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Protein

Annexin A2

Gene

ANXA2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.

GO - Molecular functioni

  • calcium channel activity Source: AgBase
  • calcium-dependent phospholipid binding Source: UniProtKB-KW
  • calcium ion binding Source: InterPro
  • phospholipase inhibitor activity Source: InterPro
  • virion binding Source: AgBase
  • voltage-gated calcium channel activity involved in regulation of cytosolic calcium ion concentration Source: AgBase

GO - Biological processi

  • bone mineralization Source: AgBase
  • calcium ion homeostasis Source: AgBase
  • endocardial cell differentiation Source: AgBase
  • growth plate cartilage development Source: AgBase
  • positive regulation of calcium ion transport Source: AgBase
  • positive regulation of chondrocyte differentiation Source: AgBase
  • regulation of plasminogen activation Source: AgBase
  • transforming growth factor beta3 activation Source: AgBase
  • transforming growth factor beta3 production Source: AgBase
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Enzyme and pathway databases

ReactomeiR-GGA-6798695. Neutrophil degranulation.
R-GGA-75205. Dissolution of Fibrin Clot.

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A2
Alternative name(s):
Annexin II
Annexin-2
Calpactin I heavy chain
Calpactin-1 heavy chain
Chromobindin-8
Lipocortin II
Placental anticoagulant protein IV
Short name:
PAP-IV
Protein I
p36
Gene namesi
Name:ANXA2
Synonyms:ANX2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

  • basement membrane Source: UniProtKB-SubCell
  • calcium channel complex Source: AgBase
  • extracellular matrix Source: AgBase
  • plasma membrane Source: AgBase
  • protein complex Source: AgBase
  • vesicle Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved3 Publications
ChainiPRO_00000674742 – 339Annexin A2Add BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine2 Publications1
Modified residuei24Phosphotyrosine; by SRCBy similarity1
Modified residuei26Phosphothreonine; by PKCBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP17785.
PRIDEiP17785.

PTM databases

iPTMnetiP17785.

Expressioni

Gene expression databases

BgeeiENSGALG00000003770.

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038695.

Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 11Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BT6X-ray2.40C/D2-14[»]
ProteinModelPortaliP17785.
SMRiP17785.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17785.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati42 – 102Annexin 1Add BLAST61
Repeati114 – 174Annexin 2Add BLAST61
Repeati199 – 259Annexin 3Add BLAST61
Repeati274 – 334Annexin 4Add BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 24S100A10-binding siteSequence analysisAdd BLAST23

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP17785.
KOiK17092.
OMAiFIQQDTK.
OrthoDBiEOG091G0H6H.
PhylomeDBiP17785.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
PANTHERiPTHR10502:SF111. PTHR10502:SF111. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17785-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVHEILSK LSLEGDHSLP PSAYATVKAY SNFDADRDAA ALEAAIKTKG
60 70 80 90 100
VDEVTIINIL TNRSNEQRQD IAFAYQRRTK KELSAALKSA LSGHLEAVIL
110 120 130 140 150
GLLKTPSQYD ASELKAAMKG LGTDEDTLIE IICSRTNQEL NEINRVYREM
160 170 180 190 200
YKTELEKDII SDTSGDFRKL MVALAKGKRC EDTSVIDYEL IDQDARELYD
210 220 230 240 250
AGVKRKGTDV PKWINIMTER SVPHLQKVFE RYKSYSPYDM LESIKKEVKG
260 270 280 290 300
DLENAFLNLV QCIQNKQLYF ADRLYDSMKG KGTRDKVLIR IMVSRCEVDM
310 320 330
LKIKSEFKRK YGKSLYYFIQ QDTKGDYQRA LLNLCGGED
Length:339
Mass (Da):38,640
Last modified:January 23, 2007 - v2
Checksum:i4B621506C4BFCD73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53334 mRNA. Translation: CAA37421.1.
PIRiS10501. LUCH2.
RefSeqiNP_990682.1. NM_205351.1.
XP_015134249.1. XM_015278763.1.
UniGeneiGga.3641.

Genome annotation databases

EnsembliENSGALT00000005981; ENSGALP00000005971; ENSGALG00000003770.
ENSGALT00000050124; ENSGALP00000048954; ENSGALG00000003770.
GeneIDi396297.
KEGGigga:396297.

Cross-referencesi

Web resourcesi

Protein Spotlight

Red velvet - Issue 86 of September 2007

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53334 mRNA. Translation: CAA37421.1.
PIRiS10501. LUCH2.
RefSeqiNP_990682.1. NM_205351.1.
XP_015134249.1. XM_015278763.1.
UniGeneiGga.3641.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BT6X-ray2.40C/D2-14[»]
ProteinModelPortaliP17785.
SMRiP17785.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038695.

PTM databases

iPTMnetiP17785.

Proteomic databases

PaxDbiP17785.
PRIDEiP17785.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000005981; ENSGALP00000005971; ENSGALG00000003770.
ENSGALT00000050124; ENSGALP00000048954; ENSGALG00000003770.
GeneIDi396297.
KEGGigga:396297.

Organism-specific databases

CTDi302.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP17785.
KOiK17092.
OMAiFIQQDTK.
OrthoDBiEOG091G0H6H.
PhylomeDBiP17785.
TreeFamiTF105452.

Enzyme and pathway databases

ReactomeiR-GGA-6798695. Neutrophil degranulation.
R-GGA-75205. Dissolution of Fibrin Clot.

Miscellaneous databases

EvolutionaryTraceiP17785.
PROiP17785.

Gene expression databases

BgeeiENSGALG00000003770.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
PANTHERiPTHR10502:SF111. PTHR10502:SF111. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANXA2_CHICK
AccessioniPrimary (citable) accession number: P17785
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.