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Protein

Tick anticoagulant peptide

Gene
N/A
Organism
Ornithodoros moubata (Soft tick) (Argasid tick)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

TAP is a slow, tight-binding inhibitor of blood coagulation, specific for factor Xa.

Miscellaneous

The inhibition of factor Xa seems to be reversible and stoichiometric.

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI52.001

Names & Taxonomyi

Protein namesi
Recommended name:
Tick anticoagulant peptide
Short name:
TAP
OrganismiOrnithodoros moubata (Soft tick) (Argasid tick)
Taxonomic identifieri6938 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaArgasidaeOrnithodoros

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001554571 – 60Tick anticoagulant peptideAdd BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi5 ↔ 591 Publication
Disulfide bondi15 ↔ 391 Publication
Disulfide bondi33 ↔ 551 Publication

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

MINTiP17726

Structurei

Secondary structure

160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 5Combined sources3
Turni11 – 14Combined sources4
Helixi17 – 19Combined sources3
Beta strandi22 – 27Combined sources6
Beta strandi29 – 38Combined sources10
Turni40 – 42Combined sources3
Helixi52 – 59Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D0DX-ray1.62A1-60[»]
1KIGX-ray3.00I1-60[»]
1TAPNMR-A1-60[»]
1TCPNMR-A1-60[»]
ProteinModelPortaliP17726
SMRiP17726
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17726

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 59BPTI/Kunitz inhibitorAdd BLAST55

Family and domain databases

Gene3Di4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR036880 Kunitz_BPTI_sf
SUPFAMiSSF57362 SSF57362, 1 hit

Sequencei

Sequence statusi: Complete.

P17726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
YNRLCIKPRD WIDECDSNEG GERAYFRNGK GGCDSFWICP EDHTGADYYS
60
SYRDCFNACI
Length:60
Mass (Da):6,985
Last modified:August 1, 1990 - v1
Checksum:i700D3D1245E83099
GO

Sequence databases

PIRiA41212

Entry informationi

Entry nameiTAP_ORNMO
AccessioniPrimary (citable) accession number: P17726
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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