P17710 (HXK1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hexokinase-1
EC=2.7.1.1

Alternative name(s):
Hexokinase type I
Short name=HK I
Hexokinase, tumor isozyme

Gene names

Name:

Hk1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	974 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + D-hexose = ADP + D-hexose 6-phosphate.
Enzyme regulation	Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P.
Pathway	Carbohydrate metabolism; hexose metabolism.
Subunit structure	Monomer.
Subcellular location	Isoform HK1: Mitochondrion outer membrane; Peripheral membrane protein Ref.5. Isoform HK1-SC: Membrane. Note: Isoform HK1-SC is an integral membrane protein. Ref.5
Tissue specificity	In rapidly growing tumor cells exhibiting high glucose catabolic rates, isoform HK1 is markedly elevated. Isoform HK1-SA, isoform HK1-SB and isoform HK1-SC are found only in spermatogenic cells. Isoform HK1-SC is detected in round spermatids, condensing spermatids and mature sperm where it is found in the head membranes, mitochondria of the midpiece and the fibrous sheath of the flagellum.
Developmental stage	Isoform HK1-SA is first expressed during meiosis and continues to be present in postmeiotic germ cells while isoform HK1-SB is present only in postmeiotic germ cells. Ref.2 Ref.5
Domain	The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain can bind a single glucose and Gluc-6-P molecule By similarity.
Post-translational modification	Isoform HK1-SC is tyrosine-phosphorylated. Ref.5
Miscellaneous	In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).
Sequence similarities	Belongs to the hexokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Membrane Mitochondrion Mitochondrion outer membrane
Coding sequence diversity	Alternative initiation Alternative splicing
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Allosteric enzyme Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cellular glucose homeostasis Inferred from Biological aspect of Ancestor. Source: RefGenome glycolysis Traceable author statement PubMed 12420306. Source: MGI
Cellular_component	cytosol Inferred from direct assay PubMed 12420306. Source: MGI membrane raft Inferred from direct assay PubMed 19144954. Source: MGI mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from direct assay PubMed 12420306PubMed 14651853PubMed 18614015. Source: MGI nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW fructokinase activity Inferred from Biological aspect of Ancestor. Source: RefGenome glucokinase activity Inferred from Biological aspect of Ancestor. Source: RefGenome mannokinase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing and alternative initiation. [Align] [Select]

Isoform HK1-SA (identifier: P17710-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform HK1-SB (identifier: P17710-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.
     400-400: T → TGWELSPDRRWYQAYMRCTQDTHR

Note: Produced by alternative splicing and alternative initiation at Met-53 of isoform HK1-SA.

Isoform HK1 (identifier: P17710-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MGWGAPLLSR...PKIRPPLTEE → MIAAQLLAYYFTELKDDQVK

Isoform HK1-SC (identifier: P17710-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.

