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P17717 (UDB17_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2B17

EC=2.4.1.17
Alternative name(s):
M-1
UDP-glucuronosyltransferase 2B5
Short name=UDPGT 2B5
Gene names
Name:Ugt2b17
Synonyms:Ugt2b5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 530507UDP-glucuronosyltransferase 2B17
PRO_0000036029

Regions

Transmembrane494 – 51017Helical; Potential

Amino acid modifications

Glycosylation3161N-linked (GlcNAc...) Potential
Glycosylation4831N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P17717 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 7BAFEE9EFA8866B3

FASTA53060,856
        10         20         30         40         50         60 
MPGKWISALL LLQISCCFRS VKCGKVLVWP MEFSHWMNIK IILDELVQRG HEVTVLRPSA 

        70         80         90        100        110        120 
YYVLDPKKSP GLKFETFPTS VSKDNLENFF IKFVDVWTYE MPRDTCLSYS PLLQNMIDEF 

       130        140        150        160        170        180 
SDYFLSLCKD VVSNKELMTK LQESKFDVLL SDPVASCGEL IAELLQIPFL YSIRFSPGYQ 

       190        200        210        220        230        240 
IEKSSGRFLL PPSYVPVILS GLGGQMTFIE RIKNMICMLY FDFWFQMFND KKWDSFYSEY 

       250        260        270        280        290        300 
LGRPTTLVET MGQAEMWLIR SNWDLEFPHP TLPNVDYVGG LHCKPAKPLP KDMEEFVQSS 

       310        320        330        340        350        360 
GDHGVVVFSL GSMVSNMTEE KANAIAWALA QIPQKVLWKF DGKTPATLGH NTRVYKWLPQ 

       370        380        390        400        410        420 
NDLLGHPKTK AFVTHGGANG VYEAIYHGIP MIGIPLFGEQ HDNIAHMVAK GAAVALNIRT 

       430        440        450        460        470        480 
MSKSDVLNAL EEVIENPFYK KNAIWLSTIH HDQPMKPLDR AVFWIEFVMR HKRAKHLRPL 

       490        500        510        520        530 
GHNLTWYQYH SLDVIGFLLS CVATTIVLSV KCLLFIYRFF VKKENKMKNE 

« Hide

References

[1]"Mouse UDP glucuronosyltransferase. cDNA and complete amino acid sequence and regulation."
Kimura T., Owens I.S.
Eur. J. Biochem. 168:515-521(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6N.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X06358 mRNA. Translation: CAA29657.1.
PIRS00163.
UniGeneMm.291575.

3D structure databases

ProteinModelPortalP17717.
SMRP17717. Positions 258-447.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP17717. 3 interactions.
MINTMINT-1854185.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSiteP17717.

Proteomic databases

PaxDbP17717.
PRIDEP17717.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:98900. Ugt2b5.

Phylogenomic databases

eggNOGCOG1819.
HOGENOMHOG000220831.
HOVERGENHBG004033.
InParanoidP17717.

Gene expression databases

GenevestigatorP17717.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP17717.
SOURCESearch...

Entry information

Entry nameUDB17_MOUSE
AccessionPrimary (citable) accession number: P17717
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: February 19, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot