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P17785

- ANXA2_CHICK

UniProt

P17785 - ANXA2_CHICK

Protein

Annexin A2

Gene

ANXA2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.

    GO - Molecular functioni

    1. calcium channel activity Source: AgBase
    2. calcium-dependent phospholipid binding Source: UniProtKB-KW
    3. calcium ion binding Source: InterPro
    4. phospholipase inhibitor activity Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. calcium ion homeostasis Source: AgBase
    3. calcium ion transmembrane transport Source: GOC
    4. cellular response to acid chemical Source: Ensembl
    5. collagen fibril organization Source: Ensembl
    6. fibrinolysis Source: Ensembl
    7. positive regulation of binding Source: Ensembl
    8. positive regulation of vesicle fusion Source: Ensembl

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Annexin A2
    Alternative name(s):
    Annexin II
    Annexin-2
    Calpactin I heavy chain
    Calpactin-1 heavy chain
    Chromobindin-8
    Lipocortin II
    Placental anticoagulant protein IV
    Short name:
    PAP-IV
    Protein I
    p36
    Gene namesi
    Name:ANXA2
    Synonyms:ANX2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 10

    Subcellular locationi

    Secretedextracellular spaceextracellular matrixbasement membrane
    Note: In the lamina beneath the plasma membrane.

    GO - Cellular componenti

    1. basement membrane Source: UniProtKB-SubCell
    2. calcium channel complex Source: AgBase
    3. early endosome Source: Ensembl
    4. extracellular vesicular exosome Source: Ensembl
    5. extrinsic component of plasma membrane Source: Ensembl
    6. lipid particle Source: Ensembl
    7. midbody Source: Ensembl
    8. myelin sheath adaxonal region Source: Ensembl
    9. sarcolemma Source: Ensembl
    10. Schmidt-Lanterman incisure Source: Ensembl
    11. vesicle Source: AgBase

    Keywords - Cellular componenti

    Basement membrane, Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 339338Annexin A2PRO_0000067474Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications
    Modified residuei24 – 241Phosphotyrosine; by SRCBy similarity
    Modified residuei26 – 261Phosphothreonine; by PKCBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiP17785.
    PRIDEiP17785.

    Interactioni

    Subunit structurei

    Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36.

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000005971.

    Structurei

    Secondary structure

    1
    339
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 119

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BT6X-ray2.40C/D2-14[»]
    ProteinModelPortaliP17785.
    SMRiP17785. Positions 21-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP17785.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati42 – 10261Annexin 1Add
    BLAST
    Repeati114 – 17461Annexin 2Add
    BLAST
    Repeati199 – 25961Annexin 3Add
    BLAST
    Repeati274 – 33461Annexin 4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 2423S100A10-binding siteSequence AnalysisAdd
    BLAST

    Domaini

    A pair of annexin repeats may form one binding site for calcium and phospholipid.

    Sequence similaritiesi

    Belongs to the annexin family.Curated
    Contains 4 annexin repeats.Curated

    Keywords - Domaini

    Annexin, Repeat

    Phylogenomic databases

    eggNOGiNOG259189.
    GeneTreeiENSGT00680000099735.
    HOGENOMiHOG000158803.
    HOVERGENiHBG061815.
    KOiK17092.
    OMAiFIQQDTK.
    OrthoDBiEOG74XS72.
    PhylomeDBiP17785.
    TreeFamiTF105452.

