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P17600

- SYN1_HUMAN

UniProt

P17600 - SYN1_HUMAN

Protein

Synapsin-1

Gene

SYN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 3 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. catalytic activity Source: InterPro
    3. protein binding Source: IntAct
    4. protein kinase binding Source: ParkinsonsUK-UCL
    5. transporter activity Source: ProtInc

    GO - Biological processi

    1. neurotransmitter secretion Source: InterPro
    2. synaptic transmission Source: ProtInc

    Keywords - Ligandi

    Actin-binding

    Enzyme and pathway databases

    ReactomeiREACT_15293. Dopamine Neurotransmitter Release Cycle.
    REACT_15425. Serotonin Neurotransmitter Release Cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synapsin-1
    Alternative name(s):
    Brain protein 4.1
    Synapsin I
    Gene namesi
    Name:SYN1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:11494. SYN1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytosol Source: Ensembl
    3. dendrite Source: Ensembl
    4. Golgi apparatus Source: UniProtKB-SubCell
    5. synaptic vesicle Source: ParkinsonsUK-UCL

    Keywords - Cellular componenti

    Cell junction, Golgi apparatus, Synapse

    Pathology & Biotechi

    Involvement in diseasei

    Epilepsy X-linked, with variable learning disabilities and behavior disorders (XELBD) [MIM:300491]: A neurologic disorder characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Epilepsy

    Organism-specific databases

    MIMi300491. phenotype.
    Orphaneti85294. X-linked epilepsy - learning disabilities - behavior disorders.
    PharmGKBiPA36276.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 705705Synapsin-1PRO_0000183018Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei9 – 91Phosphoserine; by CaMK1 and PKABy similarity
    Glycosylationi55 – 551O-linked (GlcNAc)By similarity
    Glycosylationi87 – 871O-linked (GlcNAc)By similarity
    Glycosylationi96 – 961O-linked (GlcNAc)By similarity
    Glycosylationi103 – 1031O-linked (GlcNAc)By similarity
    Glycosylationi261 – 2611O-linked (GlcNAc)By similarity
    Modified residuei312 – 3121PhosphotyrosineBy similarity
    Modified residuei427 – 4271PhosphoserineBy similarity
    Glycosylationi432 – 4321O-linked (GlcNAc)By similarity
    Glycosylationi526 – 5261O-linked (GlcNAc)By similarity
    Modified residuei551 – 5511Phosphoserine; by PDPK12 Publications
    Modified residuei553 – 5531Phosphoserine2 Publications
    Glycosylationi564 – 5641O-linked (GlcNAc)By similarity
    Modified residuei568 – 5681Phosphoserine; by CaMK2By similarity
    Glycosylationi578 – 5781O-linked (GlcNAc)By similarity
    Modified residuei605 – 6051Phosphoserine; by CaMK2By similarity

    Post-translational modificationi

    Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal.2 Publications
    Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP17600.
    PaxDbiP17600.
    PRIDEiP17600.

    PTM databases

    PhosphoSiteiP17600.

    Expressioni

    Gene expression databases

    BgeeiP17600.
    CleanExiHS_SYN1.
    GenevestigatoriP17600.

    Organism-specific databases

    HPAiCAB021929.
    HPA000397.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1. Isoform Ib interacts with PRNP By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SNCAP378402EBI-717274,EBI-985879

    Protein-protein interaction databases

    BioGridi112719. 22 interactions.
    IntActiP17600. 4 interactions.
    MINTiMINT-1370745.
    STRINGi9606.ENSP00000295987.

    Structurei

    3D structure databases

    ProteinModelPortaliP17600.
    SMRiP17600. Positions 112-417.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2828AAdd
    BLAST
    Regioni29 – 11284B; linkerAdd
    BLAST
    Regioni113 – 420308C; actin-binding and synaptic-vesicle bindingAdd
    BLAST
    Regioni421 – 655235D; Pro-rich linkerAdd
    BLAST
    Regioni656 – 70550EAdd
    BLAST

    Domaini

    The A region binds phospholipids with a preference for negatively charged species.By similarity

