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Protein

GTP-binding protein ryh1

Gene

ryh1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in retrograde traffricking of proteins from the endosome to the Golgi. Involved in protein transport to the plasma membrane. Involved in the secretory pathway where it has a role in acid phosphatase secretion. Required also in normal glycosylation trafficking pathways.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25GTPBy similarity8
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi124 – 127GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: PomBase
  • GTP binding Source: PomBase

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-6798695. Neutrophil degranulation.
R-SPO-6811440. Retrograde transport at the Trans-Golgi-Network.
R-SPO-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein ryh1
Gene namesi
Name:ryh1
Synonyms:hos1, its6
ORF Names:SPAC4C5.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4C5.02c.
PomBaseiSPAC4C5.02c. ryh1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • endosome membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: PomBase
  • Golgi membrane Source: UniProtKB-SubCell
  • nucleus Source: PomBase
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi25T → N: Growth inhibited in ypt3-i5 mutant cells; no effect on wild-type cells. 1 Publication1
Mutagenesisi70Q → L: Growth inhibited in wild-type cells; localizes to the plasma membrane. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001213071 – 201GTP-binding protein ryh1Add BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi199S-geranylgeranyl cysteineBy similarity1
Modified residuei201Cysteine methyl esterBy similarity1
Lipidationi201S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP17608.
PRIDEiP17608.

Interactioni

Protein-protein interaction databases

BioGridi279947. 161 interactors.
MINTiMINT-4687426.

Structurei

3D structure databases

ProteinModelPortaliP17608.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 48Effector regionCurated9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

HOGENOMiHOG000233968.
InParanoidiP17608.
KOiK07893.
OMAiENESSCN.
OrthoDBiEOG092C5MDH.
PhylomeDBiP17608.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P17608-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSENYSFSLR KFKLVFLGEQ SVGKTSLITR FMYDQFDNTY QATIGIDFLS
60 70 80 90 100
KTMYLEDRTV RLQLWDTAGQ ERFRSLIPSY IRDSSVAIIV YDITNHNSFV
110 120 130 140 150
NTEKWIEDVR AERGDDVIIV LVGNKTDLAD KRQVTQEEGE KKAKELKIMH
160 170 180 190 200
METSAKAGHN VKLLFRKIAQ MLPGMENVET QSTQMIDVSI QPNENESSCN

C
Length:201
Mass (Da):23,136
Last modified:August 1, 1990 - v1
Checksum:i353493CBF987D1E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52475 Genomic DNA. Translation: CAA36715.1.
CU329670 Genomic DNA. Translation: CAB11173.1.
PIRiS12789.
RefSeqiNP_593249.1. NM_001018646.2.

Genome annotation databases

EnsemblFungiiSPAC4C5.02c.1; SPAC4C5.02c.1:pep; SPAC4C5.02c.
GeneIDi2543529.
KEGGispo:SPAC4C5.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52475 Genomic DNA. Translation: CAA36715.1.
CU329670 Genomic DNA. Translation: CAB11173.1.
PIRiS12789.
RefSeqiNP_593249.1. NM_001018646.2.

3D structure databases

ProteinModelPortaliP17608.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279947. 161 interactors.
MINTiMINT-4687426.

Proteomic databases

MaxQBiP17608.
PRIDEiP17608.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC4C5.02c.1; SPAC4C5.02c.1:pep; SPAC4C5.02c.
GeneIDi2543529.
KEGGispo:SPAC4C5.02c.

Organism-specific databases

EuPathDBiFungiDB:SPAC4C5.02c.
PomBaseiSPAC4C5.02c. ryh1.

Phylogenomic databases

HOGENOMiHOG000233968.
InParanoidiP17608.
KOiK07893.
OMAiENESSCN.
OrthoDBiEOG092C5MDH.
PhylomeDBiP17608.

Enzyme and pathway databases

ReactomeiR-SPO-6798695. Neutrophil degranulation.
R-SPO-6811440. Retrograde transport at the Trans-Golgi-Network.
R-SPO-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

PROiP17608.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRYH1_SCHPO
AccessioniPrimary (citable) accession number: P17608
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.