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Protein

Cytochrome c oxidase subunit 7C, mitochondrial

Gene

Cox7c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BRENDAi1.9.3.1. 3474.
ReactomeiR-MMU-5628897. TP53 Regulates Metabolic Genes.
R-MMU-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIc
Gene namesi
Name:Cox7c
Synonyms:Cox7c1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:103226. Cox7c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 3317Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei34 – 6027HelicalBy similarityAdd
BLAST
Topological domaini61 – 633Mitochondrial intermembraneBy similarity

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1616MitochondrionBy similarityAdd
BLAST
Chaini17 – 6347Cytochrome c oxidase subunit 7C, mitochondrialPRO_0000006166Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251N6-acetyllysine; alternateCombined sources
Modified residuei25 – 251N6-succinyllysine; alternateCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP17665.
MaxQBiP17665.
PaxDbiP17665.
PRIDEiP17665.
TopDownProteomicsiP17665.

PTM databases

iPTMnetiP17665.
PhosphoSiteiP17665.

Expressioni

Gene expression databases

BgeeiP17665.
CleanExiMM_COX7C.
ExpressionAtlasiP17665. baseline.
GenevisibleiP17665. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115419.

Structurei

3D structure databases

ProteinModelPortaliP17665.
SMRiP17665. Positions 18-63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIc family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4527. Eukaryota.
ENOG4112B97. LUCA.
GeneTreeiENSGT00390000018086.
HOVERGENiHBG051093.
InParanoidiP17665.
KOiK02272.
OMAiVRHQILK.
PhylomeDBiP17665.
TreeFamiTF105069.

Family and domain databases

Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PANTHERiPTHR13313. PTHR13313. 1 hit.
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17665-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGQSIRRFT TSVVRRSHYE EGPGKNLPFS VENKWRLLAM MTVYFGSGFA
60
APFFIVRHQL LKK
Length:63
Mass (Da):7,333
Last modified:August 1, 1990 - v1
Checksum:iC6A2AD4ABFEB2C7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52940 mRNA. Translation: CAA37115.1.
AK002494 mRNA. Translation: BAB22142.1.
AK027989 mRNA. Translation: BAC25693.1.
AK131871 mRNA. Translation: BAE20843.1.
AK153444 mRNA. Translation: BAE31999.1.
AK168077 mRNA. Translation: BAE40050.1.
BC010772 mRNA. Translation: AAH10772.1.
BC086792 mRNA. Translation: AAH86792.1.
CCDSiCCDS26668.1.
PIRiS10303.
RefSeqiNP_031775.1. NM_007749.3.
XP_006543745.1. XM_006543682.2.
UniGeneiMm.378898.
Mm.439961.

Genome annotation databases

EnsembliENSMUST00000131011; ENSMUSP00000115419; ENSMUSG00000017778.
GeneIDi102642884.
12867.
KEGGimmu:102642884.
mmu:12867.
UCSCiuc007riy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52940 mRNA. Translation: CAA37115.1.
AK002494 mRNA. Translation: BAB22142.1.
AK027989 mRNA. Translation: BAC25693.1.
AK131871 mRNA. Translation: BAE20843.1.
AK153444 mRNA. Translation: BAE31999.1.
AK168077 mRNA. Translation: BAE40050.1.
BC010772 mRNA. Translation: AAH10772.1.
BC086792 mRNA. Translation: AAH86792.1.
CCDSiCCDS26668.1.
PIRiS10303.
RefSeqiNP_031775.1. NM_007749.3.
XP_006543745.1. XM_006543682.2.
UniGeneiMm.378898.
Mm.439961.

3D structure databases

ProteinModelPortaliP17665.
SMRiP17665. Positions 18-63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115419.

PTM databases

iPTMnetiP17665.
PhosphoSiteiP17665.

Proteomic databases

EPDiP17665.
MaxQBiP17665.
PaxDbiP17665.
PRIDEiP17665.
TopDownProteomicsiP17665.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000131011; ENSMUSP00000115419; ENSMUSG00000017778.
GeneIDi102642884.
12867.
KEGGimmu:102642884.
mmu:12867.
UCSCiuc007riy.1. mouse.

Organism-specific databases

CTDi1350.
MGIiMGI:103226. Cox7c.

Phylogenomic databases

eggNOGiKOG4527. Eukaryota.
ENOG4112B97. LUCA.
GeneTreeiENSGT00390000018086.
HOVERGENiHBG051093.
InParanoidiP17665.
KOiK02272.
OMAiVRHQILK.
PhylomeDBiP17665.
TreeFamiTF105069.

Enzyme and pathway databases

BRENDAi1.9.3.1. 3474.
ReactomeiR-MMU-5628897. TP53 Regulates Metabolic Genes.
R-MMU-611105. Respiratory electron transport.

Miscellaneous databases

NextBioi282444.
PROiP17665.
SOURCEiSearch...

Gene expression databases

BgeeiP17665.
CleanExiMM_COX7C.
ExpressionAtlasiP17665. baseline.
GenevisibleiP17665. MM.

Family and domain databases

Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PANTHERiPTHR13313. PTHR13313. 1 hit.
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a cDNA for mouse cytochrome c oxidase subunit VIIc."
    Akamatsu M., Grossman L.I.
    Nucleic Acids Res. 18:3645-3645(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Heart.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Kidney and Small intestine.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain and Colon.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 37-57, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue and Kidney.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCOX7C_MOUSE
AccessioniPrimary (citable) accession number: P17665
Secondary accession number(s): Q3U5S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: March 16, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.