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Protein

Calpain-2 catalytic subunit

Gene

CAPN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity).By similarity1 Publication

Catalytic activityi

Broad endopeptidase specificity.

Cofactori

Ca2+By similarityNote: Binds 7 Ca2+ ions.By similarity

Enzyme regulationi

Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi89Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi91Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi96Calcium 3By similarity1
Active sitei105By similarity1
Metal bindingi175Calcium 3By similarity1
Metal bindingi229Calcium 2By similarity1
Metal bindingi230Calcium 2By similarity1
Active sitei262By similarity1
Active sitei286By similarity1
Metal bindingi292Calcium 4By similarity1
Metal bindingi299Calcium 4By similarity1
Metal bindingi323Calcium 4; via carbonyl oxygenBy similarity1
Metal bindingi542Calcium 5; via carbonyl oxygenBy similarity1
Metal bindingi545Calcium 5By similarity1
Metal bindingi547Calcium 5; via carbonyl oxygenBy similarity1
Metal bindingi552Calcium 5By similarity1
Metal bindingi585Calcium 6By similarity1
Metal bindingi587Calcium 6By similarity1
Metal bindingi589Calcium 6; via carbonyl oxygenBy similarity1
Metal bindingi591Calcium 6; via carbonyl oxygenBy similarity1
Metal bindingi596Calcium 6By similarity1
Metal bindingi615Calcium 7By similarity1
Metal bindingi617Calcium 7By similarity1
Metal bindingi619Calcium 7; via carbonyl oxygenBy similarity1
Metal bindingi621Calcium 7; via carbonyl oxygenBy similarity1
Metal bindingi626Calcium 7By similarity1
Metal bindingi658Calcium 1By similarity1
Metal bindingi661Calcium 1By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi585 – 5961Add BLAST12
Calcium bindingi615 – 6262Add BLAST12

GO - Molecular functioni

  • calcium-dependent cysteine-type endopeptidase activity Source: UniProtKB
  • calcium ion binding Source: Ensembl
  • cysteine-type peptidase activity Source: ProtInc
  • cytoskeletal protein binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS08758-MONOMER.
BRENDAi3.4.22.53. 2681.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.
SIGNORiP17655.

Protein family/group databases

MEROPSiC02.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-2 catalytic subunit (EC:3.4.22.53)
Alternative name(s):
Calcium-activated neutral proteinase 2
Short name:
CANP 2
Calpain M-type
Calpain large polypeptide L2
Calpain-2 large subunit
Millimolar-calpain
Short name:
M-calpain
Gene namesi
Name:CAPN2
Synonyms:CANPL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1479. CAPN2.

Subcellular locationi

GO - Cellular componenti

  • chromatin Source: Ensembl
  • cortical actin cytoskeleton Source: BHF-UCL
  • cytoplasm Source: UniProtKB
  • cytosol Source: BHF-UCL
  • dendrite Source: UniProtKB
  • endoplasmic reticulum Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • Golgi apparatus Source: BHF-UCL
  • lysosome Source: Ensembl
  • membrane raft Source: BHF-UCL
  • nucleus Source: Ensembl
  • perinuclear endoplasmic reticulum Source: BHF-UCL
  • plasma membrane Source: BHF-UCL
  • pseudopodium Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi824.
OpenTargetsiENSG00000162909.
PharmGKBiPA26060.

Chemistry databases

ChEMBLiCHEMBL2382.
GuidetoPHARMACOLOGYi2337.

Polymorphism and mutation databases

BioMutaiCAPN2.
DMDMi317373596.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
PropeptideiPRO_00000264872 – 19Anchors to the small subunitSequence analysisAdd BLAST18
ChainiPRO_000002648820 – 700Calpain-2 catalytic subunitAdd BLAST681

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP17655.
MaxQBiP17655.
PaxDbiP17655.
PeptideAtlasiP17655.
PRIDEiP17655.

PTM databases

iPTMnetiP17655.
PhosphoSitePlusiP17655.
SwissPalmiP17655.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000162909.
CleanExiHS_CAPN2.
ExpressionAtlasiP17655. baseline and differential.
GenevisibleiP17655. HS.

Organism-specific databases

HPAiHPA024470.

