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P17741 (HMGB2_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
High mobility group protein B2
Alternative name(s):
High mobility group protein 2
Short name=HMG-2
Gene names
Name:HMGB2
Synonyms:HMG2
OrganismSus scrofa (Pig) [Complete proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) By similarity.

Subunit structure

Component of the SET complex, which also contains SET, ANP32A, APEX1 and NME1. Directly interacts with SET. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2 By similarity.

Subcellular location

Nucleus By similarity. Chromosome By similarity.

Sequence similarities

Belongs to the HMGB family.

Contains 2 HMG box DNA-binding domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 210209High mobility group protein B2
PRO_0000048536

Regions

DNA binding9 – 7971HMG box 1
DNA binding95 – 16369HMG box 2
Compositional bias186 – 21025Asp/Glu-rich (acidic)

Amino acid modifications

Modified residue301N6-acetyllysine By similarity
Modified residue351Phosphoserine By similarity
Modified residue591N6-acetyllysine By similarity
Modified residue1551Phosphotyrosine By similarity
Modified residue1621Phosphotyrosine By similarity
Modified residue1721N6-acetyllysine By similarity
Modified residue1731N6-acetyllysine By similarity

Secondary structure

...................... 210
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P17741 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 28FF308D9B341D83

FASTA21024,133
        10         20         30         40         50         60 
MGKGDPNKPR GKMSSYAFFV QTCREEHKKK HPDSSVNFAE FSKKCSERWK TMSAKEKSKF 

        70         80         90        100        110        120 
EDMAKSDKAR YDREMKNYVP PKGDKKGKKK DPNAPKRPPS AFFLFCSEHR PKIKSEHPGL 

       130        140        150        160        170        180 
SIGDTAKKLG EMWSEQSAKD KQPYEQKAAK LKEKYEKDIA AYRAKGKGEA GKKGPGRPTG 

       190        200        210 
SKKKNEPEDE EEEEEEEEDE DEEEEDEDEE 

« Hide

References

[1]"Primary structure of non-histone chromosomal protein HMG2 revealed by the nucleotide sequence."
Shirakawa H., Tsuda K., Yoshida M.
Biochemistry 29:4419-4423(1990) [PubMed: 2350545] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Thymus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02895 mRNA. Translation: AAA31051.1.
PIRA34719.
RefSeqNP_999228.1. NM_214063.1.
UniGeneSsc.226.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1J3CNMR-A88-164[»]
1J3DNMR-A89-164[»]
1J3XNMR-A1-77[»]
ProteinModelPortalP17741.
SMRP17741. Positions 5-166.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397130.
KEGGssc:397130.

Organism-specific databases

CTD3148.

Phylogenomic databases

GeneTreeENSGT00560000076717.
HOVERGENHBG009000.
OrthoDBEOG4TTGK2.

Family and domain databases

InterProIPR011989. ARM-like.
IPR017967. HMG_boxA_CS.
IPR000910. HMG_HMG1/HMG2.
IPR000135. HMG_HMG1/HMG2_subgr.
IPR009071. HMG_superfamily.
[Graphical view]
Gene3DG3DSA:1.25.10.10. ARM-like. 1 hit.
G3DSA:1.10.30.10. HMG-box. 2 hits.
KOK11295.
PfamPF00505. HMG_box. 2 hits.
[Graphical view]
PRINTSPR00886. HIGHMOBLTY12.
SMARTSM00398. HMG. 2 hits.
[Graphical view]
SUPFAMSSF47095. HMG-box. 2 hits.
PROSITEPS00353. HMG_BOX_1. 1 hit.
PS50118. HMG_BOX_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHMGB2_PIG
AccessionPrimary (citable) accession number: P17741
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: November 16, 2011
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families