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P17717

- UDB17_MOUSE

UniProt

P17717 - UDB17_MOUSE

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Protein
UDP-glucuronosyltransferase 2B17
Gene
Ugt2b17, Ugt2b5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B17 (EC:2.4.1.17)
Alternative name(s):
M-1
UDP-glucuronosyltransferase 2B5
Short name:
UDPGT 2B5
Gene namesi
Name:Ugt2b17
Synonyms:Ugt2b5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:98900. Ugt2b5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei494 – 51017Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrial inner membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 By similarity
Add
BLAST
Chaini24 – 530507UDP-glucuronosyltransferase 2B17
PRO_0000036029Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi316 – 3161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi483 – 4831N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP17717.
PaxDbiP17717.
PRIDEiP17717.

PTM databases

PhosphoSiteiP17717.

Expressioni

Gene expression databases

GenevestigatoriP17717.

Interactioni

Protein-protein interaction databases

IntActiP17717. 3 interactions.
MINTiMINT-1854185.

Structurei

3D structure databases

ProteinModelPortaliP17717.
SMRiP17717. Positions 258-447.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP17717.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17717-1 [UniParc]FASTAAdd to Basket

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MPGKWISALL LLQISCCFRS VKCGKVLVWP MEFSHWMNIK IILDELVQRG    50
HEVTVLRPSA YYVLDPKKSP GLKFETFPTS VSKDNLENFF IKFVDVWTYE 100
MPRDTCLSYS PLLQNMIDEF SDYFLSLCKD VVSNKELMTK LQESKFDVLL 150
SDPVASCGEL IAELLQIPFL YSIRFSPGYQ IEKSSGRFLL PPSYVPVILS 200
GLGGQMTFIE RIKNMICMLY FDFWFQMFND KKWDSFYSEY LGRPTTLVET 250
MGQAEMWLIR SNWDLEFPHP TLPNVDYVGG LHCKPAKPLP KDMEEFVQSS 300
GDHGVVVFSL GSMVSNMTEE KANAIAWALA QIPQKVLWKF DGKTPATLGH 350
NTRVYKWLPQ NDLLGHPKTK AFVTHGGANG VYEAIYHGIP MIGIPLFGEQ 400
HDNIAHMVAK GAAVALNIRT MSKSDVLNAL EEVIENPFYK KNAIWLSTIH 450
HDQPMKPLDR AVFWIEFVMR HKRAKHLRPL GHNLTWYQYH SLDVIGFLLS 500
CVATTIVLSV KCLLFIYRFF VKKENKMKNE 530
Length:530
Mass (Da):60,856
Last modified:August 1, 1990 - v1
Checksum:i7BAFEE9EFA8866B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06358 mRNA. Translation: CAA29657.1.
CCDSiCCDS19385.3.
PIRiS00163.
UniGeneiMm.291575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06358 mRNA. Translation: CAA29657.1 .
CCDSi CCDS19385.3.
PIRi S00163.
UniGenei Mm.291575.

3D structure databases

ProteinModelPortali P17717.
SMRi P17717. Positions 258-447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P17717. 3 interactions.
MINTi MINT-1854185.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSitei P17717.

Proteomic databases

MaxQBi P17717.
PaxDbi P17717.
PRIDEi P17717.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:98900. Ugt2b5.

Phylogenomic databases

eggNOGi COG1819.
HOGENOMi HOG000220831.
HOVERGENi HBG004033.
InParanoidi P17717.

Miscellaneous databases

PROi P17717.
SOURCEi Search...

Gene expression databases

Genevestigatori P17717.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse UDP glucuronosyltransferase. cDNA and complete amino acid sequence and regulation."
    Kimura T., Owens I.S.
    Eur. J. Biochem. 168:515-521(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6N.
    Tissue: Liver.

Entry informationi

Entry nameiUDB17_MOUSE
AccessioniPrimary (citable) accession number: P17717
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi