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P17693

- HLAG_HUMAN

UniProt

P17693 - HLAG_HUMAN

Protein

HLA class I histocompatibility antigen, alpha chain G

Gene

HLA-G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.

    GO - Molecular functioni

    1. peptide antigen binding Source: InterPro
    2. protein homodimerization activity Source: BHF-UCL
    3. receptor binding Source: BHF-UCL

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
    4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    5. cellular defense response Source: ProtInc
    6. cytokine-mediated signaling pathway Source: Reactome
    7. immune response-inhibiting cell surface receptor signaling pathway Source: BHF-UCL
    8. interferon-gamma-mediated signaling pathway Source: Reactome
    9. negative regulation of dendritic cell differentiation Source: BHF-UCL
    10. negative regulation of T cell proliferation Source: BHF-UCL
    11. positive regulation of interleukin-12 production Source: BHF-UCL
    12. positive regulation of regulatory T cell differentiation Source: BHF-UCL
    13. positive regulation of T cell mediated cytotoxicity Source: InterPro
    14. positive regulation of T cell tolerance induction Source: BHF-UCL
    15. regulation of immune response Source: Reactome
    16. type I interferon signaling pathway Source: Reactome

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class I histocompatibility antigen, alpha chain G
    Alternative name(s):
    HLA G antigen
    MHC class I antigen G
    Gene namesi
    Name:HLA-G
    Synonyms:HLA-6.0, HLAG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4964. HLA-G.

    Subcellular locationi

    GO - Cellular componenti

    1. early endosome membrane Source: Reactome
    2. ER to Golgi transport vesicle membrane Source: Reactome
    3. Golgi membrane Source: Reactome
    4. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    5. membrane Source: UniProtKB
    6. MHC class I protein complex Source: UniProtKB-KW
    7. phagocytic vesicle membrane Source: Reactome
    8. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, MHC I

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi66 – 661C → S: Abolishes homodimerization. 1 Publication

    Organism-specific databases

    PharmGKBiPA35083.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Add
    BLAST
    Chaini25 – 338314HLA class I histocompatibility antigen, alpha chain GPRO_0000018886Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi66 – 66Interchain2 PublicationsPROSITE-ProRule annotation
    Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
    Disulfide bondi125 ↔ 1881 PublicationPROSITE-ProRule annotation
    Disulfide bondi227 ↔ 2831 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP17693.
    PRIDEiP17693.

    PTM databases

    PhosphoSiteiP17693.

    Expressioni

    Tissue specificityi

    Expressed in trophoblasts.

    Gene expression databases

    ArrayExpressiP17693.
    BgeeiP17693.
    CleanExiHS_HLA-G.
    GenevestigatoriP17693.

    Organism-specific databases

    HPAiCAB016158.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Homodimer; disulfide-linked. Binds to LILRB1 and LILRB2.2 Publications

    Protein-protein interaction databases

    BioGridi109380. 10 interactions.
    DIPiDIP-46121N.
    IntActiP17693. 1 interaction.
    STRINGi9606.ENSP00000387624.

    Structurei

    Secondary structure

    1
    338
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi27 – 3610
    Beta strandi41 – 433
    Beta strandi45 – 528
    Beta strandi55 – 617
    Beta strandi64 – 663
    Beta strandi70 – 734
    Helixi74 – 763
    Helixi81 – 10828
    Beta strandi113 – 1153
    Beta strandi118 – 13215
    Beta strandi134 – 1429
    Beta strandi145 – 1506
    Beta strandi157 – 1615
    Helixi162 – 17312
    Helixi176 – 18510
    Helixi187 – 19812
    Helixi200 – 2034
    Beta strandi210 – 2189
    Turni219 – 2213
    Beta strandi222 – 23514
    Beta strandi238 – 2436
    Beta strandi246 – 2483
    Helixi249 – 2513
    Beta strandi261 – 2633
    Beta strandi265 – 27410
    Helixi278 – 2803
    Beta strandi281 – 2866
    Beta strandi290 – 2923
    Beta strandi294 – 2963

