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P17787

- ACHB2_HUMAN

UniProt

P17787 - ACHB2_HUMAN

Protein

Neuronal acetylcholine receptor subunit beta-2

Gene

CHRNB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 156 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.1 Publication

    GO - Molecular functioni

    1. acetylcholine-activated cation-selective channel activity Source: UniProtKB
    2. acetylcholine binding Source: UniProtKB
    3. acetylcholine receptor activity Source: UniProtKB
    4. drug binding Source: Ensembl
    5. ligand-gated ion channel activity Source: DFLAT

    GO - Biological processi

    1. action potential Source: Ensembl
    2. associative learning Source: UniProtKB
    3. B cell activation Source: UniProtKB
    4. behavioral response to nicotine Source: UniProtKB
    5. calcium ion transport Source: UniProtKB
    6. central nervous system projection neuron axonogenesis Source: UniProtKB
    7. cognition Source: UniProtKB
    8. conditioned taste aversion Source: Ensembl
    9. ion transmembrane transport Source: GOC
    10. ion transport Source: UniProtKB
    11. lateral geniculate nucleus development Source: UniProtKB
    12. learning Source: UniProtKB
    13. locomotory behavior Source: UniProtKB
    14. membrane depolarization Source: UniProtKB
    15. memory Source: UniProtKB
    16. negative regulation of action potential Source: UniProtKB
    17. neurological system process Source: UniProtKB
    18. optic nerve morphogenesis Source: UniProtKB
    19. positive regulation of B cell proliferation Source: UniProtKB
    20. positive regulation of dopamine secretion Source: UniProtKB
    21. positive regulation of synaptic transmission, dopaminergic Source: Ensembl
    22. protein heterooligomerization Source: Ensembl
    23. regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
    24. regulation of circadian sleep/wake cycle, REM sleep Source: UniProtKB
    25. regulation of dendrite morphogenesis Source: UniProtKB
    26. regulation of dopamine metabolic process Source: UniProtKB
    27. regulation of dopamine secretion Source: UniProtKB
    28. regulation of synapse assembly Source: UniProtKB
    29. regulation of synaptic transmission, dopaminergic Source: UniProtKB
    30. response to cocaine Source: UniProtKB
    31. response to ethanol Source: UniProtKB
    32. response to hypoxia Source: UniProtKB
    33. response to nicotine Source: UniProtKB
    34. sensory perception of pain Source: UniProtKB
    35. sensory perception of sound Source: UniProtKB
    36. signal transduction Source: UniProtKB
    37. smooth muscle contraction Source: UniProtKB
    38. social behavior Source: UniProtKB
    39. synaptic transmission Source: Reactome
    40. synaptic transmission, cholinergic Source: UniProtKB
    41. synaptic transmission involved in micturition Source: UniProtKB
    42. vestibulocochlear nerve development Source: UniProtKB
    43. visual learning Source: UniProtKB
    44. visual perception Source: UniProtKB

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_22223. Highly sodium permeable acetylcholine nicotinic receptors.
    REACT_22303. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
    REACT_22352. Highly calcium permeable nicotinic acetylcholine receptors.

    Protein family/group databases

    TCDBi1.A.9.1.6. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuronal acetylcholine receptor subunit beta-2
    Gene namesi
    Name:CHRNB2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:1962. CHRNB2.

    Subcellular locationi

    GO - Cellular componenti

    1. acetylcholine-gated channel complex Source: UniProtKB
    2. cell junction Source: UniProtKB-KW
    3. external side of plasma membrane Source: UniProtKB
    4. integral component of membrane Source: UniProtKB
    5. plasma membrane Source: Reactome
    6. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Involvement in diseasei

    Epilepsy, nocturnal frontal lobe, 3 (ENFL3) [MIM:605375]: An autosomal dominant focal epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti287 – 2871V → L in ENFL3. 1 Publication
    VAR_012714
    Natural varianti287 – 2871V → M in ENFL3; approximately 10-fold increase in acetylcholine sensitivity. 1 Publication
    VAR_012715

    Keywords - Diseasei

    Disease mutation, Epilepsy

    Organism-specific databases

    MIMi605375. phenotype.
    Orphaneti98784. Autosomal dominant nocturnal frontal lobe epilepsy.
    PharmGKBiPA115.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525By similarityAdd
    BLAST
    Chaini26 – 502477Neuronal acetylcholine receptor subunit beta-2PRO_0000000379Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi155 ↔ 169By similarity
    Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi485 – 4851N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP17787.
    PRIDEiP17787.

    Expressioni

    Gene expression databases

    ArrayExpressiP17787.
    BgeeiP17787.
    CleanExiHS_CHRNB2.
    GenevestigatoriP17787.

    Interactioni

    Subunit structurei

    Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-2 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors, complexes with beta-2 may be heteropentamers. Interacts with RIC3; which is required for proper folding and assembly.2 Publications

    Protein-protein interaction databases

    MINTiMINT-6629945.
    STRINGi9606.ENSP00000357461.

