Reviewed,
UniProtKB/Swiss-Prot P17677 (NEUM_HUMAN)
Last modified
July 7, 2009.
Version 103.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Neuromodulin Alternative name(s): Axonal membrane protein GAP-43 Growth-associated protein 43 PP46 Neural phosphoprotein B-50 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 238 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. |
| Subunit structure | Binds calmodulin with a greater affinity in the absence of Ca2+ than in its presence By similarity. |
| Subcellular location | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection › growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction › synapse. Note: Cytoplasmic surface of growth cone and synaptic plasma membranes. |
| Post-translational modification | Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity. |
| Sequence similarities | Belongs to the neuromodulin family. Contains 1 IQ domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Differentiation Growth regulation Neurogenesis |
| Cellular component | Cell junction Cell membrane Cell projection Membrane Synapse |
| Coding sequence diversity | Polymorphism |
| Ligand | Calmodulin-binding |
| Molecular function | Developmental protein |
| PTM | Lipoprotein Palmitate Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway Ref.1 Traceable author statement. Source: ProtInc regulation of growthInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cell junction Inferred from electronic annotation. Source: UniProtKB-SubCell growth cone membraneInferred from electronic annotation. Source: UniProtKB-SubCell synapseInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 238 | 238 | Neuromodulin | PRO_0000159596 | |||||
Regions | |||||||||
| Domain | 31 – 60 | 30 | IQ | ||||||
| Region | 1 – 4 | 4 | Important for membrane binding | ||||||
Amino acid modifications | |||||||||
| Modified residue | 41 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 94 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 181 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 202 | 1 | Phosphoserine; by CK2 By similarity | ||||||
| Modified residue | 203 | 1 | Phosphoserine; by CK2 By similarity | ||||||
| Lipidation | 3 | 1 | S-palmitoyl cysteine By similarity | ||||||
| Lipidation | 4 | 1 | S-palmitoyl cysteine By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 59 | 1 | V → I: dbSNP rs6291. Ref.6 | VAR_014172 | |||||
| Natural variant | 162 | 1 | K → E: dbSNP rs11557762. | VAR_050271 | |||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| M25667 mRNA. Translation: AAA52516.1. S66541, S66533, S66534 Genomic DNA. Translation: AAB28649.1. AY842481 Genomic DNA. Translation: AAV88094.1. BC007936 mRNA. Translation: AAH07936.1. | |
| IPI | IPI00015964. |
| PIR | I52638. |
| RefSeq | NP_002036.1. |
| UniGene | Hs.134974 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:452N. |
| IntAct | P17677. 1 interaction. |
PTM databases | |
| PhosphoSite | P17677. |
Proteomic databases | |
| PRIDE | P17677. |
Genome annotation databases | |
| Ensembl | ENSG00000172020. Homo sapiens. [Contig view] |
| GeneID | 2596. |
| UCSC | uc003ebq.1. human. |
Organism-specific databases | |
| GeneCards | GC03P116825. |
| H-InvDB | HIX0003572. |
| HGNC | HGNC:4140. GAP43. |
| HPA | CAB004417. HPA013392. HPA015600. |
| MIM | 162060. gene. |
| PharmGKB | PA28553. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P17677. |
| HOVERGEN | P17677. |
Gene expression databases | |
| ArrayExpress | P17677. |
| Bgee | P17677. |
| CleanEx | HS_GAP43. |
| GermOnline | ENSG00000172020. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000048. IQ_CaM_bd_region. IPR001422. Neuromodulin. IPR017454. Neuromodulin_C. IPR018947. Neuromodulin_gap-junction_N. IPR018243. Neuromodulin_palmitoyl/P. [Graphical view] |
| Pfam | PF00612. IQ. 1 hit. PF06614. Neuromodulin. 1 hit. PF10580. Neuromodulin_N. 1 hit. [Graphical view] |
| PRINTS | PR00215. NEUROMODULIN. |
| SMART | SM00015. IQ. 1 hit. [Graphical view] |
| PROSITE | PS50096. IQ. 1 hit. PS00412. NEUROMODULIN_1. 1 hit. PS00413. NEUROMODULIN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 10267. |
| SOURCE | Search... |
Entry information
| Entry name | NEUM_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P17677 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


