P17658 (KCNA6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily A member 6

Alternative name(s):
Voltage-gated potassium channel HBK2
Voltage-gated potassium channel subunit Kv1.6

Gene names

Name:

KCNA6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Subunit structure	Heterotetramer of potassium channel proteins By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Domain	The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similarities	Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	voltage-gated potassium channel complex Traceable author statement Ref.1. Source: ProtInc
Molecular_function	delayed rectifier potassium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 529	529	Potassium voltage-gated channel subfamily A member 6		PRO_0000053990
Regions
	Transmembrane	175 – 193	19	Helical; Name=Segment S1; Potential
	Transmembrane	263 – 284	22	Helical; Name=Segment S2; Potential
	Transmembrane	296 – 316	21	Helical; Name=Segment S3; Potential
	Transmembrane	340 – 360	21	Helical; Voltage-sensor; Name=Segment S4; Potential
	Transmembrane	376 – 396	21	Helical; Name=Segment S5; Potential
	Transmembrane	437 – 457	21	Helical; Name=Segment S6; Potential
	Motif	422 – 427	6	Selectivity filter By similarity
	Motif	527 – 529	3	PDZ-binding Potential
Amino acid modifications
	Modified residue	8	1	Phosphothreonine By similarity
	Modified residue	511	1	Phosphoserine; by PKA Probable
	Lipidation	285	1	S-palmitoyl cysteine Potential
	Glycosylation	46	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P17658 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: CFF0710A1F9CD69F	FASTA	529	58,729
	10 20 30 40 50 60 MRSEKSLTLA APGEVRGPEG EQQDAGDFPE AGGGGGCCSS ERLVINISGL RFETQLRTLS 70 80 90 100 110 120 LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY QSGGRLRRPV NVPLDIFLEE 130 140 150 160 170 180 IRFYQLGDEA LAAFREDEGC LPEGGEDEKP LPSQPFQRQV WLLFEYPESS GPARGIAIVS 190 200 210 220 230 240 VLVILISIVI FCLETLPQFR VDGRGGNNGG VSRVSPVSRG SQEEEEDEDD SYTFHHGITP 250 260 270 280 290 300 GEMGTGGSSS LSTLGGSFFT DPFFLVETLC IVWFTFELLV RFSACPSKPA FFRNIMNIID 310 320 330 340 350 360 LVAIFPYFIT LGTELVQQQE QQPASGGGGQ NGQQAMSLAI LRVIRLVRVF RIFKLSRHSK 370 380 390 400 410 420 GLQILGKTLQ ASMRELGLLI FFLFIGVILF SSAVYFAEAD DDDSLFPSIP DAFWWAVVTM 430 440 450 460 470 480 TTVGYGDMYP MTVGGKIVGS LCAIAGVLTI ALPVPVIVSN FNYFYHRETE QEEQGQYTHV 490 500 510 520 TCGQPAPDLR ATDNGLGKPD FPEANRERRP SYLPTPHRAY AEKRMLTEV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family." Grupe A., Schroeter K.H., Ruppersberg J.P., Stocker M., Drewes T., Beckh S., Pongs O. EMBO J. 9:1749-1756(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X17622 mRNA. Translation: CAA35623.1. BC069355 mRNA. Translation: AAH69355.1.
IPI	IPI00015931.
PIR	S12787.
RefSeq	NP_002226.1. NM_002235.3.
UniGene	Hs.306190.
3D structure databases
ProteinModelPortal	P17658.
ModBase	Search...
Protein-protein interaction databases
IntAct	P17658. 1 interaction.
STRING	9606.ENSP00000280684.
PTM databases
PhosphoSite	P17658.
Polymorphism databases
DMDM	116434.
Proteomic databases
PaxDb	P17658.
PRIDE	P17658.
Protocols and materials databases
DNASU	3742.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000280684; ENSP00000280684; ENSG00000151079. ENST00000433855; ENSP00000408321; ENSG00000151079.
GeneID	3742.
KEGG	hsa:3742.
UCSC	uc001qng.3. human.
Organism-specific databases
CTD	3742.
GeneCards	GC12P004918.
HGNC	HGNC:6225. KCNA6.
HPA	CAB011539. HPA014418.
MIM	176257. gene.
neXtProt	NX_P17658.
PharmGKB	PA30022.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1226.
HOGENOM	HOG000231015.
HOVERGEN	HBG052230.
InParanoid	P17658.
KO	K04879.
OMA	GKPEFSE.
OrthoDB	EOG43JC4R.
PhylomeDB	P17658.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
Bgee	P17658.
CleanEx	HS_KCNA6.
Genevestigator	P17658.
GermOnline	ENSG00000151079. Homo sapiens.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003972. K_chnl_volt-dep_Kv1. IPR004053. K_chnl_volt-dep_Kv1.6. IPR003131. T1-type_BTB. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01513. KV16CHANNEL. PR01491. KVCHANNEL. PR01496. SHAKERCHANEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
BindingDB	P17658.
ChEMBL	CHEMBL5279.
GenomeRNAi	3742.
NextBio	14643.
SOURCE	Search...

Entry information

Entry name

KCNA6_HUMAN

Accession

Primary (citable) accession number: P17658

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	May 1, 2013
This is version 123 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.