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P17658 (KCNA6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily A member 6
Alternative name(s):
Voltage-gated potassium channel HBK2
Voltage-gated potassium channel subunit Kv1.6
Gene names
Name:KCNA6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit structure

Heterotetramer of potassium channel proteins By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Domain

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529Potassium voltage-gated channel subfamily A member 6
PRO_0000053990

Regions

Transmembrane175 – 19319Helical; Name=Segment S1; Potential
Transmembrane263 – 28422Helical; Name=Segment S2; Potential
Transmembrane296 – 31621Helical; Name=Segment S3; Potential
Transmembrane340 – 36021Helical; Voltage-sensor; Name=Segment S4; Potential
Transmembrane376 – 39621Helical; Name=Segment S5; Potential
Transmembrane437 – 45721Helical; Name=Segment S6; Potential
Motif422 – 4276Selectivity filter By similarity
Motif527 – 5293PDZ-binding Potential

Amino acid modifications

Modified residue5111Phosphoserine; by PKA Probable
Lipidation2851S-palmitoyl cysteine Potential
Glycosylation461N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P17658 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: CFF0710A1F9CD69F

FASTA52958,729
        10         20         30         40         50         60 
MRSEKSLTLA APGEVRGPEG EQQDAGDFPE AGGGGGCCSS ERLVINISGL RFETQLRTLS 

        70         80         90        100        110        120 
LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY QSGGRLRRPV NVPLDIFLEE 

       130        140        150        160        170        180 
IRFYQLGDEA LAAFREDEGC LPEGGEDEKP LPSQPFQRQV WLLFEYPESS GPARGIAIVS 

       190        200        210        220        230        240 
VLVILISIVI FCLETLPQFR VDGRGGNNGG VSRVSPVSRG SQEEEEDEDD SYTFHHGITP 

       250        260        270        280        290        300 
GEMGTGGSSS LSTLGGSFFT DPFFLVETLC IVWFTFELLV RFSACPSKPA FFRNIMNIID 

       310        320        330        340        350        360 
LVAIFPYFIT LGTELVQQQE QQPASGGGGQ NGQQAMSLAI LRVIRLVRVF RIFKLSRHSK 

       370        380        390        400        410        420 
GLQILGKTLQ ASMRELGLLI FFLFIGVILF SSAVYFAEAD DDDSLFPSIP DAFWWAVVTM 

       430        440        450        460        470        480 
TTVGYGDMYP MTVGGKIVGS LCAIAGVLTI ALPVPVIVSN FNYFYHRETE QEEQGQYTHV 

       490        500        510        520 
TCGQPAPDLR ATDNGLGKPD FPEANRERRP SYLPTPHRAY AEKRMLTEV 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family."
Grupe A., Schroeter K.H., Ruppersberg J.P., Stocker M., Drewes T., Beckh S., Pongs O.
EMBO J. 9:1749-1756(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X17622 mRNA. Translation: CAA35623.1.
BC069355 mRNA. Translation: AAH69355.1.
CCDSCCDS8534.1.
PIRS12787.
RefSeqNP_002226.1. NM_002235.3.
XP_005253743.1. XM_005253686.1.
UniGeneHs.306190.

3D structure databases

ProteinModelPortalP17658.
SMRP17658. Positions 41-469.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109944. 1 interaction.
IntActP17658. 1 interaction.
STRING9606.ENSP00000280684.

Chemistry

BindingDBP17658.
ChEMBLCHEMBL2362996.
GuidetoPHARMACOLOGY543.

PTM databases

PhosphoSiteP17658.

Polymorphism databases

DMDM116434.

Proteomic databases

PaxDbP17658.
PRIDEP17658.

Protocols and materials databases

DNASU3742.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000280684; ENSP00000280684; ENSG00000151079.
ENST00000433855; ENSP00000408321; ENSG00000151079.
GeneID3742.
KEGGhsa:3742.
UCSCuc001qng.3. human.

Organism-specific databases

CTD3742.
GeneCardsGC12P004918.
HGNCHGNC:6225. KCNA6.
HPACAB011539.
HPA014418.
MIM176257. gene.
neXtProtNX_P17658.
PharmGKBPA30022.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1226.
HOGENOMHOG000231015.
HOVERGENHBG052230.
InParanoidP17658.
KOK04879.
OMADDSYTFH.
OrthoDBEOG7M0NRD.
PhylomeDBP17658.
TreeFamTF313103.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

BgeeP17658.
CleanExHS_KCNA6.
GenevestigatorP17658.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR004053. K_chnl_volt-dep_Kv1.6.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01513. KV16CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

GeneWikiKCNA6.
GenomeRNAi3742.
NextBio14643.
PROP17658.
SOURCESearch...

Entry information

Entry nameKCNA6_HUMAN
AccessionPrimary (citable) accession number: P17658
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 9, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM