Reviewed, UniProtKB/Swiss-Prot P17627 (PHL_LEPIN)

Names and origin

Protein names

Recommended name:
    Sphingomyelinase C
    EC=3.1.4.12
Alternative name(s):
    Sphingomyelin phosphodiesterase
      Short name=SMase

Gene names

Name:

sph

Organism

Leptospira interrogans

Taxonomic identifier

173 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Leptospiraceae › Leptospira

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	Sphingomyelin + H2O = N-acylsphingosine + choline phosphate.
Subcellular location	Secreted.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sphingomyelin phosphodiesterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 556	529	Sphingomyelinase C		PRO_0000022052

Sequences

	Sequence		Length	Mass (Da)
	P17627-1 [UniParc]. Last modified August 1, 1990. Version 1. Checksum: 6D0EACDB9A5CD6FD	FASTA	556	63,269
	10 20 30 40 50 60 MRIKKYTKVR LLVNCCLLLF FLIDCGADRQ SLYKDLLASL IYISDNKNIG STNSDLTGSG 70 80 90 100 110 120 SVSSSPADAA PENSILANSI PENMGIKILT HNVFLLPKTL PGWGNWGQNE RAQRIVSSNY 130 140 150 160 170 180 IQNQDVIVFD EAFDTDARKI LLDGVRSEYP YQTDVIGRTK KGWDATLGLY RTDAFTNGGV 190 200 210 220 230 240 VIVSKWPIEE KIQHVFKEKG CGADVFSNKG FAYVRIDKNG RKFHIIGTHV QAQDSGCANL 250 260 270 280 290 300 GVVSRVNQFN EIRDFIDSKK IPKNEMVLIA GDLNVIKGSR EYHQMLCILN VNNPKYVGVP 310 320 330 340 350 360 FTWDTKTNEI AAFYYKKVEP AYLDYIFVSK SHFQPPIWQN LAYDPISAKT WTAKGYTSDE 370 380 390 400 410 420 FSDHYPVYGF IYADSSTPTK SGRKRKYDRV SFVSVATGKK IQANSEKSNA WLKVNATTET 430 440 450 460 470 480 DLTKFNLVQT NDPDSNPSCM KSGHVRIESS HSLNYFWNWW LGGGKGNYAY YPKFNDGSNR 490 500 510 520 530 540 IQIINLDGGC LQDGSRVAFK DYDTISRRQY FLTVWEGGNW DKYLYLWRSH IGLREIFYLK 550 LDSSPEMNWS KKLIYR

References

[1]

"Molecular analysis of a sphingomyelinase C gene from Leptospira interrogans serovar hardjo." Segers R.P.A.M., van der Drift A., de Nijs A., Corcione P., van der Zeijst B.A.M., Gaastra W. Infect. Immun. 58:2177-2185(1990) [PubMed: 2163985] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sponselee / Serogroup Sejroe / Serovar hardjo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X52176 Genomic DNA. Translation: CAA36424.1.
PIR	S22634.
3D structure databases
SMR	P17627. Positions 86-371.
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.1.4.12. 258108.
Family and domain databases
InterPro	IPR005135. Endo/exonuclease/phosphatase. IPR017766. Sphingomyelinase/phospholipase. [Graphical view]
Pfam	PF03372. Exo_endo_phos. 1 hit. [Graphical view]
TIGRFAMs	TIGR03395. sphingomy. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PHL_LEPIN

Accession

Primary (citable) accession number: P17627

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
Last sequence update:	August 1, 1990
Last modified:	February 9, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)