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P17659 (KCNA6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily A member 6
Alternative name(s):
RCK2
Voltage-gated potassium channel subunit Kv1.6
Voltage-gated potassium channel subunit Kv2
Gene names
Name:Kcna6
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit structure

Heterotetramer of potassium channel proteins By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Domain

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530Potassium voltage-gated channel subfamily A member 6
PRO_0000053992

Regions

Transmembrane175 – 19319Helical; Name=Segment S1; Potential
Transmembrane264 – 28522Helical; Name=Segment S2; Potential
Transmembrane297 – 31721Helical; Name=Segment S3; Potential
Transmembrane341 – 36121Helical; Voltage-sensor; Name=Segment S4; Potential
Transmembrane377 – 39721Helical; Name=Segment S5; Potential
Transmembrane438 – 45821Helical; Name=Segment S6; Potential
Motif423 – 4286Selectivity filter By similarity
Motif527 – 5293PDZ-binding Potential

Amino acid modifications

Modified residue2221Phosphoserine; by CK2 Potential
Modified residue5121Phosphoserine; by PKA Probable
Modified residue5281Phosphothreonine; by PKA Potential
Lipidation2861S-palmitoyl cysteine Potential
Glycosylation461N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2411S → L no nucleotide entry Ref.3
Sequence conflict3331R → G in AAA41499. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P17659 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 30A9774B66CF1DA5

FASTA53058,884
        10         20         30         40         50         60 
MRSEKSLTLA APGEVRGPEG EQQDAGEFQE AEGGGGCCSS ERLVINISGL RYETQLRTLS 

        70         80         90        100        110        120 
LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY QSGGRLRRPV NVPLDIFMEE 

       130        140        150        160        170        180 
IRFYQLGDEA LAAFREDEGC LPEGGEDEKP LPSQPFQRQV WLLFEYPESS GPARGIAIVS 

       190        200        210        220        230        240 
VLVILISIVI FCLETLPQFR ADGRGGSNEG SGTRMSPASR GSHEEEDEDE DSYAFPGSIP 

       250        260        270        280        290        300 
SGGLGTGGTS SFSTLGGSFF TDPFFLVETL CIVWFTFELL VRFSACPSKA AFFRNIMNII 

       310        320        330        340        350        360 
DLVAIFPYFI TLGTELVQRH EQQPVSGGSG QNRQQAMSLA ILRVIRLVRV FRIFKLSRHS 

       370        380        390        400        410        420 
KGLQILGKTL QASMRELGLL IFFLFIGVIL FSSAVYFAEA DDVDSLFPSI PDAFWWAVVT 

       430        440        450        460        470        480 
MTTVGYGDMY PMTVGGKIVG SLCAIAGVLT IALPVPVIVS NFNYFYHRET EQEEQGQYTH 

       490        500        510        520        530 
VTCGQPTPDL KATDNGLGKP DFAEASRERR SSYLPTPHRA YAEKRMLTEV 

« Hide

References

[1]"Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family."
Grupe A., Schroeter K.H., Ruppersberg J.P., Stocker M., Drewes T., Beckh S., Pongs O.
EMBO J. 9:1749-1756(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain cortex.
[2]"Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain."
Swanson R., Marshall J., Smith J., Williams J., Boyle M.B., Folander K., Luneau C.J., Antanavage J., Oliva C., Buhrow S.A., Bennett C., Stein R.B., Kaczmarek L.M.
Neuron 4:929-939(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Brain.
[3]"Electrophysiological characterization of a new member of the RCK family of rat brain K+ channels."
Kirsch G.E., Drewe J.A., Verma S., Brown A.M., Joho R.H.
FEBS Lett. 278:55-60(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X17621 mRNA. Translation: CAA35622.1.
M27159 Genomic DNA. Translation: AAA41499.1. Sequence problems.
PIRJH0167.
UniGeneRn.60676.

3D structure databases

ProteinModelPortalP17659.
SMRP17659. Positions 40-470.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000026737.

Chemistry

GuidetoPHARMACOLOGY543.

PTM databases

PhosphoSiteP17659.

Proteomic databases

PaxDbP17659.
PRIDEP17659.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:62083. rat.

Organism-specific databases

RGD62083. Kcna6.

Phylogenomic databases

eggNOGCOG1226.
HOGENOMHOG000231015.
HOVERGENHBG052230.
InParanoidP17659.
PhylomeDBP17659.

Gene expression databases

GenevestigatorP17659.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004053. K_chnl_volt-dep_Kv1.6.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01513. KV16CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

PROP17659.

Entry information

Entry nameKCNA6_RAT
AccessionPrimary (citable) accession number: P17659
Secondary accession number(s): P19025
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families