Reviewed,
UniProtKB/Swiss-Prot P17741 (HMGB2_PIG)
Last modified
January 19, 2010.
Version 79.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: High mobility group protein B2 Alternative name(s): High mobility group protein 2 Short name=HMG-2 | ||||
| Gene names |
| ||||
| Organism | Sus scrofa (Pig) | ||||
| Taxonomic identifier | 9823 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus |
Protein attributes
| Sequence length | 210 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Binds preferentially single-stranded DNA and unwinds double stranded DNA. |
| Subunit structure | Component of the SET complex, which also contains SET, ANP32A, APEX1 and NME1. Directly interacts with SET By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the HMGB family. Contains 2 HMG box DNA-binding domains. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Chromosomal protein Nucleus |
| Domain | Repeat |
| Ligand | DNA-binding |
| PTM | Acetylation Phosphoprotein |
| Technical term | 3D-structure |
| Gene Ontology (GO) | |
| Biological process | base-excision repair, DNA ligation Inferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | condensed chromosome Inferred from sequence or structural similarity. Source: UniProtKB perinuclear region of cytoplasmInferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | DNA bending activity Inferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed | |||||||||||||||||||||||||||
| Chain | 2 – 210 | 209 | High mobility group protein B2 | PRO_0000048536 | ||||||||||||||||||||||||||
Regions | ||||||||||||||||||||||||||||||
| DNA binding | 9 – 79 | 71 | HMG box 1 | |||||||||||||||||||||||||||
| DNA binding | 95 – 163 | 69 | HMG box 2 | |||||||||||||||||||||||||||
| Compositional bias | 186 – 210 | 25 | Asp/Glu-rich (acidic) | |||||||||||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||||||||||
| Modified residue | 30 | 1 | N6-acetyllysine By similarity | |||||||||||||||||||||||||||
| Modified residue | 35 | 1 | Phosphoserine By similarity | |||||||||||||||||||||||||||
| Modified residue | 59 | 1 | N6-acetyllysine By similarity | |||||||||||||||||||||||||||
| Modified residue | 155 | 1 | Phosphotyrosine By similarity | |||||||||||||||||||||||||||
| Modified residue | 162 | 1 | Phosphotyrosine By similarity | |||||||||||||||||||||||||||
| Modified residue | 172 | 1 | N6-acetyllysine By similarity | |||||||||||||||||||||||||||
| Modified residue | 173 | 1 | N6-acetyllysine By similarity | |||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||
| Beta strand | 6 – 8 | 3 | ||||||||||||||||||||||||||||
| Helix | 15 – 25 | 11 | ||||||||||||||||||||||||||||
| Helix | 28 – 30 | 3 | ||||||||||||||||||||||||||||
| Helix | 38 – 51 | 14 | ||||||||||||||||||||||||||||
| Helix | 54 – 70 | 17 | ||||||||||||||||||||||||||||
| Turn | 71 – 74 | 4 | ||||||||||||||||||||||||||||
| Beta strand | 92 – 94 | 3 | ||||||||||||||||||||||||||||
| Helix | 102 – 116 | 15 | ||||||||||||||||||||||||||||
| Helix | 122 – 135 | 14 | ||||||||||||||||||||||||||||
| Helix | 147 – 149 | 3 | ||||||||||||||||||||||||||||
| Helix | 152 – 163 | 12 | ||||||||||||||||||||||||||||
Sequences
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References
| [1] | "Primary structure of non-histone chromosomal protein HMG2 revealed by the nucleotide sequence." Shirakawa H., Tsuda K., Yoshida M. Biochemistry 29:4419-4423(1990) [PubMed: 2350545] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Thymus. |
Cross-references
Sequence databases | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | J02895 mRNA. Translation: AAA31051.1. | ||||||||||||||||||||||||
| PIR | A34719. | ||||||||||||||||||||||||
| RefSeq | NP_999228.1. | ||||||||||||||||||||||||
| UniGene | Ssc.226 | ||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||||||||
| SMR | P17741. Positions 5-166. | ||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||
| Ensembl | ENSSSCT00000010639; ENSSSCP00000010363; ENSSSCG00000009704; Sus scrofa. [Genome view] | ||||||||||||||||||||||||
| GeneID | 397130. | ||||||||||||||||||||||||
| KEGG | ssc:397130. | ||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||
| CTD | 397130. | ||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||
| HOVERGEN | P17741. | ||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||
| InterPro | IPR017967. HMG_boxA_CS. IPR000910. HMG_HMG1/HMG2. IPR000135. HMG_HMG1/HMG2_subgr. IPR009071. HMG_superfamily. [Graphical view] | ||||||||||||||||||||||||
| Gene3D | G3DSA:1.10.30.10. HMG-box. 2 hits. | ||||||||||||||||||||||||
| Pfam | PF00505. HMG_box. 2 hits. [Graphical view] | ||||||||||||||||||||||||
| PRINTS | PR00886. HIGHMOBLTY12. | ||||||||||||||||||||||||
| SMART | SM00398. HMG. 2 hits. [Graphical view] | ||||||||||||||||||||||||
| PROSITE | PS00353. HMG_BOX_1. 1 hit. PS50118. HMG_BOX_2. 2 hits. [Graphical view] | ||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||
Entry information
| Entry name | HMGB2_PIG | ||||||||
| Accession | Primary (citable) accession number: P17741 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


