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P17785 (ANXA2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Annexin A2
Alternative name(s):
Annexin II
Annexin-2
Calpactin I heavy chain
Calpactin-1 heavy chain
Chromobindin-8
Lipocortin II
Placental anticoagulant protein IV
Short name=PAP-IV
Protein I
p36
Gene names
Name:ANXA2
Synonyms:ANX2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.

Subunit structure

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36.

Subcellular location

Secretedextracellular spaceextracellular matrixbasement membrane. Note: In the lamina beneath the plasma membrane.

Domain

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Miscellaneous

It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

Sequence similarities

Belongs to the annexin family.

Contains 4 annexin repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2 Ref.3 Ref.4
Chain2 – 339338Annexin A2
PRO_0000067474

Regions

Repeat42 – 10261Annexin 1
Repeat114 – 17461Annexin 2
Repeat199 – 25961Annexin 3
Repeat274 – 33461Annexin 4
Region2 – 2423S100A10-binding site Potential

Amino acid modifications

Modified residue21N-acetylserine Ref.3 Ref.4
Modified residue241Phosphotyrosine; by SRC By similarity
Modified residue261Phosphothreonine; by PKC By similarity

Secondary structure

... 339
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P17785 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 4B621506C4BFCD73

FASTA33938,640
        10         20         30         40         50         60 
MSTVHEILSK LSLEGDHSLP PSAYATVKAY SNFDADRDAA ALEAAIKTKG VDEVTIINIL 

        70         80         90        100        110        120 
TNRSNEQRQD IAFAYQRRTK KELSAALKSA LSGHLEAVIL GLLKTPSQYD ASELKAAMKG 

       130        140        150        160        170        180 
LGTDEDTLIE IICSRTNQEL NEINRVYREM YKTELEKDII SDTSGDFRKL MVALAKGKRC 

       190        200        210        220        230        240 
EDTSVIDYEL IDQDARELYD AGVKRKGTDV PKWINIMTER SVPHLQKVFE RYKSYSPYDM 

       250        260        270        280        290        300 
LESIKKEVKG DLENAFLNLV QCIQNKQLYF ADRLYDSMKG KGTRDKVLIR IMVSRCEVDM 

       310        320        330 
LKIKSEFKRK YGKSLYYFIQ QDTKGDYQRA LLNLCGGED 

« Hide

References

[1]"The cDNA sequence of chicken annexin II."
Gerke V., Koch W.
Nucleic Acids Res. 18:4246-4246(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A discontinuous epitope on p36, the major substrate of src tyrosine-protein-kinase, brings the phosphorylation site into the neighbourhood of a consensus sequence for Ca2+/lipid-binding proteins."
Johnsson N., Johnsson K., Weber K.
FEBS Lett. 236:201-204(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-70.
[3]"p36, the major cytoplasmic substrate of src tyrosine protein kinase, binds to its p11 regulatory subunit via a short amino-terminal amphiphatic helix."
Johnsson N., Marriott G., Weber K.
EMBO J. 7:2435-2442(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-30, ACETYLATION AT SER-2.
[4]Bienvenut W.V., Black E.J., Gillespie D.A.
Submitted (JAN-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-63; 69-77 AND 314-324, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: B-cell lymphoma.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Red velvet - Issue 86 of September 2007

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53334 mRNA. Translation: CAA37421.1.
PIRLUCH2. S10501.
RefSeqNP_990682.1. NM_205351.1.
UniGeneGga.3641.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BT6X-ray2.40C/D2-14[»]
ProteinModelPortalP17785.
SMRP17785. Positions 21-339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000005971.

Proteomic databases

PaxDbP17785.
PRIDEP17785.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000005981; ENSGALP00000005971; ENSGALG00000003770.
GeneID396297.
KEGGgga:396297.

Organism-specific databases

CTD302.

Phylogenomic databases

eggNOGNOG259189.
GeneTreeENSGT00680000099735.
HOGENOMHOG000158803.
HOVERGENHBG061815.
KOK17092.
OMAFIQQDTK.
OrthoDBEOG74XS72.
PhylomeDBP17785.
TreeFamTF105452.

Family and domain databases

Gene3D1.10.220.10. 4 hits.
InterProIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
PANTHERPTHR10502:SF18. PTHR10502:SF18. 1 hit.
PfamPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTSM00335. ANX. 4 hits.
[Graphical view]
PROSITEPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP17785.
NextBio20816347.
PROP17785.

Entry information

Entry nameANXA2_CHICK
AccessionPrimary (citable) accession number: P17785
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references