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Protein

Cytochrome c oxidase subunit 7C, mitochondrial

Gene

Cox7c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BRENDAi1.9.3.1. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIc
Gene namesi
Name:Cox7c
Synonyms:Cox7c1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:103226. Cox7c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 33Mitochondrial matrixBy similarityAdd BLAST17
Transmembranei34 – 60HelicalBy similarityAdd BLAST27
Topological domaini61 – 63Mitochondrial intermembraneBy similarity3

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrial respiratory chain complex IV Source: GO_Central
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16MitochondrionBy similarityAdd BLAST16
ChainiPRO_000000616617 – 63Cytochrome c oxidase subunit 7C, mitochondrialAdd BLAST47

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25N6-acetyllysine; alternateCombined sources1
Modified residuei25N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP17665.
MaxQBiP17665.
PaxDbiP17665.
PeptideAtlasiP17665.
PRIDEiP17665.
TopDownProteomicsiP17665.

PTM databases

iPTMnetiP17665.
PhosphoSitePlusiP17665.

Expressioni

Gene expression databases

BgeeiENSMUSG00000017778.
CleanExiMM_COX7C.
ExpressionAtlasiP17665. baseline and differential.
GenevisibleiP17665. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115419.

Structurei

3D structure databases

ProteinModelPortaliP17665.
SMRiP17665.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIc family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4527. Eukaryota.
ENOG4112B97. LUCA.
GeneTreeiENSGT00390000018086.
HOVERGENiHBG051093.
InParanoidiP17665.
KOiK02272.
OMAiVRHQILK.
OrthoDBiEOG091G16OJ.
PhylomeDBiP17665.
TreeFamiTF105069.

Family and domain databases

CDDicd00929. Cyt_c_Oxidase_VIIc. 1 hit.
Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PANTHERiPTHR13313. PTHR13313. 1 hit.
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17665-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGQSIRRFT TSVVRRSHYE EGPGKNLPFS VENKWRLLAM MTVYFGSGFA
60
APFFIVRHQL LKK
Length:63
Mass (Da):7,333
Last modified:August 1, 1990 - v1
Checksum:iC6A2AD4ABFEB2C7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52940 mRNA. Translation: CAA37115.1.
AK002494 mRNA. Translation: BAB22142.1.
AK027989 mRNA. Translation: BAC25693.1.
AK131871 mRNA. Translation: BAE20843.1.
AK153444 mRNA. Translation: BAE31999.1.
AK168077 mRNA. Translation: BAE40050.1.
BC010772 mRNA. Translation: AAH10772.1.
BC086792 mRNA. Translation: AAH86792.1.
CCDSiCCDS26668.1.
PIRiS10303.
RefSeqiNP_031775.1. NM_007749.3.
UniGeneiMm.378898.
Mm.439961.

Genome annotation databases

EnsembliENSMUST00000131011; ENSMUSP00000115419; ENSMUSG00000017778.
GeneIDi12867.
KEGGimmu:12867.
UCSCiuc007riy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52940 mRNA. Translation: CAA37115.1.
AK002494 mRNA. Translation: BAB22142.1.
AK027989 mRNA. Translation: BAC25693.1.
AK131871 mRNA. Translation: BAE20843.1.
AK153444 mRNA. Translation: BAE31999.1.
AK168077 mRNA. Translation: BAE40050.1.
BC010772 mRNA. Translation: AAH10772.1.
BC086792 mRNA. Translation: AAH86792.1.
CCDSiCCDS26668.1.
PIRiS10303.
RefSeqiNP_031775.1. NM_007749.3.
UniGeneiMm.378898.
Mm.439961.

3D structure databases

ProteinModelPortaliP17665.
SMRiP17665.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115419.

PTM databases

iPTMnetiP17665.
PhosphoSitePlusiP17665.

Proteomic databases

EPDiP17665.
MaxQBiP17665.
PaxDbiP17665.
PeptideAtlasiP17665.
PRIDEiP17665.
TopDownProteomicsiP17665.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000131011; ENSMUSP00000115419; ENSMUSG00000017778.
GeneIDi12867.
KEGGimmu:12867.
UCSCiuc007riy.1. mouse.

Organism-specific databases

CTDi1350.
MGIiMGI:103226. Cox7c.

Phylogenomic databases

eggNOGiKOG4527. Eukaryota.
ENOG4112B97. LUCA.
GeneTreeiENSGT00390000018086.
HOVERGENiHBG051093.
InParanoidiP17665.
KOiK02272.
OMAiVRHQILK.
OrthoDBiEOG091G16OJ.
PhylomeDBiP17665.
TreeFamiTF105069.

Enzyme and pathway databases

BRENDAi1.9.3.1. 3474.

Miscellaneous databases

PROiP17665.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017778.
CleanExiMM_COX7C.
ExpressionAtlasiP17665. baseline and differential.
GenevisibleiP17665. MM.

Family and domain databases

CDDicd00929. Cyt_c_Oxidase_VIIc. 1 hit.
Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PANTHERiPTHR13313. PTHR13313. 1 hit.
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX7C_MOUSE
AccessioniPrimary (citable) accession number: P17665
Secondary accession number(s): Q3U5S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.