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Protein

Synapsin-1

Gene

SYN1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synapsin-1
Alternative name(s):
Synapsin I
Gene namesi
Name:SYN1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Golgi apparatus, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830161 – 706Synapsin-1Add BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9Phosphoserine; by CaMK1 and PKABy similarity1
Modified residuei39PhosphoserineBy similarity1
Glycosylationi55O-linked (GlcNAc)By similarity1
Modified residuei62PhosphoserineBy similarity1
Modified residuei67PhosphoserineBy similarity1
Glycosylationi87O-linked (GlcNAc)By similarity1
Glycosylationi96O-linked (GlcNAc)By similarity1
Glycosylationi103O-linked (GlcNAc)By similarity1
Glycosylationi261O-linked (GlcNAc)By similarity1
Modified residuei312PhosphotyrosineBy similarity1
Modified residuei427PhosphoserineBy similarity1
Modified residuei430Omega-N-methylarginineBy similarity1
Modified residuei432Phosphoserine; alternateBy similarity1
Glycosylationi432O-linked (GlcNAc); alternateBy similarity1
Modified residuei434PhosphoserineBy similarity1
Modified residuei436PhosphothreonineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei476Omega-N-methylarginineBy similarity1
Glycosylationi526O-linked (GlcNAc)By similarity1
Modified residuei534Omega-N-methylarginineBy similarity1
Modified residuei547Omega-N-methylarginineBy similarity1
Modified residuei551Phosphoserine; by PDPK11 Publication1
Modified residuei553PhosphoserineBy similarity1
Modified residuei556Omega-N-methylarginineBy similarity1
Glycosylationi564O-linked (GlcNAc)By similarity1
Modified residuei568Phosphoserine; by CaMK21 Publication1
Glycosylationi578O-linked (GlcNAc)By similarity1
Modified residuei605Phosphoserine; by CaMK21 Publication1
Modified residuei622Omega-N-methylarginineBy similarity1
Modified residuei664PhosphoserineBy similarity1
Modified residuei666PhosphoserineBy similarity1
Modified residuei680Asymmetric dimethylarginineBy similarity1
Modified residuei684PhosphoserineBy similarity1

Post-translational modificationi

Substrate of at least four different protein kinases. Phosphorylation may play a role in the regulation of synapsin-1 in the nerve terminal.2 Publications
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.By similarity

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP17599.
PRIDEiP17599.

PTM databases

iPTMnetiP17599.
UniCarbKBiP17599.

Interactioni

Subunit structurei

Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1. Isoform Ib interacts with PRNP (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-139117.
STRINGi9913.ENSBTAP00000027503.

Structurei

Secondary structure

1706
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi114 – 119Combined sources6
Helixi126 – 130Combined sources5
Turni136 – 138Combined sources3
Beta strandi141 – 146Combined sources6
Helixi148 – 150Combined sources3
Beta strandi151 – 155Combined sources5
Beta strandi161 – 169Combined sources9
Turni170 – 172Combined sources3
Beta strandi173 – 178Combined sources6
Beta strandi181 – 185Combined sources5
Beta strandi189 – 191Combined sources3
Turni192 – 195Combined sources4
Helixi199 – 207Combined sources9
Beta strandi212 – 214Combined sources3
Helixi216 – 221Combined sources6
Helixi225 – 239Combined sources15
Turni241 – 243Combined sources3
Beta strandi250 – 254Combined sources5
Helixi255 – 257Combined sources3
Beta strandi262 – 272Combined sources11
Turni275 – 278Combined sources4
Beta strandi279 – 282Combined sources4
Helixi285 – 296Combined sources12
Turni297 – 299Combined sources3
Beta strandi302 – 306Combined sources5
Beta strandi310 – 319Combined sources10
Beta strandi322 – 328Combined sources7
Beta strandi345 – 347Combined sources3
Helixi351 – 360Combined sources10
Helixi361 – 365Combined sources5
Beta strandi368 – 377Combined sources10
Beta strandi382 – 388Combined sources7
Helixi399 – 415Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AUVX-ray2.15A/B110-420[»]
1AUXX-ray2.30A/B110-420[»]
ProteinModelPortaliP17599.
SMRiP17599.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17599.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28AAdd BLAST28
Regioni29 – 112B; linkerAdd BLAST84
Regioni113 – 420C; actin-binding and synaptic-vesicle bindingAdd BLAST308
Regioni421 – 656D; Pro-rich linkerAdd BLAST236
Regioni657 – 706EAdd BLAST50

Domaini

The A region binds phospholipids with a preference for negatively charged species.By similarity

