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P17739 (OSPB_BORBU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Outer surface protein B
Gene names
Name:ospB
Ordered Locus Names:BB_A16
Encoded onPlasmid lp54
OrganismBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) [Reference proteome] [HAMAP]
Taxonomic identifier224326 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cell outer membrane; Lipid-anchor.

Ontologies

Keywords
   Cellular componentCell outer membrane
Membrane
   DomainSignal
   PTMLipoprotein
Palmitate
   Technical term3D-structure
Complete proteome
Plasmid
Reference proteome
Gene Ontology (GO)
   Cellular_componentcell outer membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515
Chain16 – 296281Outer surface protein B
PRO_0000018081

Amino acid modifications

Lipidation161N-palmitoyl cysteine Probable
Lipidation161S-diacylglycerol cysteine Probable

Natural variations

Natural variant421H → Y in strain: CA7.
Natural variant891K → R in strain: 41552MA.
Natural variant1231T → S in strain: CA8.
Natural variant1261A → T in strain: 21343WI, 41552MA, 42373NY3, HB19 and HB19CT1.
Natural variant1281D → N in strain: 21343WI, 41552MA, HB19 and HB19CT1.
Natural variant1321Q → P in strain: CA8.
Natural variant1761A → T in strain: CA8.
Natural variant1891S → G in strain: CA8.
Natural variant1921L → F in strain: CA8.
Natural variant1981G → V in strain: 21343WI, CA3 and CA7.
Natural variant2181K → Q in strain: CA8.
Natural variant2531K → T in strain: 21343WI, 41552MA, 42373NY3, HB19 and HB19CT1.

Experimental info

Sequence conflict121A → R in AAA63758. Ref.3
Sequence conflict1981G → V in CAA32580. Ref.1
Sequence conflict2141R → I in AAA63758. Ref.3

Secondary structure

.............................. 296
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P17739 [UniParc].

Last modified April 18, 2012. Version 2.
Checksum: 4B54CBABC39880A5

FASTA29631,733
        10         20         30         40         50         60 
MRLLIGFALA LALIGCAQKG AESIGSQKEN DLNLEDSSKK SHQNAKQDLP AVTEDSVSLF 

        70         80         90        100        110        120 
NGNKIFVSKE KNSSGKYDLR ATIDQVELKG TSDKNNGSGT LEGSKPDKSK VKLTVSADLN 

       130        140        150        160        170        180 
TVTLEAFDAS NQKISSKVTK KQGSITEETL KANKLDSKKL TRSNGTTLEY SQITDADNAT 

       190        200        210        220        230        240 
KAVETLKNSI KLEGSLVGGK TTVEIKEGTV TLKREIEKDG KVKVFLNDTA GSNKKTGKWE 

       250        260        270        280        290 
DSTSTLTISA DSKKTKDLVF LTDGTITVQQ YNTAGTSLEG SASEIKNLSE LKNALK 

« Hide

References

« Hide 'large scale' references
[1]"Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi."
Bergstroem S., Bundoc V., Barbour A.G.
Mol. Microbiol. 3:479-486(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
[2]"Sequence variation in the outer-surface-protein genes of Borrelia burgdorferi."
Caporale D.A., Kocher T.D.
Mol. Biol. Evol. 11:51-64(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Various strains.
[3]"A bactericidal antibody to Borrelia burgdorferi is directed against a variable region of the OspB protein."
Sadziene A., Jonsson M., Bergstroem S., Bright R.K., Kennedy R.C., Barbour A.G.
Infect. Immun. 62:2037-2045(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: HB19.
[4]"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi."
Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L., Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J. expand/collapse author list , Salzberg S.L., Hanson M., van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B., Smith H.O., Venter J.C.
Nature 390:580-586(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
[5]Mongodin E.F., Fraser-Liggett C.M., Qiu W.-G., Dunn J.J., Luft B.J., Schutzer S.E., Casjens S.R.
Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 198.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14407 Genomic DNA. Translation: CAA32580.1.
L23136 Genomic DNA. Translation: AAA22952.1.
L23137 Genomic DNA. Translation: AAA22954.1.
L23138 Genomic DNA. Translation: AAA20948.1.
L23139 Genomic DNA. Translation: AAA20950.1.
L23140 Genomic DNA. Translation: AAA20952.1.
L23141 Genomic DNA. Translation: AAA20954.1.
L23142 Genomic DNA. Translation: AAA20956.1.
L23143 Genomic DNA. Translation: AAA20958.1.
L23144 Genomic DNA. Translation: AAA20960.1.
L31399 Genomic DNA. Translation: AAA63758.1.
AE000790 Genomic DNA. Translation: AAC66243.2.
PIRH70208.
I40250.
I40252.
I40256.
I40258.
I40260.
I40264.
I40266.
I40267.
S06915.
RefSeqNP_045689.2. NC_001857.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1P4PX-ray2.00A152-296[»]
1RJLX-ray2.60C202-296[»]
ProteinModelPortalP17739.
SMRP17739. Positions 54-296.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC66243; AAC66243; BB_A16.
GeneID1194340.
KEGGbbu:BB_A16.
PATRIC20558958. VBIBorBur75917_1534.

Phylogenomic databases

ProtClustDBCLSK541192.

Enzyme and pathway databases

BioCycBBUR224326:G9SO-877-MONOMER.

Family and domain databases

Gene3D3.90.930.1. 1 hit.
InterProIPR001809. OM_lipoprot_Borrelia.
IPR023322. OM_lipoprot_dom.
[Graphical view]
PfamPF00820. Lipoprotein_1. 1 hit.
[Graphical view]
PRINTSPR00968. OUTRSURFACE.
ProDomPD001127. OM_lipoprot_Borrelia. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF51087. SSF51087. 1 hit.
PROSITEPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP17739.

Entry information

Entry nameOSPB_BORBU
AccessionPrimary (citable) accession number: P17739
Secondary accession number(s): O50909 expand/collapse secondary AC list , Q44963, Q44965, Q44966, Q44968, Q44970, Q44972, Q44975, Q57510
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: April 18, 2012
Last modified: November 13, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references