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P17783

- MDHM_CITLA

UniProt

P17783 - MDHM_CITLA

Protein

Malate dehydrogenase, mitochondrial

Gene

MMDH

Organism
Citrullus lanatus (Watermelon) (Citrullus vulgaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei67 – 671NADBy similarity
    Binding sitei114 – 1141SubstratePROSITE-ProRule annotation
    Binding sitei120 – 1201SubstratePROSITE-ProRule annotation
    Binding sitei127 – 1271NADBy similarity
    Binding sitei152 – 1521SubstratePROSITE-ProRule annotation
    Binding sitei186 – 1861SubstratePROSITE-ProRule annotation
    Active sitei210 – 2101Proton acceptorBy similarity
    Binding sitei261 – 2611NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi41 – 477NADBy similarity
    Nucleotide bindingi150 – 1523NADBy similarity

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenase, mitochondrial (EC:1.1.1.37)
    Gene namesi
    Name:MMDH
    OrganismiCitrullus lanatus (Watermelon) (Citrullus vulgaris)
    Taxonomic identifieri3654 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeBenincaseaeCitrullus

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Protein family/group databases

    Allergomei6159. Cit la MDH.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2727Mitochondrion1 PublicationAdd
    BLAST
    Chaini28 – 347320Malate dehydrogenase, mitochondrialPRO_0000018625Add
    BLAST

    Proteomic databases

    PRIDEiP17783.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliP17783.
    SMRiP17783. Positions 36-343.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010097. Malate_DH_type1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
    PROSITEiPS00068. MDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17783-1 [UniParc]FASTAAdd to Basket

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    MKASILRSVR SAVSRSSSSN RLLSRSFATE SVPERKVAVL GAAGGIGQPL    50
    ALLMKLNPLV SKLALYDIAG TPGVAADVGH VNTRSEVTGY VGEEQLGKAL 100
    EGSDVVIIPA GVPRKPGMTR DDLFNINAGI VKSLCTAIAK YCPNALINMI 150
    SNPVNSTVPI AAEVFKKAGT YDEKKLFGVT TLDVVRAKTF YAGKANVPVA 200
    EVNVPVIGGH AGITILPLFS QATPRANLSD DTIVALTKRT QDGGTEVVEA 250
    KAGKGSATLS MAYAGALFAD ACLKGLNGVP DVVECSFVQS TVTELPFFAS 300
    KVKLGKNGVE SVLDLGPLSD FEKEGLEKLK PELKASIEKG IQFANAN 347
    Length:347
    Mass (Da):36,201
    Last modified:August 1, 1990 - v1
    Checksum:i31474F15018D30CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17362 mRNA. Translation: CAA35239.1.
    PIRiS10162. DEPUMW.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17362 mRNA. Translation: CAA35239.1 .
    PIRi S10162. DEPUMW.

    3D structure databases

    ProteinModelPortali P17783.
    SMRi P17783. Positions 36-343.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 6159. Cit la MDH.

    Proteomic databases

    PRIDEi P17783.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010097. Malate_DH_type1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
    PROSITEi PS00068. MDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mitochondrial malate dehydrogenase from watermelon: sequence of cDNA clones and primary structure of the higher-plant precursor protein."
      Gietl C., Lehnerer M., Olsen O.
      Plant Mol. Biol. 14:1019-1030(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Strain: cv. Sugar Baby.
      Tissue: Cotyledon.
    2. "Sequence homologies between glyoxysomal and mitochondrial malate dehydrogenase."
      Gietl C., Lottspeich F., Hock B.
      Planta 169:555-558(1986)
      Cited for: PROTEIN SEQUENCE OF 28-55.

    Entry informationi

    Entry nameiMDHM_CITLA
    AccessioniPrimary (citable) accession number: P17783
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3