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P17713 (STK_HYDVU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase STK

EC=2.7.10.2
Alternative name(s):
P57-STK
Gene names
Name:STK
OrganismHydra vulgaris (Hydra) (Hydra attenuata)
Taxonomic identifier6087 [NCBI]
Taxonomic lineageEukaryotaMetazoaCnidariaHydrozoaHydroidaAnthomedusaeHydridaeHydra

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 509508Tyrosine-protein kinase STK
PRO_0000088162

Regions

Domain59 – 12062SH3
Domain126 – 21893SH2
Domain240 – 495256Protein kinase
Nucleotide binding246 – 2549ATP By similarity

Sites

Active site3601Proton acceptor By similarity
Binding site2681ATP By similarity

Amino acid modifications

Modified residue3901Phosphotyrosine; by autocatalysis By similarity
Lipidation21N-myristoyl glycine By similarity

Sequences

Sequence LengthMass (Da)Tools
P17713 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: D0614B12B35F9953

FASTA50956,886
        10         20         30         40         50         60 
MGPCCSKQTK ALNNQPDKSK SKDVVLKENT SPFSQNTNNI MHVSHNQPPN INPPMLGGPG 

        70         80         90        100        110        120 
VTIFVALYDY EARISEDLSF KKGERLQIIN TADGDWWYAR SLITNSEGYI PSTYVAPEKS 

       130        140        150        160        170        180 
YEAEEWYFGD VKRAEAEKRL MVRGLPSGTF LIRKAETAVG NFSLSVRDGD SVKHYRVRKL 

       190        200        210        220        230        240 
DTGGYFITTR APFNSLYELV QHYTKDADGL VCALTLPCPK DKPVTGGIAK DAWEIPRESL 

       250        260        270        280        290        300 
RLNRKLGAGQ FGEVWAGVWN NTTQVAVKTL KPGTMSPASF LDEAGVMKKL RHKHLVQLYA 

       310        320        330        340        350        360 
ICSDREPIYI VTEYMSGGSL LDYLSKGEGV NLQLPTLIDM AAQVASGMAF LEAQGYIHRD 

       370        380        390        400        410        420 
LAARNILVGE NYICKVADFG LARLIEDDEY TAHEGAKFPI KWTAPEAALY NRFTIKSDVW 

       430        440        450        460        470        480 
SFGILMAEIV TKGRIPYPGM TNAQTIAEVE KGYRMPIMPG CPEPLYNIML QTWNKDPENR 

       490        500 
PTFDYLQGVL EDYFVSTEQG YRDLGEANS 

« Hide

References

[1]"Structure and expression of STK, a src-related gene in the simple metazoan Hydra attenuata."
Bosch T.C.G., Unger T.F., Fisher D.A., Steele R.E.
Mol. Cell. Biol. 9:4141-4151(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M25245 mRNA. Translation: AAA29217.1.
PIRTVHAST. A34094.
RefSeqNP_001274717.1. NM_001287788.1.
UniGeneHma.4857.

3D structure databases

ProteinModelPortalP17713.
SMRP17713. Positions 61-502.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100198593.

Enzyme and pathway databases

BRENDA2.7.10.2. 2720.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSTK_HYDVU
AccessionPrimary (citable) accession number: P17713
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families