    Family and domain databases

    Gene3Di1.10.220.10. 4 hits.
    InterProiIPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002389. AnnexinII.
    [Graphical view]
    PANTHERiPTHR10502:SF18. PTHR10502:SF18. 1 hit.
    PfamiPF00191. Annexin. 4 hits.
    [Graphical view]
    PRINTSiPR00196. ANNEXIN.
    PR00198. ANNEXINII.
    SMARTiSM00335. ANX. 4 hits.
    [Graphical view]
    PROSITEiPS00223. ANNEXIN. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17785-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTVHEILSK LSLEGDHSLP PSAYATVKAY SNFDADRDAA ALEAAIKTKG    50
    VDEVTIINIL TNRSNEQRQD IAFAYQRRTK KELSAALKSA LSGHLEAVIL 100
    GLLKTPSQYD ASELKAAMKG LGTDEDTLIE IICSRTNQEL NEINRVYREM 150
    YKTELEKDII SDTSGDFRKL MVALAKGKRC EDTSVIDYEL IDQDARELYD 200
    AGVKRKGTDV PKWINIMTER SVPHLQKVFE RYKSYSPYDM LESIKKEVKG 250
    DLENAFLNLV QCIQNKQLYF ADRLYDSMKG KGTRDKVLIR IMVSRCEVDM 300
    LKIKSEFKRK YGKSLYYFIQ QDTKGDYQRA LLNLCGGED 339
    Length:339
    Mass (Da):38,640
    Last modified:January 23, 2007 - v2
    Checksum:i4B621506C4BFCD73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53334 mRNA. Translation: CAA37421.1.
    PIRiS10501. LUCH2.
    RefSeqiNP_990682.1. NM_205351.1.
    UniGeneiGga.3641.

    Genome annotation databases

    EnsembliENSGALT00000005981; ENSGALP00000005971; ENSGALG00000003770.
    GeneIDi396297.
    KEGGigga:396297.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Red velvet - Issue 86 of September 2007

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53334 mRNA. Translation: CAA37421.1 .
    PIRi S10501. LUCH2.
    RefSeqi NP_990682.1. NM_205351.1.
    UniGenei Gga.3641.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BT6 X-ray 2.40 C/D 2-14 [» ]
    ProteinModelPortali P17785.
    SMRi P17785. Positions 21-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000005971.

    Proteomic databases

    PaxDbi P17785.
    PRIDEi P17785.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000005981 ; ENSGALP00000005971 ; ENSGALG00000003770 .
    GeneIDi 396297.
    KEGGi gga:396297.

    Organism-specific databases

    CTDi 302.

    Phylogenomic databases

    eggNOGi NOG259189.
    GeneTreei ENSGT00680000099735.
    HOGENOMi HOG000158803.
    HOVERGENi HBG061815.
    KOi K17092.
    OMAi FIQQDTK.
    OrthoDBi EOG74XS72.
    PhylomeDBi P17785.
    TreeFami TF105452.

    Miscellaneous databases

    EvolutionaryTracei P17785.
    NextBioi 20816347.
    PROi P17785.

    Family and domain databases

    Gene3Di 1.10.220.10. 4 hits.
    InterProi IPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002389. AnnexinII.
    [Graphical view ]
    PANTHERi PTHR10502:SF18. PTHR10502:SF18. 1 hit.
    Pfami PF00191. Annexin. 4 hits.
    [Graphical view ]
    PRINTSi PR00196. ANNEXIN.
    PR00198. ANNEXINII.
    SMARTi SM00335. ANX. 4 hits.
    [Graphical view ]
    PROSITEi PS00223. ANNEXIN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cDNA sequence of chicken annexin II."
      Gerke V., Koch W.
      Nucleic Acids Res. 18:4246-4246(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A discontinuous epitope on p36, the major substrate of src tyrosine-protein-kinase, brings the phosphorylation site into the neighbourhood of a consensus sequence for Ca2+/lipid-binding proteins."
      Johnsson N., Johnsson K., Weber K.
      FEBS Lett. 236:201-204(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-70.
    3. "p36, the major cytoplasmic substrate of src tyrosine protein kinase, binds to its p11 regulatory subunit via a short amino-terminal amphiphatic helix."
      Johnsson N., Marriott G., Weber K.
      EMBO J. 7:2435-2442(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-30, ACETYLATION AT SER-2.
    4. Bienvenut W.V., Black E.J., Gillespie D.A.
      Submitted (JAN-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-63; 69-77 AND 314-324, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: B-cell lymphoma.

    Entry informationi

    Entry nameiANXA2_CHICK
    AccessioniPrimary (citable) accession number: P17785
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3