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P17658

- KCNA6_HUMAN

UniProt

P17658 - KCNA6_HUMAN

Protein

Potassium voltage-gated channel subfamily A member 6

Gene

KCNA6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 1 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome
    2. voltage-gated potassium channel activity Source: ProtInc

    GO - Biological processi

    1. potassium ion transport Source: ProtInc
    2. protein homooligomerization Source: InterPro
    3. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily A member 6
    Alternative name(s):
    Voltage-gated potassium channel HBK2
    Voltage-gated potassium channel subunit Kv1.6
    Gene namesi
    Name:KCNA6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:6225. KCNA6.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: Reactome
    2. voltage-gated potassium channel complex Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30022.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 529529Potassium voltage-gated channel subfamily A member 6PRO_0000053990Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
    Lipidationi285 – 2851S-palmitoyl cysteineSequence Analysis
    Modified residuei511 – 5111Phosphoserine; by PKACurated

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiP17658.
    PRIDEiP17658.

    PTM databases

    PhosphoSiteiP17658.

    Expressioni

    Gene expression databases

    BgeeiP17658.
    CleanExiHS_KCNA6.
    GenevestigatoriP17658.

    Organism-specific databases

    HPAiCAB011539.
    HPA014418.

    Interactioni

    Subunit structurei

    Heterotetramer of potassium channel proteins.By similarity

    Protein-protein interaction databases

    BioGridi109944. 1 interaction.
    IntActiP17658. 1 interaction.
    STRINGi9606.ENSP00000280684.

    Structurei

    3D structure databases

    ProteinModelPortaliP17658.
    SMRiP17658. Positions 41-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei175 – 19319Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28422Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei296 – 31621Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei340 – 36021Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei376 – 39621Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei437 – 45721Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi422 – 4276Selectivity filterBy similarity
    Motifi527 – 5293PDZ-bindingSequence Analysis

    Domaini

    The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231015.
    HOVERGENiHBG052230.
    InParanoidiP17658.
    KOiK04879.
    OMAiDDSYTFH.
    OrthoDBiEOG7M0NRD.
    PhylomeDBiP17658.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003972. K_chnl_volt-dep_Kv1.
    IPR004053. K_chnl_volt-dep_Kv1.6.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01513. KV16CHANNEL.
    PR01491. KVCHANNEL.
    PR01496. SHAKERCHANEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P17658-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSEKSLTLA APGEVRGPEG EQQDAGDFPE AGGGGGCCSS ERLVINISGL    50
    RFETQLRTLS LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY 100
    QSGGRLRRPV NVPLDIFLEE IRFYQLGDEA LAAFREDEGC LPEGGEDEKP 150
    LPSQPFQRQV WLLFEYPESS GPARGIAIVS VLVILISIVI FCLETLPQFR 200
    VDGRGGNNGG VSRVSPVSRG SQEEEEDEDD SYTFHHGITP GEMGTGGSSS 250
    LSTLGGSFFT DPFFLVETLC IVWFTFELLV RFSACPSKPA FFRNIMNIID 300
    LVAIFPYFIT LGTELVQQQE QQPASGGGGQ NGQQAMSLAI LRVIRLVRVF 350
    RIFKLSRHSK GLQILGKTLQ ASMRELGLLI FFLFIGVILF SSAVYFAEAD 400
    DDDSLFPSIP DAFWWAVVTM TTVGYGDMYP MTVGGKIVGS LCAIAGVLTI 450
    ALPVPVIVSN FNYFYHRETE QEEQGQYTHV TCGQPAPDLR ATDNGLGKPD 500
    FPEANRERRP SYLPTPHRAY AEKRMLTEV 529
    Length:529
    Mass (Da):58,729
    Last modified:August 1, 1990 - v1
    Checksum:iCFF0710A1F9CD69F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17622 mRNA. Translation: CAA35623.1.
    BC069355 mRNA. Translation: AAH69355.1.
    CCDSiCCDS8534.1.
    PIRiS12787.
    RefSeqiNP_002226.1. NM_002235.3.
    XP_005253743.1. XM_005253686.1.
    UniGeneiHs.306190.

    Genome annotation databases

    EnsembliENST00000433855; ENSP00000408321; ENSG00000151079.
    GeneIDi3742.
    KEGGihsa:3742.
    UCSCiuc001qng.3. human.

    Polymorphism databases

    DMDMi116434.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17622 mRNA. Translation: CAA35623.1 .
    BC069355 mRNA. Translation: AAH69355.1 .
    CCDSi CCDS8534.1.
    PIRi S12787.
    RefSeqi NP_002226.1. NM_002235.3.
    XP_005253743.1. XM_005253686.1.
    UniGenei Hs.306190.

    3D structure databases

    ProteinModelPortali P17658.
    SMRi P17658. Positions 41-469.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109944. 1 interaction.
    IntActi P17658. 1 interaction.
    STRINGi 9606.ENSP00000280684.

    Chemistry

    BindingDBi P17658.
    ChEMBLi CHEMBL2362996.
    GuidetoPHARMACOLOGYi 543.

    PTM databases

    PhosphoSitei P17658.

    Polymorphism databases

    DMDMi 116434.

    Proteomic databases

    PaxDbi P17658.
    PRIDEi P17658.

    Protocols and materials databases

    DNASUi 3742.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000433855 ; ENSP00000408321 ; ENSG00000151079 .
    GeneIDi 3742.
    KEGGi hsa:3742.
    UCSCi uc001qng.3. human.

    Organism-specific databases

    CTDi 3742.
    GeneCardsi GC12P004918.
    HGNCi HGNC:6225. KCNA6.
    HPAi CAB011539.
    HPA014418.
    MIMi 176257. gene.
    neXtProti NX_P17658.
    PharmGKBi PA30022.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231015.
    HOVERGENi HBG052230.
    InParanoidi P17658.
    KOi K04879.
    OMAi DDSYTFH.
    OrthoDBi EOG7M0NRD.
    PhylomeDBi P17658.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNA6.
    GenomeRNAii 3742.
    NextBioi 14643.
    PROi P17658.
    SOURCEi Search...

    Gene expression databases

    Bgeei P17658.
    CleanExi HS_KCNA6.
    Genevestigatori P17658.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003972. K_chnl_volt-dep_Kv1.
    IPR004053. K_chnl_volt-dep_Kv1.6.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01513. KV16CHANNEL.
    PR01491. KVCHANNEL.
    PR01496. SHAKERCHANEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family."
      Grupe A., Schroeter K.H., Ruppersberg J.P., Stocker M., Drewes T., Beckh S., Pongs O.
      EMBO J. 9:1749-1756(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiKCNA6_HUMAN
    AccessioniPrimary (citable) accession number: P17658
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 135 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3