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P17666 (CP2CE_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C14

EC=1.14.14.1
Alternative name(s):
CYPIIC14
Cytochrome P450 PHP3
Gene names
Name:CYP2C14
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Cytochrome P450 2C14
PRO_0000051704

Sites

Metal binding4351Iron (heme axial ligand)

Sequences

Sequence LengthMass (Da)Tools
P17666 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 2572163B0AAA076E

FASTA49055,721
        10         20         30         40         50         60 
MDPVVVLVLC LSCLLLLSLW KQSHGGGKLP PGPTPLPILG NILQIDFKDI SKSLQNLSKV 

        70         80         90        100        110        120 
YGNVFTVYMG MKPTVVMYGY EAVKEALVDL GEEFSGRNLS PINKKVNKGL GVIFSNGKRW 

       130        140        150        160        170        180 
KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR CLVEELRKTN GSPCDPTFIL GAAPCNVICS 

       190        200        210        220        230        240 
VIFQNRFDYK DETFLNLMGK FNENFRILNS PWLQVCNIFP ILMDYLPGTH KTVFENFDYV 

       250        260        270        280        290        300 
RNFVLEKTKE HQESLDINNP RDFIDCFLIK MKQEKHNQQS EFTIENLMAT VTDVFAAGTE 

       310        320        330        340        350        360 
TTSTTLRYGL LLLMKHPEVT AKVQEEIERV IGRHRSPCMQ DRSRMPYTDA TVHEIQRYIN 

       370        380        390        400        410        420 
LVPNNVPHAT TCNVKFRNYF IPKGTAVLTS LTSVLHDNQE FLKPDKFDPG HFLDASGNFK 

       430        440        450        460        470        480 
KSDYFMPFST GKRVCMGEAL ARMELFLFLT AILQNFTLKP LVDPKDIDTT PLVSGARSCA 

       490 
TLYQLSFIPA 

« Hide

References

[1]"Cytochrome P-450 related to P-4504 from phenobarbital-treated rabbit liver: molecular cloning of cDNA and characterization of cytochrome P-450 obtained by its expression in yeast cells."
Imai Y.
J. Biochem. 101:1129-1139(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D00190 mRNA. Translation: BAA00130.1.
PIRA26921.
RefSeqNP_001164591.1. NM_001171120.1.
UniGeneOcu.2494.

3D structure databases

ProteinModelPortalP17666.
SMRP17666. Positions 28-489.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100328936.

Organism-specific databases

CTD100328936.

Phylogenomic databases

HOGENOMHOG000036992.
HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2CE_RABIT
AccessionPrimary (citable) accession number: P17666
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: December 11, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families