Note: Produced by alternative initiation at Met-53 of isoform HK1-SA.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 974	974	Hexokinase-1		PRO_0000013399
Regions
	Nucleotide binding	140 – 145	6	ATP 1 Potential
	Nucleotide binding	481 – 482	2	ATP 1 By similarity
	Nucleotide binding	588 – 593	6	ATP 2 By similarity
	Nucleotide binding	803 – 804	2	ATP 2 By similarity
	Nucleotide binding	840 – 844	5	ATP 2 By similarity
	Nucleotide binding	919 – 923	5	ATP 2 By similarity
	Region	1 – 52	52	Hydrophobic
	Region	53 – 531	479	Regulatory
	Region	140 – 144	5	Glucose-6-phosphate 1 binding By similarity
	Region	228 – 229	2	Substrate 1 binding By similarity
	Region	264 – 265	2	Substrate 1 binding By similarity
	Region	347 – 350	4	Substrate 1 binding By similarity
	Region	469 – 471	3	Glucose-6-phosphate 1 binding By similarity
	Region	532 – 974	443	Catalytic
	Region	588 – 592	5	Glucose-6-phosphate 2 binding By similarity
	Region	659 – 660	2	Substrate 2 binding By similarity
	Region	676 – 677	2	Substrate 2 binding By similarity
	Region	712 – 713	2	Substrate 2 binding By similarity
	Region	917 – 919	3	Glucose-6-phosphate 2 binding By similarity
Sites
	Binding site	86	1	ATP 1 By similarity
	Binding site	211	1	Substrate 1 By similarity
	Binding site	265	1	Glucose-6-phosphate 1 By similarity
	Binding site	288	1	Glucose-6-phosphate 1 By similarity
	Binding site	291	1	Substrate 1 By similarity
	Binding site	316	1	Substrate 1 By similarity
	Binding site	505	1	Glucose-6-phosphate 1 By similarity
	Binding site	659	1	Glucose-6-phosphate 2 By similarity
	Binding site	713	1	Glucose-6-phosphate 2 By similarity
	Binding site	736	1	ATP 2 By similarity
	Binding site	736	1	Glucose-6-phosphate 2 By similarity
	Binding site	739	1	Substrate 2 By similarity
	Binding site	764	1	Substrate 2 By similarity
	Binding site	798	1	Substrate 2 By similarity
	Binding site	953	1	Glucose-6-phosphate 2 By similarity
Amino acid modifications
	Modified residue	83	1	Phosphotyrosine Ref.7
Natural variations
	Alternative sequence	1 – 76	76	MGWGA…PLTEE → MIAAQLLAYYFTELKDDQVK in isoform HK1.		VSP_007327
	Alternative sequence	1 – 52	52	Missing in isoform HK1-SB and isoform HK1-SC.		VSP_018747
	Alternative sequence	400	1	T → TGWELSPDRRWYQAYMRCTQ DTHR in isoform HK1-SB.		VSP_007328
Experimental info
	Mutagenesis	67	1	P → A: Disrupts targeting to membrane; when associated with N-68; Q-70; P-73; A-74 and Q-75. Ref.6
	Mutagenesis	68	1	K → N: Disrupts targeting to membrane; when associated with A-67; Q-70; P-73; A-74 and Q-75. Ref.6
	Mutagenesis	70	1	R → Q: Disrupts targeting to membrane; when associated with A-67; N-68; P-73; A-74 and Q-75. Ref.6
	Mutagenesis	73	1	L → P: Disrupts targeting to membrane; when associated with A-67; N-68; Q-70; A-74 and Q-75. Ref.6
	Mutagenesis	74	1	T → A: Disrupts targeting to membrane; when associated with A-67; N-68; Q-70; P-73 and Q-75. Ref.6
	Mutagenesis	75	1	E → Q: Disrupts targeting to membrane; when associated with A-67; N-68; Q-70; P-73 and A-74. Ref.6
	Sequence conflict	870	1	D → S in AAA37804. Ref.1
	Sequence conflict	899	1	E → Q in AAB57759. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform HK1-SA [UniParc]. Last modified July 27, 2011. Version 3. Checksum: 6122505622F7BA3D	FASTA	974	108,303
