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Protein

Antifungal protein

Gene

afp

Organism
Aspergillus giganteus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein inhibits the growth of a variety of fungal species.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Fungicide

Names & Taxonomyi

Protein namesi
Recommended name:
Antifungal protein
Gene namesi
Name:afp
OrganismiAspergillus giganteus
Taxonomic identifieri5060 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – 4322Sequence analysisPRO_0000020639Add
BLAST
Chaini44 – 9451Antifungal protein1 PublicationPRO_0000020640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 761 Publication
Disulfide bondi57 ↔ 831 Publication
Disulfide bondi69 ↔ 711 Publication
Disulfide bondi92 ↔ 941 Publication

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1
94
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi48 – 514Combined sources
Turni52 – 554Combined sources
Beta strandi56 – 594Combined sources
Beta strandi81 – 844Combined sources
Turni87 – 893Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AFPNMR-A44-94[»]
ProteinModelPortaliP17737.
SMRiP17737. Positions 44-94.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17737.

Family & Domainsi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.40.50.60. 1 hit.
InterProiIPR023112. Antifungal-protein_domain.
IPR022706. Antifungal_prot.
[Graphical view]
PfamiPF11402. Antifungal_prot. 1 hit.
[Graphical view]
SUPFAMiSSF57598. SSF57598. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17737-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFVSLASLG FALVAALGAV ATPVEADSLT AGGLDARDES AVLATYNGKC
60 70 80 90
YKKDNICKYK AQSGKTAICK CYVKKCPRDG AKCEFDSYKG KCYC
Length:94
Mass (Da):9,994
Last modified:November 1, 1995 - v2
Checksum:i0084E4F9047A8E1F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 417DARDESA → MQEMRAR (PubMed:2374718).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60771 Genomic DNA. Translation: CAA43181.1.
X53432 mRNA. Translation: CAA37523.1.
PIRiS44064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60771 Genomic DNA. Translation: CAA43181.1.
X53432 mRNA. Translation: CAA37523.1.
PIRiS44064.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AFPNMR-A44-94[»]
ProteinModelPortaliP17737.
SMRiP17737. Positions 44-94.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP17737.

Family and domain databases

Gene3Di2.40.50.60. 1 hit.
InterProiIPR023112. Antifungal-protein_domain.
IPR022706. Antifungal_prot.
[Graphical view]
PfamiPF11402. Antifungal_prot. 1 hit.
[Graphical view]
SUPFAMiSSF57598. SSF57598. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAFP_ASPGI
AccessioniPrimary (citable) accession number: P17737
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1995
Last modified: December 9, 2015
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.