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Protein

Outer surface protein B

Gene

ospB

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-877-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer surface protein B
Gene namesi
Name:ospB
Ordered Locus Names:BB_A16
Encoded oniPlasmid lp540 Publication
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807 Componenti: Plasmid lp54

Subcellular locationi

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Add
BLAST
Chaini16 – 296281Outer surface protein BPRO_0000018081Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi16 – 161N-palmitoyl cysteineCurated
Lipidationi16 – 161S-diacylglycerol cysteineCurated

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

DIPiDIP-60765N.

Structurei

Secondary structure

1
296
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi158 – 1614Combined sources
Beta strandi167 – 17711Combined sources
Beta strandi179 – 1868Combined sources
Helixi187 – 1893Combined sources
Beta strandi190 – 1978Combined sources
Beta strandi200 – 2078Combined sources
Beta strandi210 – 2167Combined sources
Beta strandi218 – 22811Combined sources
Beta strandi231 – 2333Combined sources
Beta strandi235 – 2406Combined sources
Helixi241 – 2433Combined sources
Beta strandi245 – 2506Combined sources
Beta strandi253 – 2608Combined sources
Beta strandi266 – 2716Combined sources
Beta strandi275 – 2784Combined sources
Helixi288 – 2947Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1P4PX-ray2.00A152-296[»]
1RJLX-ray2.60C202-296[»]
ProteinModelPortaliP17739.
SMRiP17739. Positions 54-296.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17739.

Family & Domainsi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.90.930.1. 1 hit.
InterProiIPR001809. OM_lipoprot_Borrelia.
IPR023322. OM_lipoprot_dom.
[Graphical view]
PfamiPF00820. Lipoprotein_1. 1 hit.
[Graphical view]
PRINTSiPR00968. OUTRSURFACE.
ProDomiPD001127. OM_lipoprot_Borrelia. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF51087. SSF51087. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLIGFALA LALIGCAQKG AESIGSQKEN DLNLEDSSKK SHQNAKQDLP
60 70 80 90 100
AVTEDSVSLF NGNKIFVSKE KNSSGKYDLR ATIDQVELKG TSDKNNGSGT
110 120 130 140 150
LEGSKPDKSK VKLTVSADLN TVTLEAFDAS NQKISSKVTK KQGSITEETL
160 170 180 190 200
KANKLDSKKL TRSNGTTLEY SQITDADNAT KAVETLKNSI KLEGSLVGGK
210 220 230 240 250
TTVEIKEGTV TLKREIEKDG KVKVFLNDTA GSNKKTGKWE DSTSTLTISA
260 270 280 290
DSKKTKDLVF LTDGTITVQQ YNTAGTSLEG SASEIKNLSE LKNALK
Length:296
Mass (Da):31,733
Last modified:April 18, 2012 - v2
Checksum:i4B54CBABC39880A5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121A → R in AAA63758 (PubMed:7513309).Curated
Sequence conflicti198 – 1981G → V in CAA32580 (PubMed:2761388).Curated
Sequence conflicti214 – 2141R → I in AAA63758 (PubMed:7513309).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421H → Y in strain: CA7.
Natural varianti89 – 891K → R in strain: 41552MA.
Natural varianti123 – 1231T → S in strain: CA8.
Natural varianti126 – 1261A → T in strain: 21343WI, 41552MA, 42373NY3, HB19 and HB19CT1.
Natural varianti128 – 1281D → N in strain: 21343WI, 41552MA, HB19 and HB19CT1.
Natural varianti132 – 1321Q → P in strain: CA8.
Natural varianti176 – 1761A → T in strain: CA8.
Natural varianti189 – 1891S → G in strain: CA8.
Natural varianti192 – 1921L → F in strain: CA8.
Natural varianti198 – 1981G → V in strain: 21343WI, CA3 and CA7.
Natural varianti218 – 2181K → Q in strain: CA8.
Natural varianti253 – 2531K → T in strain: 21343WI, 41552MA, 42373NY3, HB19 and HB19CT1.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14407 Genomic DNA. Translation: CAA32580.1.
L23136 Genomic DNA. Translation: AAA22952.1.
L23137 Genomic DNA. Translation: AAA22954.1.
L23138 Genomic DNA. Translation: AAA20948.1.
L23139 Genomic DNA. Translation: AAA20950.1.
L23140 Genomic DNA. Translation: AAA20952.1.
L23141 Genomic DNA. Translation: AAA20954.1.
L23142 Genomic DNA. Translation: AAA20956.1.
L23143 Genomic DNA. Translation: AAA20958.1.
L23144 Genomic DNA. Translation: AAA20960.1.
L31399 Genomic DNA. Translation: AAA63758.1.
AE000790 Genomic DNA. Translation: AAC66243.2.
PIRiH70208.
I40250.
I40252.
I40256.
I40258.
I40260.
I40264.
I40266.
I40267.
S06915.
RefSeqiNP_045689.2. NC_001857.2.
WP_010890379.1. NC_001857.2.

