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Protein

Outer membrane protein YopM

Gene

yopM

Organism
Yersinia pestis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi246Calcium 11
Metal bindingi266Calcium 11
Metal bindingi266Calcium 21
Metal bindingi307Calcium 21
Metal bindingi308Calcium 21
Metal bindingi326Calcium 11

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein YopM
Gene namesi
Name:yopM
Synonyms:yop48
Ordered Locus Names:YPCD1.26c, y5054, y0059, YP_pCD60
Encoded oniPlasmid pCD10 Publication
OrganismiYersinia pestis
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Plasmid pCD1
  • UP000001019 Componenti: Plasmid pCD1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000663691 – 409Outer membrane protein YopMAdd BLAST409

Interactioni

Subunit structurei

Homotetramer forming a hollow cylinder with an inner diameter of approximately 35 angstroms.

Protein-protein interaction databases

IntActiP17778. 37 interactors.

Structurei

Secondary structure

1409
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi36 – 48Combined sources13
Beta strandi52 – 54Combined sources3
Helixi58 – 71Combined sources14
Beta strandi74 – 77Combined sources4
Beta strandi94 – 97Combined sources4
Beta strandi115 – 117Combined sources3
Beta strandi135 – 137Combined sources3
Helixi149 – 151Combined sources3
Beta strandi157 – 159Combined sources3
Beta strandi177 – 179Combined sources3
Beta strandi199 – 201Combined sources3
Beta strandi219 – 221Combined sources3
Beta strandi241 – 243Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi281 – 283Combined sources3
Beta strandi290 – 293Combined sources4
Beta strandi301 – 303Combined sources3
Beta strandi310 – 312Combined sources3
Beta strandi321 – 323Combined sources3
Beta strandi341 – 343Combined sources3
Beta strandi361 – 363Combined sources3
Beta strandi381 – 383Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G9UX-ray2.35A1-409[»]
1JL5X-ray2.10A1-409[»]
ProteinModelPortaliP17778.
SMRiP17778.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17778.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati72 – 91LRR 1Add BLAST20
Repeati92 – 113LRR 2Add BLAST22
Repeati114 – 131LRR 3Add BLAST18
Repeati132 – 153LRR 4Add BLAST22
Repeati154 – 173LRR 5Add BLAST20
Repeati174 – 195LRR 6Add BLAST22
Repeati196 – 215LRR 7Add BLAST20
Repeati216 – 237LRR 8Add BLAST22
Repeati238 – 257LRR 9Add BLAST20
Repeati258 – 279LRR 10Add BLAST22
Repeati280 – 297LRR 11Add BLAST18
Repeati298 – 317LRR 12Add BLAST20
Repeati318 – 339LRR 13Add BLAST22
Repeati340 – 357LRR 14Add BLAST18
Repeati358 – 379LRR 15Add BLAST22

Sequence similaritiesi

Contains 15 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

HOGENOMiHOG000219598.
OMAiKLHVREN.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR032674. LRR_E3_ligase_N.
[Graphical view]
PfamiPF12468. TTSSLRR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFINPRNVSN TFLQEPLRHS SNLTEMPVEA ENVKSKTEYY NAWSEWERNA
60 70 80 90 100
PPGNGEQREM AVSRLRDCLD RQAHELELNN LGLSSLPELP PHLESLVASC
110 120 130 140 150
NSLTELPELP QSLKSLLVDN NNLKALSDLP PLLEYLGVSN NQLEKLPELQ
160 170 180 190 200
NSSFLKIIDV DNNSLKKLPD LPPSLEFIAA GNNQLEELPE LQNLPFLTAI
210 220 230 240 250
YADNNSLKKL PDLPLSLESI VAGNNILEEL PELQNLPFLT TIYADNNLLK
260 270 280 290 300
TLPDLPPSLE ALNVRDNYLT DLPELPQSLT FLDVSENIFS GLSELPPNLY
310 320 330 340 350
YLNASSNEIR SLCDLPPSLE ELNVSNNKLI ELPALPPRLE RLIASFNHLA
360 370 380 390 400
EVPELPQNLK QLHVEYNPLR EFPDIPESVE DLRMNSERVV DPYEFAHETT

DKLEDDVFE
Length:409
Mass (Da):46,203
Last modified:November 16, 2001 - v2
Checksum:iE22400C671A59951
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142 – 183Missing no nucleotide entry (PubMed:2670888).CuratedAdd BLAST42
Sequence conflicti195 – 236Missing in AAS58577 (PubMed:15368893).CuratedAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074612 Genomic DNA. Translation: AAC69806.1.
AF053946 Genomic DNA. Translation: AAC62580.1.
AL117189 Genomic DNA. Translation: CAB54903.1.
AE017043 Genomic DNA. Translation: AAS58577.1.
PIRiA33950.
T43599.
RefSeqiNP_395161.1. NC_003131.1.
NP_857756.1. NC_004836.1.
NP_857953.1. NC_004839.1.
WP_002229779.1. NZ_LQBA01000166.1.

Genome annotation databases

EnsemblBacteriaiAAS58577; AAS58577; YP_pCD60.
GeneIDi1149317.
1172671.
15151810.
KEGGiype:YPCD1.26c.
ypm:YP_pCD60.
PATRICi18588574. VBIYerPes7843_0032.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074612 Genomic DNA. Translation: AAC69806.1.
AF053946 Genomic DNA. Translation: AAC62580.1.
AL117189 Genomic DNA. Translation: CAB54903.1.
AE017043 Genomic DNA. Translation: AAS58577.1.
PIRiA33950.
T43599.
RefSeqiNP_395161.1. NC_003131.1.
NP_857756.1. NC_004836.1.
NP_857953.1. NC_004839.1.
WP_002229779.1. NZ_LQBA01000166.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G9UX-ray2.35A1-409[»]
1JL5X-ray2.10A1-409[»]
ProteinModelPortaliP17778.
SMRiP17778.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP17778. 37 interactors.

Protocols and materials databases

DNASUi1149317.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS58577; AAS58577; YP_pCD60.
GeneIDi1149317.
1172671.
15151810.
KEGGiype:YPCD1.26c.
ypm:YP_pCD60.
PATRICi18588574. VBIYerPes7843_0032.

Phylogenomic databases

HOGENOMiHOG000219598.
OMAiKLHVREN.

Miscellaneous databases

EvolutionaryTraceiP17778.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR032674. LRR_E3_ligase_N.
[Graphical view]
PfamiPF12468. TTSSLRR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYOPM_YERPE
AccessioniPrimary (citable) accession number: P17778
Secondary accession number(s): O68701
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 16, 2001
Last modified: November 30, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.