Interactioni

Subunit structurei

Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Interacts with CPEB3; this leads to cleavage of CPEB3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CAPNS1P046323EBI-1028956,EBI-711828
ZDHHC17Q8IUH52EBI-1028956,EBI-524753

GO - Molecular functioni

  • cytoskeletal protein binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107274. 50 interactors.
IntActiP17655. 12 interactors.
MINTiMINT-120195.
STRINGi9606.ENSP00000295006.

Chemistry databases

BindingDBiP17655.

Structurei

Secondary structure

1700
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 16Combined sources13
Turni17 – 19Combined sources3
Helixi27 – 29Combined sources3
Helixi32 – 42Combined sources11
Beta strandi49 – 51Combined sources3
Helixi55 – 58Combined sources4
Beta strandi60 – 68Combined sources9
Beta strandi74 – 76Combined sources3
Helixi78 – 81Combined sources4
Beta strandi82 – 84Combined sources3
Helixi94 – 96Combined sources3
Beta strandi97 – 99Combined sources3
Helixi105 – 115Combined sources11
Helixi118 – 124Combined sources7
Beta strandi131 – 134Combined sources4
Beta strandi136 – 144Combined sources9
Beta strandi146 – 155Combined sources10
Beta strandi158 – 161Combined sources4
Beta strandi164 – 167Combined sources4
Beta strandi169 – 175Combined sources7
Helixi177 – 189Combined sources13
Beta strandi190 – 192Combined sources3
Helixi193 – 195Combined sources3
Beta strandi196 – 199Combined sources4
Turni204 – 206Combined sources3
Helixi207 – 209Combined sources3
Beta strandi212 – 216Combined sources5
Helixi224 – 233Combined sources10
Beta strandi237 – 241Combined sources5
Helixi247 – 249Combined sources3
Beta strandi259 – 261Combined sources3
Beta strandi264 – 274Combined sources11
Beta strandi277 – 285Combined sources9
Beta strandi294 – 297Combined sources4
Beta strandi299 – 301Combined sources3
Helixi302 – 306Combined sources5
Helixi309 – 315Combined sources7
Beta strandi321 – 327Combined sources7
Helixi328 – 334Combined sources7
Beta strandi336 – 341Combined sources6
Helixi344 – 346Combined sources3
Beta strandi347 – 349Combined sources3
Beta strandi363 – 365Combined sources3
Turni367 – 370Combined sources4
Turni378 – 380Combined sources3
Helixi381 – 383Combined sources3
Beta strandi388 – 390Combined sources3
Beta strandi400 – 402Combined sources3
Beta strandi406 – 413Combined sources8
Beta strandi420 – 425Combined sources6
Beta strandi429 – 435Combined sources7
Turni442 – 444Combined sources3
Helixi450 – 455Combined sources6
Beta strandi459 – 461Combined sources3
Beta strandi466 – 471Combined sources6
Beta strandi474 – 476Combined sources3
Beta strandi479 – 492Combined sources14
Beta strandi495 – 505Combined sources11
Beta strandi507 – 509Combined sources3
Beta strandi527 – 530Combined sources4
Helixi533 – 541Combined sources9
Beta strandi542 – 546Combined sources5
Helixi550 – 560Combined sources11
Turni561 – 564Combined sources4
Helixi574 – 582Combined sources9
Beta strandi586 – 588Combined sources3
Beta strandi590 – 592Combined sources3
Helixi595 – 612Combined sources18
Beta strandi622 – 624Combined sources3
Helixi627 – 630Combined sources4
Turni631 – 635Combined sources5
Helixi640 – 650Combined sources11
Beta strandi655 – 657Combined sources3
Helixi659 – 679Combined sources21
Beta strandi687 – 690Combined sources4
Helixi691 – 698Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KFUX-ray2.50L2-700[»]
1KFXX-ray3.15L2-700[»]
2NQAX-ray2.20A/B48-346[»]
ProteinModelPortaliP17655.
SMRiP17655.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17655.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 344Calpain catalyticPROSITE-ProRule annotationAdd BLAST300
Domaini572 – 605EF-hand 1PROSITE-ProRule annotationAdd BLAST34
Domaini602 – 637EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini667 – 700EF-hand 3PROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni345 – 514Domain IIIAdd BLAST170
Regioni515 – 529LinkerAdd BLAST15
Regioni530 – 700Domain IVAdd BLAST171