	10 20 30 40 50 60 MGWGAPLLSR MLHGPGQAGE TSPVPERQSG SENPASEDRR PLEKQCSHHL YTMGQNCQRG 70 80 90 100 110 120 QAVDVEPKIR PPLTEEKIDK YLYAMRLSDE ILIDILTRFK KEMKNGLSRD YNPTASVKML 130 140 150 160 170 180 PTFVRSIPDG SEKGDFIALD LGGSSFRILR VQVNHEKSQN VSMESEVYDT PENIVHGSGS 190 200 210 220 230 240 QLFDHVAECL GDFMEKRKIK DKKLPVGFTF SFPCRQSKID EAVLITWTKR FKASGVEGAD 250 260 270 280 290 300 VVKLLNKAIK KRGDYDANIV AVVNDTVGTM MTCGYDDQQC EVGLIIGTGT NACYMEELRH 310 320 330 340 350 360 IDLVEGDEGR MCINTEWGAF GDDGSLEDIR TEFDRELDRG SLNPGKQLFE KMVSGMYMGE 370 380 390 400 410 420 LVRLILVKMA KESLLFEGRI TPELLTRGKF TTSDVAAIET DKEGVQNAKE ILTRLGVEPS 430 440 450 460 470 480 HDDCVSVQHV CTIVSFRSAN LVAATLGAIL NRLRDNKGTP RLRTTVGVDG SLYKMHPQYS 490 500 510 520 530 540 RRFHKTLRRL VPDSDVRFLL SESGSGKGAA MVTAVAYRLA EQHRQIEETL SHFRLSKQAL 550 560 570 580 590 600 MEVKKKLRSE MEMGLRKETN SRATVKMLPS YVRSIPDGTE HGDFLALDLG GTNFRVLLVK 610 620 630 640 650 660 IRSGKKRTVE MHNKIYSIPL EIMQGTGDEL FDHIVSCISD FLDYMGIKGP RMPLGFTFSF 670 680 690 700 710 720 PCKQTSLDCG ILITWTKGFK ATDCVGHDVA TLLRDAVKRR EEFDLDVVAV VNDTVGTMMT 730 740 750 760 770 780 CAYEEPSCEI GLIVGTGSNA CYMEEMKNVE MVEGNQGQMC INMEWGAFGD NGCLDDIRTD 790 800 810 820 830 840 FDKVVDEYSL NSGKQRFEKM ISGMYLGEIV RNILIDFTKK GFLFRGQISE PLKTRGIFET 850 860 870 880 890 900 KFLSQIESDR LALLQVRAIL QQLGLNSTCD DSILVKTVCG VVSKRAAQLC GAGMAAVVEK 910 920 930 940 950 960 IRENRGLDHL NVTVGVDGTL YKLHPHFSRI MHQTVKELSP KCTVSFLLSE DGSGKGAALI 970 TAVGVRLRGD PTNA
	Isoform HK1-SB [UniParc]. Checksum: 770DED5C144B9DE7	FASTA	945	105,575
	10 20 30 40 50 60 MGQNCQRGQA VDVEPKIRPP LTEEKIDKYL YAMRLSDEIL IDILTRFKKE MKNGLSRDYN 70 80 90 100 110 120 PTASVKMLPT FVRSIPDGSE KGDFIALDLG GSSFRILRVQ VNHEKSQNVS MESEVYDTPE 130 140 150 160 170 180 NIVHGSGSQL FDHVAECLGD FMEKRKIKDK KLPVGFTFSF PCRQSKIDEA VLITWTKRFK 190 200 210 220 230 240 ASGVEGADVV KLLNKAIKKR GDYDANIVAV VNDTVGTMMT CGYDDQQCEV GLIIGTGTNA 250 260 270 280 290 300 CYMEELRHID LVEGDEGRMC INTEWGAFGD DGSLEDIRTE FDRELDRGSL NPGKQLFEKM 310 320 330 340 350 360 VSGMYMGELV RLILVKMAKE SLLFEGRITP ELLTRGKFTT SDVAAIETGW ELSPDRRWYQ 370 380 390 400 410 420 AYMRCTQDTH RDKEGVQNAK EILTRLGVEP SHDDCVSVQH VCTIVSFRSA NLVAATLGAI 430 440 450 460 470 480 LNRLRDNKGT PRLRTTVGVD GSLYKMHPQY SRRFHKTLRR LVPDSDVRFL LSESGSGKGA 490 500 510 520 530 540 AMVTAVAYRL AEQHRQIEET LSHFRLSKQA LMEVKKKLRS EMEMGLRKET NSRATVKMLP 550 560 570 580 590 600 SYVRSIPDGT EHGDFLALDL GGTNFRVLLV KIRSGKKRTV EMHNKIYSIP LEIMQGTGDE 610 620 630 640 650 660 LFDHIVSCIS DFLDYMGIKG PRMPLGFTFS FPCKQTSLDC GILITWTKGF KATDCVGHDV 670 680 690 700 710 720 ATLLRDAVKR REEFDLDVVA VVNDTVGTMM TCAYEEPSCE IGLIVGTGSN ACYMEEMKNV 730 740 750 760 770 780 EMVEGNQGQM CINMEWGAFG DNGCLDDIRT DFDKVVDEYS LNSGKQRFEK MISGMYLGEI 790 800 810 820 830 840 VRNILIDFTK KGFLFRGQIS EPLKTRGIFE TKFLSQIESD RLALLQVRAI LQQLGLNSTC 850 860 870 880 890 900 DDSILVKTVC GVVSKRAAQL CGAGMAAVVE KIRENRGLDH LNVTVGVDGT LYKLHPHFSR 910 920 930 940 IMHQTVKELS PKCTVSFLLS EDGSGKGAAL ITAVGVRLRG DPTNA
	Isoform HK1 [UniParc]. Checksum: 4F0E6923F1EEC9B5	FASTA	918	102,302