    Sequence similaritiesi

    Belongs to the synapsin family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG284201.
    HOGENOMiHOG000231323.
    HOVERGENiHBG016354.
    InParanoidiP17600.
    OMAiPIRQASQ.
    OrthoDBiEOG793B7G.
    PhylomeDBiP17600.
    TreeFamiTF319919.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    InterProiIPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR028713. SYN1.
    IPR001359. Synapsin.
    IPR020898. Synapsin_ATP-bd_dom.
    IPR019735. Synapsin_CS.
    IPR019736. Synapsin_P_site.
    IPR020897. Synapsin_pre-ATP-grasp_dom.
    [Graphical view]
    PANTHERiPTHR10841. PTHR10841. 1 hit.
    PTHR10841:SF8. PTHR10841:SF8. 1 hit.
    PfamiPF02078. Synapsin. 1 hit.
    PF02750. Synapsin_C. 1 hit.
    PF10581. Synapsin_N. 1 hit.
    [Graphical view]
    PRINTSiPR01368. SYNAPSIN.
    SUPFAMiSSF52440. SSF52440. 1 hit.
    PROSITEiPS00415. SYNAPSIN_1. 1 hit.
    PS00416. SYNAPSIN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform IA (identifier: P17600-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNYLRRRLSD SNFMANLPNG YMTDLQRPQP PPPPPGAHSP GATPGPGTAT    50
    AERSSGVAPA ASPAAPSPGS SGGGGFFSSL SNAVKQTTAA AAATFSEQVG 100
    GGSGGAGRGG AASRVLLVID EPHTDWAKYF KGKKIHGEID IKVEQAEFSD 150
    LNLVAHANGG FSVDMEVLRN GVKVVRSLKP DFVLIRQHAF SMARNGDYRS 200
    LVIGLQYAGI PSVNSLHSVY NFCDKPWVFA QMVRLHKKLG TEEFPLIDQT 250
    FYPNHKEMLS STTYPVVVKM GHAHSGMGKV KVDNQHDFQD IASVVALTKT 300
    YATAEPFIDA KYDVRVQKIG QNYKAYMRTS VSGNWKTNTG SAMLEQIAMS 350
    DRYKLWVDTC SEIFGGLDIC AVEALHGKDG RDHIIEVVGS SMPLIGDHQD 400
    EDKQLIVELV VNKMAQALPR QRQRDASPGR GSHGQTPSPG ALPLGRQTSQ 450
    QPAGPPAQQR PPPQGGPPQP GPGPQRQGPP LQQRPPPQGQ QHLSGLGPPA 500
    GSPLPQRLPS PTSAPQQPAS QAAPPTQGQG RQSRPVAGGP GAPPAARPPA 550
    SPSPQRQAGP PQATRQTSVS GPAPPKASGA PPGGQQRQGP PQKPPGPAGP 600
    TRQASQAGPV PRTGPPTTQQ PRPSGPGPAG RPKPQLAQKP SQDVPPPATA 650
    AAGGPPHPQL NKSQSLTNAF NLPEPAPPRP SLSQDEVKAE TIRSLRKSFA 700
    SLFSD 705
    Length:705
    Mass (Da):74,111
    Last modified:August 30, 2005 - v3
    Checksum:iBE4CE46C942300B0
    GO
    Isoform IB (identifier: P17600-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         661-669: NKSQSLTNA → KASPAQAQP
         670-705: Missing.

    Show »
    Length:669
    Mass (Da):70,033
    Checksum:i5E400115415D3E32
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti138 – 1381E → G in AAC41930. (PubMed:2110562)Curated
    Sequence conflicti138 – 1381E → G in AAC41931. (PubMed:2110562)Curated
    Sequence conflicti631 – 6311R → A in AAC41930. (PubMed:2110562)Curated
    Sequence conflicti631 – 6311R → A in AAC41931. (PubMed:2110562)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei661 – 6699NKSQSLTNA → KASPAQAQP in isoform IB. CuratedVSP_006316
    Alternative sequencei670 – 70536Missing in isoform IB. CuratedVSP_006317Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58378
    , M58321, M58341, M58351, M58353, M58359, M58371, M58372, M58373, M58374, M58375, M58376, M58377 Genomic DNA. Translation: AAC41930.1.
    M58378
    , M58321, M58341, M58351, M58353, M58359, M58371, M58372, M58373, M58374, M58375, M58376, M58377 Genomic DNA. Translation: AAC41931.1. Sequence problems.
    AL009172, Z84466 Genomic DNA. Translation: CAI42445.1.
    AL009172, Z84466 Genomic DNA. Translation: CAI42446.1.
    Z84466, AL009172 Genomic DNA. Translation: CAI42461.1.
    Z84466, AL009172 Genomic DNA. Translation: CAI42462.1.
    CH471164 Genomic DNA. Translation: EAW59313.1.
    M55301 Genomic DNA. Translation: AAA60608.1.
    CCDSiCCDS14280.1. [P17600-1]
    CCDS35233.1. [P17600-2]
    PIRiA35363.
    RefSeqiNP_008881.2. NM_006950.3. [P17600-1]
    NP_598006.1. NM_133499.2. [P17600-2]
    UniGeneiHs.225936.

    Genome annotation databases

    EnsembliENST00000295987; ENSP00000295987; ENSG00000008056. [P17600-1]
    ENST00000340666; ENSP00000343206; ENSG00000008056. [P17600-2]
    GeneIDi6853.
    KEGGihsa:6853.
    UCSCiuc004did.3. human. [P17600-2]
    uc004die.3. human. [P17600-1]

