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P17693

- HLAG_HUMAN

UniProt

P17693 - HLAG_HUMAN

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Protein

HLA class I histocompatibility antigen, alpha chain G

Gene

HLA-G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.

GO - Molecular functioni

  1. peptide antigen binding Source: InterPro
  2. protein homodimerization activity Source: BHF-UCL
  3. receptor binding Source: BHF-UCL

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  5. cellular defense response Source: ProtInc
  6. cytokine-mediated signaling pathway Source: Reactome
  7. immune response-inhibiting cell surface receptor signaling pathway Source: BHF-UCL
  8. interferon-gamma-mediated signaling pathway Source: Reactome
  9. negative regulation of dendritic cell differentiation Source: BHF-UCL
  10. negative regulation of T cell proliferation Source: BHF-UCL
  11. positive regulation of interleukin-12 production Source: BHF-UCL
  12. positive regulation of regulatory T cell differentiation Source: BHF-UCL
  13. positive regulation of T cell mediated cytotoxicity Source: InterPro
  14. positive regulation of T cell tolerance induction Source: BHF-UCL
  15. regulation of immune response Source: Reactome
  16. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, alpha chain G
Alternative name(s):
HLA G antigen
MHC class I antigen G
Gene namesi
Name:HLA-G
Synonyms:HLA-6.0, HLAG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4964. HLA-G.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284ExtracellularSequence AnalysisAdd
BLAST
Transmembranei309 – 33224HelicalSequence AnalysisAdd
BLAST
Topological domaini333 – 3386CytoplasmicSequence Analysis

GO - Cellular componenti

  1. early endosome membrane Source: Reactome
  2. ER to Golgi transport vesicle membrane Source: Reactome
  3. Golgi membrane Source: Reactome
  4. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  5. membrane Source: UniProtKB
  6. MHC class I protein complex Source: UniProtKB-KW
  7. phagocytic vesicle membrane Source: Reactome
  8. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi66 – 661C → S: Abolishes homodimerization. 1 Publication

Organism-specific databases

PharmGKBiPA35083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 338314HLA class I histocompatibility antigen, alpha chain GPRO_0000018886Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi66 – 66Interchain1 PublicationPROSITE-ProRule annotation
Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
Disulfide bondi125 ↔ 1881 PublicationPROSITE-ProRule annotation
Disulfide bondi227 ↔ 2831 PublicationPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP17693.
PaxDbiP17693.
PRIDEiP17693.

PTM databases

PhosphoSiteiP17693.

Expressioni

Tissue specificityi

Expressed in trophoblasts.

Gene expression databases

BgeeiP17693.
CleanExiHS_HLA-G.
ExpressionAtlasiP17693. baseline and differential.
GenevestigatoriP17693.

Organism-specific databases

HPAiCAB016158.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Homodimer; disulfide-linked. Binds to LILRB1 and LILRB2.2 Publications

Protein-protein interaction databases

BioGridi109380. 11 interactions.
DIPiDIP-46121N.
IntActiP17693. 1 interaction.
STRINGi9606.ENSP00000387624.

