Reviewed,
UniProtKB/Swiss-Prot P17658 (KCNA6_HUMAN)
Last modified
June 16, 2009.
Version 87.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Potassium voltage-gated channel subfamily A member 6 Alternative name(s): Voltage-gated potassium channel subunit Kv1.6 HBK2 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 529 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. |
| Subunit structure | Heterotetramer of potassium channel proteins By similarity. |
| Subcellular location | |
| Domain | The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. |
| Sequence similarities | Belongs to the potassium channel family. A (Shaker) subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ion transport Potassium transport Transport |
| Cellular component | Membrane |
| Domain | Transmembrane |
| Ligand | Potassium |
| Molecular function | Ionic channel Potassium channel Voltage-gated channel |
| PTM | Glycoprotein Lipoprotein Palmitate Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | potassium ion transport Ref.1 Traceable author statement. Source: ProtInc |
| Cellular component | voltage-gated potassium channel complex Ref.1 Traceable author statement. Source: ProtInc |
| Molecular function | potassium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from electronic annotation. Source: InterPro voltage-gated potassium channel activity Ref.1Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 529 | 529 | Potassium voltage-gated channel subfamily A member 6 | PRO_0000053990 | |||||
Regions | |||||||||
| Transmembrane | 175 – 193 | 19 | Segment S1 | ||||||
| Transmembrane | 263 – 284 | 22 | Segment S2 | ||||||
| Transmembrane | 296 – 316 | 21 | Segment S3 | ||||||
| Transmembrane | 340 – 360 | 21 | Segment S4 | ||||||
| Transmembrane | 376 – 396 | 21 | Segment S5 | ||||||
| Transmembrane | 437 – 457 | 21 | Segment S6 | ||||||
| Motif | 422 – 427 | 6 | Selectivity filter By similarity | ||||||
| Motif | 527 – 529 | 3 | PDZ-binding Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 8 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 511 | 1 | Phosphoserine; by PKA Probable | ||||||
| Lipidation | 285 | 1 | S-palmitoyl cysteine Potential | ||||||
| Glycosylation | 46 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family." Grupe A., Schroeter K.H., Ruppersberg J.P., Stocker M., Drewes T., Beckh S., Pongs O. EMBO J. 9:1749-1756(1990) [PubMed: 2347305] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X17622 mRNA. Translation: CAA35623.1. BC069355 mRNA. Translation: AAH69355.1. | |
| IPI | IPI00015931. |
| PIR | S12787. |
| RefSeq | NP_002226.1. |
| UniGene | Hs.306190 Hs.426162 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1HO2 based on UniProtKB P08510. |
| SMR | P17658. Positions 260-469. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P17658. |
Proteomic databases | |
| PRIDE | P17658. |
Genome annotation databases | |
| Ensembl | ENSG00000151079. Homo sapiens. [Contig view] |
| GeneID | 3742. |
| KEGG | hsa:3742. |
Organism-specific databases | |
| GeneCards | GC12P004788. |
| H-InvDB | HIX0036823. |
| HGNC | HGNC:6225. KCNA6. |
| HPA | CAB011539. HPA014418. |
| MIM | 176257. gene. |
| PharmGKB | PA30022. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P17658. |
| HOVERGEN | P17658. |
| OMA | P17658. KATDNGL. |
Gene expression databases | |
| ArrayExpress | P17658. |
| Bgee | P17658. |
| CleanEx | HS_KCNA6. |
| GermOnline | ENSG00000151079. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003972. K_chnl_volt-dep_Kv1. IPR004053. K_chnl_volt-dep_Kv1.6. IPR003131. K_chnl_volt-dep_Kv_tetra. [Graphical view] |
| Gene3D | G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. |
| Pfam | PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view] |
| PRINTS | PR00169. KCHANNEL. PR01513. KV16CHANNEL. PR01491. KVCHANNEL. PR01496. SHAKERCHANEL. |
| SMART | SM00225. BTB. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 14643. |
| SOURCE | Search... |
Entry information
| Entry name | KCNA6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P17658 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


