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Protein

Basigin

Gene

BSG

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in targeting monocarboxylate transporters to the plasma membrane (By similarity). Probable receptor involved in cell surface recognition at the blood-brain barrier. Involved in neuronal-glial interactions in retinal development.By similarity

Enzyme and pathway databases

ReactomeiR-GGA-1474228. Degradation of the extracellular matrix.
R-GGA-210991. Basigin interactions.
R-GGA-216083. Integrin cell surface interactions.
R-GGA-373920. Pyruvate metabolism.
R-GGA-433692. Proton-coupled monocarboxylate transport.
R-GGA-70268. Pyruvate metabolism.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Basigin
Alternative name(s):
5A11 antigen
Blood-brain barrier HT7 antigen
Neurothelin
Gene namesi
Name:BSG
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 28

Subcellular locationi

  • Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
  • Melanosome By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 323297ExtracellularSequence analysisAdd
BLAST
Transmembranei324 – 34421HelicalSequence analysisAdd
BLAST
Topological domaini345 – 38844CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 388367BasiginPRO_0000014522Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi162 ↔ 211PROSITE-ProRule annotation
Glycosylationi163 – 1631N-linked (GlcNAc...)
Glycosylationi222 – 2221N-linked (GlcNAc...)
Disulfide bondi250 ↔ 306PROSITE-ProRule annotation
Glycosylationi280 – 2801N-linked (GlcNAc...)
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence analysis
Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP17790.

Expressioni

Tissue specificityi

Endothelial cells of the central nervous system.

Interactioni

Subunit structurei

Homooligomer.By similarity

Protein-protein interaction databases

BioGridi691081. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP17790.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 21876Ig-like C2-typeAdd
BLAST
Domaini229 – 32395Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000010516.
HOVERGENiHBG008120.
InParanoidiP17790.
KOiK06535.
OMAiQANVFVI.
PhylomeDBiP17790.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR009151. Basigin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10075:SF12. PTHR10075:SF12. 1 hit.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17790-1) [UniParc]FASTAAdd to basket

Also known as: Long, Basigin-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGADVPCA VLALLVLGSL AAGGDATAGF IKSPLSQRRL TQDSVELHCE
60 70 80 90 100
AVGSPIPEIQ WWFEGNEPNE TSAQLWDGAW QDRVQINATY NLHSTSTIYI
110 120 130 140 150
ANLTSDDSGT YECRASNDPD RNHLSKSPKV KWIRSQANVL VIERPVITGQ
160 170 180 190 200
YSSSADKVVL SCNISAPPTL IKGHKWMLGD KVLKTDESDA SSYISYTIEG
210 220 230 240 250
KVEDHSGVYE CIYNTNPVAK GNVSIEVEPQ VVAYKKSEHG NEGDVGVLTC
260 270 280 290 300
KSPSYPPVDH WAWYKSGQTV PLESSAGIYN ISRTGNKTEL RILKLNIEQD
310 320 330 340 350
MGDYSCNGTN MKGSGSATVN LRVRSRLAAL WPFLGIVAEV LVLVTIIFIY
360 370 380
EKRRKPDEVL DDDDGGSAPL KSNATNHKDK NVRQRNAN
Length:388
Mass (Da):42,414
Last modified:August 31, 2004 - v2
Checksum:i9B04428F1A7DE759
GO
Isoform 2 (identifier: P17790-2) [UniParc]FASTAAdd to basket

Also known as: Short, Basigin

The sequence of this isoform differs from the canonical sequence as follows:
     28-144: AGFIKSPLSQ...SQANVLVIER → G

Show »
Length:272
Mass (Da):29,202
Checksum:i2E8D4CCBBCFC64F2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei28 – 144117AGFIK…LVIER → G in isoform 2. CuratedVSP_011504Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52751 mRNA. Translation: CAA36962.1.
AY248696 mRNA. Translation: AAP80139.1.
RefSeqiNP_001185919.1. NM_001198990.2. [P17790-1]
NP_001185921.1. NM_001198992.1. [P17790-2]
UniGeneiGga.39023.
Gga.50612.

Genome annotation databases

EnsembliENSGALT00000002022; ENSGALP00000002020; ENSGALG00000001328. [P17790-1]
GeneIDi770363.
KEGGigga:770363.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52751 mRNA. Translation: CAA36962.1.
AY248696 mRNA. Translation: AAP80139.1.
RefSeqiNP_001185919.1. NM_001198990.2. [P17790-1]
NP_001185921.1. NM_001198992.1. [P17790-2]
UniGeneiGga.39023.
Gga.50612.

3D structure databases

ProteinModelPortaliP17790.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi691081. 1 interaction.

Protein family/group databases

MEROPSiI43.001.

Proteomic databases

PRIDEiP17790.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000002022; ENSGALP00000002020; ENSGALG00000001328. [P17790-1]
GeneIDi770363.
KEGGigga:770363.

Organism-specific databases

CTDi682.

Phylogenomic databases

GeneTreeiENSGT00390000010516.
HOVERGENiHBG008120.
InParanoidiP17790.
KOiK06535.
OMAiQANVFVI.
PhylomeDBiP17790.

Enzyme and pathway databases

ReactomeiR-GGA-1474228. Degradation of the extracellular matrix.
R-GGA-210991. Basigin interactions.
R-GGA-216083. Integrin cell surface interactions.
R-GGA-373920. Pyruvate metabolism.
R-GGA-433692. Proton-coupled monocarboxylate transport.
R-GGA-70268. Pyruvate metabolism.

Miscellaneous databases

PROiP17790.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR009151. Basigin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10075:SF12. PTHR10075:SF12. 1 hit.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The inducible blood-brain barrier specific molecule HT7 is a novel immunoglobulin-like cell surface glycoprotein."
    Seulberger H., Lottspeich F., Risau W.
    EMBO J. 9:2151-2158(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE (ISOFORM 2), SUBCELLULAR LOCATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Retina.
  3. "Neurothelin: amino acid sequence, cell surface dynamics and actin colocalization."
    Schlosshauer B., Bauch H., Frank R.
    Eur. J. Cell Biol. 68:159-166(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
    Strain: White leghorn.
    Tissue: Retina.

Entry informationi

Entry nameiBASI_CHICK
AccessioniPrimary (citable) accession number: P17790
Secondary accession number(s): Q6X975
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 31, 2004
Last modified: June 8, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.