SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P17739

- OSPB_BORBU

UniProt

P17739 - OSPB_BORBU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Outer surface protein B

Gene
ospB, BB_A16
Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-877-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer surface protein B
Gene namesi
Name:ospB
Ordered Locus Names:BB_A16
Encoded oniPlasmid lp540 Publication
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807: Plasmid lp54

Subcellular locationi

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Add
BLAST
Chaini16 – 296281Outer surface protein BPRO_0000018081Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi16 – 161N-palmitoyl cysteine Inferred
Lipidationi16 – 161S-diacylglycerol cysteine Inferred

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

DIPiDIP-60765N.

Structurei

Secondary structure

1
296
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi158 – 1614
Beta strandi167 – 17711
Beta strandi179 – 1868
Helixi187 – 1893
Beta strandi190 – 1978
Beta strandi200 – 2078
Beta strandi210 – 2167
Beta strandi218 – 22811
Beta strandi231 – 2333
Beta strandi235 – 2406
Helixi241 – 2433
Beta strandi245 – 2506
Beta strandi253 – 2608
Beta strandi266 – 2716
Beta strandi275 – 2784
Helixi288 – 2947

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1P4PX-ray2.00A152-296[»]
1RJLX-ray2.60C202-296[»]
ProteinModelPortaliP17739.
SMRiP17739. Positions 54-296.

Miscellaneous databases

EvolutionaryTraceiP17739.

Family & Domainsi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.90.930.1. 1 hit.
InterProiIPR001809. OM_lipoprot_Borrelia.
IPR023322. OM_lipoprot_dom.
[Graphical view]
PfamiPF00820. Lipoprotein_1. 1 hit.
[Graphical view]
PRINTSiPR00968. OUTRSURFACE.
ProDomiPD001127. OM_lipoprot_Borrelia. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF51087. SSF51087. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17739-1 [UniParc]FASTAAdd to Basket

« Hide

MRLLIGFALA LALIGCAQKG AESIGSQKEN DLNLEDSSKK SHQNAKQDLP    50
AVTEDSVSLF NGNKIFVSKE KNSSGKYDLR ATIDQVELKG TSDKNNGSGT 100
LEGSKPDKSK VKLTVSADLN TVTLEAFDAS NQKISSKVTK KQGSITEETL 150
KANKLDSKKL TRSNGTTLEY SQITDADNAT KAVETLKNSI KLEGSLVGGK 200
TTVEIKEGTV TLKREIEKDG KVKVFLNDTA GSNKKTGKWE DSTSTLTISA 250
DSKKTKDLVF LTDGTITVQQ YNTAGTSLEG SASEIKNLSE LKNALK 296
Length:296
Mass (Da):31,733
Last modified:April 18, 2012 - v2
Checksum:i4B54CBABC39880A5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421H → Y in strain: CA7.
Natural varianti89 – 891K → R in strain: 41552MA.
Natural varianti123 – 1231T → S in strain: CA8.
Natural varianti126 – 1261A → T in strain: 21343WI, 41552MA, 42373NY3, HB19 and HB19CT1.
Natural varianti128 – 1281D → N in strain: 21343WI, 41552MA, HB19 and HB19CT1.
Natural varianti132 – 1321Q → P in strain: CA8.
Natural varianti176 – 1761A → T in strain: CA8.
Natural varianti189 – 1891S → G in strain: CA8.
Natural varianti192 – 1921L → F in strain: CA8.
Natural varianti198 – 1981G → V in strain: 21343WI, CA3 and CA7.
Natural varianti218 – 2181K → Q in strain: CA8.
Natural varianti253 – 2531K → T in strain: 21343WI, 41552MA, 42373NY3, HB19 and HB19CT1.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121A → R in AAA63758. 1 Publication
Sequence conflicti198 – 1981G → V in CAA32580. 1 Publication
Sequence conflicti214 – 2141R → I in AAA63758. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14407 Genomic DNA. Translation: CAA32580.1.
L23136 Genomic DNA. Translation: AAA22952.1.
L23137 Genomic DNA. Translation: AAA22954.1.
L23138 Genomic DNA. Translation: AAA20948.1.
L23139 Genomic DNA. Translation: AAA20950.1.
L23140 Genomic DNA. Translation: AAA20952.1.
L23141 Genomic DNA. Translation: AAA20954.1.
L23142 Genomic DNA. Translation: AAA20956.1.
L23143 Genomic DNA. Translation: AAA20958.1.
L23144 Genomic DNA. Translation: AAA20960.1.
L31399 Genomic DNA. Translation: AAA63758.1.
AE000790 Genomic DNA. Translation: AAC66243.2.
PIRiH70208.
I40250.
I40252.
I40256.
I40258.
I40260.
I40264.
I40266.
I40267.
S06915.
RefSeqiNP_045689.2. NC_001857.2.
WP_010890379.1. NC_001857.2.

