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P17783

- MDHM_CITLA

UniProt

P17783 - MDHM_CITLA

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Protein
Malate dehydrogenase, mitochondrial
Gene
MMDH
Organism
Citrullus lanatus (Watermelon) (Citrullus vulgaris)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei67 – 671NAD By similarity
Binding sitei114 – 1141Substrate By similarity
Binding sitei120 – 1201Substrate By similarity
Binding sitei127 – 1271NAD By similarity
Binding sitei152 – 1521Substrate By similarity
Binding sitei186 – 1861Substrate By similarity
Active sitei210 – 2101Proton acceptor By similarity
Binding sitei261 – 2611NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 477NAD By similarity
Nucleotide bindingi150 – 1523NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase, mitochondrial (EC:1.1.1.37)
Gene namesi
Name:MMDH
OrganismiCitrullus lanatus (Watermelon) (Citrullus vulgaris)
Taxonomic identifieri3654 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeBenincaseaeCitrullus

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Protein family/group databases

Allergomei6159. Cit la MDH.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727Mitochondrion1 Publication
Add
BLAST
Chaini28 – 347320Malate dehydrogenase, mitochondrial
PRO_0000018625Add
BLAST

Proteomic databases

PRIDEiP17783.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP17783.
SMRiP17783. Positions 36-343.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17783-1 [UniParc]FASTAAdd to Basket

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MKASILRSVR SAVSRSSSSN RLLSRSFATE SVPERKVAVL GAAGGIGQPL    50
ALLMKLNPLV SKLALYDIAG TPGVAADVGH VNTRSEVTGY VGEEQLGKAL 100
EGSDVVIIPA GVPRKPGMTR DDLFNINAGI VKSLCTAIAK YCPNALINMI 150
SNPVNSTVPI AAEVFKKAGT YDEKKLFGVT TLDVVRAKTF YAGKANVPVA 200
EVNVPVIGGH AGITILPLFS QATPRANLSD DTIVALTKRT QDGGTEVVEA 250
KAGKGSATLS MAYAGALFAD ACLKGLNGVP DVVECSFVQS TVTELPFFAS 300
KVKLGKNGVE SVLDLGPLSD FEKEGLEKLK PELKASIEKG IQFANAN 347
Length:347
Mass (Da):36,201
Last modified:August 1, 1990 - v1
Checksum:i31474F15018D30CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17362 mRNA. Translation: CAA35239.1.
PIRiS10162. DEPUMW.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17362 mRNA. Translation: CAA35239.1 .
PIRi S10162. DEPUMW.

3D structure databases

ProteinModelPortali P17783.
SMRi P17783. Positions 36-343.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 6159. Cit la MDH.

Proteomic databases

PRIDEi P17783.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mitochondrial malate dehydrogenase from watermelon: sequence of cDNA clones and primary structure of the higher-plant precursor protein."
    Gietl C., Lehnerer M., Olsen O.
    Plant Mol. Biol. 14:1019-1030(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: cv. Sugar Baby.
    Tissue: Cotyledon.
  2. "Sequence homologies between glyoxysomal and mitochondrial malate dehydrogenase."
    Gietl C., Lottspeich F., Hock B.
    Planta 169:555-558(1986)
    Cited for: PROTEIN SEQUENCE OF 28-55.

Entry informationi

Entry nameiMDHM_CITLA
AccessioniPrimary (citable) accession number: P17783
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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