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Protein

Tyrosine-protein kinase STK

Gene

STK

Organism
Hydra vulgaris (Hydra) (Hydra attenuata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei268ATPPROSITE-ProRule annotation1
Active sitei360Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi246 – 254ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2720.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase STK (EC:2.7.10.2)
Alternative name(s):
P57-STK
Gene namesi
Name:STK
OrganismiHydra vulgaris (Hydra) (Hydra attenuata)
Taxonomic identifieri6087 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidolinaAnthoathecataAplanulataHydridaeHydra

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000881622 – 509Tyrosine-protein kinase STKAdd BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei390Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PRIDEiP17713.

Structurei

3D structure databases

ProteinModelPortaliP17713.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 120SH3PROSITE-ProRule annotationAdd BLAST62
Domaini126 – 218SH2PROSITE-ProRule annotationAdd BLAST93
Domaini240 – 495Protein kinasePROSITE-ProRule annotationAdd BLAST256

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

KOiK05705.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR028459. FGR.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF224. PTHR24418:SF224. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17713-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPCCSKQTK ALNNQPDKSK SKDVVLKENT SPFSQNTNNI MHVSHNQPPN
60 70 80 90 100
INPPMLGGPG VTIFVALYDY EARISEDLSF KKGERLQIIN TADGDWWYAR
110 120 130 140 150
SLITNSEGYI PSTYVAPEKS YEAEEWYFGD VKRAEAEKRL MVRGLPSGTF
160 170 180 190 200
LIRKAETAVG NFSLSVRDGD SVKHYRVRKL DTGGYFITTR APFNSLYELV
210 220 230 240 250
QHYTKDADGL VCALTLPCPK DKPVTGGIAK DAWEIPRESL RLNRKLGAGQ
260 270 280 290 300
FGEVWAGVWN NTTQVAVKTL KPGTMSPASF LDEAGVMKKL RHKHLVQLYA
310 320 330 340 350
ICSDREPIYI VTEYMSGGSL LDYLSKGEGV NLQLPTLIDM AAQVASGMAF
360 370 380 390 400
LEAQGYIHRD LAARNILVGE NYICKVADFG LARLIEDDEY TAHEGAKFPI
410 420 430 440 450
KWTAPEAALY NRFTIKSDVW SFGILMAEIV TKGRIPYPGM TNAQTIAEVE
460 470 480 490 500
KGYRMPIMPG CPEPLYNIML QTWNKDPENR PTFDYLQGVL EDYFVSTEQG

YRDLGEANS
Length:509
Mass (Da):56,886
Last modified:August 1, 1990 - v1
Checksum:iD0614B12B35F9953
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25245 mRNA. Translation: AAA29217.1.
PIRiA34094. TVHAST.
RefSeqiNP_001274717.1. NM_001287788.1.
UniGeneiHma.4857.

Genome annotation databases

GeneIDi100198593.
KEGGihmg:100198593.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25245 mRNA. Translation: AAA29217.1.
PIRiA34094. TVHAST.
RefSeqiNP_001274717.1. NM_001287788.1.
UniGeneiHma.4857.

3D structure databases

ProteinModelPortaliP17713.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP17713.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100198593.
KEGGihmg:100198593.

Phylogenomic databases

KOiK05705.

Enzyme and pathway databases

BRENDAi2.7.10.2. 2720.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR028459. FGR.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF224. PTHR24418:SF224. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTK_HYDVU
AccessioniPrimary (citable) accession number: P17713
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.