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P17666

- CP2CE_RABIT

UniProt

P17666 - CP2CE_RABIT

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Protein

Cytochrome P450 2C14

Gene

CYP2C14

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C14 (EC:1.14.14.1)
Alternative name(s):
CYPIIC14
Cytochrome P450 PHP3
Gene namesi
Name:CYP2C14
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C14PRO_0000051704Add
BLAST

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Structurei

3D structure databases

ProteinModelPortaliP17666.
SMRiP17666. Positions 28-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP17666.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17666-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPVVVLVLC LSCLLLLSLW KQSHGGGKLP PGPTPLPILG NILQIDFKDI
60 70 80 90 100
SKSLQNLSKV YGNVFTVYMG MKPTVVMYGY EAVKEALVDL GEEFSGRNLS
110 120 130 140 150
PINKKVNKGL GVIFSNGKRW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTN GSPCDPTFIL GAAPCNVICS VIFQNRFDYK DETFLNLMGK
210 220 230 240 250
FNENFRILNS PWLQVCNIFP ILMDYLPGTH KTVFENFDYV RNFVLEKTKE
260 270 280 290 300
HQESLDINNP RDFIDCFLIK MKQEKHNQQS EFTIENLMAT VTDVFAAGTE
310 320 330 340 350
TTSTTLRYGL LLLMKHPEVT AKVQEEIERV IGRHRSPCMQ DRSRMPYTDA
360 370 380 390 400
TVHEIQRYIN LVPNNVPHAT TCNVKFRNYF IPKGTAVLTS LTSVLHDNQE
410 420 430 440 450
FLKPDKFDPG HFLDASGNFK KSDYFMPFST GKRVCMGEAL ARMELFLFLT
460 470 480 490
AILQNFTLKP LVDPKDIDTT PLVSGARSCA TLYQLSFIPA
Length:490
Mass (Da):55,721
Last modified:August 1, 1990 - v1
Checksum:i2572163B0AAA076E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00190 mRNA. Translation: BAA00130.1.
PIRiA26921.
RefSeqiNP_001164591.1. NM_001171120.1.
UniGeneiOcu.2494.

Genome annotation databases

GeneIDi100328936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00190 mRNA. Translation: BAA00130.1 .
PIRi A26921.
RefSeqi NP_001164591.1. NM_001171120.1.
UniGenei Ocu.2494.

3D structure databases

ProteinModelPortali P17666.
SMRi P17666. Positions 28-489.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100328936.

Organism-specific databases

CTDi 100328936.

Phylogenomic databases

HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi P17666.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cytochrome P-450 related to P-4504 from phenobarbital-treated rabbit liver: molecular cloning of cDNA and characterization of cytochrome P-450 obtained by its expression in yeast cells."
    Imai Y.
    J. Biochem. 101:1129-1139(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP2CE_RABIT
AccessioniPrimary (citable) accession number: P17666
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3