Genome annotation databases

EnsemblBacteriaiAAC66243; AAC66243; BB_A16.
GeneIDi1194340.
KEGGibbu:BB_A16.
PATRICi20558958. VBIBorBur75917_1534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14407 Genomic DNA. Translation: CAA32580.1.
L23136 Genomic DNA. Translation: AAA22952.1.
L23137 Genomic DNA. Translation: AAA22954.1.
L23138 Genomic DNA. Translation: AAA20948.1.
L23139 Genomic DNA. Translation: AAA20950.1.
L23140 Genomic DNA. Translation: AAA20952.1.
L23141 Genomic DNA. Translation: AAA20954.1.
L23142 Genomic DNA. Translation: AAA20956.1.
L23143 Genomic DNA. Translation: AAA20958.1.
L23144 Genomic DNA. Translation: AAA20960.1.
L31399 Genomic DNA. Translation: AAA63758.1.
AE000790 Genomic DNA. Translation: AAC66243.2.
PIRiH70208.
I40250.
I40252.
I40256.
I40258.
I40260.
I40264.
I40266.
I40267.
S06915.
RefSeqiNP_045689.2. NC_001857.2.
WP_010890379.1. NC_001857.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1P4PX-ray2.00A152-296[»]
1RJLX-ray2.60C202-296[»]
ProteinModelPortaliP17739.
SMRiP17739. Positions 54-296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60765N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC66243; AAC66243; BB_A16.
GeneIDi1194340.
KEGGibbu:BB_A16.
PATRICi20558958. VBIBorBur75917_1534.

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-877-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP17739.

Family and domain databases

Gene3Di3.90.930.1. 1 hit.
InterProiIPR001809. OM_lipoprot_Borrelia.
IPR023322. OM_lipoprot_dom.
[Graphical view]
PfamiPF00820. Lipoprotein_1. 1 hit.
[Graphical view]
PRINTSiPR00968. OUTRSURFACE.
ProDomiPD001127. OM_lipoprot_Borrelia. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF51087. SSF51087. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi."
    Bergstroem S., Bundoc V., Barbour A.G.
    Mol. Microbiol. 3:479-486(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  2. "Sequence variation in the outer-surface-protein genes of Borrelia burgdorferi."
    Caporale D.A., Kocher T.D.
    Mol. Biol. Evol. 11:51-64(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Various strains.
  3. "A bactericidal antibody to Borrelia burgdorferi is directed against a variable region of the OspB protein."
    Sadziene A., Jonsson M., Bergstroem S., Bright R.K., Kennedy R.C., Barbour A.G.
    Infect. Immun. 62:2037-2045(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: HB19.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  5. Mongodin E.F., Fraser-Liggett C.M., Qiu W.-G., Dunn J.J., Luft B.J., Schutzer S.E., Casjens S.R.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 198.

Entry informationi

Entry nameiOSPB_BORBU
AccessioniPrimary (citable) accession number: P17739
Secondary accession number(s): O50909
, Q44963, Q44965, Q44966, Q44968, Q44970, Q44972, Q44975, Q57510
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: April 18, 2012
Last modified: January 7, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.