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P17653 (KITH_GAHVR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
OrganismGallid herpesvirus 2 (strain RB-1b) (GaHV-2) (Marek's disease herpesvirus type 1)
Taxonomic identifier33707 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
Virus hostGallus gallus (Chicken) [TaxID: 9031]

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

TMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 352352Thymidine kinase
PRO_0000175076

Regions

Nucleotide binding26 – 338ATP By similarity
Compositional bias76 – 794Poly-Arg

Sites

Active site541Proton acceptor Potential
Binding site951Substrate By similarity
Binding site1401Substrate By similarity
Binding site1851ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P17653 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 34A65B16BB18D002

FASTA35240,366
        10         20         30         40         50         60 
MSEPQSWSVM ASQMTSAQLI RVYLDGSMGI GKTSMLNEIP THSLMGVPVL KVFEPMKYWR 

        70         80         90        100        110        120 
YYFTDLVTTV NDTCDRRRRG EFSLFQSSMI VTALQSKFAD PYLVFHERLS SKCHRITGTR 

       130        140        150        160        170        180 
GNPSLILILD RHPISATVCF PIARHLTGDC SLEMLISMII RLPQEPPGCN LVIVDLHDEK 

       190        200        210        220        230        240 
EHVSRLSSRN RTGEKTDLLM LRALNAVYSC LVDTIMYANH ICPYSKDEWE SEWLDLPWFD 

       250        260        270        280        290        300 
TSLATTFINE PRTDYRGSRV SLHHTLLAIF KRRELCAEDG SLSTTHAWIL WGLLMKLRNI 

       310        320        330        340        350 
NVERFNITGL STTKCVESFM DTMSERLVTH SSWNDAFEIE ADVLAYNKEM AM 

« Hide

References

[1]"Nucleotide and predicted amino acid sequences of the Marek's disease virus and turkey herpesvirus thymidine kinase genes; comparison with thymidine kinase genes of other herpesviruses."
Scott S.D., Ross N.L.J., Binns M.M.
J. Gen. Virol. 70:3055-3065(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D13956 Genomic DNA. Translation: BAA03049.1.
PIRKIBEMV. B33375.

3D structure databases

ProteinModelPortalP17653.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_GAHVR
AccessionPrimary (citable) accession number: P17653
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families