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Protein

Tick anticoagulant peptide

Gene
N/A
Organism
Ornithodoros moubata (Soft tick) (Argasid tick)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

TAP is a slow, tight-binding inhibitor of blood coagulation, specific for factor Xa.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI52.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Tick anticoagulant peptide
Short name:
TAP
OrganismiOrnithodoros moubata (Soft tick) (Argasid tick)
Taxonomic identifieri6938 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaArgasidaeOrnithodoros

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6060Tick anticoagulant peptidePRO_0000155457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi5 ↔ 591 Publication
Disulfide bondi15 ↔ 391 Publication
Disulfide bondi33 ↔ 551 Publication

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

MINTiMINT-124564.

Structurei

Secondary structure

1
60
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 53Combined sources
Turni11 – 144Combined sources
Helixi17 – 193Combined sources
Beta strandi22 – 276Combined sources
Beta strandi29 – 3810Combined sources
Turni40 – 423Combined sources
Helixi52 – 598Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D0DX-ray1.62A1-60[»]
1KIGX-ray3.00I1-60[»]
1TAPNMR-A1-60[»]
1TCPNMR-A1-60[»]
ProteinModelPortaliP17726.
SMRiP17726. Positions 1-60.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17726.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 5955BPTI/Kunitz inhibitorAdd
BLAST

Sequence similaritiesi

Contains 1 BPTI/Kunitz inhibitor domain.Curated

Family and domain databases

Gene3Di4.10.410.10. 1 hit.
InterProiIPR002223. Kunitz_BPTI.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 1 hit.

Sequencei

Sequence statusi: Complete.

P17726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
YNRLCIKPRD WIDECDSNEG GERAYFRNGK GGCDSFWICP EDHTGADYYS
60
SYRDCFNACI
Length:60
Mass (Da):6,985
Last modified:August 1, 1990 - v1
Checksum:i700D3D1245E83099
GO

Sequence databases

PIRiA41212.

Cross-referencesi

Sequence databases

PIRiA41212.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D0DX-ray1.62A1-60[»]
1KIGX-ray3.00I1-60[»]
1TAPNMR-A1-60[»]
1TCPNMR-A1-60[»]
ProteinModelPortaliP17726.
SMRiP17726. Positions 1-60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-124564.

Protein family/group databases

MEROPSiI52.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP17726.

Family and domain databases

Gene3Di4.10.410.10. 1 hit.
InterProiIPR002223. Kunitz_BPTI.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTAP_ORNMO
AccessioniPrimary (citable) accession number: P17726
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 11, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

The inhibition of factor Xa seems to be reversible and stoichiometric.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.