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P17599

- SYN1_BOVIN

UniProt

P17599 - SYN1_BOVIN

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Protein

Synapsin-1

Gene

SYN1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. catalytic activity Source: InterPro

GO - Biological processi

  1. neurotransmitter secretion Source: AgBase
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synapsin-1
Alternative name(s):
Synapsin I
Gene namesi
Name:SYN1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. Golgi apparatus Source: UniProtKB-KW
  3. synapse Source: AgBase
  4. synaptic vesicle Source: AgBase
  5. synaptic vesicle membrane Source: AgBase
  6. synaptonemal complex Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Golgi apparatus, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Synapsin-1PRO_0000183016Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91Phosphoserine; by CaMK1 and PKABy similarity
Glycosylationi55 – 551O-linked (GlcNAc)By similarity
Glycosylationi87 – 871O-linked (GlcNAc)By similarity
Glycosylationi96 – 961O-linked (GlcNAc)By similarity
Glycosylationi103 – 1031O-linked (GlcNAc)By similarity
Glycosylationi261 – 2611O-linked (GlcNAc)By similarity
Modified residuei312 – 3121PhosphotyrosineBy similarity
Modified residuei427 – 4271PhosphoserineBy similarity
Glycosylationi432 – 4321O-linked (GlcNAc)By similarity
Glycosylationi526 – 5261O-linked (GlcNAc)By similarity
Modified residuei551 – 5511Phosphoserine; by PDPK11 Publication
Modified residuei553 – 5531PhosphoserineBy similarity
Glycosylationi564 – 5641O-linked (GlcNAc)By similarity
Modified residuei568 – 5681Phosphoserine; by CaMK21 Publication
Glycosylationi578 – 5781O-linked (GlcNAc)By similarity
Modified residuei605 – 6051Phosphoserine; by CaMK21 Publication

Post-translational modificationi

Substrate of at least four different protein kinases. Phosphorylation may play a role in the regulation of synapsin-1 in the nerve terminal.2 Publications
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP17599.

PTM databases

UniCarbKBiP17599.

Interactioni

Subunit structurei

Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1. Isoform Ib interacts with PRNP (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-139117.

Structurei

Secondary structure

1
706
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi114 – 1196
Helixi126 – 1305
Turni136 – 1383
Beta strandi141 – 1466
Helixi148 – 1503
Beta strandi151 – 1555
Beta strandi161 – 1699
Turni170 – 1723
Beta strandi173 – 1786
Beta strandi181 – 1855
Beta strandi189 – 1913
Turni192 – 1954
Helixi199 – 2079
Beta strandi212 – 2143
Helixi216 – 2216
Helixi225 – 23915
Turni241 – 2433
Beta strandi250 – 2545
Helixi255 – 2573
Beta strandi262 – 27211
Turni275 – 2784
Beta strandi279 – 2824
Helixi285 – 29612
Turni297 – 2993
Beta strandi302 – 3065
Beta strandi310 – 31910
Beta strandi322 – 3287
Beta strandi345 – 3473
Helixi351 – 36010
Helixi361 – 3655
Beta strandi368 – 37710
Beta strandi382 – 3887
Helixi399 – 41517

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AUVX-ray2.15A/B110-420[»]
1AUXX-ray2.30A/B110-420[»]
ProteinModelPortaliP17599.
SMRiP17599. Positions 112-417.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17599.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2828AAdd
BLAST
Regioni29 – 11284B; linkerAdd
BLAST
Regioni113 – 420308C; actin-binding and synaptic-vesicle bindingAdd
BLAST
Regioni421 – 656236D; Pro-rich linkerAdd
BLAST
Regioni657 – 70650EAdd
BLAST

Domaini

The A region binds phospholipids with a preference for negatively charged species.By similarity

