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P17785

- ANXA2_CHICK

UniProt

P17785 - ANXA2_CHICK

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Protein

Annexin A2

Gene

ANXA2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.

GO - Molecular functioni

  1. calcium channel activity Source: AgBase
  2. calcium-dependent phospholipid binding Source: UniProtKB-KW
  3. calcium ion binding Source: InterPro
  4. phospholipase A2 inhibitor activity Source: Ensembl
  5. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. calcium ion homeostasis Source: AgBase
  3. calcium ion transmembrane transport Source: GOC
  4. cellular response to acid chemical Source: Ensembl
  5. collagen fibril organization Source: Ensembl
  6. fibrinolysis Source: Ensembl
  7. membrane budding Source: Ensembl
  8. membrane raft assembly Source: Ensembl
  9. osteoclast development Source: Ensembl
  10. positive regulation of binding Source: Ensembl
  11. positive regulation of vesicle fusion Source: Ensembl
  12. protein heterotetramerization Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Enzyme and pathway databases

ReactomeiREACT_252950. Dissolution of Fibrin Clot.
REACT_269679. Orphan transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A2
Alternative name(s):
Annexin II
Annexin-2
Calpactin I heavy chain
Calpactin-1 heavy chain
Chromobindin-8
Lipocortin II
Placental anticoagulant protein IV
Short name:
PAP-IV
Protein I
p36
Gene namesi
Name:ANXA2
Synonyms:ANX2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 10

Subcellular locationi

Secretedextracellular spaceextracellular matrixbasement membrane
Note: In the lamina beneath the plasma membrane.

GO - Cellular componenti

  1. basement membrane Source: UniProtKB-KW
  2. calcium channel complex Source: AgBase
  3. cell surface Source: Ensembl
  4. early endosome Source: Ensembl
  5. extracellular space Source: Ensembl
  6. extracellular vesicular exosome Source: Ensembl
  7. extrinsic component of plasma membrane Source: Ensembl
  8. late endosome membrane Source: Ensembl
  9. lipid particle Source: Ensembl
  10. lysosomal membrane Source: Ensembl
  11. membrane raft Source: Ensembl
  12. midbody Source: Ensembl
  13. myelin sheath adaxonal region Source: Ensembl
  14. nucleus Source: Ensembl
  15. sarcolemma Source: Ensembl
  16. Schmidt-Lanterman incisure Source: Ensembl
  17. vesicle Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 339338Annexin A2PRO_0000067474Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications
Modified residuei24 – 241Phosphotyrosine; by SRCBy similarity
Modified residuei26 – 261Phosphothreonine; by PKCBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP17785.
PRIDEiP17785.

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005971.

Structurei

Secondary structure

1
339
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 119Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BT6X-ray2.40C/D2-14[»]
ProteinModelPortaliP17785.
SMRiP17785. Positions 21-339.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17785.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati42 – 10261Annexin 1Add
BLAST
Repeati114 – 17461Annexin 2Add
BLAST
Repeati199 – 25961Annexin 3Add
BLAST
Repeati274 – 33461Annexin 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 2423S100A10-binding siteSequence AnalysisAdd
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiNOG259189.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP17785.
KOiK17092.
OMAiFIQQDTK.
OrthoDBiEOG74XS72.
PhylomeDBiP17785.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
PANTHERiPTHR10502:SF18. PTHR10502:SF18. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17785-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTVHEILSK LSLEGDHSLP PSAYATVKAY SNFDADRDAA ALEAAIKTKG
60 70 80 90 100
VDEVTIINIL TNRSNEQRQD IAFAYQRRTK KELSAALKSA LSGHLEAVIL
110 120 130 140 150
GLLKTPSQYD ASELKAAMKG LGTDEDTLIE IICSRTNQEL NEINRVYREM
160 170 180 190 200
YKTELEKDII SDTSGDFRKL MVALAKGKRC EDTSVIDYEL IDQDARELYD
210 220 230 240 250
AGVKRKGTDV PKWINIMTER SVPHLQKVFE RYKSYSPYDM LESIKKEVKG
260 270 280 290 300
DLENAFLNLV QCIQNKQLYF ADRLYDSMKG KGTRDKVLIR IMVSRCEVDM
310 320 330
LKIKSEFKRK YGKSLYYFIQ QDTKGDYQRA LLNLCGGED
Length:339
Mass (Da):38,640
Last modified:January 23, 2007 - v2
Checksum:i4B621506C4BFCD73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53334 mRNA. Translation: CAA37421.1.
PIRiS10501. LUCH2.
RefSeqiNP_990682.1. NM_205351.1.
UniGeneiGga.3641.

Genome annotation databases

EnsembliENSGALT00000005981; ENSGALP00000005971; ENSGALG00000003770.
GeneIDi396297.
KEGGigga:396297.

Cross-referencesi

Web resourcesi

Protein Spotlight

Red velvet - Issue 86 of September 2007

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53334 mRNA. Translation: CAA37421.1 .
PIRi S10501. LUCH2.
RefSeqi NP_990682.1. NM_205351.1.
UniGenei Gga.3641.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BT6 X-ray 2.40 C/D 2-14 [» ]
ProteinModelPortali P17785.
SMRi P17785. Positions 21-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000005971.

Proteomic databases

PaxDbi P17785.
PRIDEi P17785.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000005981 ; ENSGALP00000005971 ; ENSGALG00000003770 .
GeneIDi 396297.
KEGGi gga:396297.

Organism-specific databases

CTDi 302.

Phylogenomic databases

eggNOGi NOG259189.
GeneTreei ENSGT00760000118972.
HOGENOMi HOG000158803.
HOVERGENi HBG061815.
InParanoidi P17785.
KOi K17092.
OMAi FIQQDTK.
OrthoDBi EOG74XS72.
PhylomeDBi P17785.
TreeFami TF105452.

Enzyme and pathway databases

Reactomei REACT_252950. Dissolution of Fibrin Clot.
REACT_269679. Orphan transporters.

Miscellaneous databases

EvolutionaryTracei P17785.
NextBioi 20816347.
PROi P17785.

Family and domain databases

Gene3Di 1.10.220.10. 4 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view ]
PANTHERi PTHR10502:SF18. PTHR10502:SF18. 1 hit.
Pfami PF00191. Annexin. 4 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTi SM00335. ANX. 4 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The cDNA sequence of chicken annexin II."
    Gerke V., Koch W.
    Nucleic Acids Res. 18:4246-4246(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A discontinuous epitope on p36, the major substrate of src tyrosine-protein-kinase, brings the phosphorylation site into the neighbourhood of a consensus sequence for Ca2+/lipid-binding proteins."
    Johnsson N., Johnsson K., Weber K.
    FEBS Lett. 236:201-204(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-70.
  3. "p36, the major cytoplasmic substrate of src tyrosine protein kinase, binds to its p11 regulatory subunit via a short amino-terminal amphiphatic helix."
    Johnsson N., Marriott G., Weber K.
    EMBO J. 7:2435-2442(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-30, ACETYLATION AT SER-2.
  4. Bienvenut W.V., Black E.J., Gillespie D.A.
    Submitted (JAN-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-63; 69-77 AND 314-324, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.

Entry informationi

Entry nameiANXA2_CHICK
AccessioniPrimary (citable) accession number: P17785
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3