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P17599 (SYN1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synapsin-1
Alternative name(s):
Synapsin I
Gene names
Name:SYN1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length706 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level By similarity.

Subunit structure

Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1. Isoform Ib interacts with PRNP By similarity.

Subcellular location

Cell junction › synapse. Golgi apparatus By similarity.

Domain

The A region binds phospholipids with a preference for negatively charged species By similarity.

Post-translational modification

Substrate of at least four different protein kinases. Phosphorylation may play a role in the regulation of synapsin-1 in the nerve terminal.

Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles By similarity.

Sequence similarities

Belongs to the synapsin family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform IA (identifier: P17599-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform IB (identifier: P17599-2)

The sequence of this isoform differs from the canonical sequence as follows:
     662-670: NKSQSLTNA → KASPAQAQP
     671-706: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 706706Synapsin-1
PRO_0000183016

Regions

Region1 – 2828A
Region29 – 11284B; linker
Region113 – 420308C; actin-binding and synaptic-vesicle binding
Region421 – 656236D; Pro-rich linker
Region657 – 70650E

Amino acid modifications

Modified residue91Phosphoserine; by CaMK1 and PKA; alternate
Modified residue91Phosphoserine; by PKA and CaMK1; alternate By similarity
Modified residue621Phosphoserine By similarity
Modified residue671Phosphoserine By similarity
Modified residue3121Phosphotyrosine By similarity
Modified residue3371Phosphothreonine By similarity
Modified residue4271Phosphoserine By similarity
Modified residue5101Phosphoserine By similarity
Modified residue5121Phosphothreonine By similarity
Modified residue5201Phosphoserine By similarity
Modified residue5511Phosphoserine; by PDPK1 Ref.2
Modified residue5531Phosphoserine By similarity
Modified residue5681Phosphoserine; by CaMK2
Modified residue6051Phosphoserine; by CaMK2
Modified residue6661Phosphoserine By similarity
Modified residue7051Phosphoserine By similarity
Glycosylation551O-linked (GlcNAc) By similarity
Glycosylation871O-linked (GlcNAc) By similarity
Glycosylation961O-linked (GlcNAc) By similarity
Glycosylation1031O-linked (GlcNAc) By similarity
Glycosylation2611O-linked (GlcNAc) By similarity
Glycosylation4321O-linked (GlcNAc) By similarity
Glycosylation5261O-linked (GlcNAc) By similarity
Glycosylation5641O-linked (GlcNAc) By similarity
Glycosylation5781O-linked (GlcNAc) By similarity

Natural variations

Alternative sequence662 – 6709NKSQSLTNA → KASPAQAQP in isoform IB.
VSP_006314
Alternative sequence671 – 70636Missing in isoform IB.
VSP_006315

Secondary structure

1 ........................................................... 706
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform IA [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 89373750BF014340

FASTA70674,518
        10         20         30         40         50         60 
MNYLRRRLSD SNFMANLPNG YMTDLQRPQP PPPPPAAPSP GATTGPATAT AERASSAAPV 

        70         80         90        100        110        120 
ASPAAPSPGS SGGGGFFSSL SNAVKQTTAA AAATFSEQVG GGSGGAGRGG AAARVLLVID 

       130        140        150        160        170        180 
EPHTDWAKYF KGKKIHGEID IKVEQAEFSD LNLVAHANGG FSVDMEVLRN GVKVVRSLKP 

       190        200        210        220        230        240 
DFVLIRQHAF SMARNGDYRS LVIGLQYAGI PSINSLHSVY NFCDKPWVFA QMVRLHKKLG 

       250        260        270        280        290        300 
TEEFPLINQT FYPNHKEMLS STTYPVVVKM GHAHSGMGKV KVDNQHDFQD IASVVALTKT 

       310        320        330        340        350        360 
YATTEPFIDA KYDVRIQKIG QNYKAYMRTS VSGNWKTNTG SAMLEQIAMS DRYKLWVDTC 

       370        380        390        400        410        420 
SEIFGGLDIC AVEALHGKDG RDHIIQVVGS SMPLIGDHQD EDKQLIVELV VNKMAQALPR 

       430        440        450        460        470        480 
QRQRDASPGR GSHSQTPSPG ALPLGRQISQ QPAGPPAQQR PPPQGGPPQP GPGPQRQGPP 

       490        500        510        520        530        540 
LQQRPTPQGQ QHLSGLGPPA GSPLPQRLPS PTSVPQQPAS QATPMTQGQG RQSRPVAGGP 

       550        560        570        580        590        600 
GAPPATRPPA SPSPQRQAGP PQATRQTSVS GQAPPKASGV PPGGQQRQGP PQKPPGPAGP 

       610        620        630        640        650        660 
TRQASQAGPM PRTGPPTTQQ PRPSGPGPAG RPTKPQLAQK PSQDVPPPAT AAAGGPPHPQ 

       670        680        690        700 
LNKSQSLTNA FNLPEPAPPR PSLSQDEVKA ETIRSLRKSF ASLFSD

« Hide

Isoform IB [UniParc].

Checksum: D330C4C4E23E2ED1
Show »

FASTA67070,439

References

[1]"Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins."
Suedhof T.C., Czernik A.J., Kao H.-T., Takei K., Johnston P.A., Horiuchi A., Kanazir S.D., Wagner M.A., Perin M.S., de Camilli P., Greengard P.
Science 245:1474-1480(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IA AND IB).
Tissue: Brain.
[2]"Phosphorylation of synapsin I at a novel site by proline-directed protein kinase."
Hall F.L., Mitchell J.P., Vulliet P.R.
J. Biol. Chem. 265:6944-6948(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT SER-551 BY PDPK.
[3]"Synapsin I is structurally similar to ATP-utilizing enzymes."
Esser L., Wang C.-R., Hosaka M., Smagula C.S., Suedhof T.C., Deisenhofer J.
EMBO J. 17:977-984(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 112-417.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M27810 mRNA. Translation: AAA30761.1.
M27811 mRNA. Translation: AAA30762.1.
IPIIPI00705843.
IPI00904518.
PIRE30411.
RefSeqNP_776616.1. NM_174191.2.
UniGeneBt.62979.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1AUVX-ray2.15A/B110-420[»]
1AUXX-ray2.30A/B110-420[»]
ProteinModelPortalP17599.
SMRP17599. Positions 112-417.
ModBaseSearch...

PTM databases

GlycoSuiteDBP17599.

Proteomic databases

PRIDEP17599.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID281510.
KEGGbta:281510.

Organism-specific databases

CTD6853.

Phylogenomic databases

eggNOGNOG284201.
HOGENOMHOG000231323.
HOVERGENHBG016354.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProIPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR019735. Synapsin_CS.
IPR019736. Synapsin_P_site.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view]
PfamPF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
PF10581. Synapsin_N. 1 hit.
[Graphical view]
PRINTSPR01368. SYNAPSIN.
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
PROSITEPS00415. SYNAPSIN_1. 1 hit.
PS00416. SYNAPSIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP17599.
NextBio20805477.

Entry information

Entry nameSYN1_BOVIN
AccessionPrimary (citable) accession number: P17599
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 1, 1996
Last modified: April 3, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents