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Protein

Thymidine kinase

Gene

TK

Organism
Gallid herpesvirus 2 (strain RB-1b) (GaHV-2) (Marek's disease herpesvirus type 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.UniRule annotation

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei54Proton acceptorUniRule annotation1
Binding sitei95SubstrateUniRule annotation1
Binding sitei185ATPUniRule annotation1
Binding sitei191SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 33ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processDNA synthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:TKUniRule annotation
OrganismiGallid herpesvirus 2 (strain RB-1b) (GaHV-2) (Marek's disease herpesvirus type 1)
Taxonomic identifieri33707 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001750761 – 352Thymidine kinaseAdd BLAST352

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP17653
SMRiP17653
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi76 – 79Poly-Arg4

Sequence similaritiesi

Belongs to the herpesviridae thymidine kinase family.UniRule annotation

Family and domain databases

HAMAPiMF_04029 HSV_KITH, 1 hit
InterProiView protein in InterPro
IPR001889 Herpes_TK
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00693 Herpes_TK, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

P17653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPQSWSVM ASQMTSAQLI RVYLDGSMGI GKTSMLNEIP THSLMGVPVL
60 70 80 90 100
KVFEPMKYWR YYFTDLVTTV NDTCDRRRRG EFSLFQSSMI VTALQSKFAD
110 120 130 140 150
PYLVFHERLS SKCHRITGTR GNPSLILILD RHPISATVCF PIARHLTGDC
160 170 180 190 200
SLEMLISMII RLPQEPPGCN LVIVDLHDEK EHVSRLSSRN RTGEKTDLLM
210 220 230 240 250
LRALNAVYSC LVDTIMYANH ICPYSKDEWE SEWLDLPWFD TSLATTFINE
260 270 280 290 300
PRTDYRGSRV SLHHTLLAIF KRRELCAEDG SLSTTHAWIL WGLLMKLRNI
310 320 330 340 350
NVERFNITGL STTKCVESFM DTMSERLVTH SSWNDAFEIE ADVLAYNKEM

AM
Length:352
Mass (Da):40,366
Last modified:August 1, 1990 - v1
Checksum:i34A65B16BB18D002
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13956 Genomic DNA Translation: BAA03049.1
PIRiB33375 KIBEMV

Similar proteinsi

Entry informationi

Entry nameiKITH_GAHVR
AccessioniPrimary (citable) accession number: P17653
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

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