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P17739

- OSPB_BORBU

UniProt

P17739 - OSPB_BORBU

Protein

Outer surface protein B

Gene

ospB

Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    BioCyciBBUR224326:G9SO-877-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Outer surface protein B
    Gene namesi
    Name:ospB
    Ordered Locus Names:BB_A16
    Encoded oniPlasmid lp540 Publication
    OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
    Taxonomic identifieri224326 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
    ProteomesiUP000001807: Plasmid lp54

    Subcellular locationi

    GO - Cellular componenti

    1. cell outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell outer membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Add
    BLAST
    Chaini16 – 296281Outer surface protein BPRO_0000018081Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi16 – 161N-palmitoyl cysteineCurated
    Lipidationi16 – 161S-diacylglycerol cysteineCurated

    Keywords - PTMi

    Lipoprotein, Palmitate

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60765N.

    Structurei

    Secondary structure

    1
    296
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi158 – 1614
    Beta strandi167 – 17711
    Beta strandi179 – 1868
    Helixi187 – 1893
    Beta strandi190 – 1978
    Beta strandi200 – 2078
    Beta strandi210 – 2167
    Beta strandi218 – 22811
    Beta strandi231 – 2333
    Beta strandi235 – 2406
    Helixi241 – 2433
    Beta strandi245 – 2506
    Beta strandi253 – 2608
    Beta strandi266 – 2716
    Beta strandi275 – 2784
    Helixi288 – 2947

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1P4PX-ray2.00A152-296[»]
    1RJLX-ray2.60C202-296[»]
    ProteinModelPortaliP17739.
    SMRiP17739. Positions 54-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP17739.

    Family & Domainsi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.90.930.1. 1 hit.
    InterProiIPR001809. OM_lipoprot_Borrelia.
    IPR023322. OM_lipoprot_dom.
    [Graphical view]
    PfamiPF00820. Lipoprotein_1. 1 hit.
    [Graphical view]
    PRINTSiPR00968. OUTRSURFACE.
    ProDomiPD001127. OM_lipoprot_Borrelia. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF51087. SSF51087. 1 hit.
    PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17739-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLLIGFALA LALIGCAQKG AESIGSQKEN DLNLEDSSKK SHQNAKQDLP    50
    AVTEDSVSLF NGNKIFVSKE KNSSGKYDLR ATIDQVELKG TSDKNNGSGT 100
    LEGSKPDKSK VKLTVSADLN TVTLEAFDAS NQKISSKVTK KQGSITEETL 150
    KANKLDSKKL TRSNGTTLEY SQITDADNAT KAVETLKNSI KLEGSLVGGK 200
    TTVEIKEGTV TLKREIEKDG KVKVFLNDTA GSNKKTGKWE DSTSTLTISA 250
    DSKKTKDLVF LTDGTITVQQ YNTAGTSLEG SASEIKNLSE LKNALK 296
    Length:296
    Mass (Da):31,733
    Last modified:April 18, 2012 - v2
    Checksum:i4B54CBABC39880A5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121A → R in AAA63758. (PubMed:7513309)Curated
    Sequence conflicti198 – 1981G → V in CAA32580. (PubMed:2761388)Curated
    Sequence conflicti214 – 2141R → I in AAA63758. (PubMed:7513309)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421H → Y in strain: CA7.
    Natural varianti89 – 891K → R in strain: 41552MA.
    Natural varianti123 – 1231T → S in strain: CA8.
    Natural varianti126 – 1261A → T in strain: 21343WI, 41552MA, 42373NY3, HB19 and HB19CT1.
    Natural varianti128 – 1281D → N in strain: 21343WI, 41552MA, HB19 and HB19CT1.
    Natural varianti132 – 1321Q → P in strain: CA8.
    Natural varianti176 – 1761A → T in strain: CA8.
    Natural varianti189 – 1891S → G in strain: CA8.
    Natural varianti192 – 1921L → F in strain: CA8.
    Natural varianti198 – 1981G → V in strain: 21343WI, CA3 and CA7.
    Natural varianti218 – 2181K → Q in strain: CA8.
    Natural varianti253 – 2531K → T in strain: 21343WI, 41552MA, 42373NY3, HB19 and HB19CT1.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14407 Genomic DNA. Translation: CAA32580.1.
    L23136 Genomic DNA. Translation: AAA22952.1.
    L23137 Genomic DNA. Translation: AAA22954.1.
    L23138 Genomic DNA. Translation: AAA20948.1.
    L23139 Genomic DNA. Translation: AAA20950.1.
    L23140 Genomic DNA. Translation: AAA20952.1.
    L23141 Genomic DNA. Translation: AAA20954.1.
    L23142 Genomic DNA. Translation: AAA20956.1.
    L23143 Genomic DNA. Translation: AAA20958.1.
    L23144 Genomic DNA. Translation: AAA20960.1.
    L31399 Genomic DNA. Translation: AAA63758.1.
    AE000790 Genomic DNA. Translation: AAC66243.2.
    PIRiH70208.
    I40250.
    I40252.
    I40256.
    I40258.
    I40260.
    I40264.
    I40266.
    I40267.
    S06915.
    RefSeqiNP_045689.2. NC_001857.2.
    WP_010890379.1. NC_001857.2.