    Structurei

    Secondary structure

    1
    502
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi233 – 2364
    Helixi242 – 25716
    Helixi267 – 28519
    Helixi289 – 2913
    Helixi294 – 31320
    Helixi315 – 3228
    Helixi456 – 47924
    Turni480 – 4823

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2GVTmodel-B/D/E30-233[»]
    2K58NMR-B231-265[»]
    2K59NMR-B264-291[»]
    2KSRNMR-A231-330[»]
    A453-486[»]
    2LM2NMR-A231-330[»]
    A458-485[»]
    ProteinModelPortaliP17787.
    SMRiP17787. Positions 26-338, 426-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP17787.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 233208ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini259 – 2657CytoplasmicSequence Analysis
    Topological domaini285 – 29915ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini322 – 458137CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei234 – 25825HelicalSequence AnalysisAdd
    BLAST
    Transmembranei266 – 28419HelicalSequence AnalysisAdd
    BLAST
    Transmembranei300 – 32122HelicalSequence AnalysisAdd
    BLAST
    Transmembranei459 – 47820HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG290206.
    HOGENOMiHOG000006757.
    HOVERGENiHBG003756.
    InParanoidiP17787.
    KOiK04813.
    OMAiDPTYVDI.
    OrthoDBiEOG72JWGV.
    PhylomeDBiP17787.
    TreeFamiTF315605.

    Family and domain databases

    Gene3Di1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProiIPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17787-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARRCGPVAL LLGFGLLRLC SGVWGTDTEE RLVEHLLDPS RYNKLIRPAT    50
    NGSELVTVQL MVSLAQLISV HEREQIMTTN VWLTQEWEDY RLTWKPEEFD 100
    NMKKVRLPSK HIWLPDVVLY NNADGMYEVS FYSNAVVSYD GSIFWLPPAI 150
    YKSACKIEVK HFPFDQQNCT MKFRSWTYDR TEIDLVLKSE VASLDDFTPS 200
    GEWDIVALPG RRNENPDDST YVDITYDFII RRKPLFYTIN LIIPCVLITS 250
    LAILVFYLPS DCGEKMTLCI SVLLALTVFL LLISKIVPPT SLDVPLVGKY 300
    LMFTMVLVTF SIVTSVCVLN VHHRSPTTHT MAPWVKVVFL EKLPALLFMQ 350
    QPRHHCARQR LRLRRRQRER EGAGALFFRE APGADSCTCF VNRASVQGLA 400
    GAFGAEPAPV AGPGRSGEPC GCGLREAVDG VRFIADHMRS EDDDQSVSED 450
    WKYVAMVIDR LFLWIFVFVC VFGTIGMFLQ PLFQNYTTTT FLHSDHSAPS 500
    SK 502
    Length:502
    Mass (Da):57,019
    Last modified:August 1, 1990 - v1
    Checksum:i7EEDEF6ADFDC9F23
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261T → A in CAA05108. (PubMed:9921897)Curated
    Sequence conflicti426 – 4261E → A in CAA05108. (PubMed:9921897)Curated
    Sequence conflicti446 – 4461S → SVR in CAA05108. (PubMed:9921897)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti287 – 2871V → L in ENFL3. 1 Publication
    VAR_012714
    Natural varianti287 – 2871V → M in ENFL3; approximately 10-fold increase in acetylcholine sensitivity. 1 Publication
    VAR_012715
    Natural varianti397 – 3971Q → H.1 Publication
    Corresponds to variant rs55685423 [ dbSNP | Ensembl ].
    VAR_021564

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53179 mRNA. Translation: CAA37320.1.
    U62437 mRNA. Translation: AAB40115.1.
    Y08415 mRNA. Translation: CAA69692.1.
    AJ001935
    , AJ001936, AJ001937, AJ001938, AJ001939 Genomic DNA. Translation: CAA05108.1.
    AF077186 Genomic DNA. Translation: AAD45422.1.
    BC075040 mRNA. Translation: AAH75040.1.
    BC075041 mRNA. Translation: AAH75041.1.
    CCDSiCCDS1070.1.
    PIRiS10505.
    RefSeqiNP_000739.1. NM_000748.2.
    XP_006711206.1. XM_006711143.1.
    UniGeneiHs.2306.

    Genome annotation databases

    EnsembliENST00000368476; ENSP00000357461; ENSG00000160716.
    GeneIDi1141.
    KEGGihsa:1141.
    UCSCiuc001ffg.3. human.

    Polymorphism databases

    DMDMi113105.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53179 mRNA. Translation: CAA37320.1 .
    U62437 mRNA. Translation: AAB40115.1 .
    Y08415 mRNA. Translation: CAA69692.1 .
    AJ001935
    , AJ001936 , AJ001937 , AJ001938 , AJ001939 Genomic DNA. Translation: CAA05108.1 .
    AF077186 Genomic DNA. Translation: AAD45422.1 .
    BC075040 mRNA. Translation: AAH75040.1 .
    BC075041 mRNA. Translation: AAH75041.1 .
    CCDSi CCDS1070.1.
    PIRi S10505.
    RefSeqi NP_000739.1. NM_000748.2.
    XP_006711206.1. XM_006711143.1.
    UniGenei Hs.2306.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2GVT model - B/D/E 30-233 [» ]
    2K58 NMR - B 231-265 [» ]
    2K59 NMR - B 264-291 [» ]
    2KSR NMR - A 231-330 [» ]
    A 453-486 [» ]
    2LM2 NMR - A 231-330 [» ]
    A 458-485 [» ]
    ProteinModelPortali P17787.
    SMRi P17787. Positions 26-338, 426-486.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-6629945.
    STRINGi 9606.ENSP00000357461.

