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P17658

- KCNA6_HUMAN

UniProt

P17658 - KCNA6_HUMAN

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Protein

Potassium voltage-gated channel subfamily A member 6

Gene
KCNA6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome
  2. voltage-gated potassium channel activity Source: ProtInc

GO - Biological processi

  1. potassium ion transport Source: ProtInc
  2. protein homooligomerization Source: InterPro
  3. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 6
Alternative name(s):
Voltage-gated potassium channel HBK2
Voltage-gated potassium channel subunit Kv1.6
Gene namesi
Name:KCNA6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:6225. KCNA6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei175 – 19319Helical; Name=Segment S1; Reviewed predictionAdd
BLAST
Transmembranei263 – 28422Helical; Name=Segment S2; Reviewed predictionAdd
BLAST
Transmembranei296 – 31621Helical; Name=Segment S3; Reviewed predictionAdd
BLAST
Transmembranei340 – 36021Helical; Voltage-sensor; Name=Segment S4; Reviewed predictionAdd
BLAST
Transmembranei376 – 39621Helical; Name=Segment S5; Reviewed predictionAdd
BLAST
Transmembranei437 – 45721Helical; Name=Segment S6; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. plasma membrane Source: Reactome
  2. voltage-gated potassium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30022.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Potassium voltage-gated channel subfamily A member 6PRO_0000053990Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...) Reviewed prediction
Lipidationi285 – 2851S-palmitoyl cysteine Reviewed prediction
Modified residuei511 – 5111Phosphoserine; by PKA Inferred

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP17658.
PRIDEiP17658.

PTM databases

PhosphoSiteiP17658.

Expressioni

Gene expression databases

BgeeiP17658.
CleanExiHS_KCNA6.
GenevestigatoriP17658.

Organism-specific databases

HPAiCAB011539.
HPA014418.

Interactioni

Subunit structurei

Heterotetramer of potassium channel proteins By similarity.

Protein-protein interaction databases

BioGridi109944. 1 interaction.
IntActiP17658. 1 interaction.
STRINGi9606.ENSP00000280684.

Structurei

3D structure databases

ProteinModelPortaliP17658.
SMRiP17658. Positions 41-469.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi422 – 4276Selectivity filter By similarity
Motifi527 – 5293PDZ-binding Reviewed prediction

Domaini

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiP17658.
KOiK04879.
OMAiDDSYTFH.
OrthoDBiEOG7M0NRD.
PhylomeDBiP17658.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004053. K_chnl_volt-dep_Kv1.6.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01513. KV16CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

P17658-1 [UniParc]FASTAAdd to Basket

« Hide

MRSEKSLTLA APGEVRGPEG EQQDAGDFPE AGGGGGCCSS ERLVINISGL    50
RFETQLRTLS LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY 100
QSGGRLRRPV NVPLDIFLEE IRFYQLGDEA LAAFREDEGC LPEGGEDEKP 150
LPSQPFQRQV WLLFEYPESS GPARGIAIVS VLVILISIVI FCLETLPQFR 200
VDGRGGNNGG VSRVSPVSRG SQEEEEDEDD SYTFHHGITP GEMGTGGSSS 250
LSTLGGSFFT DPFFLVETLC IVWFTFELLV RFSACPSKPA FFRNIMNIID 300
LVAIFPYFIT LGTELVQQQE QQPASGGGGQ NGQQAMSLAI LRVIRLVRVF 350
RIFKLSRHSK GLQILGKTLQ ASMRELGLLI FFLFIGVILF SSAVYFAEAD 400
DDDSLFPSIP DAFWWAVVTM TTVGYGDMYP MTVGGKIVGS LCAIAGVLTI 450
ALPVPVIVSN FNYFYHRETE QEEQGQYTHV TCGQPAPDLR ATDNGLGKPD 500
FPEANRERRP SYLPTPHRAY AEKRMLTEV 529
Length:529
Mass (Da):58,729
Last modified:August 1, 1990 - v1
Checksum:iCFF0710A1F9CD69F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17622 mRNA. Translation: CAA35623.1.
BC069355 mRNA. Translation: AAH69355.1.
CCDSiCCDS8534.1.
PIRiS12787.
RefSeqiNP_002226.1. NM_002235.3.
XP_005253743.1. XM_005253686.1.
UniGeneiHs.306190.

Genome annotation databases

EnsembliENST00000280684; ENSP00000280684; ENSG00000151079.
ENST00000433855; ENSP00000408321; ENSG00000151079.
GeneIDi3742.
KEGGihsa:3742.
UCSCiuc001qng.3. human.

Polymorphism databases

DMDMi116434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17622 mRNA. Translation: CAA35623.1 .
BC069355 mRNA. Translation: AAH69355.1 .
CCDSi CCDS8534.1.
PIRi S12787.
RefSeqi NP_002226.1. NM_002235.3.
XP_005253743.1. XM_005253686.1.
UniGenei Hs.306190.

3D structure databases

ProteinModelPortali P17658.
SMRi P17658. Positions 41-469.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109944. 1 interaction.
IntActi P17658. 1 interaction.
STRINGi 9606.ENSP00000280684.

Chemistry

BindingDBi P17658.
ChEMBLi CHEMBL2362996.
GuidetoPHARMACOLOGYi 543.

PTM databases

PhosphoSitei P17658.

Polymorphism databases

DMDMi 116434.

Proteomic databases

PaxDbi P17658.
PRIDEi P17658.

Protocols and materials databases

DNASUi 3742.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000280684 ; ENSP00000280684 ; ENSG00000151079 .
ENST00000433855 ; ENSP00000408321 ; ENSG00000151079 .
GeneIDi 3742.
KEGGi hsa:3742.
UCSCi uc001qng.3. human.

Organism-specific databases

CTDi 3742.
GeneCardsi GC12P004918.
HGNCi HGNC:6225. KCNA6.
HPAi CAB011539.
HPA014418.
MIMi 176257. gene.
neXtProti NX_P17658.
PharmGKBi PA30022.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
HOGENOMi HOG000231015.
HOVERGENi HBG052230.
InParanoidi P17658.
KOi K04879.
OMAi DDSYTFH.
OrthoDBi EOG7M0NRD.
PhylomeDBi P17658.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikii KCNA6.
GenomeRNAii 3742.
NextBioi 14643.
PROi P17658.
SOURCEi Search...

Gene expression databases

Bgeei P17658.
CleanExi HS_KCNA6.
Genevestigatori P17658.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004053. K_chnl_volt-dep_Kv1.6.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01513. KV16CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family."
    Grupe A., Schroeter K.H., Ruppersberg J.P., Stocker M., Drewes T., Beckh S., Pongs O.
    EMBO J. 9:1749-1756(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiKCNA6_HUMAN
AccessioniPrimary (citable) accession number: P17658
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 3, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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