	10 20 30 40 50 60 MIAAQLLAYY FTELKDDQVK KIDKYLYAMR LSDEILIDIL TRFKKEMKNG LSRDYNPTAS 70 80 90 100 110 120 VKMLPTFVRS IPDGSEKGDF IALDLGGSSF RILRVQVNHE KSQNVSMESE VYDTPENIVH 130 140 150 160 170 180 GSGSQLFDHV AECLGDFMEK RKIKDKKLPV GFTFSFPCRQ SKIDEAVLIT WTKRFKASGV 190 200 210 220 230 240 EGADVVKLLN KAIKKRGDYD ANIVAVVNDT VGTMMTCGYD DQQCEVGLII GTGTNACYME 250 260 270 280 290 300 ELRHIDLVEG DEGRMCINTE WGAFGDDGSL EDIRTEFDRE LDRGSLNPGK QLFEKMVSGM 310 320 330 340 350 360 YMGELVRLIL VKMAKESLLF EGRITPELLT RGKFTTSDVA AIETDKEGVQ NAKEILTRLG 370 380 390 400 410 420 VEPSHDDCVS VQHVCTIVSF RSANLVAATL GAILNRLRDN KGTPRLRTTV GVDGSLYKMH 430 440 450 460 470 480 PQYSRRFHKT LRRLVPDSDV RFLLSESGSG KGAAMVTAVA YRLAEQHRQI EETLSHFRLS 490 500 510 520 530 540 KQALMEVKKK LRSEMEMGLR KETNSRATVK MLPSYVRSIP DGTEHGDFLA LDLGGTNFRV 550 560 570 580 590 600 LLVKIRSGKK RTVEMHNKIY SIPLEIMQGT GDELFDHIVS CISDFLDYMG IKGPRMPLGF 610 620 630 640 650 660 TFSFPCKQTS LDCGILITWT KGFKATDCVG HDVATLLRDA VKRREEFDLD VVAVVNDTVG 670 680 690 700 710 720 TMMTCAYEEP SCEIGLIVGT GSNACYMEEM KNVEMVEGNQ GQMCINMEWG AFGDNGCLDD 730 740 750 760 770 780 IRTDFDKVVD EYSLNSGKQR FEKMISGMYL GEIVRNILID FTKKGFLFRG QISEPLKTRG 790 800 810 820 830 840 IFETKFLSQI ESDRLALLQV RAILQQLGLN STCDDSILVK TVCGVVSKRA AQLCGAGMAA 850 860 870 880 890 900 VVEKIRENRG LDHLNVTVGV DGTLYKLHPH FSRIMHQTVK ELSPKCTVSF LLSEDGSGKG 910 AALITAVGVR LRGDPTNA
	Isoform HK1-SC [UniParc]. Checksum: 4449779BF37D6EB7	FASTA	922	102,637
	10 20 30 40 50 60 MGQNCQRGQA VDVEPKIRPP LTEEKIDKYL YAMRLSDEIL IDILTRFKKE MKNGLSRDYN 70 80 90 100 110 120 PTASVKMLPT FVRSIPDGSE KGDFIALDLG GSSFRILRVQ VNHEKSQNVS MESEVYDTPE 130 140 150 160 170 180 NIVHGSGSQL FDHVAECLGD FMEKRKIKDK KLPVGFTFSF PCRQSKIDEA VLITWTKRFK 190 200 210 220 230 240 ASGVEGADVV KLLNKAIKKR GDYDANIVAV VNDTVGTMMT CGYDDQQCEV GLIIGTGTNA 250 260 270 280 290 300 CYMEELRHID LVEGDEGRMC INTEWGAFGD DGSLEDIRTE FDRELDRGSL NPGKQLFEKM 310 320 330 340 350 360 VSGMYMGELV RLILVKMAKE SLLFEGRITP ELLTRGKFTT SDVAAIETDK EGVQNAKEIL 370 380 390 400 410 420 TRLGVEPSHD DCVSVQHVCT IVSFRSANLV AATLGAILNR LRDNKGTPRL RTTVGVDGSL 430 440 450 460 470 480 YKMHPQYSRR FHKTLRRLVP DSDVRFLLSE SGSGKGAAMV TAVAYRLAEQ HRQIEETLSH 490 500 510 520 530 540 FRLSKQALME VKKKLRSEME MGLRKETNSR ATVKMLPSYV RSIPDGTEHG DFLALDLGGT 550 560 570 580 590 600 NFRVLLVKIR SGKKRTVEMH NKIYSIPLEI MQGTGDELFD HIVSCISDFL DYMGIKGPRM 610 620 630 640 650 660 PLGFTFSFPC KQTSLDCGIL ITWTKGFKAT DCVGHDVATL LRDAVKRREE FDLDVVAVVN 670 680 690 700 710 720 DTVGTMMTCA YEEPSCEIGL IVGTGSNACY MEEMKNVEMV EGNQGQMCIN MEWGAFGDNG 730 740 750 760 770 780 CLDDIRTDFD KVVDEYSLNS GKQRFEKMIS GMYLGEIVRN ILIDFTKKGF LFRGQISEPL 790 800 810 820 830 840 KTRGIFETKF LSQIESDRLA LLQVRAILQQ LGLNSTCDDS ILVKTVCGVV SKRAAQLCGA 850 860 870 880 890 900 GMAAVVEKIR ENRGLDHLNV TVGVDGTLYK LHPHFSRIMH QTVKELSPKC TVSFLLSEDG 910 920 SGKGAALITA VGVRLRGDPT NA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Glucose phosphorylation in tumor cells. Cloning, sequencing, and overexpression in active form of a full-length cDNA encoding a mitochondrial bindable form of hexokinase." Arora K.K., Fanciulli M., Pedersen P.L. J. Biol. Chem. 265:6481-6488(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM HK1).
