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Protein

HLA class I histocompatibility antigen, alpha chain G

Gene

HLA-G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.

GO - Molecular functioni

  • antigen binding Source: GO_Central
  • protein homodimerization activity Source: UniProtKB
  • receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168745-MONOMER.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
SIGNORiP17693.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, alpha chain G
Alternative name(s):
HLA G antigen
MHC class I antigen G
Gene namesi
Name:HLA-G
Synonyms:HLA-6.0, HLAG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4964. HLA-G.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 338CytoplasmicSequence analysis6

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi66C → S: Abolishes homodimerization. 1 Publication1

Organism-specific databases

DisGeNETi3135.
MalaCardsiHLA-G.
OpenTargetsiENSG00000204632.
ENSG00000206506.
ENSG00000230413.
ENSG00000233095.
ENSG00000235346.
ENSG00000235680.
ENSG00000237216.
PharmGKBiPA35083.

Polymorphism and mutation databases

BioMutaiHLA-G.
DMDMi122132.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001888625 – 338HLA class I histocompatibility antigen, alpha chain GAdd BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi66InterchainPROSITE-ProRule annotation1 Publication
Glycosylationi110N-linked (GlcNAc...)By similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation1 Publication
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP17693.
PaxDbiP17693.
PeptideAtlasiP17693.
PRIDEiP17693.

PTM databases

iPTMnetiP17693.
PhosphoSitePlusiP17693.
SwissPalmiP17693.

Expressioni

Tissue specificityi

Expressed in trophoblasts.

Gene expression databases

BgeeiENSG00000204632.
CleanExiHS_HLA-G.
ExpressionAtlasiP17693. baseline and differential.
GenevisibleiP17693. HS.

Organism-specific databases

HPAiCAB016158.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Homodimer; disulfide-linked. Binds to LILRB1 and LILRB2.2 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109380. 15 interactors.
DIPiDIP-46121N.
IntActiP17693. 1 interactor.
STRINGi9606.ENSP00000353472.

Structurei

Secondary structure

1338
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Beta strandi70 – 73Combined sources4
Helixi74 – 76Combined sources3
Helixi81 – 108Combined sources28
Beta strandi113 – 115Combined sources3
Beta strandi118 – 132Combined sources15
Beta strandi134 – 142Combined sources9
Beta strandi145 – 150Combined sources6
Beta strandi157 – 161Combined sources5
Helixi162 – 173Combined sources12
Helixi176 – 185Combined sources10
Helixi187 – 198Combined sources12
Helixi200 – 203Combined sources4
Beta strandi210 – 218Combined sources9
Turni219 – 221Combined sources3
Beta strandi222 – 235Combined sources14
Beta strandi238 – 243Combined sources6
Beta strandi246 – 248Combined sources3
Helixi249 – 251Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Helixi278 – 280Combined sources3
Beta strandi281 – 286Combined sources6
Beta strandi290 – 292Combined sources3
Beta strandi294 – 296Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YDPX-ray1.90A26-300[»]
2D31X-ray3.20A/D25-300[»]
2DYPX-ray2.50A25-300[»]
3BZEX-ray2.50P/Q/R/S3-11[»]
3CDGX-ray3.40P/Q3-11[»]
3CIIX-ray4.41C/F3-11[»]
3KYNX-ray2.40A26-299[»]
3KYOX-ray1.70A/C26-298[»]
ProteinModelPortaliP17693.
SMRiP17693.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17693.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 299Ig-like C1-typeAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
GeneTreeiENSGT00760000118960.
HOVERGENiHBG016709.
InParanoidiP17693.
KOiK06751.
PhylomeDBiP17693.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17693-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG
60 70 80 90 100
YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM
110 120 130 140 150
NLQTLRGYYN QSEASSHTLQ WMIGCDLGSD GRLLRGYEQY AYDGKDYLAL
160 170 180 190 200
NEDLRSWTAA DTAAQISKRK CEAANVAEQR RAYLEGTCVE WLHRYLENGK
210 220 230 240 250
EMLQRADPPK THVTHHPVFD YEATLRCWAL GFYPAEIILT WQRDGEDQTQ
260 270 280 290 300
DVELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLMLRWKQ
310 320 330
SSLPTIPIMG IVAGLVVLAA VVTGAAVAAV LWRKKSSD
Length:338
Mass (Da):38,224
Last modified:August 1, 1990 - v1
Checksum:i0678E263BE8962FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17273 mRNA. Translation: CAA35174.1.
J03027 Genomic DNA. Translation: AAA98745.1.
M90683 mRNA. Translation: AAA52673.1.
AF055066 Genomic DNA. Translation: AAC24826.1.
BA000025 Genomic DNA. Translation: BAB63336.1.
CCDSiCCDS4668.1.
PIRiA39953.
RefSeqiNP_002118.1. NM_002127.5.
UniGeneiHs.512152.

