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Protein

Conantokin-T

Gene
N/A
Organism
Conus tulipa (Fish-hunting cone snail) (Tulip cone)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin inhibits both NR2A/GRIN2A and NR2B/GRIN2B subunits of N-methyl-D-aspartate (NMDA) receptor-mediated calcium influx in central nervous system neurons. Induces sleep-like symptoms in young mice and hyperactivity in older mice.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei5 – 51Important for selectivity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Ionotropic glutamate receptor inhibitor, Neurotoxin, Postsynaptic neurotoxin, Toxin

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Conantokin-T
Short name:
Con-T
OrganismiConus tulipa (Fish-hunting cone snail) (Tulip cone)
Taxonomic identifieri6495 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri1269. Conantokin-T.

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Failed in phase II clinical trial. Was tested by Cognetix Inc. to treat antinociceptive effects in several models of injury-induced pain.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi5 – 51Y → F: No loss of inhibition of NR1a/NR2B receptor; little loss of inhibition of NR1a/NR2A receptor. 1 Publication
Mutagenesisi5 – 51Y → V: Little loss of inhibition of NR1a/NR2B receptor; important loss of inhibition of NR1a/NR2A receptor. 1 Publication
Mutagenesisi5 – 51Y → W: Little loss of inhibition of NR1a/NR2B receptor; complete loss of inhibition of NR1a/NR2A receptor. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 2121Conantokin-TPRO_0000044504Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei3 – 314-carboxyglutamate1 Publication
Modified residuei4 – 414-carboxyglutamate1 Publication
Modified residuei10 – 1014-carboxyglutamate1 Publication
Modified residuei14 – 1414-carboxyglutamate1 Publication
Modified residuei21 – 211Alanine amide1 Publication

Keywords - PTMi

Amidation, Gamma-carboxyglutamic acid

Expressioni

Tissue specificityi

Expressed by the venom duct.Curated

Structurei

Secondary structure

1
21
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 2018Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ONTNMR-A1-21[»]
2DPRX-ray1.70A/B1-21[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17684.

Family & Domainsi

Sequence similaritiesi

Belongs to the conotoxin B superfamily.Curated

Family and domain databases

InterProiIPR005918. Conantokin_CS.
[Graphical view]
PfamiPF10550. Toxin_36. 1 hit.
[Graphical view]
PROSITEiPS60025. CONANTOKIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
GEEEYQKMLE NLREAEVKKN A
Length:21
Mass (Da):2,509
Last modified:August 1, 1990 - v1
Checksum:i7F7B893AC4842C38
GO

Sequence databases

PIRiA35225.

Cross-referencesi

Sequence databases

PIRiA35225.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ONTNMR-A1-21[»]
2DPRX-ray1.70A/B1-21[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1269. Conantokin-T.

Miscellaneous databases

EvolutionaryTraceiP17684.

Family and domain databases

InterProiIPR005918. Conantokin_CS.
[Graphical view]
PfamiPF10550. Toxin_36. 1 hit.
[Graphical view]
PROSITEiPS60025. CONANTOKIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCKT_CONTU
AccessioniPrimary (citable) accession number: P17684
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 22, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

The mature peptide does not contain cysteine residue.Curated

Keywords - Technical termi

3D-structure, Direct protein sequencing, Pharmaceutical

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.