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Protein

Interferon gamma

Gene

IFNG

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Gene namesi
Name:IFNG
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000001645924 – 166Interferon gammaAdd BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acidBy similarity1
Glycosylationi39N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi106N-linked (GlcNAc...) asparagineBy similarity1

Keywords - PTMi

Glycoprotein, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP17773
SMRiP17773
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000007831
HOVERGENiHBG056912
KOiK04687
OMAiWKEESDK
OrthoDBiEOG091G0ZH0

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002069 Interferon_gamma
PANTHERiPTHR11419 PTHR11419, 1 hit
PfamiView protein in Pfam
PF00714 IFN-gamma, 1 hit
PIRSFiPIRSF001936 IFN-gamma, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002435 Interferon_gamma, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYTSSFLAL LLCVLLGFSG SYGQGPFFKE IENLKEYFNA SNPDVAKGGP
60 70 80 90 100
LFSEILKNWK EESDKKIIQS QIVSFYFKLF ENLKDNQVIQ RSMDIIKQDM
110 120 130 140 150
FQKFLNGSSE KLEDFKRLIQ IPVDDLQIQR KAINELIKVM NDLSPKSNLR
160
KRKRSQNLFR GRRASM
Length:166
Mass (Da):19,370
Last modified:August 1, 1990 - v1
Checksum:i9232D31269805D0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52640 mRNA Translation: CAA36862.1
DQ410715 mRNA Translation: ABD64367.1
PIRiS12723
RefSeqiNP_001009803.1, NM_001009803.1
UniGeneiOar.457

Genome annotation databases

EnsembliENSOART00000002109; ENSOARP00000002060; ENSOARG00000001958
GeneIDi443396
KEGGioas:443396

Similar proteinsi

Entry informationi

Entry nameiIFNG_SHEEP
AccessioniPrimary (citable) accession number: P17773
Secondary accession number(s): Q204I9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health