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Protein

Interferon gamma

Gene

IFNG

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:IFNG
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 166143Interferon gammaPRO_0000016455Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Glycosylationi39 – 391N-linked (GlcNAc...)By similarity
Glycosylationi106 – 1061N-linked (GlcNAc...)By similarity

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP17803.

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Gene expression databases

ExpressionAtlasiP17803. differential.
GenevisibleiP17803. SS.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000511.

Structurei

3D structure databases

ProteinModelPortaliP17803.
SMRiP17803. Positions 24-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWSY. Eukaryota.
ENOG410Z8I5. LUCA.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP17803.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
TreeFamiTF336308.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17803-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYTTYFLAF QLCVTLCFSG SYCQAPFFKE ITILKDYFNA STSDVPNGGP
60 70 80 90 100
LFLEILKNWK EESDKKIIQS QIVSFYFKFF EIFKDNQAIQ RSMDVIKQDM
110 120 130 140 150
FQRFLNGSSG KLNDFEKLIK IPVDNLQIQR KAISELIKVM NDLSPRSNLR
160
KRKRSQTMFQ GQRASK
Length:166
Mass (Da):19,419
Last modified:August 1, 1990 - v1
Checksum:i19B51CC05D5ED276
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53085 Genomic DNA. Translation: CAA37252.1.
S63967 Genomic DNA. Translation: AAB20280.2.
AF493993 mRNA. Translation: AAM27193.1.
AY188090 mRNA. Translation: AAO34390.1.
AY293733 mRNA. Translation: AAQ24335.1.
DQ666352 mRNA. Translation: ABG56234.1.
PIRiS10513.
RefSeqiNP_999113.1. NM_213948.1.
UniGeneiSsc.4093.

Genome annotation databases

EnsembliENSSSCT00000000519; ENSSSCP00000000511; ENSSSCG00000000481.
GeneIDi396991.
KEGGissc:396991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53085 Genomic DNA. Translation: CAA37252.1.
S63967 Genomic DNA. Translation: AAB20280.2.
AF493993 mRNA. Translation: AAM27193.1.
AY188090 mRNA. Translation: AAO34390.1.
AY293733 mRNA. Translation: AAQ24335.1.
DQ666352 mRNA. Translation: ABG56234.1.
PIRiS10513.
RefSeqiNP_999113.1. NM_213948.1.
UniGeneiSsc.4093.

3D structure databases

ProteinModelPortaliP17803.
SMRiP17803. Positions 24-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000511.

Proteomic databases

PaxDbiP17803.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000000519; ENSSSCP00000000511; ENSSSCG00000000481.
GeneIDi396991.
KEGGissc:396991.

Organism-specific databases

CTDi3458.

Phylogenomic databases

eggNOGiENOG410IWSY. Eukaryota.
ENOG410Z8I5. LUCA.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP17803.
KOiK04687.
OMAiKEYFNAS.
OrthoDBiEOG7VHSZM.
TreeFamiTF336308.

Gene expression databases

ExpressionAtlasiP17803. differential.
GenevisibleiP17803. SS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002069. Interferon_gamma.
[Graphical view]
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiPF00714. IFN-gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiPD002435. Interferon_gamma. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequence of the porcine interferon-gamma (IFN-gamma) gene."
    Dukmans R., Vandenbroeck K., Beuken E., Billiau A.
    Nucleic Acids Res. 18:4259-4259(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  2. "Engineering by PCR-based exon amplification of the genomic porcine interferon-gamma DNA for expression in Escherichia coli."
    Vandenbroeck K., Dijkmans R., van Aerschot A., Billiau A.
    Biochem. Biophys. Res. Commun. 180:1408-1415(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning and sequence analysis of gamma interferon gene from Chenghua swine."
    Li J., Gao R., Wu M., Long Z., Tang M., Shen Y., Liu S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Chenghua.
    Tissue: Blood.
  4. "Isolation of porcine interferon gamma (IFN-gamma) cDNA."
    Fan Y.-H., Chiou S.-H.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Cloning and analyzing of interferon gamma cDNA from the lymphocyte of Tibet pig."
    Li H., Gao R., Wu M., Wang L., Din X., Liu S.
    Zhongguo Shouyi Ke-ji 5:48-51(2003)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Tibetan.
  6. "Cloning and expression of Meishan porcine interferon-gamma."
    Yao Q., Qian P., Chen H.
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Meishan.

Entry informationi

Entry nameiIFNG_PIG
AccessioniPrimary (citable) accession number: P17803
Secondary accession number(s): Q53ZP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 11, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.