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P17713

- STK_HYDVU

UniProt

P17713 - STK_HYDVU

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Protein

Tyrosine-protein kinase STK

Gene

STK

Organism
Hydra vulgaris (Hydra) (Hydra attenuata)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei268 – 2681ATPPROSITE-ProRule annotation
Active sitei360 – 3601Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi246 – 2549ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 2720.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase STK (EC:2.7.10.2)
Alternative name(s):
P57-STK
Gene namesi
Name:STK
OrganismiHydra vulgaris (Hydra) (Hydra attenuata)
Taxonomic identifieri6087 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidaAnthomedusaeHydridaeHydra

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 509508Tyrosine-protein kinase STKPRO_0000088162Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Modified residuei390 – 3901Phosphotyrosine; by autocatalysisBy similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP17713.
SMRiP17713. Positions 61-502.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 12062SH3PROSITE-ProRule annotationAdd
BLAST
Domaini126 – 21893SH2PROSITE-ProRule annotationAdd
BLAST
Domaini240 – 495256Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

KOiK05705.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17713 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPCCSKQTK ALNNQPDKSK SKDVVLKENT SPFSQNTNNI MHVSHNQPPN
60 70 80 90 100
INPPMLGGPG VTIFVALYDY EARISEDLSF KKGERLQIIN TADGDWWYAR
110 120 130 140 150
SLITNSEGYI PSTYVAPEKS YEAEEWYFGD VKRAEAEKRL MVRGLPSGTF
160 170 180 190 200
LIRKAETAVG NFSLSVRDGD SVKHYRVRKL DTGGYFITTR APFNSLYELV
210 220 230 240 250
QHYTKDADGL VCALTLPCPK DKPVTGGIAK DAWEIPRESL RLNRKLGAGQ
260 270 280 290 300
FGEVWAGVWN NTTQVAVKTL KPGTMSPASF LDEAGVMKKL RHKHLVQLYA
310 320 330 340 350
ICSDREPIYI VTEYMSGGSL LDYLSKGEGV NLQLPTLIDM AAQVASGMAF
360 370 380 390 400
LEAQGYIHRD LAARNILVGE NYICKVADFG LARLIEDDEY TAHEGAKFPI
410 420 430 440 450
KWTAPEAALY NRFTIKSDVW SFGILMAEIV TKGRIPYPGM TNAQTIAEVE
460 470 480 490 500
KGYRMPIMPG CPEPLYNIML QTWNKDPENR PTFDYLQGVL EDYFVSTEQG

YRDLGEANS
Length:509
Mass (Da):56,886
Last modified:August 1, 1990 - v1
Checksum:iD0614B12B35F9953
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25245 mRNA. Translation: AAA29217.1.
PIRiA34094. TVHAST.
RefSeqiNP_001274717.1. NM_001287788.1.
UniGeneiHma.4857.

Genome annotation databases

GeneIDi100198593.
KEGGihmg:100198593.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25245 mRNA. Translation: AAA29217.1 .
PIRi A34094. TVHAST.
RefSeqi NP_001274717.1. NM_001287788.1.
UniGenei Hma.4857.

3D structure databases

ProteinModelPortali P17713.
SMRi P17713. Positions 61-502.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100198593.
KEGGi hmg:100198593.

Phylogenomic databases

KOi K05705.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 2720.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and expression of STK, a src-related gene in the simple metazoan Hydra attenuata."
    Bosch T.C.G., Unger T.F., Fisher D.A., Steele R.E.
    Mol. Cell. Biol. 9:4141-4151(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSTK_HYDVU
AccessioniPrimary (citable) accession number: P17713
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 1, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3