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P17596 (FRDB_WOLSU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fumarate reductase iron-sulfur subunit

EC=1.3.5.1
Gene names
Name:frdB
Ordered Locus Names:WS0830
OrganismWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes) [Complete proteome] [HAMAP]
Taxonomic identifier273121 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor. Ref.2

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster.

Binds 1 3Fe-4S cluster.

Binds 1 4Fe-4S cluster.

Subunit structure

Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur protein, and cytochrome b-556.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 239239Fumarate reductase iron-sulfur subunit
PRO_0000158708

Regions

Domain5 – 95912Fe-2S ferredoxin-type
Domain142 – 171304Fe-4S ferredoxin-type

Sites

Metal binding571Iron-sulfur 1 (2Fe-2S)
Metal binding621Iron-sulfur 1 (2Fe-2S)
Metal binding651Iron-sulfur 1 (2Fe-2S)
Metal binding771Iron-sulfur 1 (2Fe-2S)
Metal binding1511Iron-sulfur 2 (4Fe-4S)
Metal binding1541Iron-sulfur 2 (4Fe-4S)
Metal binding1571Iron-sulfur 2 (4Fe-4S)
Metal binding1611Iron-sulfur 3 (3Fe-4S)
Metal binding2081Iron-sulfur 3 (3Fe-4S)
Metal binding2141Iron-sulfur 3 (3Fe-4S)
Metal binding2181Iron-sulfur 2 (4Fe-4S)

Secondary structure

........................................... 239
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P17596 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 24D1992489B8FFD1

FASTA23927,165
        10         20         30         40         50         60 
MGRMLTIRVF KYDPQSAVSK PHFQEYKIEE APSMTIFIVL NMIRETYDPD LNFDFVCRAG 

        70         80         90        100        110        120 
ICGSCGMMIN GRPSLACRTL TKDFEDGVIT LLPLPAFKLI KDLSVDTGNW FNGMSQRVES 

       130        140        150        160        170        180 
WIHAQKEHDI SKLEERIEPE VAQEVFELDR CIECGCCIAA CGTKIMREDF VGAAGLNRVV 

       190        200        210        220        230 
RFMIDPHDER TDEDYYELIG DDDGVFGCMT LLACHDVCPK NLPLQSKIAY LRRKMVSVN 

« Hide

References

« Hide 'large scale' references
[1]"The fumarate reductase operon of Wolinella succinogenes. Sequence and expression of the frdA and frdB genes."
Lauterbach F., Koertner C., Albracht S.P., Unden G., Kroeger A.
Arch. Microbiol. 154:386-393(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Deletion and site-directed mutagenesis of the Wolinella succinogenes fumarate reductase operon."
Simon J., Gross R., Ringel M., Schmidt E., Kroeger A.
Eur. J. Biochem. 251:418-426(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[3]"Complete genome sequence and analysis of Wolinella succinogenes."
Baar C., Eppinger M., Raddatz G., Simon J., Lanz C., Klimmek O., Nandakumar R., Gross R., Rosinus A., Keller H., Jagtap P., Linke B., Meyer F., Lederer H., Schuster S.C.
Proc. Natl. Acad. Sci. U.S.A. 100:11690-11695(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W.
[4]"Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution."
Lancaster C.R.D., Kroeger A., Auer M., Michel H.
Nature 402:377-385(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
[5]"A third crystal form of Wolinella succinogenes quinol:fumarate reductase reveals domain closure at the site of fumarate reduction."
Lancaster C.R.D., Gross R., Simon J.
Eur. J. Biochem. 268:1820-1827(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ000662 Genomic DNA. Translation: CAA04215.1.
BX571659 Genomic DNA. Translation: CAE09941.1.
PIRC44954.
RefSeqNP_907041.1. NC_005090.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1E7PX-ray3.10B/E/H/K1-239[»]
1QLBX-ray2.33B/E1-239[»]
2BS2X-ray1.78B/E1-239[»]
2BS3X-ray2.19B/E1-239[»]
2BS4X-ray2.76B/E1-239[»]
ProteinModelPortalP17596.
SMRP17596. Positions 1-239.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273121.WS0830.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE09941; CAE09941; WS0830.
GeneID2555194.
KEGGwsu:WS0830.
PATRIC24038706. VBIWolSuc63014_0782.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0479.
HOGENOMHOG000160590.
KOK00245.
OMACHDTCPK.
OrthoDBEOG6CS02W.
ProtClustDBPRK13552.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP17596.

Entry information

Entry nameFRDB_WOLSU
AccessionPrimary (citable) accession number: P17596
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: April 16, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references