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated
Contains 1 calpain catalytic domain.PROSITE-ProRule annotation
Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00760000118971.
HOVERGENiHBG012645.
InParanoidiP17655.
KOiK03853.
OMAiDTYKKWK.
OrthoDBiEOG091G049E.
PhylomeDBiP17655.
TreeFamiTF314748.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029539. CAPN2.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF268. PTHR10183:SF268. 1 hit.
PfamiPF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P17655-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGIAAKLAK DREAAEGLGS HDRAIKYLNQ DYEALRNECL EAGTLFQDPS
60 70 80 90 100
FPAIPSALGF KELGPYSSKT RGIEWKRPTE ICADPQFIIG GATRTDICQG
110 120 130 140 150
ALGDCWLLAA IASLTLNEEI LARVVPLNQS FQENYAGIFH FQFWQYGEWV
160 170 180 190 200
EVVVDDRLPT KDGELLFVHS AEGSEFWSAL LEKAYAKING CYEALSGGAT
210 220 230 240 250
TEGFEDFTGG IAEWYELKKP PPNLFKIIQK ALQKGSLLGC SIDITSAADS
260 270 280 290 300
EAITFQKLVK GHAYSVTGAE EVESNGSLQK LIRIRNPWGE VEWTGRWNDN
310 320 330 340 350
CPSWNTIDPE ERERLTRRHE DGEFWMSFSD FLRHYSRLEI CNLTPDTLTS
360 370 380 390 400
DTYKKWKLTK MDGNWRRGST AGGCRNYPNT FWMNPQYLIK LEEEDEDEED
410 420 430 440 450
GESGCTFLVG LIQKHRRRQR KMGEDMHTIG FGIYEVPEEL SGQTNIHLSK
460 470 480 490 500
NFFLTNRARE RSDTFINLRE VLNRFKLPPG EYILVPSTFE PNKDGDFCIR
510 520 530 540 550
VFSEKKADYQ AVDDEIEANL EEFDISEDDI DDGFRRLFAQ LAGEDAEISA
560 570 580 590 600
FELQTILRRV LAKRQDIKSD GFSIETCKIM VDMLDSDGSG KLGLKEFYIL
610 620 630 640 650
WTKIQKYQKI YREIDVDRSG TMNSYEMRKA LEEAGFKMPC QLHQVIVARF
660 670 680 690 700
ADDQLIIDFD NFVRCLVRLE TLFKIFKQLD PENTGTIELD LISWLCFSVL
Length:700
Mass (Da):79,995
Last modified:January 11, 2011 - v6
Checksum:i8CF8294351A024E3
GO
Isoform 2 (identifier: P17655-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.
     79-79: T → M

Note: No experimental confirmation available.
Show »
Length:622
Mass (Da):71,476
Checksum:i60ED3A3498F6DD5D
GO

Sequence cautioni

The sequence AAH07686 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH11828 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73 – 74IE → MR in AAA35645 (PubMed:2852952).Curated2
Sequence conflicti256Q → K in AAF99682 (PubMed:10944468).Curated1
Sequence conflicti300N → S in AAF99682 (PubMed:10944468).Curated1
Sequence conflicti534F → V in AAA35645 (PubMed:2852952).Curated1
Sequence conflicti534F → V in AAF99682 (PubMed:10944468).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01443522D → E.Combined sources5 PublicationsCorresponds to variant rs25655dbSNPEnsembl.1
Natural variantiVAR_02140468S → G.2 PublicationsCorresponds to variant rs2230083dbSNPEnsembl.1
Natural variantiVAR_021405476K → R.1 PublicationCorresponds to variant rs9804140dbSNPEnsembl.1
Natural variantiVAR_021406521E → Q.1 PublicationCorresponds to variant rs28370127dbSNPEnsembl.1
Natural variantiVAR_014436568K → Q.1 PublicationCorresponds to variant rs17599dbSNPEnsembl.1
Natural variantiVAR_021407677K → Q.1 PublicationCorresponds to variant rs2230082dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0430271 – 78Missing in isoform 2. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_04302879T → M in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23254 mRNA. Translation: AAA35645.1.
AF261089 mRNA. Translation: AAF99682.1.
AK316211 mRNA. Translation: BAH14582.1.
AY835586 Genomic DNA. Translation: AAV80421.1.
AC096542 Genomic DNA. No translation available.
AC099065 Genomic DNA. No translation available.
BC007686 mRNA. Translation: AAH07686.1. Sequence problems.
BC011828 mRNA. Translation: AAH11828.1. Sequence problems.
BC021303 mRNA. Translation: AAH21303.1.
J04700 Genomic DNA. Translation: AAA52760.1.
CCDSiCCDS31035.1. [P17655-1]
CCDS53478.1. [P17655-2]
PIRiS10590. CIHUH2.
RefSeqiNP_001139540.1. NM_001146068.1. [P17655-2]
NP_001739.2. NM_001748.4.
UniGeneiHs.350899.

