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Protein

Tick anticoagulant peptide

Gene
N/A
Organism
Ornithodoros moubata (Soft tick) (Argasid tick)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

TAP is a slow, tight-binding inhibitor of blood coagulation, specific for factor Xa.

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI52.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Tick anticoagulant peptide
Short name:
TAP
OrganismiOrnithodoros moubata (Soft tick) (Argasid tick)
Taxonomic identifieri6938 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaArgasidaeOrnithodoros

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6060Tick anticoagulant peptidePRO_0000155457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi5 ↔ 591 Publication
Disulfide bondi15 ↔ 391 Publication
Disulfide bondi33 ↔ 551 Publication

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

MINTiMINT-124564.

Structurei

Secondary structure

1
60
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 53Combined sources
Turni11 – 144Combined sources
Helixi17 – 193Combined sources
Beta strandi22 – 276Combined sources
Beta strandi29 – 3810Combined sources
Turni40 – 423Combined sources
Helixi52 – 598Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D0DX-ray1.62A1-60[»]
1KIGX-ray3.00I1-60[»]
1TAPNMR-A1-60[»]
1TCPNMR-A1-60[»]
ProteinModelPortaliP17726.
SMRiP17726. Positions 1-60.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17726.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 5955BPTI/Kunitz inhibitorAdd
BLAST

Sequence similaritiesi

Contains 1 BPTI/Kunitz inhibitor domain.Curated

Family and domain databases

Gene3Di4.10.410.10. 1 hit.
InterProiIPR002223. Prot_inh_Kunz-m.
[Graphical view]
PfamiPF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 1 hit.

Sequencei

Sequence statusi: Complete.

P17726-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
YNRLCIKPRD WIDECDSNEG GERAYFRNGK GGCDSFWICP EDHTGADYYS
60
SYRDCFNACI
Length:60
Mass (Da):6,985
Last modified:August 1, 1990 - v1
Checksum:i700D3D1245E83099
GO

Sequence databases

PIRiA41212.

Cross-referencesi

Sequence databases

PIRiA41212.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D0DX-ray1.62A1-60[»]
1KIGX-ray3.00I1-60[»]
1TAPNMR-A1-60[»]
1TCPNMR-A1-60[»]
ProteinModelPortaliP17726.
SMRiP17726. Positions 1-60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-124564.

Protein family/group databases

MEROPSiI52.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP17726.

Family and domain databases

Gene3Di4.10.410.10. 1 hit.
InterProiIPR002223. Prot_inh_Kunz-m.
[Graphical view]
PfamiPF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa."
    Waxman L., Smith D.E., Arcuri K.E., Vlasuk G.P.
    Science 248:593-596(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
  2. "Determination of disulfide bond pairs and stability in recombinant tick anticoagulant peptide."
    Sardana M., Sardana V., Rodkey J., Wood T., Ng A., Vlasuk G.P., Waxman L.
    J. Biol. Chem. 266:13560-13563(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.
  3. "NMR solution structure of the recombinant tick anticoagulant protein (rTAP), a factor Xa inhibitor from the tick Ornithodoros moubata."
    Antuch W., Guntert P., Billeter M., Hawthorne T., Grossenbacher H., Wuethrich K.
    FEBS Lett. 352:251-257(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  4. "NMR structure determination of tick anticoagulant peptide (TAP)."
    Lim-Wilby M.S.L., Hallenga K., de Maeyer M., Lasters I., Vlasuk G.P., Brunck T.K.
    Protein Sci. 4:178-186(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiTAP_ORNMO
AccessioniPrimary (citable) accession number: P17726
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

The inhibition of factor Xa seems to be reversible and stoichiometric.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.