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Protein

Annexin A2

Gene

ANXA2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.

Miscellaneous

It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Calcium/phospholipid-binding

Enzyme and pathway databases

ReactomeiR-GGA-6798695 Neutrophil degranulation
R-GGA-75205 Dissolution of Fibrin Clot

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A2
Alternative name(s):
Annexin II
Annexin-2
Calpactin I heavy chain
Calpactin-1 heavy chain
Chromobindin-8
Lipocortin II
Placental anticoagulant protein IV
Short name:
PAP-IV
Protein I
p36
Gene namesi
Name:ANXA2
Synonyms:ANX2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved3 Publications
ChainiPRO_00000674742 – 339Annexin A2Add BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine2 Publications1
Modified residuei24Phosphotyrosine; by SRCBy similarity1
Modified residuei26Phosphothreonine; by PKCBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP17785
PRIDEiP17785

PTM databases

iPTMnetiP17785

Expressioni

Gene expression databases

BgeeiENSGALG00000003770

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038695

Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 11Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BT6X-ray2.40C/D2-14[»]
ProteinModelPortaliP17785
SMRiP17785
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17785

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati42 – 102Annexin 1Add BLAST61
Repeati114 – 174Annexin 2Add BLAST61
Repeati199 – 259Annexin 3Add BLAST61
Repeati274 – 334Annexin 4Add BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 24S100A10-binding siteSequence analysisAdd BLAST23

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiP17785
KOiK17092
OMAiFIQQDTK
OrthoDBiEOG091G0H6H
PhylomeDBiP17785
TreeFamiTF105452

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002389 ANX2
PANTHERiPTHR10502:SF18 PTHR10502:SF18, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR00198 ANNEXINII
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17785-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVHEILSK LSLEGDHSLP PSAYATVKAY SNFDADRDAA ALEAAIKTKG
60 70 80 90 100
VDEVTIINIL TNRSNEQRQD IAFAYQRRTK KELSAALKSA LSGHLEAVIL
110 120 130 140 150
GLLKTPSQYD ASELKAAMKG LGTDEDTLIE IICSRTNQEL NEINRVYREM
160 170 180 190 200
YKTELEKDII SDTSGDFRKL MVALAKGKRC EDTSVIDYEL IDQDARELYD
210 220 230 240 250
AGVKRKGTDV PKWINIMTER SVPHLQKVFE RYKSYSPYDM LESIKKEVKG
260 270 280 290 300
DLENAFLNLV QCIQNKQLYF ADRLYDSMKG KGTRDKVLIR IMVSRCEVDM
310 320 330
LKIKSEFKRK YGKSLYYFIQ QDTKGDYQRA LLNLCGGED
Length:339
Mass (Da):38,640
Last modified:January 23, 2007 - v2
Checksum:i4B621506C4BFCD73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53334 mRNA Translation: CAA37421.1
PIRiS10501 LUCH2
RefSeqiNP_990682.1, NM_205351.1
XP_015134249.1, XM_015278763.1
UniGeneiGga.3641

Genome annotation databases

EnsembliENSGALT00000005981; ENSGALP00000005971; ENSGALG00000003770
ENSGALT00000050124; ENSGALP00000048954; ENSGALG00000003770
ENSGALT00000083426; ENSGALP00000060891; ENSGALG00000003770
ENSGALT00000085466; ENSGALP00000063929; ENSGALG00000003770
ENSGALT00000089656; ENSGALP00000059946; ENSGALG00000003770
GeneIDi396297
KEGGigga:396297

Similar proteinsi

Entry informationi

Entry nameiANXA2_CHICK
AccessioniPrimary (citable) accession number: P17785
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health