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Protein

Cytochrome P450 2C14

Gene

CYP2C14

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C14 (EC:1.14.14.1)
Alternative name(s):
CYPIIC14
Cytochrome P450 PHP3
Gene namesi
Name:CYP2C14
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517041 – 490Cytochrome P450 2C14Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei100PhosphoserineBy similarity1
Modified residuei127PhosphoserineBy similarity1
Modified residuei249N6-acetyllysineBy similarity1
Modified residuei375N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Structurei

3D structure databases

ProteinModelPortaliP17666.
SMRiP17666.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP17666.
KOiK07413.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

P17666-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPVVVLVLC LSCLLLLSLW KQSHGGGKLP PGPTPLPILG NILQIDFKDI
60 70 80 90 100
SKSLQNLSKV YGNVFTVYMG MKPTVVMYGY EAVKEALVDL GEEFSGRNLS
110 120 130 140 150
PINKKVNKGL GVIFSNGKRW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR
160 170 180 190 200
CLVEELRKTN GSPCDPTFIL GAAPCNVICS VIFQNRFDYK DETFLNLMGK
210 220 230 240 250
FNENFRILNS PWLQVCNIFP ILMDYLPGTH KTVFENFDYV RNFVLEKTKE
260 270 280 290 300
HQESLDINNP RDFIDCFLIK MKQEKHNQQS EFTIENLMAT VTDVFAAGTE
310 320 330 340 350
TTSTTLRYGL LLLMKHPEVT AKVQEEIERV IGRHRSPCMQ DRSRMPYTDA
360 370 380 390 400
TVHEIQRYIN LVPNNVPHAT TCNVKFRNYF IPKGTAVLTS LTSVLHDNQE
410 420 430 440 450
FLKPDKFDPG HFLDASGNFK KSDYFMPFST GKRVCMGEAL ARMELFLFLT
460 470 480 490
AILQNFTLKP LVDPKDIDTT PLVSGARSCA TLYQLSFIPA
Length:490
Mass (Da):55,721
Last modified:August 1, 1990 - v1
Checksum:i2572163B0AAA076E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00190 mRNA. Translation: BAA00130.1.
PIRiA26921.
RefSeqiNP_001164591.1. NM_001171120.1.
UniGeneiOcu.2494.

Genome annotation databases

GeneIDi100328936.
KEGGiocu:100328936.

Similar proteinsi

Entry informationi

Entry nameiCP2CE_RABIT
AccessioniPrimary (citable) accession number: P17666
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: August 30, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families