    Chemistry

    BindingDBi P17787.
    ChEMBLi CHEMBL2109233.
    DrugBanki DB00514. Dextromethorphan.
    DB00674. Galantamine.
    DB00184. Nicotine.
    GuidetoPHARMACOLOGYi 472.

    Protein family/group databases

    TCDBi 1.A.9.1.6. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

    Polymorphism databases

    DMDMi 113105.

    Proteomic databases

    PaxDbi P17787.
    PRIDEi P17787.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368476 ; ENSP00000357461 ; ENSG00000160716 .
    GeneIDi 1141.
    KEGGi hsa:1141.
    UCSCi uc001ffg.3. human.

    Organism-specific databases

    CTDi 1141.
    GeneCardsi GC01P154540.
    GeneReviewsi CHRNB2.
    HGNCi HGNC:1962. CHRNB2.
    MIMi 118507. gene.
    605375. phenotype.
    neXtProti NX_P17787.
    Orphaneti 98784. Autosomal dominant nocturnal frontal lobe epilepsy.
    PharmGKBi PA115.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG290206.
    HOGENOMi HOG000006757.
    HOVERGENi HBG003756.
    InParanoidi P17787.
    KOi K04813.
    OMAi DPTYVDI.
    OrthoDBi EOG72JWGV.
    PhylomeDBi P17787.
    TreeFami TF315605.

    Enzyme and pathway databases

    Reactomei REACT_22223. Highly sodium permeable acetylcholine nicotinic receptors.
    REACT_22303. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
    REACT_22352. Highly calcium permeable nicotinic acetylcholine receptors.

    Miscellaneous databases

    EvolutionaryTracei P17787.
    GeneWikii CHRNB2.
    GenomeRNAii 1141.
    NextBioi 4748.
    PROi P17787.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P17787.
    Bgeei P17787.
    CleanExi HS_CHRNB2.
    Genevestigatori P17787.

    Family and domain databases

    Gene3Di 1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProi IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the human nicotinic acetylcholine receptor beta 2 subunit gene."
      Anand R., Lindstrom J.
      Nucleic Acids Res. 18:4272-4272(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    2. "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."
      Elliott K.J., Ellis S.B., Berckhan K.J., Urrutia A., Chavez-Noriega L.E., Johnson E.C., Velicelebi G., Harpold M.M.
      J. Mol. Neurosci. 7:217-228(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32."
      Groot Kormelink P.J., Luyten W.H.M.L.
      FEBS Lett. 400:309-314(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Frontal cortex.
    4. "The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3)."
      Rempel N., Heyers S., Engels H., Sleegers E., Steinlein O.K.
      Hum. Genet. 103:645-653(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes."
      Lueders K.K., Elliott R.W., Marenholz I., Mischke D., DuPree M., Hamer D.
      Mamm. Genome 10:900-905(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. "RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."
      Lansdell S.J., Gee V.J., Harkness P.C., Doward A.I., Baker E.R., Gibb A.J., Millar N.S.
      Mol. Pharmacol. 68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RIC3.
    8. "NMR structure of the transmembrane domain of the n-acetylcholine receptor beta2 subunit."
      Bondarenko V., Tillman T., Xu Y., Tang P.
      Biochim. Biophys. Acta 1798:1608-1614(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 231-486.
    9. "NMR structures of the transmembrane domains of the alpha4beta2 nAChR."
      Bondarenko V., Mowrey D., Tillman T., Cui T., Liu L.T., Xu Y., Tang P.
      Biochim. Biophys. Acta 1818:1261-1268(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 234-484, SUBUNIT, FUNCTION.
    10. "The nicotinic receptor beta-2 subunit is mutant in nocturnal frontal lobe epilepsy."
      De Fusco M., Becchetti A., Patrignani A., Annesi G., Gambardella A., Quattrone A., Ballabio A., Wanke E., Casari G.
      Nat. Genet. 26:275-276(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ENFL3 LEU-287.
    11. "CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy."
      Phillips H.A., Favre I., Kirkpatrick M., Zuberi S.M., Goudie D., Heron S.E., Scheffer I.E., Sutherland G.R., Berkovic S.F., Bertrand D., Mulley J.C.
      Am. J. Hum. Genet. 68:225-231(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ENFL3 MET-287.
    12. "Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2)."
      Lueders K.K., Hu S., McHugh L., Myakishev M.V., Sirota L.A., Hamer D.H.
      Nicotine Tob. Res. 4:115-125(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HIS-397.

    Entry informationi

    Entry nameiACHB2_HUMAN
    AccessioniPrimary (citable) accession number: P17787
    Secondary accession number(s): Q9UEH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 156 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3