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P17787

- ACHB2_HUMAN

UniProt

P17787 - ACHB2_HUMAN

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Protein
Neuronal acetylcholine receptor subunit beta-2
Gene
CHRNB2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.1 Publication

GO - Molecular functioni

  1. acetylcholine binding Source: UniProtKB
  2. acetylcholine receptor activity Source: UniProtKB
  3. acetylcholine-activated cation-selective channel activity Source: UniProtKB
  4. drug binding Source: Ensembl
  5. ligand-gated ion channel activity Source: DFLAT

GO - Biological processi

  1. B cell activation Source: UniProtKB
  2. action potential Source: Ensembl
  3. associative learning Source: UniProtKB
  4. behavioral response to nicotine Source: UniProtKB
  5. calcium ion transport Source: UniProtKB
  6. central nervous system projection neuron axonogenesis Source: UniProtKB
  7. cognition Source: UniProtKB
  8. conditioned taste aversion Source: Ensembl
  9. ion transmembrane transport Source: GOC
  10. ion transport Source: UniProtKB
  11. lateral geniculate nucleus development Source: UniProtKB
  12. learning Source: UniProtKB
  13. locomotory behavior Source: UniProtKB
  14. membrane depolarization Source: UniProtKB
  15. memory Source: UniProtKB
  16. negative regulation of action potential Source: UniProtKB
  17. neurological system process Source: UniProtKB
  18. optic nerve morphogenesis Source: UniProtKB
  19. positive regulation of B cell proliferation Source: UniProtKB
  20. positive regulation of dopamine secretion Source: UniProtKB
  21. positive regulation of synaptic transmission, dopaminergic Source: Ensembl
  22. protein heterooligomerization Source: Ensembl
  23. regulation of circadian sleep/wake cycle, REM sleep Source: UniProtKB
  24. regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
  25. regulation of dendrite morphogenesis Source: UniProtKB
  26. regulation of dopamine metabolic process Source: UniProtKB
  27. regulation of dopamine secretion Source: UniProtKB
  28. regulation of synapse assembly Source: UniProtKB
  29. regulation of synaptic transmission, dopaminergic Source: UniProtKB
  30. response to cocaine Source: UniProtKB
  31. response to ethanol Source: UniProtKB
  32. response to hypoxia Source: UniProtKB
  33. response to nicotine Source: UniProtKB
  34. sensory perception of pain Source: UniProtKB
  35. sensory perception of sound Source: UniProtKB
  36. signal transduction Source: UniProtKB
  37. smooth muscle contraction Source: UniProtKB
  38. social behavior Source: UniProtKB
  39. synaptic transmission Source: Reactome
  40. synaptic transmission involved in micturition Source: UniProtKB
  41. synaptic transmission, cholinergic Source: UniProtKB
  42. vestibulocochlear nerve development Source: UniProtKB
  43. visual learning Source: UniProtKB
  44. visual perception Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_22223. Highly sodium permeable acetylcholine nicotinic receptors.
REACT_22303. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
REACT_22352. Highly calcium permeable nicotinic acetylcholine receptors.

Protein family/group databases

TCDBi1.A.9.1.6. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit beta-2
Gene namesi
Name:CHRNB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:1962. CHRNB2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 233208Extracellular Reviewed prediction
Add
BLAST
Transmembranei234 – 25825Helical; Reviewed prediction
Add
BLAST
Topological domaini259 – 2657Cytoplasmic Reviewed prediction
Transmembranei266 – 28419Helical; Reviewed prediction
Add
BLAST
Topological domaini285 – 29915Extracellular Reviewed prediction
Add
BLAST
Transmembranei300 – 32122Helical; Reviewed prediction
Add
BLAST
Topological domaini322 – 458137Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei459 – 47820Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. acetylcholine-gated channel complex Source: UniProtKB
  2. cell junction Source: UniProtKB-KW
  3. external side of plasma membrane Source: UniProtKB
  4. integral component of membrane Source: UniProtKB
  5. plasma membrane Source: Reactome
  6. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Epilepsy, nocturnal frontal lobe, 3 (ENFL3) [MIM:605375]: An autosomal dominant focal epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti287 – 2871V → L in ENFL3. 1 Publication
VAR_012714
Natural varianti287 – 2871V → M in ENFL3; approximately 10-fold increase in acetylcholine sensitivity. 1 Publication
VAR_012715

Keywords - Diseasei

Disease mutation, Epilepsy

Organism-specific databases

MIMi605375. phenotype.
Orphaneti98784. Autosomal dominant nocturnal frontal lobe epilepsy.
PharmGKBiPA115.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 By similarity
Add
BLAST
Chaini26 – 502477Neuronal acetylcholine receptor subunit beta-2
PRO_0000000379Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi155 ↔ 169 By similarity
Glycosylationi168 – 1681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi485 – 4851N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP17787.
PRIDEiP17787.