    Polymorphism databases

    DMDMi73920800.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58378
    , M58321 , M58341 , M58351 , M58353 , M58359 , M58371 , M58372 , M58373 , M58374 , M58375 , M58376 , M58377 Genomic DNA. Translation: AAC41930.1 .
    M58378
    , M58321 , M58341 , M58351 , M58353 , M58359 , M58371 , M58372 , M58373 , M58374 , M58375 , M58376 , M58377 Genomic DNA. Translation: AAC41931.1 . Sequence problems.
    AL009172 , Z84466 Genomic DNA. Translation: CAI42445.1 .
    AL009172 , Z84466 Genomic DNA. Translation: CAI42446.1 .
    Z84466 , AL009172 Genomic DNA. Translation: CAI42461.1 .
    Z84466 , AL009172 Genomic DNA. Translation: CAI42462.1 .
    CH471164 Genomic DNA. Translation: EAW59313.1 .
    M55301 Genomic DNA. Translation: AAA60608.1 .
    CCDSi CCDS14280.1. [P17600-1 ]
    CCDS35233.1. [P17600-2 ]
    PIRi A35363.
    RefSeqi NP_008881.2. NM_006950.3. [P17600-1 ]
    NP_598006.1. NM_133499.2. [P17600-2 ]
    UniGenei Hs.225936.

    3D structure databases

    ProteinModelPortali P17600.
    SMRi P17600. Positions 112-417.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112719. 22 interactions.
    IntActi P17600. 4 interactions.
    MINTi MINT-1370745.
    STRINGi 9606.ENSP00000295987.

    PTM databases

    PhosphoSitei P17600.

    Polymorphism databases

    DMDMi 73920800.

    Proteomic databases

    MaxQBi P17600.
    PaxDbi P17600.
    PRIDEi P17600.

    Protocols and materials databases

    DNASUi 6853.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295987 ; ENSP00000295987 ; ENSG00000008056 . [P17600-1 ]
    ENST00000340666 ; ENSP00000343206 ; ENSG00000008056 . [P17600-2 ]
    GeneIDi 6853.
    KEGGi hsa:6853.
    UCSCi uc004did.3. human. [P17600-2 ]
    uc004die.3. human. [P17600-1 ]

    Organism-specific databases

    CTDi 6853.
    GeneCardsi GC0XM047431.
    HGNCi HGNC:11494. SYN1.
    HPAi CAB021929.
    HPA000397.
    MIMi 300491. phenotype.
    313440. gene.
    neXtProti NX_P17600.
    Orphaneti 85294. X-linked epilepsy - learning disabilities - behavior disorders.
    PharmGKBi PA36276.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284201.
    HOGENOMi HOG000231323.
    HOVERGENi HBG016354.
    InParanoidi P17600.
    OMAi PIRQASQ.
    OrthoDBi EOG793B7G.
    PhylomeDBi P17600.
    TreeFami TF319919.

    Enzyme and pathway databases

    Reactomei REACT_15293. Dopamine Neurotransmitter Release Cycle.
    REACT_15425. Serotonin Neurotransmitter Release Cycle.

    Miscellaneous databases

    ChiTaRSi SYN1. human.
    GeneWikii Synapsin_I.
    GenomeRNAii 6853.
    NextBioi 26745.
    PROi P17600.
    SOURCEi Search...

    Gene expression databases

    Bgeei P17600.
    CleanExi HS_SYN1.
    Genevestigatori P17600.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    InterProi IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR028713. SYN1.
    IPR001359. Synapsin.
    IPR020898. Synapsin_ATP-bd_dom.
    IPR019735. Synapsin_CS.
    IPR019736. Synapsin_P_site.
    IPR020897. Synapsin_pre-ATP-grasp_dom.
    [Graphical view ]
    PANTHERi PTHR10841. PTHR10841. 1 hit.
    PTHR10841:SF8. PTHR10841:SF8. 1 hit.
    Pfami PF02078. Synapsin. 1 hit.
    PF02750. Synapsin_C. 1 hit.
    PF10581. Synapsin_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01368. SYNAPSIN.
    SUPFAMi SSF52440. SSF52440. 1 hit.
    PROSITEi PS00415. SYNAPSIN_1. 1 hit.
    PS00416. SYNAPSIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The structure of the human synapsin I gene and protein."
      Suedhof T.C.
      J. Biol. Chem. 265:7849-7852(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
      Tissue: Brain.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The 5'-flanking region of the synapsin I gene. A G+C-rich, TATA- and CAAT-less, phylogenetically conserved sequence with cell type-specific promoter function."
      Sauerwald A., Hoesche C., Oschwald R., Kilimann M.W.
      J. Biol. Chem. 265:14932-14937(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-125.
    5. "Identification of a mutation in synapsin I, a synaptic vesicle protein, in a family with epilepsy."
      Garcia C.C., Blair H.J., Seager M., Coulthard A., Tennant S., Buddles M., Curtis A., Goodship J.A.
      J. Med. Genet. 41:183-187(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN XELBD.
    6. "Phosphoproteomic analysis of synaptosomes from human cerebral cortex."
      DeGiorgis J.A., Jaffe H., Moreira J.E., Carlotti C.G. Jr., Leite J.P., Pant H.C., Dosemeci A.
      J. Proteome Res. 4:306-315(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-551 AND SER-553, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-551 AND SER-553, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSYN1_HUMAN
    AccessioniPrimary (citable) accession number: P17600
    Secondary accession number(s): B1AJQ1, O75825, Q5H9A9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1990
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 149 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3