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Protein

Bowman-Birk type seed trypsin and chymotrypsin inhibitor

Gene
N/A
Organism
Vigna unguiculata (Cowpea)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei26 – 272Reactive bond for trypsinBy similarity
Sitei53 – 542Reactive bond for chymotrypsinBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI12.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Bowman-Birk type seed trypsin and chymotrypsin inhibitor
Short name:
BTCI
OrganismiVigna unguiculata (Cowpea)
Taxonomic identifieri3917 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeVigna

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8383Bowman-Birk type seed trypsin and chymotrypsin inhibitorPRO_0000105856Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi18 ↔ 721 Publication
Disulfide bondi19 ↔ 341 Publication
Disulfide bondi22 ↔ 681 Publication
Disulfide bondi24 ↔ 321 Publication
Disulfide bondi42 ↔ 491 Publication
Disulfide bondi46 ↔ 611 Publication
Disulfide bondi51 ↔ 591 Publication

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1
83
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi16 – 183Combined sources
Beta strandi20 – 2910Combined sources
Beta strandi32 – 343Combined sources
Beta strandi37 – 415Combined sources
Beta strandi47 – 5610Combined sources
Beta strandi58 – 614Combined sources
Beta strandi64 – 674Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G81X-ray1.55I1-77[»]
3RU4X-ray1.68B14-74[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17734.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.10.69.10. 1 hit.
InterProiIPR000877. Prot_inh_BBI.
[Graphical view]
SMARTiSM00269. BowB. 1 hit.
[Graphical view]
SUPFAMiSSF57247. SSF57247. 1 hit.
PROSITEiPS00281. BOWMAN_BIRK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGHHZBSTBZ ASZSSKPCCR ZCACTKSIPP ZCRCSZVRLN SCHSACKSCA
60 70 80
CTFSIPAZCF CGBIBBFCYK PCKSSHSBBB BWN
Length:83
Mass (Da):9,101
Last modified:August 1, 1990 - v1
Checksum:i409C4D2D3A54B976
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G81X-ray1.55I1-77[»]
3RU4X-ray1.68B14-74[»]
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI12.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP17734.

Family and domain databases

Gene3Di2.10.69.10. 1 hit.
InterProiIPR000877. Prot_inh_BBI.
[Graphical view]
SMARTiSM00269. BowB. 1 hit.
[Graphical view]
SUPFAMiSSF57247. SSF57247. 1 hit.
PROSITEiPS00281. BOWMAN_BIRK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete amino acid sequence of the Vigna unguiculata (L.) Walp. seed trypsin and chymotrypsin inhibitor."
    Morhy L., Ventura M.M.
    An. Acad. Bras. Cienc. 59:71-81(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Strain: cv. Serido.
  2. "Crystal structure of the Bowman-Birk Inhibitor from Vigna unguiculata seeds in complex with beta-trypsin at 1.55 A resolution and its structural properties in association with proteinases."
    Barbosa J.A., Silva L.P., Teles R.C., Esteves G.F., Azevedo R.B., Ventura M.M., de Freitas S.M.
    Biophys. J. 92:1638-1650(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 1-77, DISULFIDE BONDS.

Entry informationi

Entry nameiIBB_VIGUN
AccessioniPrimary (citable) accession number: P17734
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 16, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.