Expressioni

Gene expression databases

ArrayExpressiP17787.
BgeeiP17787.
CleanExiHS_CHRNB2.
GenevestigatoriP17787.

Interactioni

Subunit structurei

Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-2 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers. Interacts with RIC3; which is required for proper folding and assembly.2 Publications

Protein-protein interaction databases

MINTiMINT-6629945.
STRINGi9606.ENSP00000357461.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi233 – 2364
Helixi242 – 25716
Helixi267 – 28519
Helixi289 – 2913
Helixi294 – 31320
Helixi315 – 3228
Helixi456 – 47924
Turni480 – 4823

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GVTmodel-B/D/E30-233[»]
2K58NMR-B231-265[»]
2K59NMR-B264-291[»]
2KSRNMR-A231-330[»]
A453-486[»]
2LM2NMR-A231-330[»]
A458-485[»]
ProteinModelPortaliP17787.
SMRiP17787. Positions 26-338, 426-486.

Miscellaneous databases

EvolutionaryTraceiP17787.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG290206.
HOGENOMiHOG000006757.
HOVERGENiHBG003756.
InParanoidiP17787.
KOiK04813.
OMAiDPTYVDI.
OrthoDBiEOG72JWGV.
PhylomeDBiP17787.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17787-1 [UniParc]FASTAAdd to Basket

« Hide

MARRCGPVAL LLGFGLLRLC SGVWGTDTEE RLVEHLLDPS RYNKLIRPAT    50
NGSELVTVQL MVSLAQLISV HEREQIMTTN VWLTQEWEDY RLTWKPEEFD 100
NMKKVRLPSK HIWLPDVVLY NNADGMYEVS FYSNAVVSYD GSIFWLPPAI 150
YKSACKIEVK HFPFDQQNCT MKFRSWTYDR TEIDLVLKSE VASLDDFTPS 200
GEWDIVALPG RRNENPDDST YVDITYDFII RRKPLFYTIN LIIPCVLITS 250
LAILVFYLPS DCGEKMTLCI SVLLALTVFL LLISKIVPPT SLDVPLVGKY 300
LMFTMVLVTF SIVTSVCVLN VHHRSPTTHT MAPWVKVVFL EKLPALLFMQ 350
QPRHHCARQR LRLRRRQRER EGAGALFFRE APGADSCTCF VNRASVQGLA 400
GAFGAEPAPV AGPGRSGEPC GCGLREAVDG VRFIADHMRS EDDDQSVSED 450
WKYVAMVIDR LFLWIFVFVC VFGTIGMFLQ PLFQNYTTTT FLHSDHSAPS 500
SK 502
Length:502
Mass (Da):57,019
Last modified:August 1, 1990 - v1
Checksum:i7EEDEF6ADFDC9F23
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti287 – 2871V → L in ENFL3. 1 Publication
VAR_012714
Natural varianti287 – 2871V → M in ENFL3; approximately 10-fold increase in acetylcholine sensitivity. 1 Publication
VAR_012715
Natural varianti397 – 3971Q → H.1 Publication
Corresponds to variant rs55685423 [ dbSNP | Ensembl ].
VAR_021564

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261T → A in CAA05108. 1 Publication
Sequence conflicti426 – 4261E → A in CAA05108. 1 Publication
Sequence conflicti446 – 4461S → SVR in CAA05108. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53179 mRNA. Translation: CAA37320.1.
U62437 mRNA. Translation: AAB40115.1.
Y08415 mRNA. Translation: CAA69692.1.
AJ001935
, AJ001936, AJ001937, AJ001938, AJ001939 Genomic DNA. Translation: CAA05108.1.
AF077186 Genomic DNA. Translation: AAD45422.1.
BC075040 mRNA. Translation: AAH75040.1.
BC075041 mRNA. Translation: AAH75041.1.
CCDSiCCDS1070.1.
PIRiS10505.
RefSeqiNP_000739.1. NM_000748.2.
XP_006711206.1. XM_006711143.1.
UniGeneiHs.2306.

Genome annotation databases

EnsembliENST00000368476; ENSP00000357461; ENSG00000160716.
GeneIDi1141.
KEGGihsa:1141.
UCSCiuc001ffg.3. human.

Polymorphism databases

DMDMi113105.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53179 mRNA. Translation: CAA37320.1 .
U62437 mRNA. Translation: AAB40115.1 .
Y08415 mRNA. Translation: CAA69692.1 .
AJ001935
, AJ001936 , AJ001937 , AJ001938 , AJ001939 Genomic DNA. Translation: CAA05108.1 .
AF077186 Genomic DNA. Translation: AAD45422.1 .
BC075040 mRNA. Translation: AAH75040.1 .
BC075041 mRNA. Translation: AAH75041.1 .
CCDSi CCDS1070.1.
PIRi S10505.
RefSeqi NP_000739.1. NM_000748.2.
XP_006711206.1. XM_006711143.1.
UniGenei Hs.2306.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2GVT model - B/D/E 30-233 [» ]
2K58 NMR - B 231-265 [» ]
2K59 NMR - B 264-291 [» ]
2KSR NMR - A 231-330 [» ]
A 453-486 [» ]
2LM2 NMR - A 231-330 [» ]
A 458-485 [» ]
ProteinModelPortali P17787.
SMRi P17787. Positions 26-338, 426-486.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-6629945.
STRINGi 9606.ENSP00000357461.

