P17790 (BASI_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Basigin

Alternative name(s):
5A11 antigen
Blood-brain barrier HT7 antigen
Neurothelin

Gene names

Name:

BSG

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable receptor involved in cell surface recognition at the blood-brain barrier. Involved in neuronal-glial interactions in retinal development.
Subunit structure	Homooligomer.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Endothelial cells of the central nervous system.
Sequence similarities	Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P17790-1)

Also known as: Long; Basigin-2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P17790-2)

Also known as: Short; Basigin;

The sequence of this isoform differs from the canonical sequence as follows:
     28-144: AGFIKSPLSQ...SQANVLVIER → G

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 388	367	Basigin		PRO_0000014522
Regions
	Topological domain	27 – 323	297	Extracellular Potential
	Transmembrane	324 – 344	21	Helical; Potential
	Topological domain	345 – 388	44	Cytoplasmic Potential
	Domain	143 – 218	76	Ig-like C2-type
	Domain	229 – 323	95	Ig-like V-type
Amino acid modifications
	Glycosylation	163	1	N-linked (GlcNAc...)
	Glycosylation	222	1	N-linked (GlcNAc...)
	Glycosylation	280	1	N-linked (GlcNAc...)
	Glycosylation	286	1	N-linked (GlcNAc...) Potential
	Glycosylation	307	1	N-linked (GlcNAc...) Potential
	Disulfide bond	162 ↔ 211		By similarity
	Disulfide bond	250 ↔ 306		By similarity
Natural variations
	Alternative sequence	28 – 144	117	AGFIK…LVIER → G in isoform 2.		VSP_011504

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) (Basigin-2) [UniParc]. Last modified August 31, 2004. Version 2. Checksum: 9B04428F1A7DE759	FASTA	388	42,414
	10 20 30 40 50 60 MAAGADVPCA VLALLVLGSL AAGGDATAGF IKSPLSQRRL TQDSVELHCE AVGSPIPEIQ 70 80 90 100 110 120 WWFEGNEPNE TSAQLWDGAW QDRVQINATY NLHSTSTIYI ANLTSDDSGT YECRASNDPD 130 140 150 160 170 180 RNHLSKSPKV KWIRSQANVL VIERPVITGQ YSSSADKVVL SCNISAPPTL IKGHKWMLGD 190 200 210 220 230 240 KVLKTDESDA SSYISYTIEG KVEDHSGVYE CIYNTNPVAK GNVSIEVEPQ VVAYKKSEHG 250 260 270 280 290 300 NEGDVGVLTC KSPSYPPVDH WAWYKSGQTV PLESSAGIYN ISRTGNKTEL RILKLNIEQD 310 320 330 340 350 360 MGDYSCNGTN MKGSGSATVN LRVRSRLAAL WPFLGIVAEV LVLVTIIFIY EKRRKPDEVL 370 380 DDDDGGSAPL KSNATNHKDK NVRQRNAN
	Isoform 2 (Short) (Basigin) [UniParc]. Checksum: 2E8D4CCBBCFC64F2	FASTA	272	29,202
	10 20 30 40 50 60 MAAGADVPCA VLALLVLGSL AAGGDATGPV ITGQYSSSAD KVVLSCNISA PPTLIKGHKW 70 80 90 100 110 120 MLGDKVLKTD ESDASSYISY TIEGKVEDHS GVYECIYNTN PVAKGNVSIE VEPQVVAYKK 130 140 150 160 170 180 SEHGNEGDVG VLTCKSPSYP PVDHWAWYKS GQTVPLESSA GIYNISRTGN KTELRILKLN 190 200 210 220 230 240 IEQDMGDYSC NGTNMKGSGS ATVNLRVRSR LAALWPFLGI VAEVLVLVTI IFIYEKRRKP 250 260 270 DEVLDDDDGG SAPLKSNATN HKDKNVRQRN AN

References

[1]	"The inducible blood-brain barrier specific molecule HT7 is a novel immunoglobulin-like cell surface glycoprotein." Seulberger H., Lottspeich F., Risau W. EMBO J. 9:2151-2158(1990) [PubMed: 2357963] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE (ISOFORM 2).
[2]	"Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily." Ochrietor J.D., Moroz T.P., van Ekeris L., Clamp M.F., Jefferson S.C., deCarvalho A.C., Fadool J.M., Wistow G., Muramatsu T., Linser P.J. Invest. Ophthalmol. Vis. Sci. 44:4086-4096(2003) [PubMed: 12939332] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Retina.
[3]	"Neurothelin: amino acid sequence, cell surface dynamics and actin colocalization." Schlosshauer B., Bauch H., Frank R. Eur. J. Cell Biol. 68:159-166(1995) [PubMed: 8575462] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE. Strain: White leghorn. Tissue: Retina.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X52751 mRNA. Translation: CAA36962.1. AY248696 mRNA. Translation: AAP80139.1.
IPI	IPI00583689. IPI00588329.
RefSeq	NP_001185919.1. NM_001198990.1.
UniGene	Gga.39023.
3D structure databases
ProteinModelPortal	P17790.
ModBase	Search...
Proteomic databases
PRIDE	P17790.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	770363.
Phylogenomic databases
eggNOG	veNOG05338.
HOVERGEN	HBG008120.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 3 hits.
Pfam	PF07679. I-set. 2 hits. [Graphical view]
SMART	SM00409. IG. 2 hits. SM00408. IGc2. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BASI_CHICK

Accession

Primary (citable) accession number: P17790
Secondary accession number(s): Q6X975

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 31, 2004
Last modified:	November 16, 2011
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program