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P17717

- UDB17_MOUSE

UniProt

P17717 - UDB17_MOUSE

Protein

UDP-glucuronosyltransferase 2B17

Gene

Ugt2b17

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B17 (EC:2.4.1.17)
    Alternative name(s):
    M-1
    UDP-glucuronosyltransferase 2B5
    Short name:
    UDPGT 2B5
    Gene namesi
    Name:Ugt2b17
    Synonyms:Ugt2b5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:98900. Ugt2b5.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. mitochondrial inner membrane Source: MGI

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 530507UDP-glucuronosyltransferase 2B17PRO_0000036029Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi483 – 4831N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP17717.
    PaxDbiP17717.
    PRIDEiP17717.

    PTM databases

    PhosphoSiteiP17717.

    Expressioni

    Gene expression databases

    GenevestigatoriP17717.

    Interactioni

    Protein-protein interaction databases

    IntActiP17717. 3 interactions.
    MINTiMINT-1854185.

    Structurei

    3D structure databases

    ProteinModelPortaliP17717.
    SMRiP17717. Positions 258-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei494 – 51017HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    HOGENOMiHOG000220831.
    HOVERGENiHBG004033.
    InParanoidiP17717.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17717-1 [UniParc]FASTAAdd to Basket

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    MPGKWISALL LLQISCCFRS VKCGKVLVWP MEFSHWMNIK IILDELVQRG    50
    HEVTVLRPSA YYVLDPKKSP GLKFETFPTS VSKDNLENFF IKFVDVWTYE 100
    MPRDTCLSYS PLLQNMIDEF SDYFLSLCKD VVSNKELMTK LQESKFDVLL 150
    SDPVASCGEL IAELLQIPFL YSIRFSPGYQ IEKSSGRFLL PPSYVPVILS 200
    GLGGQMTFIE RIKNMICMLY FDFWFQMFND KKWDSFYSEY LGRPTTLVET 250
    MGQAEMWLIR SNWDLEFPHP TLPNVDYVGG LHCKPAKPLP KDMEEFVQSS 300
    GDHGVVVFSL GSMVSNMTEE KANAIAWALA QIPQKVLWKF DGKTPATLGH 350
    NTRVYKWLPQ NDLLGHPKTK AFVTHGGANG VYEAIYHGIP MIGIPLFGEQ 400
    HDNIAHMVAK GAAVALNIRT MSKSDVLNAL EEVIENPFYK KNAIWLSTIH 450
    HDQPMKPLDR AVFWIEFVMR HKRAKHLRPL GHNLTWYQYH SLDVIGFLLS 500
    CVATTIVLSV KCLLFIYRFF VKKENKMKNE 530
    Length:530
    Mass (Da):60,856
    Last modified:August 1, 1990 - v1
    Checksum:i7BAFEE9EFA8866B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06358 mRNA. Translation: CAA29657.1.
    CCDSiCCDS19385.3.
    PIRiS00163.
    UniGeneiMm.291575.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06358 mRNA. Translation: CAA29657.1 .
    CCDSi CCDS19385.3.
    PIRi S00163.
    UniGenei Mm.291575.

    3D structure databases

    ProteinModelPortali P17717.
    SMRi P17717. Positions 258-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P17717. 3 interactions.
    MINTi MINT-1854185.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    PTM databases

    PhosphoSitei P17717.

    Proteomic databases

    MaxQBi P17717.
    PaxDbi P17717.
    PRIDEi P17717.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:98900. Ugt2b5.

    Phylogenomic databases

    eggNOGi COG1819.
    HOGENOMi HOG000220831.
    HOVERGENi HBG004033.
    InParanoidi P17717.

    Miscellaneous databases

    PROi P17717.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P17717.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse UDP glucuronosyltransferase. cDNA and complete amino acid sequence and regulation."
      Kimura T., Owens I.S.
      Eur. J. Biochem. 168:515-521(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6N.
      Tissue: Liver.

    Entry informationi

    Entry nameiUDB17_MOUSE
    AccessioniPrimary (citable) accession number: P17717
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3