[2]	"Unique hexokinase messenger ribonucleic acids lacking the porin-binding domain are developmentally expressed in mouse spermatogenic cells." Mori C., Welch J.E., Fulcher K.D., O'Brien D.A., Eddy E.M. Biol. Reprod. 49:191-203(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS HK1-SA; HK1-SB AND HK1-SC), DEVELOPMENTAL STAGE. Strain: CD-1. Tissue: Testis.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 81-98; 110-118; 134-147; 203-215; 219-229; 233-243; 300-310; 352-363; 372-409; 415-437; 438-452; 464-474; 489-518; 538-544; 549-595; 652-663; 681-694; 784-794; 800-819; 826-833; 842-884; 906-922 AND 942-974. Strain: C57BL/6. Tissue: Brain.
[5]	"Targeting of a germ cell-specific type 1 hexokinase lacking a porin-binding domain to the mitochondria as well as to the head and fibrous sheath of murine spermatozoa." Travis A.J., Foster J.A., Rosenbaum N.A., Visconti P.E., Gerton G.L., Kopf G.S., Moss S.B. Mol. Biol. Cell 9:263-276(1998) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, PHOSPHORYLATION.
[6]	"A novel NH(2)-terminal, nonhydrophobic motif targets a male germ cell-specific hexokinase to the endoplasmic reticulum and plasma membrane." Travis A.J., Sui D., Riedel K.D., Hofmann N.R., Moss S.B., Wilson J.E., Kopf G.S. J. Biol. Chem. 274:34467-34475(1999) [PubMed] [Europe PMC] [Abstract] Cited for: MUTAGENESIS OF PRO-67; LYS-68; ARG-70; LEU-73; THR-74 AND GLU-75.
[7]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-83, MASS SPECTROMETRY. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J05277 mRNA. Translation: AAA37804.1. L16948 mRNA. Translation: AAB57760.1. L16949 mRNA. Translation: AAB57759.1. L16950 mRNA. Translation: AAA53036.1. AC126428 Genomic DNA. No translation available. AC145297 Genomic DNA. No translation available.
IPI	IPI00283611. IPI00283612. IPI00468553. IPI00759938.
PIR	A35244. I49744.
UniGene	Mm.196605.
3D structure databases
ProteinModelPortal	P17710.
SMR	P17710. Positions 5-967.
ModBase	Search...
Protein-protein interaction databases
IntAct	P17710. 4 interactions.
MINT	MINT-1847872.
PTM databases
PhosphoSite	P17710.
Proteomic databases
PaxDb	P17710.
PRIDE	P17710.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000072357; ENSMUSP00000072195; ENSMUSG00000037012. ENSMUST00000099691; ENSMUSP00000097282; ENSMUSG00000037012. ENSMUST00000116238; ENSMUSP00000111946; ENSMUSG00000037012.
UCSC	uc007fgz.2. mouse.
Organism-specific databases
MGI	MGI:96103. Hk1.
Phylogenomic databases
eggNOG	COG5026.
GeneTree	ENSGT00390000017159.
HOGENOM	HOG000162671.
HOVERGEN	HBG005020.
InParanoid	P17710.
OMA	DFTKRGF.
Enzyme and pathway databases
SABIO-RK	P17710.
UniPathway	UPA00242.
Gene expression databases
ArrayExpress	P17710.
Bgee	P17710.
CleanEx	MM_HK1.
Genevestigator	P17710.
GermOnline	ENSMUSG00000037012. Mus musculus.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR019807. Hexokinase_CS. IPR022672. Hexokinase_N. [Graphical view]
PANTHER	PTHR19443. PTHR19443. 1 hit.
Pfam	PF00349. Hexokinase_1. 2 hits. PF03727. Hexokinase_2. 2 hits. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. 2 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

HXK1_MOUSE

Accession

Primary (citable) accession number: P17710
Secondary accession number(s): E9PXQ3 , Q61659, Q64476, Q64479

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	July 27, 2011
Last modified:	May 29, 2013
This is version 134 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program