Sequence similaritiesi

Belongs to the synapsin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3895. Eukaryota.
ENOG410XQH5. LUCA.
HOGENOMiHOG000231323.
HOVERGENiHBG016354.
InParanoidiP17599.
KOiK19941.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR028713. SYN1.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR019735. Synapsin_CS.
IPR019736. Synapsin_P_site.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view]
PANTHERiPTHR10841. PTHR10841. 2 hits.
PTHR10841:SF22. PTHR10841:SF22. 2 hits.
PfamiPF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
PF10581. Synapsin_N. 1 hit.
[Graphical view]
PRINTSiPR01368. SYNAPSIN.
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS00415. SYNAPSIN_1. 1 hit.
PS00416. SYNAPSIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform IA (identifier: P17599-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNYLRRRLSD SNFMANLPNG YMTDLQRPQP PPPPPAAPSP GATTGPATAT
60 70 80 90 100
AERASSAAPV ASPAAPSPGS SGGGGFFSSL SNAVKQTTAA AAATFSEQVG
110 120 130 140 150
GGSGGAGRGG AAARVLLVID EPHTDWAKYF KGKKIHGEID IKVEQAEFSD
160 170 180 190 200
LNLVAHANGG FSVDMEVLRN GVKVVRSLKP DFVLIRQHAF SMARNGDYRS
210 220 230 240 250
LVIGLQYAGI PSINSLHSVY NFCDKPWVFA QMVRLHKKLG TEEFPLINQT
260 270 280 290 300
FYPNHKEMLS STTYPVVVKM GHAHSGMGKV KVDNQHDFQD IASVVALTKT
310 320 330 340 350
YATTEPFIDA KYDVRIQKIG QNYKAYMRTS VSGNWKTNTG SAMLEQIAMS
360 370 380 390 400
DRYKLWVDTC SEIFGGLDIC AVEALHGKDG RDHIIQVVGS SMPLIGDHQD
410 420 430 440 450
EDKQLIVELV VNKMAQALPR QRQRDASPGR GSHSQTPSPG ALPLGRQISQ
460 470 480 490 500
QPAGPPAQQR PPPQGGPPQP GPGPQRQGPP LQQRPTPQGQ QHLSGLGPPA
510 520 530 540 550
GSPLPQRLPS PTSVPQQPAS QATPMTQGQG RQSRPVAGGP GAPPATRPPA
560 570 580 590 600
SPSPQRQAGP PQATRQTSVS GQAPPKASGV PPGGQQRQGP PQKPPGPAGP
610 620 630 640 650
TRQASQAGPM PRTGPPTTQQ PRPSGPGPAG RPTKPQLAQK PSQDVPPPAT
660 670 680 690 700
AAAGGPPHPQ LNKSQSLTNA FNLPEPAPPR PSLSQDEVKA ETIRSLRKSF

ASLFSD
Length:706
Mass (Da):74,518
Last modified:February 1, 1996 - v2
Checksum:i89373750BF014340
GO
Isoform IB (identifier: P17599-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     662-670: NKSQSLTNA → KASPAQAQP
     671-706: Missing.

Show »
Length:670
Mass (Da):70,439
Checksum:iD330C4C4E23E2ED1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006314662 – 670NKSQSLTNA → KASPAQAQP in isoform IB. 1 Publication9
Alternative sequenceiVSP_006315671 – 706Missing in isoform IB. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27810 mRNA. Translation: AAA30761.1.
M27811 mRNA. Translation: AAA30762.1.
PIRiE30411.
RefSeqiNP_776616.1. NM_174191.2. [P17599-1]
UniGeneiBt.62979.

Genome annotation databases

GeneIDi281510.
KEGGibta:281510.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27810 mRNA. Translation: AAA30761.1.
M27811 mRNA. Translation: AAA30762.1.
PIRiE30411.
RefSeqiNP_776616.1. NM_174191.2. [P17599-1]
UniGeneiBt.62979.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AUVX-ray2.15A/B110-420[»]
1AUXX-ray2.30A/B110-420[»]
ProteinModelPortaliP17599.
SMRiP17599.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-139117.
STRINGi9913.ENSBTAP00000027503.

PTM databases

iPTMnetiP17599.
UniCarbKBiP17599.

Proteomic databases

PaxDbiP17599.
PRIDEiP17599.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281510.
KEGGibta:281510.

Organism-specific databases

CTDi6853.

Phylogenomic databases

eggNOGiKOG3895. Eukaryota.
ENOG410XQH5. LUCA.
HOGENOMiHOG000231323.
HOVERGENiHBG016354.
InParanoidiP17599.
KOiK19941.

Miscellaneous databases

EvolutionaryTraceiP17599.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR028713. SYN1.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR019735. Synapsin_CS.
IPR019736. Synapsin_P_site.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view]
PANTHERiPTHR10841. PTHR10841. 2 hits.
PTHR10841:SF22. PTHR10841:SF22. 2 hits.
PfamiPF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
PF10581. Synapsin_N. 1 hit.
[Graphical view]
PRINTSiPR01368. SYNAPSIN.
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS00415. SYNAPSIN_1. 1 hit.
PS00416. SYNAPSIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYN1_BOVIN
AccessioniPrimary (citable) accession number: P17599
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.