Chemistry

BindingDBi P17787.
ChEMBLi CHEMBL2109233.
DrugBanki DB00184. Nicotine.
GuidetoPHARMACOLOGYi 472.

Protein family/group databases

TCDBi 1.A.9.1.6. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Polymorphism databases

DMDMi 113105.

Proteomic databases

PaxDbi P17787.
PRIDEi P17787.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368476 ; ENSP00000357461 ; ENSG00000160716 .
GeneIDi 1141.
KEGGi hsa:1141.
UCSCi uc001ffg.3. human.

Organism-specific databases

CTDi 1141.
GeneCardsi GC01P154540.
GeneReviewsi CHRNB2.
HGNCi HGNC:1962. CHRNB2.
MIMi 118507. gene.
605375. phenotype.
neXtProti NX_P17787.
Orphaneti 98784. Autosomal dominant nocturnal frontal lobe epilepsy.
PharmGKBi PA115.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG290206.
HOGENOMi HOG000006757.
HOVERGENi HBG003756.
InParanoidi P17787.
KOi K04813.
OMAi DPTYVDI.
OrthoDBi EOG72JWGV.
PhylomeDBi P17787.
TreeFami TF315605.

Enzyme and pathway databases

Reactomei REACT_22223. Highly sodium permeable acetylcholine nicotinic receptors.
REACT_22303. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
REACT_22352. Highly calcium permeable nicotinic acetylcholine receptors.

Miscellaneous databases

EvolutionaryTracei P17787.
GeneWikii CHRNB2.
GenomeRNAii 1141.
NextBioi 4748.
PROi P17787.
SOURCEi Search...

Gene expression databases

ArrayExpressi P17787.
Bgeei P17787.
CleanExi HS_CHRNB2.
Genevestigatori P17787.

Family and domain databases

Gene3Di 1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProi IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the human nicotinic acetylcholine receptor beta 2 subunit gene."
    Anand R., Lindstrom J.
    Nucleic Acids Res. 18:4272-4272(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."
    Elliott K.J., Ellis S.B., Berckhan K.J., Urrutia A., Chavez-Noriega L.E., Johnson E.C., Velicelebi G., Harpold M.M.
    J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32."
    Groot Kormelink P.J., Luyten W.H.M.L.
    FEBS Lett. 400:309-314(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Frontal cortex.
  4. "The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3)."
    Rempel N., Heyers S., Engels H., Sleegers E., Steinlein O.K.
    Hum. Genet. 103:645-653(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes."
    Lueders K.K., Elliott R.W., Marenholz I., Mischke D., DuPree M., Hamer D.
    Mamm. Genome 10:900-905(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."
    Lansdell S.J., Gee V.J., Harkness P.C., Doward A.I., Baker E.R., Gibb A.J., Millar N.S.
    Mol. Pharmacol. 68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RIC3.
  8. "NMR structure of the transmembrane domain of the n-acetylcholine receptor beta2 subunit."
    Bondarenko V., Tillman T., Xu Y., Tang P.
    Biochim. Biophys. Acta 1798:1608-1614(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 231-486.
  9. "NMR structures of the transmembrane domains of the alpha4beta2 nAChR."
    Bondarenko V., Mowrey D., Tillman T., Cui T., Liu L.T., Xu Y., Tang P.
    Biochim. Biophys. Acta 1818:1261-1268(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 234-484, SUBUNIT, FUNCTION.
  10. "The nicotinic receptor beta-2 subunit is mutant in nocturnal frontal lobe epilepsy."
    De Fusco M., Becchetti A., Patrignani A., Annesi G., Gambardella A., Quattrone A., Ballabio A., Wanke E., Casari G.
    Nat. Genet. 26:275-276(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ENFL3 LEU-287.
  11. "CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy."
    Phillips H.A., Favre I., Kirkpatrick M., Zuberi S.M., Goudie D., Heron S.E., Scheffer I.E., Sutherland G.R., Berkovic S.F., Bertrand D., Mulley J.C.
    Am. J. Hum. Genet. 68:225-231(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ENFL3 MET-287.
  12. "Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2)."
    Lueders K.K., Hu S., McHugh L., Myakishev M.V., Sirota L.A., Hamer D.H.
    Nicotine Tob. Res. 4:115-125(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT HIS-397.

Entry informationi

Entry nameiACHB2_HUMAN
AccessioniPrimary (citable) accession number: P17787
Secondary accession number(s): Q9UEH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 3, 2014
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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