Genome annotation databases

EnsembliENST00000295006; ENSP00000295006; ENSG00000162909. [P17655-1]
ENST00000433674; ENSP00000413158; ENSG00000162909. [P17655-2]
GeneIDi824.
KEGGihsa:824.
UCSCiuc001hob.5. human. [P17655-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23254 mRNA. Translation: AAA35645.1.
AF261089 mRNA. Translation: AAF99682.1.
AK316211 mRNA. Translation: BAH14582.1.
AY835586 Genomic DNA. Translation: AAV80421.1.
AC096542 Genomic DNA. No translation available.
AC099065 Genomic DNA. No translation available.
BC007686 mRNA. Translation: AAH07686.1. Sequence problems.
BC011828 mRNA. Translation: AAH11828.1. Sequence problems.
BC021303 mRNA. Translation: AAH21303.1.
J04700 Genomic DNA. Translation: AAA52760.1.
CCDSiCCDS31035.1. [P17655-1]
CCDS53478.1. [P17655-2]
PIRiS10590. CIHUH2.
RefSeqiNP_001139540.1. NM_001146068.1. [P17655-2]
NP_001739.2. NM_001748.4.
UniGeneiHs.350899.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KFUX-ray2.50L2-700[»]
1KFXX-ray3.15L2-700[»]
2NQAX-ray2.20A/B48-346[»]
ProteinModelPortaliP17655.
SMRiP17655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107274. 50 interactors.
IntActiP17655. 12 interactors.
MINTiMINT-120195.
STRINGi9606.ENSP00000295006.

Chemistry databases

BindingDBiP17655.
ChEMBLiCHEMBL2382.
GuidetoPHARMACOLOGYi2337.

Protein family/group databases

MEROPSiC02.002.

PTM databases

iPTMnetiP17655.
PhosphoSitePlusiP17655.
SwissPalmiP17655.

Polymorphism and mutation databases

BioMutaiCAPN2.
DMDMi317373596.

Proteomic databases

EPDiP17655.
MaxQBiP17655.
PaxDbiP17655.
PeptideAtlasiP17655.
PRIDEiP17655.

Protocols and materials databases

DNASUi824.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295006; ENSP00000295006; ENSG00000162909. [P17655-1]
ENST00000433674; ENSP00000413158; ENSG00000162909. [P17655-2]
GeneIDi824.
KEGGihsa:824.
UCSCiuc001hob.5. human. [P17655-1]

Organism-specific databases

CTDi824.
DisGeNETi824.
GeneCardsiCAPN2.
HGNCiHGNC:1479. CAPN2.
HPAiHPA024470.
MIMi114230. gene.
neXtProtiNX_P17655.
OpenTargetsiENSG00000162909.
PharmGKBiPA26060.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00760000118971.
HOVERGENiHBG012645.
InParanoidiP17655.
KOiK03853.
OMAiDTYKKWK.
OrthoDBiEOG091G049E.
PhylomeDBiP17655.
TreeFamiTF314748.

Enzyme and pathway databases

BioCyciZFISH:HS08758-MONOMER.
BRENDAi3.4.22.53. 2681.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.
SIGNORiP17655.

Miscellaneous databases

ChiTaRSiCAPN2. human.
EvolutionaryTraceiP17655.
GeneWikiiCAPN2.
GenomeRNAii824.
PROiP17655.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162909.
CleanExiHS_CAPN2.
ExpressionAtlasiP17655. baseline and differential.
GenevisibleiP17655. HS.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029539. CAPN2.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF268. PTHR10183:SF268. 1 hit.
PfamiPF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAN2_HUMAN
AccessioniPrimary (citable) accession number: P17655
Secondary accession number(s): A6NDG7
, B7ZA96, E7ES58, Q16738, Q6PJT3, Q8WU26, Q9HBB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 205 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.