Reviewed, UniProtKB/Swiss-Prot P17717 (UD2B5_MOUSE)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 2B5
      Short name=UDPGT 2B5
    EC=2.4.1.17
Alternative name(s):
    M-1

Gene names

Name:

Ugt2b5

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial inner membrane Inferred from direct assay. Source: MGI
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	By similarity
	Chain	24 – 530	507	UDP-glucuronosyltransferase 2B5		PRO_0000036029
Regions
	Transmembrane	494 – 510	17	Potential
Amino acid modifications
	Glycosylation	316	1	N-linked (GlcNAc...) Potential
	Glycosylation	483	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P17717-1 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: 7BAFEE9EFA8866B3	FASTA	530	60,856
	10 20 30 40 50 60 MPGKWISALL LLQISCCFRS VKCGKVLVWP MEFSHWMNIK IILDELVQRG HEVTVLRPSA 70 80 90 100 110 120 YYVLDPKKSP GLKFETFPTS VSKDNLENFF IKFVDVWTYE MPRDTCLSYS PLLQNMIDEF 130 140 150 160 170 180 SDYFLSLCKD VVSNKELMTK LQESKFDVLL SDPVASCGEL IAELLQIPFL YSIRFSPGYQ 190 200 210 220 230 240 IEKSSGRFLL PPSYVPVILS GLGGQMTFIE RIKNMICMLY FDFWFQMFND KKWDSFYSEY 250 260 270 280 290 300 LGRPTTLVET MGQAEMWLIR SNWDLEFPHP TLPNVDYVGG LHCKPAKPLP KDMEEFVQSS 310 320 330 340 350 360 GDHGVVVFSL GSMVSNMTEE KANAIAWALA QIPQKVLWKF DGKTPATLGH NTRVYKWLPQ 370 380 390 400 410 420 NDLLGHPKTK AFVTHGGANG VYEAIYHGIP MIGIPLFGEQ HDNIAHMVAK GAAVALNIRT 430 440 450 460 470 480 MSKSDVLNAL EEVIENPFYK KNAIWLSTIH HDQPMKPLDR AVFWIEFVMR HKRAKHLRPL 490 500 510 520 530 GHNLTWYQYH SLDVIGFLLS CVATTIVLSV KCLLFIYRFF VKKENKMKNE

References

[1]	"Mouse UDP glucuronosyltransferase. cDNA and complete amino acid sequence and regulation." Kimura T., Owens I.S. Eur. J. Biochem. 168:515-521(1987) [PubMed: 3117546] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6N. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X06358 mRNA. Translation: CAA29657.1.
IPI	IPI00875581.
PIR	S00163.
RefSeq	NP_033493.1.
UniGene	Mm.291575
3D structure databases
SMR	P17717. Positions 286-447.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Proteomic databases
PRIDE	P17717.
Genome annotation databases
Ensembl	ENSMUSG00000054630. Mus musculus. [Contig view]
GeneID	22238.
KEGG	mmu:22238.
Organism-specific databases
MGI	MGI:98900. Ugt2b5.
Phylogenomic databases
HOVERGEN	P17717.
Enzyme and pathway databases
BRENDA	2.4.1.17. 244.
Gene expression databases
ArrayExpress	P17717.
Bgee	P17717.
GermOnline	ENSMUSG00000054630. Mus musculus.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	302293.
SOURCE	Search...

Entry information

Entry name

UD2B5_MOUSE

Accession

Primary (citable) accession number: P17717

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	June 16, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)