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Protein

Interferon gamma

Gene

IFNG

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:IFNG
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000001645524 – 166Interferon gammaAdd BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acidBy similarity1
Glycosylationi39N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi106N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP17803.
PRIDEiP17803.

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Gene expression databases

BgeeiENSSSCG00000000481.
ExpressionAtlasiP17803. differential.
GenevisibleiP17803. SS.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000511.

Structurei

3D structure databases

ProteinModelPortaliP17803.
SMRiP17803.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWSY. Eukaryota.
ENOG410Z8I5. LUCA.
GeneTreeiENSGT00390000007831.
HOGENOMiHOG000254784.
HOVERGENiHBG056912.
InParanoidiP17803.
KOiK04687.
OMAiWKEESDK.
OrthoDBiEOG091G0ZH0.
TreeFamiTF336308.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR002069. Interferon_gamma.
PANTHERiPTHR11419. PTHR11419. 1 hit.
PfamiView protein in Pfam
PF00714. IFN-gamma. 1 hit.
PIRSFiPIRSF001936. IFN-gamma. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002435. Interferon_gamma. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17803-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYTTYFLAF QLCVTLCFSG SYCQAPFFKE ITILKDYFNA STSDVPNGGP
60 70 80 90 100
LFLEILKNWK EESDKKIIQS QIVSFYFKFF EIFKDNQAIQ RSMDVIKQDM
110 120 130 140 150
FQRFLNGSSG KLNDFEKLIK IPVDNLQIQR KAISELIKVM NDLSPRSNLR
160
KRKRSQTMFQ GQRASK
Length:166
Mass (Da):19,419
Last modified:August 1, 1990 - v1
Checksum:i19B51CC05D5ED276
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53085 Genomic DNA. Translation: CAA37252.1.
S63967 Genomic DNA. Translation: AAB20280.2.
AF493993 mRNA. Translation: AAM27193.1.
AY188090 mRNA. Translation: AAO34390.1.
AY293733 mRNA. Translation: AAQ24335.1.
DQ666352 mRNA. Translation: ABG56234.1.
PIRiS10513.
RefSeqiNP_999113.1. NM_213948.1.
UniGeneiSsc.4093.

Genome annotation databases

EnsembliENSSSCT00000000519; ENSSSCP00000000511; ENSSSCG00000000481.
GeneIDi396991.
KEGGissc:396991.

Similar proteinsi

Entry informationi

Entry nameiIFNG_PIG
AccessioniPrimary (citable) accession number: P17803
Secondary accession number(s): Q53ZP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 27, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families