Reviewed, UniProtKB/Swiss-Prot P17658 (KCNA6_HUMAN)

Names and origin

Protein names

Recommended name:
    Potassium voltage-gated channel subfamily A member 6
Alternative name(s):
    Voltage-gated potassium channel subunit Kv1.6
    HBK2

Gene names

Name:

KCNA6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Subunit structure	Heterotetramer of potassium channel proteins By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Domain	The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similarities	Belongs to the potassium channel family. A (Shaker) subfamily.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane
Ligand	Potassium
Molecular function	Ionic channel Potassium channel Voltage-gated channel
PTM	Glycoprotein Lipoprotein Palmitate Phosphoprotein
Gene Ontology (GO)
Biological process	potassium ion transport Ref.1 Traceable author statement. Source: ProtInc
Cellular component	voltage-gated potassium channel complex Ref.1 Traceable author statement. Source: ProtInc
Molecular function	potassium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: InterPro voltage-gated potassium channel activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 529	529	Potassium voltage-gated channel subfamily A member 6		PRO_0000053990
Regions
	Transmembrane	175 – 193	19	Segment S1
	Transmembrane	263 – 284	22	Segment S2
	Transmembrane	296 – 316	21	Segment S3
	Transmembrane	340 – 360	21	Segment S4
	Transmembrane	376 – 396	21	Segment S5
	Transmembrane	437 – 457	21	Segment S6
	Motif	422 – 427	6	Selectivity filter By similarity
	Motif	527 – 529	3	PDZ-binding Potential
Amino acid modifications
	Modified residue	8	1	Phosphothreonine By similarity
	Modified residue	511	1	Phosphoserine; by PKA Probable
	Lipidation	285	1	S-palmitoyl cysteine Potential
	Glycosylation	46	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P17658-1 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: CFF0710A1F9CD69F	FASTA	529	58,729
	10 20 30 40 50 60 MRSEKSLTLA APGEVRGPEG EQQDAGDFPE AGGGGGCCSS ERLVINISGL RFETQLRTLS 70 80 90 100 110 120 LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY QSGGRLRRPV NVPLDIFLEE 130 140 150 160 170 180 IRFYQLGDEA LAAFREDEGC LPEGGEDEKP LPSQPFQRQV WLLFEYPESS GPARGIAIVS 190 200 210 220 230 240 VLVILISIVI FCLETLPQFR VDGRGGNNGG VSRVSPVSRG SQEEEEDEDD SYTFHHGITP 250 260 270 280 290 300 GEMGTGGSSS LSTLGGSFFT DPFFLVETLC IVWFTFELLV RFSACPSKPA FFRNIMNIID 310 320 330 340 350 360 LVAIFPYFIT LGTELVQQQE QQPASGGGGQ NGQQAMSLAI LRVIRLVRVF RIFKLSRHSK 370 380 390 400 410 420 GLQILGKTLQ ASMRELGLLI FFLFIGVILF SSAVYFAEAD DDDSLFPSIP DAFWWAVVTM 430 440 450 460 470 480 TTVGYGDMYP MTVGGKIVGS LCAIAGVLTI ALPVPVIVSN FNYFYHRETE QEEQGQYTHV 490 500 510 520 TCGQPAPDLR ATDNGLGKPD FPEANRERRP SYLPTPHRAY AEKRMLTEV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family." Grupe A., Schroeter K.H., Ruppersberg J.P., Stocker M., Drewes T., Beckh S., Pongs O. EMBO J. 9:1749-1756(1990) [PubMed: 2347305] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X17622 mRNA. Translation: CAA35623.1. BC069355 mRNA. Translation: AAH69355.1.
IPI	IPI00015931.
PIR	S12787.
RefSeq	NP_002226.1.
UniGene	Hs.306190 Hs.426162
3D structure databases
HSSP	HSSP built from PDB template 1HO2 based on UniProtKB P08510.
SMR	P17658. Positions 260-469.
ModBase	Search...
PTM databases
PhosphoSite	P17658.
Proteomic databases
PRIDE	P17658.
Genome annotation databases
Ensembl	ENSG00000151079. Homo sapiens. [Contig view]
GeneID	3742.
KEGG	hsa:3742.
Organism-specific databases
GeneCards	GC12P004788.
H-InvDB	HIX0036823.
HGNC	HGNC:6225. KCNA6.
HPA	CAB011539. HPA014418.
MIM	176257. gene.
PharmGKB	PA30022.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P17658.
HOVERGEN	P17658.
OMA	P17658. KATDNGL.
Gene expression databases
ArrayExpress	P17658.
Bgee	P17658.
CleanEx	HS_KCNA6.
GermOnline	ENSG00000151079. Homo sapiens.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003972. K_chnl_volt-dep_Kv1. IPR004053. K_chnl_volt-dep_Kv1.6. IPR003131. K_chnl_volt-dep_Kv_tetra. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01513. KV16CHANNEL. PR01491. KVCHANNEL. PR01496. SHAKERCHANEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	14643.
SOURCE	Search...

Entry information

Entry name

KCNA6_HUMAN

Accession

Primary (citable) accession number: P17658

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	June 16, 2009
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)