSCiuc008ule.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23384 mRNA. Translation: AAA37752.1.
M22998 mRNA. Translation: AAA37707.1.
AK170873 mRNA. Translation: BAE42084.1.
AL606975 Genomic DNA. Translation: CAM21633.1.
CH466552 Genomic DNA. Translation: EDL30474.1.
BC055340 mRNA. Translation: AAH55340.1.
X69697 mRNA. Translation: CAA49367.1.
S77924 mRNA. Translation: AAB20846.2.
CCDSiCCDS18569.1.
PIRiA44887.
S09705.
RefSeqiNP_035530.2. NM_011400.3.
UniGeneiMm.21002.

3D structure databases

ProteinModelPortaliP17809.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203304. 1 interactor.
IntActiP17809. 2 interactors.
MINTiMINT-348833.
STRINGi10090.ENSMUSP00000030398.

PTM databases

iPTMnetiP17809.
PhosphoSitePlusiP17809.
SwissPalmiP17809.

Proteomic databases

EPDiP17809.
MaxQBiP17809.
PaxDbiP17809.
PeptideAtlasiP17809.
PRIDEiP17809.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030398; ENSMUSP00000030398; ENSMUSG00000028645.
GeneIDi20525.
KEGGimmu:20525.
UCSCiuc008ule.2. mouse.

Organism-specific databases

CTDi6513.
MGIiMGI:95755. Slc2a1.

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP17809.
KOiK07299.
OMAiMLMMNLL.
OrthoDBiEOG091G0A9K.
TreeFamiTF313762.

Enzyme and pathway databases

ReactomeiR-MMU-196836. Vitamin C (ascorbate) metabolism.
R-MMU-422356. Regulation of insulin secretion.
R-MMU-428790. Facilitative Na+-independent glucose transporters.
R-MMU-5653890. Lactose synthesis.
R-MMU-70153. Glucose transport.

Miscellaneous databases

ChiTaRSiSlc2a1. mouse.
PROiP17809.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028645.
ExpressionAtlasiP17809. baseline and differential.
GenevisibleiP17809. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002439. Glu_transpt_1.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01190. GLUCTRSPORT1.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR1_MOUSE
AccessioniPrimary (citable) accession number: P17809
Secondary accession number(s): Q61608, Q6GTI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 167 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.