SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P17659

- KCNA6_RAT

UniProt

P17659 - KCNA6_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Potassium voltage-gated channel subfamily A member 6
Gene
Kcna6
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 6
Alternative name(s):
RCK2
Voltage-gated potassium channel subunit Kv1.6
Voltage-gated potassium channel subunit Kv2
Gene namesi
Name:Kcna6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi62083. Kcna6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei175 – 19319Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Transmembranei264 – 28522Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Transmembranei297 – 31721Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Transmembranei341 – 36121Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Transmembranei377 – 39721Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Transmembranei438 – 45821Helical; Name=Segment S6; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Potassium voltage-gated channel subfamily A member 6
PRO_0000053992Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...) Reviewed prediction
Modified residuei222 – 2221Phosphoserine; by CK2 Reviewed prediction
Lipidationi286 – 2861S-palmitoyl cysteine Reviewed prediction
Modified residuei512 – 5121Phosphoserine; by PKA Inferred
Modified residuei528 – 5281Phosphothreonine; by PKA Reviewed prediction

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP17659.
PRIDEiP17659.

PTM databases

PhosphoSiteiP17659.

Expressioni

Gene expression databases

GenevestigatoriP17659.

Interactioni

Subunit structurei

Heterotetramer of potassium channel proteins By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026737.

Structurei

3D structure databases

ProteinModelPortaliP17659.
SMRiP17659. Positions 40-470.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi423 – 4286Selectivity filter By similarity
Motifi527 – 5293PDZ-binding Reviewed prediction

Domaini

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiP17659.
PhylomeDBiP17659.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004053. K_chnl_volt-dep_Kv1.6.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01513. KV16CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

P17659-1 [UniParc]FASTAAdd to Basket

« Hide

MRSEKSLTLA APGEVRGPEG EQQDAGEFQE AEGGGGCCSS ERLVINISGL    50
RYETQLRTLS LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY 100
QSGGRLRRPV NVPLDIFMEE IRFYQLGDEA LAAFREDEGC LPEGGEDEKP 150
LPSQPFQRQV WLLFEYPESS GPARGIAIVS VLVILISIVI FCLETLPQFR 200
ADGRGGSNEG SGTRMSPASR GSHEEEDEDE DSYAFPGSIP SGGLGTGGTS 250
SFSTLGGSFF TDPFFLVETL CIVWFTFELL VRFSACPSKA AFFRNIMNII 300
DLVAIFPYFI TLGTELVQRH EQQPVSGGSG QNRQQAMSLA ILRVIRLVRV 350
FRIFKLSRHS KGLQILGKTL QASMRELGLL IFFLFIGVIL FSSAVYFAEA 400
DDVDSLFPSI PDAFWWAVVT MTTVGYGDMY PMTVGGKIVG SLCAIAGVLT 450
IALPVPVIVS NFNYFYHRET EQEEQGQYTH VTCGQPTPDL KATDNGLGKP 500
DFAEASRERR SSYLPTPHRA YAEKRMLTEV 530
Length:530
Mass (Da):58,884
Last modified:August 1, 1990 - v1
Checksum:i30A9774B66CF1DA5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti241 – 2411S → L no nucleotide entry 1 Publication
Sequence conflicti333 – 3331R → G in AAA41499. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17621 mRNA. Translation: CAA35622.1.
M27159 Genomic DNA. Translation: AAA41499.1. Sequence problems.
PIRiJH0167.
UniGeneiRn.60676.

Genome annotation databases

UCSCiRGD:62083. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17621 mRNA. Translation: CAA35622.1 .
M27159 Genomic DNA. Translation: AAA41499.1 . Sequence problems.
PIRi JH0167.
UniGenei Rn.60676.

3D structure databases

ProteinModelPortali P17659.
SMRi P17659. Positions 40-470.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000026737.

Chemistry

GuidetoPHARMACOLOGYi 543.

PTM databases

PhosphoSitei P17659.

Proteomic databases

PaxDbi P17659.
PRIDEi P17659.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:62083. rat.

Organism-specific databases

RGDi 62083. Kcna6.

Phylogenomic databases

eggNOGi COG1226.
HOGENOMi HOG000231015.
HOVERGENi HBG052230.
InParanoidi P17659.
PhylomeDBi P17659.

Miscellaneous databases

PROi P17659.

Gene expression databases

Genevestigatori P17659.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004053. K_chnl_volt-dep_Kv1.6.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01513. KV16CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family."
    Grupe A., Schroeter K.H., Ruppersberg J.P., Stocker M., Drewes T., Beckh S., Pongs O.
    EMBO J. 9:1749-1756(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain cortex.
  2. "Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain."
    Swanson R., Marshall J., Smith J., Williams J., Boyle M.B., Folander K., Luneau C.J., Antanavage J., Oliva C., Buhrow S.A., Bennett C., Stein R.B., Kaczmarek L.M.
    Neuron 4:929-939(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  3. "Electrophysiological characterization of a new member of the RCK family of rat brain K+ channels."
    Kirsch G.E., Drewe J.A., Verma S., Brown A.M., Joho R.H.
    FEBS Lett. 278:55-60(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Brain.

Entry informationi

Entry nameiKCNA6_RAT
AccessioniPrimary (citable) accession number: P17659
Secondary accession number(s): P19025
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi