ID NEUM_HUMAN Reviewed; 238 AA. AC P17677; DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1990, sequence version 1. DT 13-OCT-2009, entry version 107. DE RecName: Full=Neuromodulin; DE AltName: Full=Axonal membrane protein GAP-43; DE AltName: Full=Growth-associated protein 43; DE AltName: Full=PP46; DE AltName: Full=Neural phosphoprotein B-50; GN Name=GAP43; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=90166498; PubMed=3272162; DOI=10.1016/0896-6273(88)90196-1; RA Kosik K.S., Orecchio L.D., Bruns G.A.P., Benowitz L.I., McDonald G.P., RA Cox D.R., Neve R.; RT "Human GAP-43: its deduced amino acid sequence and chromosomal RT localization in mouse and human."; RL Neuron 1:127-132(1988). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=90166499; PubMed=3272163; DOI=10.1016/0896-6273(88)90197-3; RA Ng S.-C., de la Monte S.M., Conboy G.L., Karns L.R., Fishman M.C.; RT "Cloning of human GAP-43: growth association and ischemic RT resurgence."; RL Neuron 1:133-139(1988). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=94049025; PubMed=8231732; DOI=10.1016/0169-328X(93)90128-C; RA Nielander H.B., de Groen P.C., Eggen B.J., Schrama L.H., Gispen W.H., RA Schotman P.; RT "Structure of the human gene for the neural phosphoprotein B-50 (GAP- RT 43)."; RL Brain Res. Mol. Brain Res. 19:293-302(1993). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RG NIEHS SNPs program; RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP VARIANT ILE-59. RX MEDLINE=99318093; PubMed=10391209; DOI=10.1038/10290; RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RT "Characterization of single-nucleotide polymorphisms in coding regions RT of human genes."; RL Nat. Genet. 22:231-238(1999). RN [7] RP ERRATUM. RA Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., RA Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., RA Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., RA Lander E.S.; RL Nat. Genet. 23:373-373(1999). CC -!- FUNCTION: This protein is associated with nerve growth. It is a CC major component of the motile "growth cones" that form the tips of CC elongating axons. CC -!- SUBUNIT: Binds calmodulin with a greater affinity in the absence CC of Ca(2+) than in its presence (By similarity). CC -!- INTERACTION: CC Q05655:PRKCD; NbExp=3; IntAct=EBI-1267511, EBI-704279; CC -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; CC Cytoplasmic side. Cell projection, growth cone membrane; CC Peripheral membrane protein; Cytoplasmic side. Cell junction, CC synapse. Note=Cytoplasmic surface of growth cone and synaptic CC plasma membranes. CC -!- PTM: Phosphorylation of this protein by a protein kinase C is CC specifically correlated with certain forms of synaptic plasticity. CC -!- SIMILARITY: Belongs to the neuromodulin family. CC -!- SIMILARITY: Contains 1 IQ domain. CC -!- WEB RESOURCE: Name=NIEHS-SNPs; CC URL="http://egp.gs.washington.edu/data/gap43/"; CC -!