Genome annotation databases

EnsembliENST00000360323; ENSP00000353472; ENSG00000204632.
ENST00000383621; ENSP00000373116; ENSG00000206506.
ENST00000423011; ENSP00000389522; ENSG00000233095.
ENST00000423373; ENSP00000405238; ENSG00000235346.
ENST00000428701; ENSP00000412927; ENSG00000204632.
ENST00000428952; ENSP00000388176; ENSG00000235680.
ENST00000444098; ENSP00000398200; ENSG00000230413.
ENST00000449127; ENSP00000408773; ENSG00000237216.
ENST00000546545; ENSP00000447762; ENSG00000230413.
ENST00000546634; ENSP00000447780; ENSG00000235346.
ENST00000547241; ENSP00000448085; ENSG00000233095.
ENST00000547931; ENSP00000448363; ENSG00000237216.
ENST00000550897; ENSP00000449903; ENSG00000235680.
ENST00000553052; ENSP00000449291; ENSG00000206506.
GeneIDi3135.
KEGGihsa:3135.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17273 mRNA. Translation: CAA35174.1.
J03027 Genomic DNA. Translation: AAA98745.1.
M90683 mRNA. Translation: AAA52673.1.
AF055066 Genomic DNA. Translation: AAC24826.1.
BA000025 Genomic DNA. Translation: BAB63336.1.
CCDSiCCDS4668.1.
PIRiA39953.
RefSeqiNP_002118.1. NM_002127.5.
UniGeneiHs.512152.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YDPX-ray1.90A26-300[»]
2D31X-ray3.20A/D25-300[»]
2DYPX-ray2.50A25-300[»]
3BZEX-ray2.50P/Q/R/S3-11[»]
3CDGX-ray3.40P/Q3-11[»]
3CIIX-ray4.41C/F3-11[»]
3KYNX-ray2.40A26-299[»]
3KYOX-ray1.70A/C26-298[»]
ProteinModelPortaliP17693.
SMRiP17693.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109380. 15 interactors.
DIPiDIP-46121N.
IntActiP17693. 1 interactor.
STRINGi9606.ENSP00000353472.

PTM databases

iPTMnetiP17693.
PhosphoSitePlusiP17693.
SwissPalmiP17693.

Polymorphism and mutation databases

BioMutaiHLA-G.
DMDMi122132.

Proteomic databases

EPDiP17693.
PaxDbiP17693.
PeptideAtlasiP17693.
PRIDEiP17693.

Protocols and materials databases

DNASUi3135.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360323; ENSP00000353472; ENSG00000204632.
ENST00000383621; ENSP00000373116; ENSG00000206506.
ENST00000423011; ENSP00000389522; ENSG00000233095.
ENST00000423373; ENSP00000405238; ENSG00000235346.
ENST00000428701; ENSP00000412927; ENSG00000204632.
ENST00000428952; ENSP00000388176; ENSG00000235680.
ENST00000444098; ENSP00000398200; ENSG00000230413.
ENST00000449127; ENSP00000408773; ENSG00000237216.
ENST00000546545; ENSP00000447762; ENSG00000230413.
ENST00000546634; ENSP00000447780; ENSG00000235346.
ENST00000547241; ENSP00000448085; ENSG00000233095.
ENST00000547931; ENSP00000448363; ENSG00000237216.
ENST00000550897; ENSP00000449903; ENSG00000235680.
ENST00000553052; ENSP00000449291; ENSG00000206506.
GeneIDi3135.
KEGGihsa:3135.

Organism-specific databases

CTDi3135.
DisGeNETi3135.
GeneCardsiHLA-G.
H-InvDBHIX0166674.
HIX0167370.
HGNCiHGNC:4964. HLA-G.
HPAiCAB016158.
MalaCardsiHLA-G.
MIMi142871. gene.
neXtProtiNX_P17693.
OpenTargetsiENSG00000204632.
ENSG00000206506.
ENSG00000230413.
ENSG00000233095.
ENSG00000235346.
ENSG00000235680.
ENSG00000237216.
PharmGKBiPA35083.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
GeneTreeiENSGT00760000118960.
HOVERGENiHBG016709.
InParanoidiP17693.
KOiK06751.
PhylomeDBiP17693.
TreeFamiTF336617.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000168745-MONOMER.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
SIGNORiP17693.

Miscellaneous databases

ChiTaRSiHLA-G. human.
EvolutionaryTraceiP17693.
GeneWikiiHLA-G.
GenomeRNAii3135.
PROiP17693.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204632.
CleanExiHS_HLA-G.
ExpressionAtlasiP17693. baseline and differential.
GenevisibleiP17693. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHLAG_HUMAN
AccessioniPrimary (citable) accession number: P17693
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 2, 2016
This is version 168 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.