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1YDPX-ray1.90A26-300[»]
    2D31X-ray3.20A/D25-300[»]
    2DYPX-ray2.50A25-300[»]
    3BZEX-ray2.50P/Q/R/S3-11[»]
    3CDGX-ray3.40P/Q3-11[»]
    3CIIX-ray4.41C/F3-11[»]
    3KYNX-ray2.40A26-299[»]
    3KYOX-ray1.70A/C26-298[»]
    ProteinModelPortaliP17693.
    SMRiP17693. Positions 26-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP17693.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 308284ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini333 – 3386CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei309 – 33224HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini209 – 29991Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 11490Alpha-1Add
    BLAST
    Regioni115 – 20692Alpha-2Add
    BLAST
    Regioni207 – 29892Alpha-3Add
    BLAST
    Regioni299 – 30810Connecting peptide

    Sequence similaritiesi

    Belongs to the MHC class I family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42056.
    HOVERGENiHBG016709.
    InParanoidiP17693.
    KOiK06751.
    PhylomeDBiP17693.
    TreeFamiTF336617.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P17693-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG    50
    YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM 100
    NLQTLRGYYN QSEASSHTLQ WMIGCDLGSD GRLLRGYEQY AYDGKDYLAL 150
    NEDLRSWTAA DTAAQISKRK CEAANVAEQR RAYLEGTCVE WLHRYLENGK 200
    EMLQRADPPK THVTHHPVFD YEATLRCWAL GFYPAEIILT WQRDGEDQTQ 250
    DVELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLMLRWKQ 300
    SSLPTIPIMG IVAGLVVLAA VVTGAAVAAV LWRKKSSD 338
    Length:338
    Mass (Da):38,224
    Last modified:August 1, 1990 - v1
    Checksum:i0678E263BE8962FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17273 mRNA. Translation: CAA35174.1.
    J03027 Genomic DNA. Translation: AAA98745.1.
    M90683 mRNA. Translation: AAA52673.1.
    AF055066 Genomic DNA. Translation: AAC24826.1.
    BA000025 Genomic DNA. Translation: BAB63336.1.
    CCDSiCCDS4668.1.
    PIRiA39953.
    RefSeqiNP_002118.1. NM_002127.5.
    UniGeneiHs.512152.

    Genome annotation databases

    EnsembliENST00000360323; ENSP00000353472; ENSG00000204632.
    ENST00000383621; ENSP00000373116; ENSG00000206506.
    ENST00000423011; ENSP00000389522; ENSG00000233095.
    ENST00000423373; ENSP00000405238; ENSG00000235346.
    ENST00000428701; ENSP00000412927; ENSG00000204632.
    ENST00000428952; ENSP00000388176; ENSG00000235680.
    ENST00000444098; ENSP00000398200; ENSG00000230413.
    ENST00000449127; ENSP00000408773; ENSG00000237216.
    ENST00000546545; ENSP00000447762; ENSG00000230413.
    ENST00000546634; ENSP00000447780; ENSG00000235346.
    ENST00000547241; ENSP00000448085; ENSG00000233095.
    ENST00000547931; ENSP00000448363; ENSG00000237216.
    ENST00000550897; ENSP00000449903; ENSG00000235680.
    ENST00000553052; ENSP00000449291; ENSG00000206506.
    GeneIDi3135.
    KEGGihsa:3135.
    UCSCiuc003nnw.2. human.

    Polymorphism databases

    DMDMi122132.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17273 mRNA. Translation: CAA35174.1 .
    J03027 Genomic DNA. Translation: AAA98745.1 .
    M90683 mRNA. Translation: AAA52673.1 .
    AF055066 Genomic DNA. Translation: AAC24826.1 .
    BA000025 Genomic DNA. Translation: BAB63336.1 .
    CCDSi CCDS4668.1.
    PIRi A39953.
    RefSeqi NP_002118.1. NM_002127.5.
    UniGenei Hs.512152.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1YDP X-ray 1.90 A 26-300 [» ]
    2D31 X-ray 3.20 A/D 25-300 [» ]
    2DYP X-ray 2.50 A 25-300 [» ]
    3BZE X-ray 2.50 P/Q/R/S 3-11 [» ]
    3CDG X-ray 3.40 P/Q 3-11 [» ]
    3CII X-ray 4.41 C/F 3-11 [» ]
    3KYN X-ray 2.40 A 26-299 [» ]
    3KYO X-ray 1.70 A/C 26-298 [» ]
    ProteinModelPortali P17693.
    SMRi P17693. Positions 26-300.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109380. 10 interactions.
    DIPi DIP-46121N.
    IntActi P17693. 1 interaction.
    STRINGi 9606.ENSP00000387624.

