Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P17713

- STK_HYDVU

UniProt

P17713 - STK_HYDVU

Protein

Tyrosine-protein kinase STK

Gene

STK

Organism
Hydra vulgaris (Hydra) (Hydra attenuata)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei268 – 2681ATPPROSITE-ProRule annotation
    Active sitei360 – 3601Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi246 – 2549ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 2720.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase STK (EC:2.7.10.2)
    Alternative name(s):
    P57-STK
    Gene namesi
    Name:STK
    OrganismiHydra vulgaris (Hydra) (Hydra attenuata)
    Taxonomic identifieri6087 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidaAnthomedusaeHydridaeHydra

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 509508Tyrosine-protein kinase STKPRO_0000088162Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity
    Modified residuei390 – 3901Phosphotyrosine; by autocatalysisBy similarity

    Keywords - PTMi

    Lipoprotein, Myristate, Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP17713.
    SMRiP17713. Positions 61-502.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini59 – 12062SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini126 – 21893SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini240 – 495256Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain, SH3 domain

    Phylogenomic databases

    KOiK05705.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17713-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPCCSKQTK ALNNQPDKSK SKDVVLKENT SPFSQNTNNI MHVSHNQPPN    50
    INPPMLGGPG VTIFVALYDY EARISEDLSF KKGERLQIIN TADGDWWYAR 100
    SLITNSEGYI PSTYVAPEKS YEAEEWYFGD VKRAEAEKRL MVRGLPSGTF 150
    LIRKAETAVG NFSLSVRDGD SVKHYRVRKL DTGGYFITTR APFNSLYELV 200
    QHYTKDADGL VCALTLPCPK DKPVTGGIAK DAWEIPRESL RLNRKLGAGQ 250
    FGEVWAGVWN NTTQVAVKTL KPGTMSPASF LDEAGVMKKL RHKHLVQLYA 300
    ICSDREPIYI VTEYMSGGSL LDYLSKGEGV NLQLPTLIDM AAQVASGMAF 350
    LEAQGYIHRD LAARNILVGE NYICKVADFG LARLIEDDEY TAHEGAKFPI 400
    KWTAPEAALY NRFTIKSDVW SFGILMAEIV TKGRIPYPGM TNAQTIAEVE 450
    KGYRMPIMPG CPEPLYNIML QTWNKDPENR PTFDYLQGVL EDYFVSTEQG 500
    YRDLGEANS 509
    Length:509
    Mass (Da):56,886
    Last modified:August 1, 1990 - v1
    Checksum:iD0614B12B35F9953
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25245 mRNA. Translation: AAA29217.1.
    PIRiA34094. TVHAST.
    RefSeqiNP_001274717.1. NM_001287788.1.
    UniGeneiHma.4857.

    Genome annotation databases

    GeneIDi100198593.
    KEGGihmg:100198593.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25245 mRNA. Translation: AAA29217.1 .
    PIRi A34094. TVHAST.
    RefSeqi NP_001274717.1. NM_001287788.1.
    UniGenei Hma.4857.

    3D structure databases

    ProteinModelPortali P17713.
    SMRi P17713. Positions 61-502.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100198593.
    KEGGi hmg:100198593.

    Phylogenomic databases

    KOi K05705.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 2720.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of STK, a src-related gene in the simple metazoan Hydra attenuata."
      Bosch T.C.G., Unger T.F., Fisher D.A., Steele R.E.
      Mol. Cell. Biol. 9:4141-4151(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiSTK_HYDVU
    AccessioniPrimary (citable) accession number: P17713
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3