    Genome annotation databases

    EnsemblBacteriaiAAC66243; AAC66243; BB_A16.
    GeneIDi1194340.
    KEGGibbu:BB_A16.
    PATRICi20558958. VBIBorBur75917_1534.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14407 Genomic DNA. Translation: CAA32580.1 .
    L23136 Genomic DNA. Translation: AAA22952.1 .
    L23137 Genomic DNA. Translation: AAA22954.1 .
    L23138 Genomic DNA. Translation: AAA20948.1 .
    L23139 Genomic DNA. Translation: AAA20950.1 .
    L23140 Genomic DNA. Translation: AAA20952.1 .
    L23141 Genomic DNA. Translation: AAA20954.1 .
    L23142 Genomic DNA. Translation: AAA20956.1 .
    L23143 Genomic DNA. Translation: AAA20958.1 .
    L23144 Genomic DNA. Translation: AAA20960.1 .
    L31399 Genomic DNA. Translation: AAA63758.1 .
    AE000790 Genomic DNA. Translation: AAC66243.2 .
    PIRi H70208.
    I40250.
    I40252.
    I40256.
    I40258.
    I40260.
    I40264.
    I40266.
    I40267.
    S06915.
    RefSeqi NP_045689.2. NC_001857.2.
    WP_010890379.1. NC_001857.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1P4P X-ray 2.00 A 152-296 [» ]
    1RJL X-ray 2.60 C 202-296 [» ]
    ProteinModelPortali P17739.
    SMRi P17739. Positions 54-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60765N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC66243 ; AAC66243 ; BB_A16 .
    GeneIDi 1194340.
    KEGGi bbu:BB_A16.
    PATRICi 20558958. VBIBorBur75917_1534.

    Enzyme and pathway databases

    BioCyci BBUR224326:G9SO-877-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P17739.

    Family and domain databases

    Gene3Di 3.90.930.1. 1 hit.
    InterProi IPR001809. OM_lipoprot_Borrelia.
    IPR023322. OM_lipoprot_dom.
    [Graphical view ]
    Pfami PF00820. Lipoprotein_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00968. OUTRSURFACE.
    ProDomi PD001127. OM_lipoprot_Borrelia. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF51087. SSF51087. 1 hit.
    PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi."
      Bergstroem S., Bundoc V., Barbour A.G.
      Mol. Microbiol. 3:479-486(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
    2. "Sequence variation in the outer-surface-protein genes of Borrelia burgdorferi."
      Caporale D.A., Kocher T.D.
      Mol. Biol. Evol. 11:51-64(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Various strains.
    3. "A bactericidal antibody to Borrelia burgdorferi is directed against a variable region of the OspB protein."
      Sadziene A., Jonsson M., Bergstroem S., Bright R.K., Kennedy R.C., Barbour A.G.
      Infect. Immun. 62:2037-2045(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: HB19.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
    5. Mongodin E.F., Fraser-Liggett C.M., Qiu W.-G., Dunn J.J., Luft B.J., Schutzer S.E., Casjens S.R.
      Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 198.

    Entry informationi

    Entry nameiOSPB_BORBU
    AccessioniPrimary (citable) accession number: P17739
    Secondary accession number(s): O50909
    , Q44963, Q44965, Q44966, Q44968, Q44970, Q44972, Q44975, Q57510
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Plasmid, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3