    PTM databases

    PhosphoSitei P17693.

    Polymorphism databases

    DMDMi 122132.

    Proteomic databases

    PaxDbi P17693.
    PRIDEi P17693.

    Protocols and materials databases

    DNASUi 3135.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360323 ; ENSP00000353472 ; ENSG00000204632 .
    ENST00000383621 ; ENSP00000373116 ; ENSG00000206506 .
    ENST00000423011 ; ENSP00000389522 ; ENSG00000233095 .
    ENST00000423373 ; ENSP00000405238 ; ENSG00000235346 .
    ENST00000428701 ; ENSP00000412927 ; ENSG00000204632 .
    ENST00000428952 ; ENSP00000388176 ; ENSG00000235680 .
    ENST00000444098 ; ENSP00000398200 ; ENSG00000230413 .
    ENST00000449127 ; ENSP00000408773 ; ENSG00000237216 .
    ENST00000546545 ; ENSP00000447762 ; ENSG00000230413 .
    ENST00000546634 ; ENSP00000447780 ; ENSG00000235346 .
    ENST00000547241 ; ENSP00000448085 ; ENSG00000233095 .
    ENST00000547931 ; ENSP00000448363 ; ENSG00000237216 .
    ENST00000550897 ; ENSP00000449903 ; ENSG00000235680 .
    ENST00000553052 ; ENSP00000449291 ; ENSG00000206506 .
    GeneIDi 3135.
    KEGGi hsa:3135.
    UCSCi uc003nnw.2. human.

    Organism-specific databases

    CTDi 3135.
    GeneCardsi GC06P029794.
    GC06Pj29788.
    GC06Pk29791.
    GC06Pl29791.
    GC06Pm29791.
    GC06Pn29791.
    GC06Po29791.
    H-InvDB HIX0166674.
    HIX0167370.
    HGNCi HGNC:4964. HLA-G.
    HPAi CAB016158.
    MIMi 142871. gene.
    neXtProti NX_P17693.
    PharmGKBi PA35083.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42056.
    HOVERGENi HBG016709.
    InParanoidi P17693.
    KOi K06751.
    PhylomeDBi P17693.
    TreeFami TF336617.

    Enzyme and pathway databases

    Reactomei REACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Miscellaneous databases

    ChiTaRSi HLA-G. human.
    EvolutionaryTracei P17693.
    GeneWikii HLA-G.
    GenomeRNAii 3135.
    NextBioi 12439.
    PROi P17693.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P17693.
    Bgeei P17693.
    CleanExi HS_HLA-G.
    Genevestigatori P17693.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mRNA of a human class I gene HLA G/HLA 6.0 exhibits a restricted pattern of expression."
      Shukla H., Swaroop A., Srivastava R., Weissman S.M.
      Nucleic Acids Res. 18:2189-2189(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal eye.
    2. "A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment."
      Geraghty D.E., Koller B.H., Orr H.T.
      Proc. Natl. Acad. Sci. U.S.A. 84:9145-9149(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Ishitani A., Geraghty D.E.
      Submitted (APR-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    4. "A 356-Kb sequence of the subtelomeric part of the MHC class I region."
      Hampe A., Coriton O., Andrieux N., Carn G., Lepourcelet M., Mottier S., Dreano S., Gatius M.T., Hitte C., Soriano N., Galibert F.
      DNA Seq. 10:263-299(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Shiina S., Tamiya G., Oka A., Inoko H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: SUBUNIT, MUTAGENESIS OF CYS-66, DISULFIDE BOND AT CYS-66.
    7. "Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface."
      Clements C.S., Kjer-Nielsen L., Kostenko L., Hoare H.L., Dunstone M.A., Moses E., Freed K., Brooks A.G., Rossjohn J., McCluskey J.
      Proc. Natl. Acad. Sci. U.S.A. 102:3360-3365(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 26-300.
    8. "Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer."
      Shiroishi M., Kuroki K., Ose T., Rasubala L., Shiratori I., Arase H., Tsumoto K., Kumagai I., Kohda D., Maenaka K.
      J. Biol. Chem. 281:10439-10447(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 25-300, DISULFIDE BONDS.

    Entry informationi

    Entry nameiHLAG_HUMAN
    AccessioniPrimary (citable) accession number: P17693
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 147 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3