- WEB RESOURCE: Name=Wikipedia; Note=Gap-43 entry; CC URL="http://en.wikipedia.org/wiki/Gap-43_protein"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M25667; AAA52516.1; -; mRNA. DR EMBL; S66541; AAB28649.1; -; Genomic_DNA. DR EMBL; S66533; AAB28649.1; JOINED; Genomic_DNA. DR EMBL; S66534; AAB28649.1; JOINED; Genomic_DNA. DR EMBL; AY842481; AAV88094.1; -; Genomic_DNA. DR EMBL; BC007936; AAH07936.1; -; mRNA. DR IPI; IPI00015964; -. DR PIR; I52638; I52638. DR RefSeq; NP_002036.1; -. DR UniGene; Hs.134974; -. DR DIP; DIP:452N; -. DR IntAct; P17677; 1. DR STRING; P17677; -. DR PhosphoSite; P17677; -. DR PRIDE; P17677; -. DR Ensembl; ENST00000305124; ENSP00000305010; ENSG00000172020; Homo sapiens. DR Ensembl; ENST00000393780; ENSP00000377372; ENSG00000172020; Homo sapiens. DR GeneID; 2596; -. DR UCSC; uc003ebq.1; human. DR CTD; 2596; -. DR GeneCards; GC03P116825; -. DR H-InvDB; HIX0003572; -. DR HGNC; HGNC:4140; GAP43. DR HPA; CAB004417; -. DR HPA; HPA013392; -. DR HPA; HPA015600; -. DR MIM; 162060; gene. DR PharmGKB; PA28553; -. DR HOGENOM; P17677; -. DR HOVERGEN; P17677; -. DR NextBio; 10267; -. DR ArrayExpress; P17677; -. DR Bgee; P17677; -. DR CleanEx; HS_GAP43; -. DR Genevestigator; P17677; -. DR GermOnline; ENSG00000172020; Homo sapiens. DR GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW. DR GO; GO:0009898; C:internal side of plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell. DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW. DR GO; GO:0007205; P:activation of protein kinase C activity by ...; TAS:ProtInc. DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW. DR InterPro; IPR000048; IQ_CaM_bd_region. DR InterPro; IPR001422; Neuromodulin. DR InterPro; IPR017454; Neuromodulin_C. DR InterPro; IPR018947; Neuromodulin_gap-junction_N. DR InterPro; IPR018243; Neuromodulin_palmitoyl/P_site. DR Pfam; PF00612; IQ; 1. DR Pfam; PF06614; Neuromodulin; 1. DR Pfam; PF10580; Neuromodulin_N; 1. DR PRINTS; PR00215; NEUROMODULIN. DR SMART; SM00015; IQ; 1. DR PROSITE; PS50096; IQ; 1. DR PROSITE; PS00412; NEUROMODULIN_1; 1. DR PROSITE; PS00413; NEUROMODULIN_2; 1. PE 1: Evidence at protein level; KW Calmodulin-binding; Cell junction; Cell membrane; Cell projection; KW Complete proteome; Developmental protein; Differentiation; KW Growth regulation; Lipoprotein; Membrane; Neurogenesis; Palmitate; KW Phosphoprotein; Polymorphism; Synapse. FT CHAIN 1 238 Neuromodulin. FT /FTId=PRO_0000159596. FT DOMAIN 31 60 IQ. FT REGION 1 4 Important for membrane binding. FT MOD_RES 41 41 Phosphoserine (By similarity). FT MOD_RES 94 94 Phosphothreonine (By similarity). FT MOD_RES 181 181 Phosphothreonine (By similarity). FT MOD_RES 202 202 Phosphoserine; by CK2 (By similarity). FT MOD_RES 203 203 Phosphoserine; by CK2 (By similarity). FT LIPID 3 3 S-palmitoyl cysteine (By similarity). FT LIPID 4 4 S-palmitoyl cysteine (By similarity). FT VARIANT 59 59 V -> I (in dbSNP:rs6291). FT /FTId=VAR_014172. FT VARIANT 162 162 K -> E (in dbSNP:rs11557762). FT /FTId=VAR_050271. SQ SEQUENCE 238 AA; 24803 MW; B3536D012A127CC8 CRC64; MLCCMRRTKQ VEKNDDDQKI EQDGIKPEDK AHKAATKIQA SFRGHITRKK LKGEKKDDVQ AAEAEANKKD EAPVADGVEK KGEGTTTAEA APATGSKPDE PGKAGETPSE EKKGEGDAAT EQAAPQAPAS SEEKAGSAET ESATKASTDN SPSSKAEDAP AKEEPKQADV PAAVTAAAAT TPAAEDAAAK ATAQPPTETG ESSQAEENIE AVDETKPKES ARQDEGKEEE PEADQEHA //