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Protein

Outer membrane protein YopM

Gene

yopM

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi246 – 2461Calcium 1
Metal bindingi266 – 2661Calcium 1
Metal bindingi266 – 2661Calcium 2
Metal bindingi307 – 3071Calcium 2
Metal bindingi308 – 3081Calcium 2
Metal bindingi326 – 3261Calcium 1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciYPES214092:GKDD-4231-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein YopM
Gene namesi
Name:yopM
Synonyms:yop48
Ordered Locus Names:YPCD1.26c, y5054, y0059, YP_pCD60
Encoded oniPlasmid pCD10 Publication
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Plasmid pCD1
  • UP000001019 Componenti: Plasmid pCD1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Outer membrane protein YopMPRO_0000066369Add
BLAST

Interactioni

Subunit structurei

Homotetramer forming a hollow cylinder with an inner diameter of approximately 35 angstroms.

Protein-protein interaction databases

IntActiP17778. 37 interactions.

Structurei

Secondary structure

1
409
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi36 – 4813Combined sources
Beta strandi52 – 543Combined sources
Helixi58 – 7114Combined sources
Beta strandi74 – 774Combined sources
Beta strandi94 – 974Combined sources
Beta strandi115 – 1173Combined sources
Beta strandi135 – 1373Combined sources
Helixi149 – 1513Combined sources
Beta strandi157 – 1593Combined sources
Beta strandi177 – 1793Combined sources
Beta strandi199 – 2013Combined sources
Beta strandi219 – 2213Combined sources
Beta strandi241 – 2433Combined sources
Beta strandi261 – 2633Combined sources
Beta strandi281 – 2833Combined sources
Beta strandi290 – 2934Combined sources
Beta strandi301 – 3033Combined sources
Beta strandi310 – 3123Combined sources
Beta strandi321 – 3233Combined sources
Beta strandi341 – 3433Combined sources
Beta strandi361 – 3633Combined sources
Beta strandi381 – 3833Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G9UX-ray2.35A1-409[»]
1JL5X-ray2.10A1-409[»]
ProteinModelPortaliP17778.
SMRiP17778. Positions 34-386.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17778.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati72 – 9120LRR 1Add
BLAST
Repeati92 – 11322LRR 2Add
BLAST
Repeati114 – 13118LRR 3Add
BLAST
Repeati132 – 15322LRR 4Add
BLAST
Repeati154 – 17320LRR 5Add
BLAST
Repeati174 – 19522LRR 6Add
BLAST
Repeati196 – 21520LRR 7Add
BLAST
Repeati216 – 23722LRR 8Add
BLAST
Repeati238 – 25720LRR 9Add
BLAST
Repeati258 – 27922LRR 10Add
BLAST
Repeati280 – 29718LRR 11Add
BLAST
Repeati298 – 31720LRR 12Add
BLAST
Repeati318 – 33922LRR 13Add
BLAST
Repeati340 – 35718LRR 14Add
BLAST
Repeati358 – 37922LRR 15Add
BLAST

Sequence similaritiesi

Contains 15 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

HOGENOMiHOG000219598.
OMAiKLHVREN.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR032674. LRR_E3_ligase_N.
[Graphical view]
PfamiPF12468. TTSSLRR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFINPRNVSN TFLQEPLRHS SNLTEMPVEA ENVKSKTEYY NAWSEWERNA
60 70 80 90 100
PPGNGEQREM AVSRLRDCLD RQAHELELNN LGLSSLPELP PHLESLVASC
110 120 130 140 150
NSLTELPELP QSLKSLLVDN NNLKALSDLP PLLEYLGVSN NQLEKLPELQ
160 170 180 190 200
NSSFLKIIDV DNNSLKKLPD LPPSLEFIAA GNNQLEELPE LQNLPFLTAI
210 220 230 240 250
YADNNSLKKL PDLPLSLESI VAGNNILEEL PELQNLPFLT TIYADNNLLK
260 270 280 290 300
TLPDLPPSLE ALNVRDNYLT DLPELPQSLT FLDVSENIFS GLSELPPNLY
310 320 330 340 350
YLNASSNEIR SLCDLPPSLE ELNVSNNKLI ELPALPPRLE RLIASFNHLA
360 370 380 390 400
EVPELPQNLK QLHVEYNPLR EFPDIPESVE DLRMNSERVV DPYEFAHETT

DKLEDDVFE
Length:409
Mass (Da):46,203
Last modified:November 16, 2001 - v2
Checksum:iE22400C671A59951
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 18342Missing no nucleotide entry (PubMed:2670888).CuratedAdd
BLAST
Sequence conflicti195 – 23642Missing in AAS58577 (PubMed:15368893).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074612 Genomic DNA. Translation: AAC69806.1.
AF053946 Genomic DNA. Translation: AAC62580.1.
AL117189 Genomic DNA. Translation: CAB54903.1.
AE017043 Genomic DNA. Translation: AAS58577.1.
PIRiA33950.
T43599.
RefSeqiNP_395161.1. NC_003131.1.
NP_857756.1. NC_004836.1.
NP_857953.1. NC_004839.1.
WP_002229779.1. NZ_LIXY01000017.1.

Genome annotation databases

EnsemblBacteriaiAAS58577; AAS58577; YP_pCD60.
GeneIDi1149317.
15151810.
KEGGipg:1149317.
pg:15151810.
ype:YPCD1.26c.
ypj:CH55_4308.
ypl:CH46_4334.
ypm:YP_pCD60.
ypv:BZ15_4381.
ypw:CH59_4466.
PATRICi18588574. VBIYerPes7843_0032.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074612 Genomic DNA. Translation: AAC69806.1.
AF053946 Genomic DNA. Translation: AAC62580.1.
AL117189 Genomic DNA. Translation: CAB54903.1.
AE017043 Genomic DNA. Translation: AAS58577.1.
PIRiA33950.
T43599.
RefSeqiNP_395161.1. NC_003131.1.
NP_857756.1. NC_004836.1.
NP_857953.1. NC_004839.1.
WP_002229779.1. NZ_LIXY01000017.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G9UX-ray2.35A1-409[»]
1JL5X-ray2.10A1-409[»]
ProteinModelPortaliP17778.
SMRiP17778. Positions 34-386.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP17778. 37 interactions.

Protocols and materials databases

DNASUi1149317.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS58577; AAS58577; YP_pCD60.
GeneIDi1149317.
15151810.
KEGGipg:1149317.
pg:15151810.
ype:YPCD1.26c.
ypj:CH55_4308.
ypl:CH46_4334.
ypm:YP_pCD60.
ypv:BZ15_4381.
ypw:CH59_4466.
PATRICi18588574. VBIYerPes7843_0032.

Phylogenomic databases

HOGENOMiHOG000219598.
OMAiKLHVREN.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-4231-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP17778.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR032674. LRR_E3_ligase_N.
[Graphical view]
PfamiPF12468. TTSSLRR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYOPM_YERPE
AccessioniPrimary (citable) accession number: P17778
Secondary accession number(s): O68701
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 16, 2001
Last modified: September 7, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.