Genome annotation databases

EnsemblBacteriaiAAC66243; AAC66243; BB_A16.
GeneIDi1194340.
KEGGibbu:BB_A16.
PATRICi20558958. VBIBorBur75917_1534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14407 Genomic DNA. Translation: CAA32580.1 .
L23136 Genomic DNA. Translation: AAA22952.1 .
L23137 Genomic DNA. Translation: AAA22954.1 .
L23138 Genomic DNA. Translation: AAA20948.1 .
L23139 Genomic DNA. Translation: AAA20950.1 .
L23140 Genomic DNA. Translation: AAA20952.1 .
L23141 Genomic DNA. Translation: AAA20954.1 .
L23142 Genomic DNA. Translation: AAA20956.1 .
L23143 Genomic DNA. Translation: AAA20958.1 .
L23144 Genomic DNA. Translation: AAA20960.1 .
L31399 Genomic DNA. Translation: AAA63758.1 .
AE000790 Genomic DNA. Translation: AAC66243.2 .
PIRi H70208.
I40250.
I40252.
I40256.
I40258.
I40260.
I40264.
I40266.
I40267.
S06915.
RefSeqi NP_045689.2. NC_001857.2.
WP_010890379.1. NC_001857.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1P4P X-ray 2.00 A 152-296 [» ]
1RJL X-ray 2.60 C 202-296 [» ]
ProteinModelPortali P17739.
SMRi P17739. Positions 54-296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60765N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC66243 ; AAC66243 ; BB_A16 .
GeneIDi 1194340.
KEGGi bbu:BB_A16.
PATRICi 20558958. VBIBorBur75917_1534.

Enzyme and pathway databases

BioCyci BBUR224326:G9SO-877-MONOMER.

Miscellaneous databases

EvolutionaryTracei P17739.

Family and domain databases

Gene3Di 3.90.930.1. 1 hit.
InterProi IPR001809. OM_lipoprot_Borrelia.
IPR023322. OM_lipoprot_dom.
[Graphical view ]
Pfami PF00820. Lipoprotein_1. 1 hit.
[Graphical view ]
PRINTSi PR00968. OUTRSURFACE.
ProDomi PD001127. OM_lipoprot_Borrelia. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF51087. SSF51087. 1 hit.
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi."
    Bergstroem S., Bundoc V., Barbour A.G.
    Mol. Microbiol. 3:479-486(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  2. "Sequence variation in the outer-surface-protein genes of Borrelia burgdorferi."
    Caporale D.A., Kocher T.D.
    Mol. Biol. Evol. 11:51-64(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Various strains.
  3. "A bactericidal antibody to Borrelia burgdorferi is directed against a variable region of the OspB protein."
    Sadziene A., Jonsson M., Bergstroem S., Bright R.K., Kennedy R.C., Barbour A.G.
    Infect. Immun. 62:2037-2045(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: HB19.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  5. Mongodin E.F., Fraser-Liggett C.M., Qiu W.-G., Dunn J.J., Luft B.J., Schutzer S.E., Casjens S.R.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 198.

Entry informationi

Entry nameiOSPB_BORBU
AccessioniPrimary (citable) accession number: P17739
Secondary accession number(s): O50909
, Q44963, Q44965, Q44966, Q44968, Q44970, Q44972, Q44975, Q57510
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: April 18, 2012
Last modified: September 3, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi