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P17726

- TAP_ORNMO

UniProt

P17726 - TAP_ORNMO

Protein

Tick anticoagulant peptide

Gene
N/A
Organism
Ornithodoros moubata (Soft tick) (Argasid tick)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    TAP is a slow, tight-binding inhibitor of blood coagulation, specific for factor Xa.

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI52.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tick anticoagulant peptide
    Short name:
    TAP
    OrganismiOrnithodoros moubata (Soft tick) (Argasid tick)
    Taxonomic identifieri6938 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaArgasidaeOrnithodoros

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6060Tick anticoagulant peptidePRO_0000155457Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi5 ↔ 591 Publication
    Disulfide bondi15 ↔ 391 Publication
    Disulfide bondi33 ↔ 551 Publication

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-124564.

    Structurei

    Secondary structure

    1
    60
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 53
    Turni11 – 144
    Helixi17 – 193
    Beta strandi22 – 276
    Beta strandi29 – 3810
    Turni40 – 423
    Helixi52 – 598

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1D0DX-ray1.62A1-60[»]
    1KIGX-ray3.00I1-60[»]
    1TAPNMR-A1-60[»]
    1TCPNMR-A1-60[»]
    ProteinModelPortaliP17726.
    SMRiP17726. Positions 1-60.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP17726.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 5955BPTI/Kunitz inhibitorAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BPTI/Kunitz inhibitor domain.Curated

    Family and domain databases

    Gene3Di4.10.410.10. 1 hit.
    InterProiIPR002223. Prot_inh_Kunz-m.
    [Graphical view]
    PfamiPF00014. Kunitz_BPTI. 1 hit.
    [Graphical view]
    SUPFAMiSSF57362. SSF57362. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P17726-1 [UniParc]FASTAAdd to Basket

    « Hide

    YNRLCIKPRD WIDECDSNEG GERAYFRNGK GGCDSFWICP EDHTGADYYS   50
    SYRDCFNACI 60
    Length:60
    Mass (Da):6,985
    Last modified:August 1, 1990 - v1
    Checksum:i700D3D1245E83099
    GO

    Sequence databases

    PIRiA41212.

    Cross-referencesi

    Sequence databases

    PIRi A41212.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1D0D X-ray 1.62 A 1-60 [» ]
    1KIG X-ray 3.00 I 1-60 [» ]
    1TAP NMR - A 1-60 [» ]
    1TCP NMR - A 1-60 [» ]
    ProteinModelPortali P17726.
    SMRi P17726. Positions 1-60.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-124564.

    Protein family/group databases

    MEROPSi I52.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P17726.

    Family and domain databases

    Gene3Di 4.10.410.10. 1 hit.
    InterProi IPR002223. Prot_inh_Kunz-m.
    [Graphical view ]
    Pfami PF00014. Kunitz_BPTI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57362. SSF57362. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa."
      Waxman L., Smith D.E., Arcuri K.E., Vlasuk G.P.
      Science 248:593-596(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
    2. "Determination of disulfide bond pairs and stability in recombinant tick anticoagulant peptide."
      Sardana M., Sardana V., Rodkey J., Wood T., Ng A., Vlasuk G.P., Waxman L.
      J. Biol. Chem. 266:13560-13563(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS.
    3. "NMR solution structure of the recombinant tick anticoagulant protein (rTAP), a factor Xa inhibitor from the tick Ornithodoros moubata."
      Antuch W., Guntert P., Billeter M., Hawthorne T., Grossenbacher H., Wuethrich K.
      FEBS Lett. 352:251-257(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.
    4. "NMR structure determination of tick anticoagulant peptide (TAP)."
      Lim-Wilby M.S.L., Hallenga K., de Maeyer M., Lasters I., Vlasuk G.P., Brunck T.K.
      Protein Sci. 4:178-186(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiTAP_ORNMO
    AccessioniPrimary (citable) accession number: P17726
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    The inhibition of factor Xa seems to be reversible and stoichiometric.

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3