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P17666

- CP2CE_RABIT

UniProt

P17666 - CP2CE_RABIT

Protein

Cytochrome P450 2C14

Gene

CYP2C14

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C14 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC14
    Cytochrome P450 PHP3
    Gene namesi
    Name:CYP2C14
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490Cytochrome P450 2C14PRO_0000051704Add
    BLAST

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Structurei

    3D structure databases

    ProteinModelPortaliP17666.
    SMRiP17666. Positions 28-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P17666-1 [UniParc]FASTAAdd to Basket

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    MDPVVVLVLC LSCLLLLSLW KQSHGGGKLP PGPTPLPILG NILQIDFKDI    50
    SKSLQNLSKV YGNVFTVYMG MKPTVVMYGY EAVKEALVDL GEEFSGRNLS 100
    PINKKVNKGL GVIFSNGKRW KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR 150
    CLVEELRKTN GSPCDPTFIL GAAPCNVICS VIFQNRFDYK DETFLNLMGK 200
    FNENFRILNS PWLQVCNIFP ILMDYLPGTH KTVFENFDYV RNFVLEKTKE 250
    HQESLDINNP RDFIDCFLIK MKQEKHNQQS EFTIENLMAT VTDVFAAGTE 300
    TTSTTLRYGL LLLMKHPEVT AKVQEEIERV IGRHRSPCMQ DRSRMPYTDA 350
    TVHEIQRYIN LVPNNVPHAT TCNVKFRNYF IPKGTAVLTS LTSVLHDNQE 400
    FLKPDKFDPG HFLDASGNFK KSDYFMPFST GKRVCMGEAL ARMELFLFLT 450
    AILQNFTLKP LVDPKDIDTT PLVSGARSCA TLYQLSFIPA 490
    Length:490
    Mass (Da):55,721
    Last modified:August 1, 1990 - v1
    Checksum:i2572163B0AAA076E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00190 mRNA. Translation: BAA00130.1.
    PIRiA26921.
    RefSeqiNP_001164591.1. NM_001171120.1.
    UniGeneiOcu.2494.

    Genome annotation databases

    GeneIDi100328936.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00190 mRNA. Translation: BAA00130.1 .
    PIRi A26921.
    RefSeqi NP_001164591.1. NM_001171120.1.
    UniGenei Ocu.2494.

    3D structure databases

    ProteinModelPortali P17666.
    SMRi P17666. Positions 28-489.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100328936.

    Organism-specific databases

    CTDi 100328936.

    Phylogenomic databases

    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cytochrome P-450 related to P-4504 from phenobarbital-treated rabbit liver: molecular cloning of cDNA and characterization of cytochrome P-450 obtained by its expression in yeast cells."
      Imai Y.
      J. Biochem. 101:1129-1139(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCP2CE_RABIT
    AccessioniPrimary (citable) accession number: P17666
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3