Sequence similaritiesi

Belongs to the synapsin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG284201.
HOGENOMiHOG000231323.
HOVERGENiHBG016354.
InParanoidiP17599.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR028713. SYN1.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR019735. Synapsin_CS.
IPR019736. Synapsin_P_site.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view]
PANTHERiPTHR10841. PTHR10841. 1 hit.
PTHR10841:SF8. PTHR10841:SF8. 1 hit.
PfamiPF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
PF10581. Synapsin_N. 1 hit.
[Graphical view]
PRINTSiPR01368. SYNAPSIN.
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS00415. SYNAPSIN_1. 1 hit.
PS00416. SYNAPSIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform IA (identifier: P17599-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNYLRRRLSD SNFMANLPNG YMTDLQRPQP PPPPPAAPSP GATTGPATAT
60 70 80 90 100
AERASSAAPV ASPAAPSPGS SGGGGFFSSL SNAVKQTTAA AAATFSEQVG
110 120 130 140 150
GGSGGAGRGG AAARVLLVID EPHTDWAKYF KGKKIHGEID IKVEQAEFSD
160 170 180 190 200
LNLVAHANGG FSVDMEVLRN GVKVVRSLKP DFVLIRQHAF SMARNGDYRS
210 220 230 240 250
LVIGLQYAGI PSINSLHSVY NFCDKPWVFA QMVRLHKKLG TEEFPLINQT
260 270 280 290 300
FYPNHKEMLS STTYPVVVKM GHAHSGMGKV KVDNQHDFQD IASVVALTKT
310 320 330 340 350
YATTEPFIDA KYDVRIQKIG QNYKAYMRTS VSGNWKTNTG SAMLEQIAMS
360 370 380 390 400
DRYKLWVDTC SEIFGGLDIC AVEALHGKDG RDHIIQVVGS SMPLIGDHQD
410 420 430 440 450
EDKQLIVELV VNKMAQALPR QRQRDASPGR GSHSQTPSPG ALPLGRQISQ
460 470 480 490 500
QPAGPPAQQR PPPQGGPPQP GPGPQRQGPP LQQRPTPQGQ QHLSGLGPPA
510 520 530 540 550
GSPLPQRLPS PTSVPQQPAS QATPMTQGQG RQSRPVAGGP GAPPATRPPA
560 570 580 590 600
SPSPQRQAGP PQATRQTSVS GQAPPKASGV PPGGQQRQGP PQKPPGPAGP
610 620 630 640 650
TRQASQAGPM PRTGPPTTQQ PRPSGPGPAG RPTKPQLAQK PSQDVPPPAT
660 670 680 690 700
AAAGGPPHPQ LNKSQSLTNA FNLPEPAPPR PSLSQDEVKA ETIRSLRKSF

ASLFSD
Length:706
Mass (Da):74,518
Last modified:February 1, 1996 - v2
Checksum:i89373750BF014340
GO
Isoform IB (identifier: P17599-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     662-670: NKSQSLTNA → KASPAQAQP
     671-706: Missing.

Show »
Length:670
Mass (Da):70,439
Checksum:iD330C4C4E23E2ED1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei662 – 6709NKSQSLTNA → KASPAQAQP in isoform IB. 1 PublicationVSP_006314
Alternative sequencei671 – 70636Missing in isoform IB. 1 PublicationVSP_006315Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27810 mRNA. Translation: AAA30761.1.
M27811 mRNA. Translation: AAA30762.1.
PIRiE30411.
RefSeqiNP_776616.1. NM_174191.2. [P17599-1]
UniGeneiBt.62979.

Genome annotation databases

GeneIDi281510.
KEGGibta:281510.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27810 mRNA. Translation: AAA30761.1 .
M27811 mRNA. Translation: AAA30762.1 .
PIRi E30411.
RefSeqi NP_776616.1. NM_174191.2. [P17599-1 ]
UniGenei Bt.62979.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AUV X-ray 2.15 A/B 110-420 [» ]
1AUX X-ray 2.30 A/B 110-420 [» ]
ProteinModelPortali P17599.
SMRi P17599. Positions 112-417.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-139117.

PTM databases

UniCarbKBi P17599.

Proteomic databases

PRIDEi P17599.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 281510.
KEGGi bta:281510.

Organism-specific databases

CTDi 6853.

Phylogenomic databases

eggNOGi NOG284201.
HOGENOMi HOG000231323.
HOVERGENi HBG016354.
InParanoidi P17599.

Miscellaneous databases

EvolutionaryTracei P17599.
NextBioi 20805477.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProi IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR028713. SYN1.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR019735. Synapsin_CS.
IPR019736. Synapsin_P_site.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR10841. PTHR10841. 1 hit.
PTHR10841:SF8. PTHR10841:SF8. 1 hit.
Pfami PF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
PF10581. Synapsin_N. 1 hit.
[Graphical view ]
PRINTSi PR01368. SYNAPSIN.
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS00415. SYNAPSIN_1. 1 hit.
PS00416. SYNAPSIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins."
    Suedhof T.C., Czernik A.J., Kao H.-T., Takei K., Johnston P.A., Horiuchi A., Kanazir S.D., Wagner M.A., Perin M.S., de Camilli P., Greengard P.
    Science 245:1474-1480(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IA AND IB).
    Tissue: Brain.
  2. "Amino acid sequences surrounding the cAMP-dependent and calcium/calmodulin-dependent phosphorylation sites in rat and bovine synapsin I."
    Czernik A.J., Pang D.T., Greengard P.
    Proc. Natl. Acad. Sci. U.S.A. 84:7518-7522(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-568 AND SER-605.
  3. "Phosphorylation of synapsin I at a novel site by proline-directed protein kinase."
    Hall F.L., Mitchell J.P., Vulliet P.R.
    J. Biol. Chem. 265:6944-6948(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-551 BY PDPK.
  4. "Synapsin I is structurally similar to ATP-utilizing enzymes."
    Esser L., Wang C.-R., Hosaka M., Smagula C.S., Suedhof T.C., Deisenhofer J.
    EMBO J. 17:977-984(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 112-417.

Entry informationi

Entry nameiSYN1_BOVIN
AccessioniPrimary (citable) accession number: P17599
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3