Structurei

Secondary structure

1
338
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 3610Combined sources
Beta strandi41 – 433Combined sources
Beta strandi45 – 528Combined sources
Beta strandi55 – 617Combined sources
Beta strandi64 – 663Combined sources
Beta strandi70 – 734Combined sources
Helixi74 – 763Combined sources
Helixi81 – 10828Combined sources
Beta strandi113 – 1153Combined sources
Beta strandi118 – 13215Combined sources
Beta strandi134 – 1429Combined sources
Beta strandi145 – 1506Combined sources
Beta strandi157 – 1615Combined sources
Helixi162 – 17312Combined sources
Helixi176 – 18510Combined sources
Helixi187 – 19812Combined sources
Helixi200 – 2034Combined sources
Beta strandi210 – 2189Combined sources
Turni219 – 2213Combined sources
Beta strandi222 – 23514Combined sources
Beta strandi238 – 2436Combined sources
Beta strandi246 – 2483Combined sources
Helixi249 – 2513Combined sources
Beta strandi261 – 2633Combined sources
Beta strandi265 – 27410Combined sources
Helixi278 – 2803Combined sources
Beta strandi281 – 2866Combined sources
Beta strandi290 – 2923Combined sources
Beta strandi294 – 2963Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YDPX-ray1.90A26-300[»]
2D31X-ray3.20A/D25-300[»]
2DYPX-ray2.50A25-300[»]
3BZEX-ray2.50P/Q/R/S3-11[»]
3CDGX-ray3.40P/Q3-11[»]
3CIIX-ray4.41C/F3-11[»]
3KYNX-ray2.40A26-299[»]
3KYOX-ray1.70A/C26-298[»]
ProteinModelPortaliP17693.
SMRiP17693. Positions 26-300.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17693.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29991Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42056.
HOVERGENiHBG016709.
InParanoidiP17693.
KOiK06751.
PhylomeDBiP17693.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17693-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG
60 70 80 90 100
YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM
110 120 130 140 150
NLQTLRGYYN QSEASSHTLQ WMIGCDLGSD GRLLRGYEQY AYDGKDYLAL
160 170 180 190 200
NEDLRSWTAA DTAAQISKRK CEAANVAEQR RAYLEGTCVE WLHRYLENGK
210 220 230 240 250
EMLQRADPPK THVTHHPVFD YEATLRCWAL GFYPAEIILT WQRDGEDQTQ
260 270 280 290 300
DVELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLMLRWKQ
310 320 330
SSLPTIPIMG IVAGLVVLAA VVTGAAVAAV LWRKKSSD
Length:338
Mass (Da):38,224
Last modified:August 1, 1990 - v1
Checksum:i0678E263BE8962FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17273 mRNA. Translation: CAA35174.1.
J03027 Genomic DNA. Translation: AAA98745.1.
M90683 mRNA. Translation: AAA52673.1.
AF055066 Genomic DNA. Translation: AAC24826.1.
BA000025 Genomic DNA. Translation: BAB63336.1.
CCDSiCCDS4668.1.
PIRiA39953.
RefSeqiNP_002118.1. NM_002127.5.
UniGeneiHs.512152.

Genome annotation databases

EnsembliENST00000360323; ENSP00000353472; ENSG00000204632.
ENST00000383621; ENSP00000373116; ENSG00000206506.
ENST00000423011; ENSP00000389522; ENSG00000233095.
ENST00000423373; ENSP00000405238; ENSG00000235346.
ENST00000428701; ENSP00000412927; ENSG00000204632.
ENST00000428952; ENSP00000388176; ENSG00000235680.
ENST00000444098; ENSP00000398200; ENSG00000230413.
ENST00000449127; ENSP00000408773; ENSG00000237216.
ENST00000546545; ENSP00000447762; ENSG00000230413.
ENST00000546634; ENSP00000447780; ENSG00000235346.
ENST00000547241; ENSP00000448085; ENSG00000233095.
ENST00000547931; ENSP00000448363; ENSG00000237216.
ENST00000550897; ENSP00000449903; ENSG00000235680.
ENST00000553052; ENSP00000449291; ENSG00000206506.
GeneIDi3135.
KEGGihsa:3135.
UCSCiuc003nnw.2. human.

Polymorphism databases

DMDMi122132.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17273 mRNA. Translation: CAA35174.1 .
J03027 Genomic DNA. Translation: AAA98745.1 .
M90683 mRNA. Translation: AAA52673.1 .
AF055066 Genomic DNA. Translation: AAC24826.1 .
BA000025 Genomic DNA. Translation: BAB63336.1 .
CCDSi CCDS4668.1.
PIRi A39953.
RefSeqi NP_002118.1. NM_002127.5.
UniGenei Hs.512152.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YDP X-ray 1.90 A 26-300 [» ]
2D31 X-ray 3.20 A/D 25-300 [» ]
2DYP X-ray 2.50 A 25-300 [» ]
3BZE X-ray 2.50 P/Q/R/S 3-11 [» ]
3CDG X-ray 3.40 P/Q 3-11 [» ]
3CII X-ray 4.41 C/F 3-11 [» ]
3KYN X-ray 2.40 A 26-299 [» ]
3KYO X-ray 1.70 A/C 26-298 [» ]
ProteinModelPortali P17693.
SMRi P17693. Positions 26-300.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109380. 11 interactions.
DIPi DIP-46121N.
IntActi P17693. 1 interaction.
STRINGi 9606.ENSP00000387624.

PTM databases

PhosphoSitei P17693.

Polymorphism databases

DMDMi 122132.

Proteomic databases

MaxQBi P17693.
PaxDbi P17693.
PRIDEi P17693.

Protocols and materials databases

DNASUi 3135.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360323 ; ENSP00000353472 ; ENSG00000204632 .
ENST00000383621 ; ENSP00000373116 ; ENSG00000206506 .
ENST00000423011 ; ENSP00000389522 ; ENSG00000233095 .
ENST00000423373 ; ENSP00000405238 ; ENSG00000235346 .
ENST00000428701 ; ENSP00000412927 ; ENSG00000204632 .
ENST00000428952 ; ENSP00000388176 ; ENSG00000235680 .
ENST00000444098 ; ENSP00000398200 ; ENSG00000230413 .
ENST00000449127 ; ENSP00000408773 ; ENSG00000237216 .
ENST00000546545 ; ENSP00000447762 ; ENSG00000230413 .
ENST00000546634 ; ENSP00000447780 ; ENSG00000235346 .
ENST00000547241 ; ENSP00000448085 ; ENSG00000233095 .
ENST00000547931 ; ENSP00000448363 ; ENSG00000237216 .
ENST00000550897 ; ENSP00000449903 ; ENSG00000235680 .
ENST00000553052 ; ENSP00000449291 ; ENSG00000206506 .
GeneIDi 3135.
KEGGi hsa:3135.
UCSCi uc003nnw.2. human.

Organism-specific databases

CTDi 3135.
GeneCardsi GC06P029794.
GC06Pj29788.
GC06Pk29791.
GC06Pl29791.
GC06Pm29791.
GC06Pn29791.
GC06Po29791.
H-InvDB HIX0166674.
HIX0167370.
HGNCi HGNC:4964. HLA-G.
HPAi CAB016158.
MIMi 142871. gene.
neXtProti NX_P17693.
PharmGKBi PA35083.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42056.
HOVERGENi HBG016709.
InParanoidi P17693.
KOi K06751.
PhylomeDBi P17693.
TreeFami TF336617.

Enzyme and pathway databases

Reactomei REACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSi HLA-G. human.
EvolutionaryTracei P17693.
GeneWikii HLA-G.
GenomeRNAii 3135.
NextBioi 12439.
PROi P17693.
SOURCEi Search...

Gene expression databases

Bgeei P17693.
CleanExi HS_HLA-G.
ExpressionAtlasi P17693. baseline and differential.
Genevestigatori P17693.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mRNA of a human class I gene HLA G/HLA 6.0 exhibits a restricted pattern of expression."
    Shukla H., Swaroop A., Srivastava R., Weissman S.M.
    Nucleic Acids Res. 18:2189-2189(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal eye.
  2. "A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment."
    Geraghty D.E., Koller B.H., Orr H.T.
    Proc. Natl. Acad. Sci. U.S.A. 84:9145-9149(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Ishitani A., Geraghty D.E.
    Submitted (APR-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  4. "A 356-Kb sequence of the subtelomeric part of the MHC class I region."
    Hampe A., Coriton O., Andrieux N., Carn G., Lepourcelet M., Mottier S., Dreano S., Gatius M.T., Hitte C., Soriano N., Galibert F.
    DNA Seq. 10:263-299(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: SUBUNIT, MUTAGENESIS OF CYS-66, DISULFIDE BOND AT CYS-66.
  7. "Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface."
    Clements C.S., Kjer-Nielsen L., Kostenko L., Hoare H.L., Dunstone M.A., Moses E., Freed K., Brooks A.G., Rossjohn J., McCluskey J.
    Proc. Natl. Acad. Sci. U.S.A. 102:3360-3365(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 26-300.
  8. "Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer."
    Shiroishi M., Kuroki K., Ose T., Rasubala L., Shiratori I., Arase H., Tsumoto K., Kumagai I., Kohda D., Maenaka K.
    J. Biol. Chem. 281:10439-10447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 25-300, DISULFIDE BONDS.

Entry informationi

Entry nameiHLAG_HUMAN
AccessioniPrimary (citable) accession number: P17693
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 26, 2014
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3